Hong-Shuo Sun, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Animal Models Cerebral Ischemia Cerebrovascular Diseases Clc-3 Chloride Channels In-Vivo Ion Channels Neuroprotection Stroke

Latest papers

TRPM7 kinase: a target for multimodal drug development in neurological disorders.
Acta pharmacologica Sinica · 2026 · senior author
Natural product-derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges.
British journal of pharmacology · 2026 · senior author
Targeting the mitochondrial thermogenesis pathway for neuroprotection in neonatal hypoxic-ischemic encephalopathy by curcumin.
Acta pharmacologica Sinica · 2026 · senior author

All 111 publications

Latest funding

Targeting Ryanodine Receptor 2 for Treating Neonatal Hypoxic-ischemic Brain Injury (HIBI)
CIHR · 2023 · Co-investigator
$1,132,200
Role of TRPM7 in Neuronal Development and Neurobiology Functions
NSERC · 2022 · Principal investigator
$84,000
Role of TRPM7 and TRPM2 Channels in Neuronal Development and Regeneration
NSERC · 2016 · Principal investigator
$155,000

All 6 grants and awards

111 publications.

01

TRPM7 kinase: a target for multimodal drug development in neurological disorders.

Zhang XY, Ho HL, Feng ZP, Sun HS

Acta pharmacologica Sinica2026Senior author

DOI: 10.1038/s41401-026-01810-z PMID: 42191897

02

Natural product-derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges.

Zhang X, Ho HL, Horgen FD, Fleig A, Feng ZP, Sun HS

British journal of pharmacology2026Senior author

DOI: 10.1111/bph.70667 PMID: 42760099

03

Targeting the mitochondrial thermogenesis pathway for neuroprotection in neonatal hypoxic-ischemic encephalopathy by curcumin.

Wang X, Zhang B, Eide S, Zhang XY, Yang M, Feng ZP, Sun HS

Acta pharmacologica Sinica2026Senior author

DOI: 10.1038/s41401-026-01813-w PMID: 42162312

04

TRPM7 kinase inhibitor TG100-115 provides neuroprotection against neonatal hypoxic-ischemic brain injury.

Zhang XY, Ho HL, Luo ZW, Horgen FD, Romo D, Hull KG, Fleig A, Feng ZP, Sun HS

Acta pharmacologica Sinica2026Senior author

DOI: 10.1038/s41401-026-01775-z PMID: 42045381

05

Inhibiting the transient receptor potential melastatin 2 channel in microglia: current evidence and therapeutic potential in neurological disorders.

Ferreira AFF, Feng ZP, Sun HS, Britto LRG

Acta pharmacologica Sinica2026

DOI: 10.1038/s41401-026-01797-7 PMID: 42020790

06

From calcium signaling to cardiovascular pharmacology: TRPM7 as a key mechanistic regulator and emerging pharmacological focus.

Zhang XY, Ho HL, Feng ZP, Sun HS

Acta pharmacologica Sinica2026Senior author

DOI: 10.1038/s41401-026-01800-1 PMID: 41951773

07

Therapeutic potential of KATP channels in the attenuation of Parkinson's disease pathogenesis and progression - A review.

Gundi B, Ho HL, Zhang X, He A, Xin D, Ferreira AFF, Britto LR, Feng ZP, Sun HS

Neurochemistry international2026Senior author

DOI: 10.1016/j.neuint.2025.106091 PMID: 41275920

08

Pharmacophore Directed Retrosynthesis Applied to Waixenicin A: Synthesis and Bioactivity of Derivatives Bearing a Minimal Proposed Pharmacophore.

Parris MR, Suzuki S, Kiledal SA, Gong XB, Zhang X, Penner R, Sun HS, Feng ZP, Horgen FD, Fleig A, Hull KG, Romo D

Organic letters2026

DOI: 10.1021/acs.orglett.6c01502 PMID: 42276815

09

SNAP-23 mediated vesicular trafficking in oligodendrocytes is necessary to maintain adult myelin integrity in mice.

Chow CH, Huang M, Regmi A, Rai J, Harada H, Eide S, Sun HS, Feng ZP, Monnier PP, Okamoto K, Zhang L, Rojas OL, Sugita S

Nature communications2026

DOI: 10.1038/s41467-026-73381-w PMID: 42185264

10

Distinct Proteomic Brain States Underlying Long-Term Memory Formation in Aversive Operant Conditioning.

