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Cheryl Arrowsmith

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ProfessorDepartment of Medical BiophysicsUniversity of Toronto

Cheryl Arrowsmith

Professor

Department of Medical Biophysics

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

ORCID

Supervision signals

Professors usually supervise graduate students in their department's programs.
17 publications in the last five years, latest in 2026.
Principal investigator on 11 research grants (8 CIHR, 3 NSERC), most recently in 2023.
Supervised 9 trainees who won CIHR awards, most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Education

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Epigenetics Structural Biology Biochemistry Chemical Probes Epigenomic Mapping Targeted Protein Degradation (Protacs)Targeted Protein Degradation Chemical Biology

Latest papers

Site-Specific Hydrogen-Deuterium Exchange Mass Spectrometry for Deep Explorations of Dynamic Shifts in Protein-Drug Interactions.
Journal of the American Chemical Society · 2026
An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions.
bioRxiv : the preprint server for biology · 2026
A synergistic interaction between PRMT5 and LSD1 inhibitors in AML.
Science advances · 2026

All 34 publications

Latest funding

Characterization of the role of the NSD2 methyltransferase for SCLC progression
CIHR · 2025 · Supervisor
$140,000
Finding vulnerabilities in advanced breast cancer from the chromatin state of repeat DNA
CIHR · 2025 · Co-investigator
$1,147,500
Mapping and Modulating Airway Type II Transmembrane Serine Protease Activity to Identify Antiviral Drug Targets
CIHR · 2025 · Supervisor
$140,000

All 33 grants and awards

34 publications.

Site-Specific Hydrogen-Deuterium Exchange Mass Spectrometry for Deep Explorations of Dynamic Shifts in Protein-Drug Interactions.

Anacleto J, Wolf E, Ackloo S, Arrowsmith C, LeBlanc Y, Lento C, Wilson DJ

Journal of the American Chemical Society2026

DOI: 10.1021/jacs.6c03259 PMID: 42420201

An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions.

Madhu P, Benz C, Simonetti L, Winters MJ, Subbanna MS, Kliche J, Gomez-Lucas L, Kotb HM, Krystkowiak I, Segal D, Darling WTP, Larsen-Ledet S, Vieler M, Zupancic A, Konstantinou A, Mihalic F, Varga JK, Pagano L, Lüchow S, Kraemer A, Ellingboe L, Görlitz K, Righetto GL, Kossmann C, Xiong R, Schueler-Furman O, Halabelian L, Santhakumar V, Arrowsmith C, Knapp S, Erdelyi M, Stein A, Vincentelli R, Pryciak PM, Davey NE, Ivarsson Y

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.07.03.735260 PMID: 42465437

A synergistic interaction between PRMT5 and LSD1 inhibitors in AML.

Param NJ, Arceci E, Fiorentino F, Pignata L, Torre D, Gutiérrez-Trejo N, Fong JY, Goy PA, Han BY, Lambona C, Di Bello E, Castiello C, Barone M, Schwarz M, Arrowsmith C, Ito K, Scherle P, Wee DKB, Ndoye S, Tabaglio T, Jeyasekharan AD, Lakshmanan M, Cirilli R, Habisch H, Madl T, Mattevi A, Valente S, Mai A, Guccione E

Science advances2026

DOI: 10.1126/sciadv.aea4059 PMID: 41894488

Development of a Dual Chemical Probe for the USP16 and HDAC6 Zinc-Finger Ubiquitin-Binding Domain.

Silva M, Mann M, Mirabi B, Szewczyk MM, Loup J, Dupeux A, Chandrasekaran R, Bajohr J, Arrowsmith C, Schapira M, Lautens M, Barsyte-Lovejoy D, Harding RJ, Santhakumar V

Journal of medicinal chemistry2026

DOI: 10.1021/acs.jmedchem.5c02976 PMID: 41718545

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.

Herasymenko O, Silva M, Correy GJ, Abu-Saleh AAA, Ackloo S, Arrowsmith C, Ashworth A, Ban F, Beck H, Bishop KP, Bohórquez HJ, Bolotokova A, Breznik M, Chau I, Chen Y, Cherkasov A, Dehaen W, Della Corte D, Denzinger K, Doering NP, Edfeldt K, Edwards A, Fayne D, Gentile F, Gibson E, Gokdemir O, Gunnarsson A, Günther J, Irwin JJ, Jensen JH, Harding RJ, Hillisch A, Hoffer L, Hogner A, Hutchinson A, Kandwal S, Karlova A, Koirala K, Kotelnikov S, Kozakov D, Lee J, Lee S, Lessel U, Liu S, Liu X, Loppnau P, Meiler J, Moretti R, Moroz YS, Muvva C, Oprea TI, Paige B, Pandit A, Park K, Poda G, Protopopov MV, Pütter V, Ravichandran R, Rognan D, Rosta E, Sabnis Y, Scott T, Seitova A, Sharma P, Sindt F, Song M, Steinmann C, Stevens R, Talagayev V, Tararina VV, Tarkhanova O, Tingey D, Trant JF, Treleaven D, Tropsha A, Walters P, Wells J, Westermaier Y, Wolber G, Wortmann L, Zheng S, Fraser JS, Schapira M

Journal of chemical information and modeling2026

DOI: 10.1021/acs.jcim.5c02441 PMID: 41565251

Site-Specific Hydrogen Deuterium Exchange Difference Mass Spectrometry Measurements for Ligand Binding.

