Faculty profile

Cynthia Guidos

ResearcherCell and Systems BiologyUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Cynthia Guidos

Researcher

Cell and Systems Biology

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
6 publications in the last five years, latest in 2026.
Principal investigator on 5 research grants (4 CIHR, 1 NSERC), most recently in 2026.
Supervised 1 trainee who won CIHR awards, most recently in 2010.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Mass Cytometry Rna Sequencing Acute Lymphoblastic Leukaemia Companion Biology Study Of Clinical Trial Biospecimens Down Syndrome Immune Profiling Infection-Related Mortality High Dimensional Data Analysis

Latest papers

TGFb signaling instructs a conserved fibrosis-associated cell state marked by LRRC15.
Proceedings of the National Academy of Sciences of the United States of America · 2026
Correction: Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.
Frontiers in immunology · 2026
Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.
Frontiers in immunology · 2026

All 9 publications

Latest funding

Mechanisms of the sex-dependent effect of obesity in enhancing central nervous system autoimmunity
CIHR · 2026 · Co-investigator
$100,000
Preventing infection-related mortality in children with Down syndrome during treatment for acute lymphoblastic leukemia
CIHR · 2026 · Nominated PI
$921,824
Understanding the immunophenotype and genetics of treatment response in children and adolescents with lupus nephritis.
CIHR · 2024 · Co-investigator
$501,076

All 12 grants and awards

9 publications.

TGFb signaling instructs a conserved fibrosis-associated cell state marked by LRRC15.

Shyer JA, Wehbe F, Davidson CD, Bender HS, Thai M, Cox C, Missarova A, Arlantico A, Hall B, Zhang R, Kim D, Altieri A, Hasan S, Namdar A, Chen T, Hakim SW, Guidos C, Brightbill HD, Kuo T, Heimberg G, Corrada Bravo H, Ratsimandresy RA, Uttarwar S, Teng G, Salem O, Arjomandi M, Wilson MS, Darmanis S, Ziai J, Scherl A, Modrusan Z, Wolters PJ, Buechler MB, Vander Heiden JA, Turley SJ

Proceedings of the National Academy of Sciences of the United States of America2026

DOI: 10.1073/pnas.2536550123 PMID: 42160341

Correction: Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.

Liu M, Duan D, Li C, Hu X, Huang J, Tang Y, Palayew S, Zhang L, Pagnoux C, Guidos C, Zhang J, Siminovitch K

Frontiers in immunology2026

DOI: 10.3389/fimmu.2026.1874627 PMID: 42212142

Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.

Liu M, Duan D, Li C, Hu X, Huang J, Tang Y, Palayew S, Zhang L, Pagnoux C, Guidos C, Zhang J, Siminovitch K

Frontiers in immunology2026

DOI: 10.3389/fimmu.2026.1726107 PMID: 41972183

Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.

Dervovic D, Malik AA, Chen ELY, Narimatsu M, Adler N, Afiuni-Zadeh S, Krenbek D, Martinez S, Tsai R, Boucher J, Berman JM, Teng K, Ayyaz A, Lü Y, Mbamalu G, Loganathan SK, Lee J, Zhang L, Guidos C, Wrana J, Valipour A, Roux PP, Reimand J, Jackson HW, Schramek D

Nature communications2023

DOI: 10.1038/s41467-023-41255-0 PMID: 37670013

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.

Nature communications2023

DOI: 10.1038/s41467-023-38841-7 PMID: 37258521

Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy.

Boukhaled GM, Gadalla R, Elsaesser HJ, Abd-Rabbo D, Quevedo R, Yang SYC, Guo M, Wang BX, Noamani B, Gray D, Lau SCM, Taylor K, Aung K, Spreafico A, Hansen AR, Saibil SD, Hirano N, Guidos C, Pugh TJ, McGaha TL, Ohashi PS, Sacher AG, Butler MO, Brooks DG

Nature immunology2022

DOI: 10.1038/s41590-022-01262-7 PMID: 35835962

An Integrated Analysis of Heterogeneous Drug Responses in Acute Myeloid Leukemia That Enables the Discovery of Predictive Biomarkers.

Chen WC, Yuan JS, Xing Y, Mitchell A, Mbong N, Popescu AC, McLeod J, Gerhard G, Kennedy JA, Bogdanoski G, Lauriault S, Perdu S, Merkulova Y, Minden MD, Hogge DE, Guidos C, Dick JE, Wang JC

Cancer research2016

DOI: 10.1158/0008-5472.can-15-2743 PMID: 26833125

Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis.

Suliman S, Tan J, Xu K, Kousis PC, Kowalski PE, Chang G, Egan SE, Guidos C

PloS one2011Senior author

DOI: 10.1371/journal.pone.0024937 PMID: 21931869

Thymus and T-lymphocyte development: what is new in the 21st century?

Guidos C

Immunological reviews2006First author

DOI: 10.1111/j.0105-2896.2006.00368.x PMID: 16448530

Mechanisms of the sex-dependent effect of obesity in enhancing central nervous system autoimmunity

Co-investigatorCIHR2026Pr. Gr.- PA: Sex/Gender in Health Res.- Understanding sex/gender mech./processes

Principal investigators: Dunn, Shannon E

Keywords: Autoimmunity; Diet-Obesity; Experimental Autoimmune Encephalomyelitis; Mice; Multiple Sclerosis; T Cells; Type I Ifns

$100,000

Preventing infection-related mortality in children with Down syndrome during treatment for acute lymphoblastic leukemia

Nominated PICIHR2026Project Grant

Principal investigators: Guidos, Cynthia J

Keywords: Acute Lymphoblastic Leukaemia; Companion Biology Study Of Clinical Trial Biospecimens; Down Syndrome; Immune Profiling; Infection-Related Mortality

$921,824

Understanding the immunophenotype and genetics of treatment response in children and adolescents with lupus nephritis.

