Faculty profile

Jeffrey Wrana

ResearcherLunenfeld-Tanenbaum Research InstituteUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Jeffrey Wrana

Researcher

Lunenfeld-Tanenbaum Research Institute

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
6 publications in the last five years, latest in 2025.
Principal investigator on 11 research grants (10 CIHR, 1 NSERC), most recently in 2023.
Supervised 6 trainees who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Adult Stem Cells Cell Signalling Intestinal Organoids Intestinal Regeneration Smurf Ubiquitin Ligases Tgf-Beta Signalling Epithelial Regeneration Fibroblasts

Latest papers

Modelling the liver's regenerative capacity across different clinical conditions.
JHEP reports : innovation in hepatology · 2025
Long-Term Recurrence Risk, Metastatic Potential, and Length of Cystoscopic Surveillance of Low-Grade Nonmuscle-Invasive Bladder Cancer.
The Journal of urology · 2025
Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.
Nature communications · 2023

All 8 publications

Latest funding

Impact of chronic inflammation on intestinal fibroblasts and colorectal cancer initiation
CIHR · 2023 · Supervisor
$135,000
Regulation of Intestinal Stem Cell Dynamics by Smurf Ubiquitin Ligases
CIHR · 2023 · Nominated PI
$1,128,375
Regulation of Mesenchymal Function by Hippo Signalling in the Intestine
CIHR · 2022 · Nominated PI
$1,071,000

All 27 grants and awards

8 publications.

Modelling the liver's regenerative capacity across different clinical conditions.

Nguyen-Lefebvre AT, Ghosh S, Baciu C, Hasjim BJ, Naimimohasses S, Oldani G, Pasini E, Brudno M, Selzner N, Wrana J, Bhat M

JHEP reports : innovation in hepatology2025

DOI: 10.1016/j.jhepr.2025.101465 PMID: 40704068

Long-Term Recurrence Risk, Metastatic Potential, and Length of Cystoscopic Surveillance of Low-Grade Nonmuscle-Invasive Bladder Cancer.

Villegas E, Lajkosz K, Din S, Kuk C, Chan A, Kwong JCC, Vitug C, Gao B, Hemminki O, Kot D, Misurka J, Black PC, Jewett M, Soloway MS, Roupret M, Compérat E, Sweet J, Seisen T, Fleshner NE, Wrana J, van der Kwast TH, Kulkarni GS, Zlotta AR

The Journal of urology2025

DOI: 10.1097/ju.0000000000004305 PMID: 39470318

Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.

Dervovic D, Malik AA, Chen ELY, Narimatsu M, Adler N, Afiuni-Zadeh S, Krenbek D, Martinez S, Tsai R, Boucher J, Berman JM, Teng K, Ayyaz A, Lü Y, Mbamalu G, Loganathan SK, Lee J, Zhang L, Guidos C, Wrana J, Valipour A, Roux PP, Reimand J, Jackson HW, Schramek D

Nature communications2023

DOI: 10.1038/s41467-023-41255-0 PMID: 37670013

Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.

Chan B, Glogauer M, Wang Y, Wrana J, Chan K, Beier F, Bali S, Hinz B, Parreno J, Ashraf S, Kandel R

Science advances2023

DOI: 10.1126/sciadv.adf1130 PMID: 37540756

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.

Nature communications2023

DOI: 10.1038/s41467-023-38841-7 PMID: 37258521

A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.

Yanchus C, Drucker KL, Kollmeyer TM, Tsai R, Winick-Ng W, Liang M, Malik A, Pawling J, De Lorenzo SB, Ali A, Decker PA, Kosel ML, Panda A, Al-Zahrani KN, Jiang L, Browning JWL, Lowden C, Geuenich M, Hernandez JJ, Gosio JT, Ahmed M, Loganathan SK, Berman J, Trcka D, Michealraj KA, Fortin J, Carson B, Hollingsworth EW, Jacinto S, Mazrooei P, Zhou L, Elia A, Lupien M, He HH, Murphy DJ, Wang L, Abyzov A, Dennis JW, Maass PG, Campbell K, Wilson MD, Lachance DH, Wrensch M, Wiencke J, Mak T, Pennacchio LA, Dickel DE, Visel A, Wrana J, Taylor MD, Zadeh G, Dirks P, Eckel-Passow JE, Attisano L, Pombo A, Ida CM, Kvon EZ, Jenkins RB, Schramek D

Science (New York, N.Y.)2022

DOI: 10.1126/science.abj2890 PMID: 36201590

Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.

Bernard D, Gebbia M, Prabha S, Gronda M, MacLean N, Wang X, Hurren R, Sukhai MA, Cho EE, Manolson MF, Datti A, Wrana J, Minden MD, Al-Awar R, Aman A, Nislow C, Giaever G, Schimmer AD

Apoptosis : an international journal on programmed cell death2015

DOI: 10.1007/s10495-015-1123-3 PMID: 25832785

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

Eberhard Y, McDermott SP, Wang X, Gronda M, Venugopal A, Wood TE, Hurren R, Datti A, Batey RA, Wrana J, Antholine WE, Dick JE, Schimmer AD

Blood2009

DOI: 10.1182/blood-2009-03-209965 PMID: 19589922

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Jeffrey Wrana

Research

Latest papers

Latest funding

Modelling the liver's regenerative capacity across different clinical conditions.

Long-Term Recurrence Risk, Metastatic Potential, and Length of Cystoscopic Surveillance of Low-Grade Nonmuscle-Invasive Bladder Cancer.

Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.

Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.

A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.

Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

Impact of chronic inflammation on intestinal fibroblasts and colorectal cancer initiation

Regulation of Intestinal Stem Cell Dynamics by Smurf Ubiquitin Ligases

Regulation of Mesenchymal Function by Hippo Signalling in the Intestine

Phenotypic diversity of intestinal fibroblasts in health and disease

The role of NOD2 in intestinal regeneration following injury

Mapping the Emergence and Functional Impact of Novel SARS-CoV-2 Variants

Development of high throughput, inexpensive and scalable testing to detect SARS-CoV-2 antibodies using home blood collection kits and a fully automated ELISA antibody assay

Regenerative plasticity in colorectal cancer

The Discovery and Optimization of NUAK Inhibitors: A Novel Approach to Target Hippo Pathway Driven Cancers

A vascularized human organoid platform for disease modelling and preclinical testing

Frequent collaborators

Daniel Schramek

Cynthia Guidos

Li Zhang

Ahmed Aman

Mamatha Bhat

Kieran Campbell

Lily Zhou

Michael Glogauer

Tak Mak

Gelareh Zadeh

Boris Hinz

Rita Kandel

Frank Beier

Mathieu Lupien

Michael Brudno

Liliana Attisano

Nazia Selzner