Bandura J, Chan C, Sun HS, Wheeler AR, Feng ZP

Journal of proteome research2025

DOI: 10.1021/acs.jproteome.4c00055 PMID: 39658033

Targeting Ryanodine Receptor 2 for Treating Neonatal Hypoxic-ischemic Brain Injury (HIBI)

Co-investigatorCIHR2023Project Grant

Principal investigators: Feng, Zhong-Ping; Chen, Sui Rong W

Keywords: Calcium Releasing Channel; Drug Development; Genetic Manipulation; Hypoxic Ischemic Brain Injury; Neonatal Stroke; Ryanodine Receptor

$1,132,200

Role of TRPM7 in Neuronal Development and Neurobiology Functions

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Sun, Hong-Shuo

$84,000

Role of TRPM7 and TRPM2 Channels in Neuronal Development and Regeneration

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Sun, HongShuo

$155,000

The Role of Chloride Channel ClC-3 in Cerebral Ischemia and Its Therapeutic Potential in Stroke

Nominated PICIHR2013China-Canada Joint Health Research Initiative

Principal investigators: Sun, Hong-Shuo; Wang, GUAN-LEI

Keywords: Animal Models; Cerebral Ischemia; Cerebrovascular Diseases; Clc-3 Chloride Channels; In-Vivo; Ion Channels; Neuroprotection; Stroke; Treatment; Volume-Regulated Aion Channels

$225,000

The role of TRPM7 channel in neurite outgrowth during development and regeneration following injury.

SupervisorCIHR2013Master's Award: Canada Graduate Scholarships

Principal investigators: Turlova, Ekaterina

Keywords: Immunoblot; Immunocytochemistry; Laser Confocal Microscopy; Neuronal Development; Neuronal Outgrowth; Neuronal Regeneration; Primary Cell Culture; Virus-Mediated Gene Silencing

$17,500

Role of TRPM7 and TRPM2 channels in neuronal development and regeneration

Principal investigatorNSERC2011Discovery Grants Program - Individual

Principal investigators: Sun, HongShuo

$165,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Division of Anatomy
Physiology
Mechanical Engineering
Cardiovascular Surgery
Department of Laboratory Medicine and Pathobiology
Surgery
Department of Pharmacology and Toxicology
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Armand Keating

Mechanical Engineering

2 shared papers, latest 2008

Ren-Ke Li

Cardiovascular Surgery

2 shared papers, latest 2008

Zhaolei Zhang

Terrence Donnelly Centre for Cellular and Biomolecular Research

1 shared papers, latest 2021

Michelle Arnot

Department of Pharmacology and Toxicology

1 shared papers, latest 2011

Daniel Winer

Department of Laboratory Medicine and Pathobiology

1 shared papers, latest 2018

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2022

Subject: Prospective PhD student: Animal Models Dear Professor Sun, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "TRPM7 kinase: a target for multimodal drug development in neurological disorders." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Role of TRPM7 in Neuronal Development and Neurobiology Functions" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Hong-Shuo Sun

Research

Latest papers

Latest funding

TRPM7 kinase: a target for multimodal drug development in neurological disorders.

Natural product-derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges.

Targeting the mitochondrial thermogenesis pathway for neuroprotection in neonatal hypoxic-ischemic encephalopathy by curcumin.

TRPM7 kinase inhibitor TG100-115 provides neuroprotection against neonatal hypoxic-ischemic brain injury.

Inhibiting the transient receptor potential melastatin 2 channel in microglia: current evidence and therapeutic potential in neurological disorders.

From calcium signaling to cardiovascular pharmacology: TRPM7 as a key mechanistic regulator and emerging pharmacological focus.

Therapeutic potential of KATP channels in the attenuation of Parkinson's disease pathogenesis and progression - A review.

Pharmacophore Directed Retrosynthesis Applied to Waixenicin A: Synthesis and Bioactivity of Derivatives Bearing a Minimal Proposed Pharmacophore.

SNAP-23 mediated vesicular trafficking in oligodendrocytes is necessary to maintain adult myelin integrity in mice.

Distinct Proteomic Brain States Underlying Long-Term Memory Formation in Aversive Operant Conditioning.

Targeting Ryanodine Receptor 2 for Treating Neonatal Hypoxic-ischemic Brain Injury (HIBI)

Role of TRPM7 in Neuronal Development and Neurobiology Functions

Role of TRPM7 and TRPM2 Channels in Neuronal Development and Regeneration

The Role of Chloride Channel ClC-3 in Cerebral Ischemia and Its Therapeutic Potential in Stroke

The role of TRPM7 channel in neurite outgrowth during development and regeneration following injury.

Role of TRPM7 and TRPM2 channels in neuronal development and regeneration

Frequent collaborators

Zhong-Ping Feng

Michael Tymianski

Shuzo Sugita

Tianru Jin

Kenichi Okamoto

Armand Keating

Ren-Ke Li

Zhaolei Zhang

Michelle Arnot

GUAN-LEI Wang

Minna Woo

Kang Lee

Daniel Winer