Kenichi Okamoto, University of Toronto

Research

Camp Cgmp Hippocampus Learning And Memory Live Imaging Mouse Optogenetics Photoactivatable Enzymes

Latest papers

SNAP-23 mediated vesicular trafficking in oligodendrocytes is necessary to maintain adult myelin integrity in mice.
Nature communications · 2026
Optogenetic elevation of postsynaptic cGMP in the hippocampal dentate gyrus enhances LTP and modifies mouse behaviors.
Frontiers in molecular neuroscience · 2024 · senior author
Fear memory regulation by the cAMP signaling pathway as an index of reexperiencing symptoms in posttraumatic stress disorder.
Molecular psychiatry · 2024

All 14 publications

Latest funding

Roles and mechanisms of vesicular fusion machinery involved in receptor trafficking
CIHR · 2019 · Co-investigator
$814,726
Novel Optogenetic Tools for Controlling Neuronal Signaling in Living Brain
NSERC · 2017 · Principal investigator
$156,000
Novel interactive roles of cAMP/cGMP in synaptic plasticity, learning and memory
CIHR · 2017 · Nominated PI
$891,225

All 6 grants and awards

14 publications.

01

SNAP-23 mediated vesicular trafficking in oligodendrocytes is necessary to maintain adult myelin integrity in mice.

Chow CH, Huang M, Regmi A, Rai J, Harada H, Eide S, Sun HS, Feng ZP, Monnier PP, Okamoto K, Zhang L, Rojas OL, Sugita S

Nature communications2026

DOI: 10.1038/s41467-026-73381-w PMID: 42185264

02

Optogenetic elevation of postsynaptic cGMP in the hippocampal dentate gyrus enhances LTP and modifies mouse behaviors.

Borovac J, Rai J, Valencia M, Li H, Georgiou J, Collingridge GL, Takao K, Okamoto K

Frontiers in molecular neuroscience2024Senior author

DOI: 10.3389/fnmol.2024.1479360 PMID: 39660172

03

Fear memory regulation by the cAMP signaling pathway as an index of reexperiencing symptoms in posttraumatic stress disorder.

Hori H, Fukushima H, Nagayoshi T, Ishikawa R, Zhuo M, Yoshida F, Kunugi H, Okamoto K, Kim Y, Kida S

Molecular psychiatry2024

DOI: 10.1038/s41380-024-02453-4 PMID: 38409596

04

Two-Photon FRET/FLIM Imaging of Cerebral Neurons.

Luyben TT, Rai J, Zhou B, Li H, Okamoto K

Methods in molecular biology (Clifton, N.J.)2024Senior author

DOI: 10.1007/978-1-0716-3810-1_4 PMID: 38630218

05

Neuronal SNAP-23 is critical for synaptic plasticity and spatial memory independently of NMDA receptor regulation.

Huang M, Bin NR, Rai J, Ma K, Chow CH, Eide S, Harada H, Xiao J, Feng D, Sun HS, Feng ZP, Gaisano HY, Pessin JE, Monnier PP, Okamoto K, Zhang L, Sugita S

iScience2023

DOI: 10.1016/j.isci.2023.106664 PMID: 37168570

06

Optogenetic Manipulation of Postsynaptic cAMP Using a Novel Transgenic Mouse Line Enables Synaptic Plasticity and Enhances Depolarization Following Tetanic Stimulation in the Hippocampal Dentate Gyrus.

Luyben TT, Rai J, Li H, Georgiou J, Avila A, Zhen M, Collingridge GL, Tominaga T, Okamoto K

Frontiers in neural circuits2020Senior author

DOI: 10.3389/fncir.2020.00024 PMID: 32581725

07

Regulation of actin dynamics during structural plasticity of dendritic spines: Signaling messengers and actin-binding proteins.

Borovac J, Bosch M, Okamoto K

Molecular and cellular neurosciences2018Senior author

DOI: 10.1016/j.mcn.2018.07.001 PMID: 30004015

08

Crucial Role of Postsynaptic Syntaxin 4 in Mediating Basal Neurotransmission and Synaptic Plasticity in Hippocampal CA1 Neurons.

Bin NR, Ma K, Harada H, Tien CW, Bergin F, Sugita K, Luyben TT, Narimatsu M, Jia Z, Wrana JL, Monnier PP, Zhang L, Okamoto K, Sugita S

Cell reports2018

DOI: 10.1016/j.celrep.2018.05.026 PMID: 29874582

09

Interplay of enzymatic and structural functions of CaMKII in long-term potentiation.

Kim K, Saneyoshi T, Hosokawa T, Okamoto K, Hayashi Y

Journal of neurochemistry2016

DOI: 10.1111/jnc.13672 PMID: 27207106

10

A Temporary Gating of Actin Remodeling during Synaptic Plasticity Consists of the Interplay between the Kinase and Structural Functions of CaMKII.

Kim K, Lakhanpal G, Lu HE, Khan M, Suzuki A, Hayashi MK, Narayanan R, Luyben TT, Matsuda T, Nagai T, Blanpied TA, Hayashi Y, Okamoto K

Neuron2015Senior author

DOI: 10.1016/j.neuron.2015.07.023 PMID: 26291163

Roles and mechanisms of vesicular fusion machinery involved in receptor trafficking

Co-investigatorCIHR2019Project Grant

Principal investigators: Sugita, Shuzo

Keywords: Electrophysiology; Exocytosis; Immunofluorescence Microscopy; Knockout Mouse; Membrane Fusion Machinery; Postsynapse; Receptors For Transmitters; Snare Proteins

$814,726