Anacleto J, Ackloo S, Arrowsmith C, Wolf E, Leblanc Y, Lento C, Wilson DJ

Journal of the American Society for Mass Spectrometry2025

DOI: 10.1021/jasms.5c00229 PMID: 40952355

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

Herasymenko O, Silva M, Abu-Saleh AAA, Ahmad A, Alvarado-Huayhuaz J, Arce OEA, Armstrong RJ, Arrowsmith C, Bachta KE, Beck H, Berta D, Bieniek MK, Blay V, Bolotokova A, Bourne PE, Breznik M, Brown PJ, Campbell ADG, Carosati E, Chau I, Cole DJ, Cree B, Dehaen W, Denzinger K, Dos Santos Machado K, Dunn I, Durai P, Edfeldt K, Edwards A, Fayne D, Felfoldi D, Friston K, Ghiabi P, Gibson E, Günther J, Gunnarsson A, Hillisch A, Houston DR, Jensen JH, Harding RJ, Harris KS, Hoffer L, Hogner A, Horton JT, Houliston S, Hultquist JF, Hutchinson A, Irwin JJ, Jukič M, Kandwal S, Karlova A, Katis VL, Kich RP, Kireev D, Koes D, Inniss NL, Lessel U, Liu S, Loppnau P, Lu W, Martino S, McGibbon M, Meiler J, Mettu A, Money-Kyrle S, Moretti R, Moroz YS, Muvva C, Newman JA, Obendorf L, Paige B, Pandit A, Park K, Perveen S, Pirie R, Poda G, Protopopov M, Pütter V, Ricci F, Roper NJ, Rosta E, Rzhetskaya M, Sabnis Y, Satchell KJF, Schmitt Kremer F, Scott T, Seitova A, Steinmann C, Talagayev V, Tarkhanova OO, Tatum NJ, Treleaven D, Velasque Werhli A, Walters WP, Wang X, Wells J, Wells G, Westermaier Y, Wolber G, Wortmann L, Zhang J, Zhao Z, Zheng S, Schapira M

Journal of chemical information and modeling2025

DOI: 10.1021/acs.jcim.5c00535 PMID: 40539604

Chemical arsenal for helicase Hunters: Striking the toughest targets in antiviral research.

Martin HJ, Hossain MA, Wellnitz J, Kelestemur E, Hochuli JE, Perveen S, Arrowsmith C, Willson TM, Muratov EN, Tropsha A

Antiviral research2025

DOI: 10.1016/j.antiviral.2025.106184 PMID: 40316178

Targeting PRC2 Enhances the Cytotoxic Capacity of Anti-CD19 CAR T Cells against Hematologic Malignancies.

Rodrigues Carvalho ML, de Oliveira Andrade C, Cabral-Piccin MP, Kinker GS, Vitiello GAF, Gonçalves Cambuí RA, de Macedo Abdo L, Mannarino Correia E, da Silva Elias BD, Araujo EVO, Chaves AS, Pereira PHB, Hajdu KL, Rondinelli A, Fagotti Gusmão A, Marques Pierre ML, Brasil-Costa I, Pouza Zanella C, Moreira Lemos MM, Batista MV, Filho JS, Arrowsmith C, Cordeiro de Lima VC, Bonamino MH, da Silva Medina T

Cancer research2025

DOI: 10.1158/0008-5472.can-24-1643 PMID: 39970330

Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1.

Mettu A, Glavatskikh M, Wang X, Lara Ordóñez AJ, Li F, Chau I, Ackloo S, Arrowsmith C, Bolotokova A, Ghiabi P, Gibson E, Halabelian L, Houliston S, Harding RJ, Hutchinson A, Loppnau P, Perveen S, Seitova A, Zeng H, Schapira M, Taymans JM, Kireev D

Chemical science2025

DOI: 10.1039/d4sc07532c PMID: 39877816

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Cheryl Arrowsmith

Research

Latest papers

Latest funding

Site-Specific Hydrogen-Deuterium Exchange Mass Spectrometry for Deep Explorations of Dynamic Shifts in Protein-Drug Interactions.

An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions.

A synergistic interaction between PRMT5 and LSD1 inhibitors in AML.

Development of a Dual Chemical Probe for the USP16 and HDAC6 Zinc-Finger Ubiquitin-Binding Domain.

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.

Site-Specific Hydrogen Deuterium Exchange Difference Mass Spectrometry Measurements for Ligand Binding.

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

Chemical arsenal for helicase Hunters: Striking the toughest targets in antiviral research.

Targeting PRC2 Enhances the Cytotoxic Capacity of Anti-CD19 CAR T Cells against Hematologic Malignancies.

Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1.

Frequent collaborators

Matthieu Schapira

Dalia Barsyte-Lovejoy

Aled Edwards

Mathieu Lupien

Razqallah Hakem

Brian Raught

Ming-Sound Tsao

Alexei Savchenko

Rennian Wang

Antonio Finelli

Paul Boutros

Mark Minden

Adrian Sacher

Moulay Alaoui-Jamali

Alexei Savchenko

Igor Stagljar

Steven Gallinger

Igor Jurisica

Jean-Yves Masson

Karim Mekhail

Artem Cherkasov

Kevin Kain

Thomas Kislinger

Stefan Hofer

Gordon Keller

Linda Penn

Nada Jabado

Laurie Ailles

David Hedley

Rama Khokha