David Andrews, University of Toronto

Research

Apoptosis Bcl-2 Family Proteins Fluorescence Spectroscopy Bh3-Mimetics Bh3-Proteins Fluorescence Imaging Fluorescence Lifetime Imaging Microscopy Programmed Cell Death

Latest papers

Cancer-Associated BCL-2 Mutants Reveal Mechanisms Towards Venetoclax Resistance.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
VB-84922 is a small molecule that inhibits ER-to-golgi transport of SREBPs-SCAP complexes.
Frontiers in pharmacology · 2026
Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.
Journal of molecular biology · 2021

All 8 publications

Latest funding

Regulation of programmed cell death by BH3-proteins Bim and Puma
CIHR · 2022 · Nominated PI
$879,750
Canada Research Chair Tier 1
CIHR · 2015 · Nominated PI
$1,400,000
Assembly of apoptotic as well as additional protein complexes on sub-cellular membranes
CIHR · 2014 · Nominated PI
$2,680,207

All 15 grants and awards

8 publications.

01

Cancer-Associated BCL-2 Mutants Reveal Mechanisms Towards Venetoclax Resistance.

Aufdermauer J, de Ridder I, Ehsani M, Khan M, Kale J, Frenzel LP, Andrews D, Karamanou S, Garcia-Saez AJ, Bultynck G

Advanced science (Weinheim, Baden-Wurttemberg, Germany)2026

DOI: 10.1002/advs.76693 PMID: 42496044

02

VB-84922 is a small molecule that inhibits ER-to-golgi transport of SREBPs-SCAP complexes.

Corbalan JJ, Schormann W, Jagadeesan P, Kale J, Huang YC, Siegel R, Beasley JR, Tung JP, Nohturfft A, Andrews D, Nickels JT

Frontiers in pharmacology2026

DOI: 10.3389/fphar.2026.1732319 PMID: 41953197

03

Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.

Saraon P, Snider J, Schormann W, Rai A, Radulovich N, Sánchez-Osuna M, Coulombe-Huntington J, Huard C, Mohammed M, Lima-Fernandes E, Thériault B, Halabelian L, Chan M, Joshi D, Drecun L, Yao Z, Pathmanathan S, Wong V, Lyakisheva A, Aboualizadeh F, Niu L, Li F, Kiyota T, Subramanian R, Joseph B, Aman A, Prakesch M, Isaac M, Mamai A, Poda G, Vedadi M, Marcellus R, Uehling D, Leighl N, Sacher A, Samaržija M, Jakopović M, Arrowsmith C, Tyers M, Tsao MS, Andrews D, Al-Awar R, Stagljar I

Journal of molecular biology2021

DOI: 10.1016/j.jmb.2021.167294 PMID: 34662547

04

Evidence Implicating Immunological Host Effects in the Efficacy of Metronomic Low-Dose Chemotherapy.

Shaked Y, Pham E, Hariharan S, Magidey K, Beyar-Katz O, Xu P, Man S, Wu FT, Miller V, Andrews D, Kerbel RS

Cancer research2016

DOI: 10.1158/0008-5472.can-16-0136 PMID: 27569209

05

Small molecules reveal an alternative mechanism of Bax activation

Brahmbhatt H, Uehling D, Al-awar R, Leber B, Andrews D

Biochemical Journal201637 citationsSenior author

DOI: 10.1042/bcj20160118

06

Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells

Oppermann S, Lam AJ, Tung S, Shi Y, McCaw L, Wang G, Ylanko J, Leber B, Andrews D, Spaner DE

Oncotarget201618 citationsOpen Access

DOI: 10.18632/oncotarget.11618 PMID: W2509041004

07

Chapter One Examining the Molecular Mechanism of Bcl-2 Family Proteins at Membranes by Fluorescence Spectroscopy

Kale J, Chi X, Leber B, Andrews D

Methods in Enzymology201436 citationsSenior author

DOI: 10.1016/b978-0-12-417158-9.00001-7

08

Involvement of ApoE E4 and H63D in sporadic Alzheimer's disease in a folate-supplemented Ontario population.

Percy M, Moalem S, Garcia A, Somerville MJ, Hicks M, Andrews D, Azad A, Schwarz P, Beheshti Zavareh R, Birkan R, Choo C, Chow V, Dhaliwal S, Duda V, Kupferschmidt AL, Lam K, Lightman D, Machalek K, Mar W, Nguyen F, Rytwinski PJ, Svara E, Tran M, Wheeler K, Yeung L, Zanibbi K, Zener R, Ziraldo M, Freedman M

Journal of Alzheimer's disease : JAD2008

DOI: 10.3233/jad-2008-14107 PMID: 18525129

Regulation of programmed cell death by BH3-proteins Bim and Puma

Nominated PICIHR2022Project Grant

Principal investigators: Andrews, David W

Keywords: Apoptosis; Bcl-2 Family Proteins; Bh3-Mimetics; Bh3-Proteins; Fluorescence Imaging; Fluorescence Lifetime Imaging Microscopy; Fluorescence Spectroscopy; Programmed Cell Death

$879,750

Canada Research Chair Tier 1

Nominated PICIHR2015Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Andrews, David F

Keywords: Crc

$1,400,000

Assembly of apoptotic as well as additional protein complexes on sub-cellular membranes

Nominated PICIHR2014Foundation Grant

Principal investigators: Andrews, David W

Keywords: Apoptosis; Bcl-2 Family Proteins; Chemotherapy Of Cancer; Fluorescence Lifetime Imaging; Fluorescence Microscopy; Fluorescence Spectroscopy; Protein Protein Interactions; Subcellular Localization; Tail-Anchor Proteins; Therapeutic Development

$2,680,207

Statistical computing access facility

Co-investigatorNSERC2001Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Reid, Nancy

$48,847

Practical statistical procedures

Principal investigatorNSERC2000Discovery Grants Program - Individual

Principal investigators: Andrews, David

$64,000

Statistical computing facility

Co-investigatorNSERC1999Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Reid, Nancy

$76,000

Mathematics of Information Technology and Complex Systems (MITACS)

Co-investigatorNSERC1998Networks of Centres of Excellence

Principal investigators: Halperin, Stephen

$18,992,250

Statistical computing facility

Co-investigatorNSERC1997Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Evans, Michael

$50,420

Statistical computing facility

Co-investigatorNSERC1995Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Evans, Michael

$42,104

Practical statistical procedures

Principal investigatorNSERC1995Discovery Grants Program - Individual

Principal investigators: Andrews, David

$49,200

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biostatistics Division
Medicine
Department of Medical Biophysics
Biochemistry
Department of Laboratory Medicine and Pathobiology
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Brian Leber

Medicine

3 shared papers, latest 2016

Adrian Sacher

Faculty

1 shared papers, latest 2021

David Uehling

Faculty

1 shared papers, latest 2016

Cheryl Arrowsmith

Department of Medical Biophysics

1 shared papers, latest 2021

Igor Stagljar

Biochemistry

1 shared papers, latest 2021

Ming-Sound Tsao

Department of Laboratory Medicine and Pathobiology

1 shared papers, latest 2021

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Apoptosis Dear Professor Andrews, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Cancer-Associated BCL-2 Mutants Reveal Mechanisms Towards Venetoclax Resistance." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Regulation of programmed cell death by BH3-proteins Bim and Puma" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]