Co-investigatorCIHR2024Project Grant

Principal investigators: Hiraki, Linda T

Keywords: Child/Adolescent Health; Disease Activity; Genetics; Kidney Pathology; Lupus Nephritis; Outcomes; Predictors; Single Cell Studies; Systemic Lupus Erythematosus; Treatment Response

$501,076

Autoimmunity as a novel mechanism in post-COVID syndrome

Co-investigatorCIHR2021Op Grant: Emerging COVID-19 Research Gaps & Priorities - Post COVID-19 condition

Principal investigators: Baker, Andrew J; Dos Santos, Claudia C

Keywords: Autoantibodies; Autoimmunity; Covid-19; Critical Care; Immune Profiling; Longitudinal Sampling; Organ Dysfunction; Post-Covid Syndrome; Sars-Cov-2

Targeting the immune landscape at presentation and relapse of Immune-Related Lobular Breast Cancer

Co-investigatorCIHR2019Project Grant

Principal investigators: Egan, Sean E

Keywords: Breast Cancer; Combination Therapy; Estrogen Receptor; Immune Checkpoint Therapy; Immunotherapy; Lobular Breast Cancer; Metastasis; Mouse Modeling; Progression; Recurrence

$956,250

High Dimensional Characterization of Effector-Memory T Lymphocytes in Early Life

Nominated PICIHR2019Project Grant

Principal investigators: Guidos, Cynthia J

Keywords: High Dimensional Data Analysis; Human T Cells; Mass Cytometry; Mouse Models; Neonatal Immunity; Notch Signaling; Rna Sequencing; T Lymphocyte Development; Thymus; Unconventional T Cells

$898,876

Mechanistic studies of macrophages and the tumour microenvironment as immunologic barriers to therapy in pancreatic ductal adenocarcinoma

Co-investigatorCIHR2018Project Grant

Principal investigators: McGaha, Tracy

Keywords: Macrophage And Dendritic Cells; Pancreatic Cancer; Stress Signaling; Tumor Immunology

$1,059,525

Standardization of Immuno-analytic Platforms for Autoimmunity Research (SIPAR)

Nominated PICIHR2017Team Grant: Human Immunology Initiative: Standardization Core - LOI

Principal investigators: Guidos, Cynthia J

Keywords: Autoimmune Disease; Bioinformatics; Flow Cytometry; Gene Expression Profiling; Immune Phenotyping; Mass Cytometry; Rna Sequencing

$25,000

Advanced Multi-Parameter Allograft Monitoring In Human Lung Transplantation

Co-investigatorCIHR2016Project Grant

Principal investigators: Martinu, Tereza; Juvet, Stephen C

Keywords: Biomarker; Bronchiolitis Obliterans; Chronic Lung Allograft Dysfunction; Epithelial Injury; Flow Cytometry; Immunology; Lung Transplantation; Mass Cytometry; Microarray; Rejection

$100,000

Functions of Notch Signaling in Marginal Zone B Cell Differentiation and Homeostasis

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Guidos, Cynthia

$265,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Cynthia Guidos

Research

Latest papers

Latest funding

TGFb signaling instructs a conserved fibrosis-associated cell state marked by LRRC15.

Correction: Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.

Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.

Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.

Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy.

An Integrated Analysis of Heterogeneous Drug Responses in Acute Myeloid Leukemia That Enables the Discovery of Predictive Biomarkers.

Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis.

Thymus and T-lymphocyte development: what is new in the 21st century?

Mechanisms of the sex-dependent effect of obesity in enhancing central nervous system autoimmunity

Preventing infection-related mortality in children with Down syndrome during treatment for acute lymphoblastic leukemia

Understanding the immunophenotype and genetics of treatment response in children and adolescents with lupus nephritis.

Autoimmunity as a novel mechanism in post-COVID syndrome

Targeting the immune landscape at presentation and relapse of Immune-Related Lobular Breast Cancer

High Dimensional Characterization of Effector-Memory T Lymphocytes in Early Life

Mechanistic studies of macrophages and the tumour microenvironment as immunologic barriers to therapy in pancreatic ductal adenocarcinoma

Standardization of Immuno-analytic Platforms for Autoimmunity Research (SIPAR)

Advanced Multi-Parameter Allograft Monitoring In Human Lung Transplantation

Functions of Notch Signaling in Marginal Zone B Cell Differentiation and Homeostasis

Frequent collaborators

Katherine Siminovitch

Jeffrey Wrana

Li Zhang

Daniel Schramek

Anna Spreafico

Naoto Hirano

Cynthia Guidos

Research

Latest papers

Latest funding

TGFb signaling instructs a conserved fibrosis-associated cell state marked by LRRC15.

Correction: Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.

Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.

Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.

Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy.

An Integrated Analysis of Heterogeneous Drug Responses in Acute Myeloid Leukemia That Enables the Discovery of Predictive Biomarkers.

Notch3 is dispensable for thymocyte &#x3b2;-selection and Notch1-induced T cell leukemogenesis.

Thymus and T-lymphocyte development: what is new in the 21st century?

Functions of Notch Signaling in Marginal Zone B Cell Differentiation and Homeostasis

Frequent collaborators

Katherine Siminovitch

Jeffrey Wrana

Li Zhang

Daniel Schramek

Anna Spreafico

Naoto Hirano

Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis.