Faculty profile

Gwyneth Zai

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Associate ProfessorDepartment of PsychiatryUniversity of Toronto

Gwyneth Zai

Associate Professor

Department of Psychiatry

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
30 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

3,321

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Latest papers

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.
Nature genetics · 2026
Addressing the dual challenge of treatment access and innovation in anxiety disorders.
The BMJ · 2026 · senior author
Using virtual reality to evaluate the difference between pathological and healthy responding to anxiety
Journal of Affective Disorders · 2026

All 59 publications

Latest funding

Influence of polygenic risk scores on longitudinal disease trajectories of individuals with schizophrenia spectrum disorders
CIHR · 2023 · Co-investigator
$757,350
Risk and protective factors of post-traumatic stress disorder in the CLSA dataset
CIHR · 2023 · Co-investigator
$70,000
Brain-Oscillation Synchronized Stimulation of the Dorsomedial Prefrontal Cortex: A Precision Medicine Treatment for Obsessive Compulsive Disorder
CIHR · 2022 · Co-investigator
$535,501

All 3 grants and awards

59 publications.

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.

Strom NI, Verhulst B, Bacanu SA, Cheesman R, Purves KL, Gedik H, Mitchell BL, Kwong AS, Faucon AB, Singh K, Medland S, Colodro-Conde L, Krebs K, Hoffmann P, Herms S, Gehlen J, Ripke S, Awasthi S, Palviainen T, Tasanko EM, Peterson RE, Adkins DE, Shabalin AA, Adams MJ, Iveson MH, Campbell A, Thomas LF, Winsvold BS, Drange OK, Børte S, Ter Kuile AR, Naamanka J, Nguyen TH, Meier SM, Corfield EC, Hannigan L, Levey DF, Czamara D, Weber H, Choi KW, Pistis G, Couvy-Duchesne B, Van der Auwera S, Teumer A, Karlsson R, Garcia-Argibay M, Lee D, Wang R, Bjerkeset O, Stordal E, Bäckman J, Salum GA, Zai CC, Kennedy JL, Zai G, Tiwari AK, Heilmann-Heimbach S, Schmidt B, Kaprio J, Kennedy MM, Boden J, Havdahl A, Middeldorp CM, Lopes FL, Akula N, McMahon FJ, Binder EB, Fehm L, Ströhle A, Castelao E, Tiemeier H, Stein DJ, Whiteman D, Olsen C, Fuller Z, Wang X, Wray NR, Byrne EM, Lewis G, Timpson NJ, Davis LK, Hickie IB, Gillespie NA, Milani L, Schumacher J, Woldbye DP, Forstner AJ, Nöthen MM, Hovatta I, Horwood J, Copeland WE, Maes HH, McIntosh AM, Andreassen OA, Zwart JA, Mors O, Børglum AD, Mortensen PB, Ask H, Reichborn-Kjennerud T, Najman JM, Stein MB, Gelernter J, Milaneschi Y, Penninx BW, Boomsma DI, Maron E, Erhardt-Lehmann A, Rück C, Kircher TT, Melzig CA, Alpers GW, Arolt V, Domschke K, Smoller JW, Preisig M, Martin NG, Lupton MK, Luik AI, Reif A, Grabe HJ, Larsson H, Magnusson PK, Oldehinkel AJ, Hartman CA, Breen G, Docherty AR, Coon H, Conrad R, Lehto K, Veterans Affairs Million Veteran Program, FinnGen, 23andMe Research Team, Deckert J, Eley TC, Mattheisen M, Hettema JM

Nature genetics202621 citationsOpen Access

DOI: 10.1038/s41588-025-02485-8 PMID: 41634414

Addressing the dual challenge of treatment access and innovation in anxiety disorders.

Laposa JM, Rowa K, Soreni N, Zai G

The BMJ2026Senior author

DOI: 10.1136/bmj.s673

Using virtual reality to evaluate the difference between pathological and healthy responding to anxiety

Julia Tomasi, Arun K. Tiwari, Clement Zai, Gwyneth Zai, Margaret A. Richter, Marcos Sanches, Richard Lachman, Calvin Gaspar, Matteo Cella, Ben Greer, Deanna Herbert, Ayeshah Mohiuddin, James L. Kennedy

Journal of Affective Disorders2026Open Access

DOI: 10.1016/j.jad.2026.122508 PMID: 42744147

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR

Nature Genetics2025100 citationsOpen Access

DOI: 10.1038/s41588-025-02189-z PMID: W4410325451

Assessing the Impact on Electronic Health Record Burden After Five Years of Physician Engagement in a Canadian Mental Health Organization: Mixed-Methods Study.

Tajirian T, Lo B, Strudwick G, Tasca A, Kendell E, Poynter B, Kumar S, Chang PB, Kung C, Schachter D, Zai G, Kiang M, Hoppe T, Ling S, Haider U, Rabel K, Coombe N, Jankowicz D, Sockalingam S

JMIR human factors20259 citationsOpen Access

DOI: 10.2196/65656 PMID: 40344205

Psychiatric Pharmacogenomic Testing: A Primer for Clinicians.

Brown LC, Zai G, Kennedy JL, Müller DJ, Tavakoli E, Bousman C, Maruf AA

The Psychiatric clinics of North America20256 citations

DOI: 10.1016/j.psc.2025.01.004 PMID: 40348416

Psychiatric Genetics in Clinical Practice: Essential Knowledge for Mental Health Professionals.

Besterman AD, Alnor MA, Castaño M, DeLisi LE, Grice DE, Lohoff FW, Middeldorp CM, Müller DJ, Quattrone D, Nurnberger J, Nurmi EL, Ross DA, Soda T, Schulze TG, Trost B, Vilella E, Yap CX, Zai G, Moreno-De-Luca D

The American journal of psychiatry20255 citationsOpen Access

DOI: 10.1176/appi.ajp.20240295 PMID: 40134266

Characterizing Rare DNA Copy-Number Variants in Pediatric Obsessive-Compulsive Disorder

Sarah B. Abdallah, Emily Olfson, Carolina Cappi, Samantha R. Greenspun, Gwyneth C. Zai, Maria Conceição do Rosário, Arthur Jeremy Willsey, Roseli Gedanke Shavitt, Eurı́pedes Constantino Miguel, James L. Kennedy, Margaret Anne Richter, Thomas V. Fernandez

Journal of the American Academy of Child & Adolescent Psychiatry20254 citationsOpen Access

DOI: 10.1016/j.jaac.2025.03.014 PMID: 40122455

Psilocybin-assisted psychotherapy for treatment-resistant obsessive-compulsive disorder: protocol for an open-label pilot study.

Ledwos N, Baer J, Husain MI, Blumberger DM, Patterson R, Hollingdrake E, Cheung E, Hawco C, Zrenner C, Zrenner B, Feusner JD, Rossell SL, Castle DJ, Zai G

BJPsych open20253 citationsSenior authorOpen Access

DOI: 10.1192/bjo.2025.10895 PMID: 41392767

The relationship between chronotype and treatment time of day on post-treatment depression symptom severity for depressed patients receiving cognitive behavioural therapy.

Lau PH, Levitan RD, Quilty LC, Kloiber S, Zai G, Laposa JM

Journal of affective disorders20252 citations

DOI: 10.1016/j.jad.2024.09.121 PMID: 39303878

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Gwyneth Zai

Research

Latest papers

Latest funding

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.

Addressing the dual challenge of treatment access and innovation in anxiety disorders.

Using virtual reality to evaluate the difference between pathological and healthy responding to anxiety

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Assessing the Impact on Electronic Health Record Burden After Five Years of Physician Engagement in a Canadian Mental Health Organization: Mixed-Methods Study.

Psychiatric Pharmacogenomic Testing: A Primer for Clinicians.

Psychiatric Genetics in Clinical Practice: Essential Knowledge for Mental Health Professionals.

Characterizing Rare DNA Copy-Number Variants in Pediatric Obsessive-Compulsive Disorder

Psilocybin-assisted psychotherapy for treatment-resistant obsessive-compulsive disorder: protocol for an open-label pilot study.

The relationship between chronotype and treatment time of day on post-treatment depression symptom severity for depressed patients receiving cognitive behavioural therapy.

Influence of polygenic risk scores on longitudinal disease trajectories of individuals with schizophrenia spectrum disorders

Risk and protective factors of post-traumatic stress disorder in the CLSA dataset

Brain-Oscillation Synchronized Stimulation of the Dorsomedial Prefrontal Cortex: A Precision Medicine Treatment for Obsessive Compulsive Disorder

Frequent collaborators

James Kennedy

Margaret Richter

Clement Zai

Paul Arnold

Daniel Mueller

Arun Tiwari

Stefan Kloiber

Manuel Mattheisen

Russel Schachar

Vincenzo De Luca

Jennifer Crosbie

Russell Schachar

Sandra Meier

Paul Sandor

Benicio Frey

Muhammad Husain

Adam Tasca

Brittany Poynter

Chad Bousman

Robert Levitan

James Marshall Bowen

Gustavo Turecki

Benoit Mulsant

Jamie Feusner

Tamara Hoppe

Neil Levitsky

Alisson Trevizol

Julie Maggi

Justine Dembo

Vanessa Gonçalves

Debbie Schachter