Faculty profile

Shuzo Sugita

ResearcherUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Shuzo Sugita

Researcher

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
12 publications in the last five years, latest in 2026.
Senior (last) author on 7 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (4 CIHR, 4 NSERC), most recently in 2024.
Supervised 2 trainees who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Knockout Mouse Demyelination Inflammation Multiple Sclerosis Myelin Neurodegeneration Oligodendrocyte Snare

Latest papers

Munc18-1 is crucial for photoreceptor function, survival and regulation of syntaxin-3 localization and expression.
Scientific reports · 2026 · senior author
Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
SNAP-23 mediated vesicular trafficking in oligodendrocytes is necessary to maintain adult myelin integrity in mice.
Nature communications · 2026 · senior author

All 48 publications

Latest funding

Investigating the role of vesicular trafficking in oligodendrocytes to maintain myelination in health and diseases
CIHR · 2024 · Nominated PI
$849,150
Defective vesicular transport in oligodendrocytes leading to demyelination and neuroinflammation in neurodegenerative diseases
CIHR · 2023 · Supervisor
$105,000
The role of vesicular transport pathways in maintaining photoreceptor health and preventing degeneration
CIHR · 2022 · Supervisor
$105,000

All 10 grants and awards

48 publications.

Munc18-1 is crucial for photoreceptor function, survival and regulation of syntaxin-3 localization and expression.

Huang M, Chow CH, Noworolski R, Charish J, Indrawinata K, Harada H, Wallace VA, Monnier PP, Sugita S

Scientific reports2026Senior author

DOI: 10.1038/s41598-026-57827-1 PMID: 42401592

Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor.

Wang Y, Deng Y, Xia N, Sugita S, Gao S

Advanced science (Weinheim, Baden-Wurttemberg, Germany)2026

DOI: 10.1002/advs.202520721 PMID: 41885399

SNAP-23 mediated vesicular trafficking in oligodendrocytes is necessary to maintain adult myelin integrity in mice.

Chow CH, Huang M, Regmi A, Rai J, Harada H, Eide S, Sun HS, Feng ZP, Monnier PP, Okamoto K, Zhang L, Rojas OL, Sugita S

Nature communications2026Senior author

DOI: 10.1038/s41467-026-73381-w PMID: 42185264

The long-term impact of neonatal hypoxic-ischemic brain injury on neural dynamics in deep-layer retrosplenial cortex and hippocampus in mice.

Du L, Yang M, Steenland HW, Luo Z, Ovcjak A, Hu R, Sugita S, Takehara-Nishiuchi K, Milosevic L, Feng ZP

iScience2026

DOI: 10.1016/j.isci.2026.115003 PMID: 42006293

The exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner at C. elegans excitatory synapses.

Wang Y, Chow CH, Zhang Y, Huang M, Higazy R, Ramakrishnan N, Chen L, Chen X, Deng Y, Wang S, Zhang C, Ma C, Sugita S, Gao S

PLoS biology2025

DOI: 10.1371/journal.pbio.3003023 PMID: 39913617

SNAP-25, but not SNAP-23, is essential for photoreceptor development, survival, and function in mice.

Huang M, Chow CH, Gurdita A, Harada H, Pham Truong VQB, Eide S, Sun HS, Feng ZP, Monnier PP, Wallace VA, Sugita S

Communications biology2024Senior author

DOI: 10.1038/s42003-023-05760-8 PMID: 38182732

Double mutation of open syntaxin and UNC-18 P334A leads to excitatory-inhibitory imbalance and impairs multiple aspects of C. elegans behavior.

Huang M, Wang Y, Chow CH, Stepien KP, Indrawinata K, Xu J, Argiropoulos P, Xie X, Sugita K, Tien CW, Lee S, Monnier PP, Rizo J, Gao S, Sugita S

bioRxiv : the preprint server for biology2023Senior author

DOI: 10.1101/2023.08.18.553709 PMID: 37645974

Progenitor division and cell autonomous neurosecretion are required for rod photoreceptor sublaminar positioning.

Gurdita A, Pham Truong VQB, Dolati P, Juric M, Tachibana N, Liu ZC, Ortín-Martínez A, Ibrahimi M, Pokrajac NT, Comanita L, Pacal M, Huang M, Sugita S, Bremner R, Wallace VA

Proceedings of the National Academy of Sciences of the United States of America2023

DOI: 10.1073/pnas.2308204120 PMID: 37812728

Structural and functional understanding of disease-associated mutations in V-ATPase subunit a1 and other isoforms.

Indrawinata K, Argiropoulos P, Sugita S

Frontiers in molecular neuroscience2023Senior author

DOI: 10.3389/fnmol.2023.1135015 PMID: 37465367

Neuronal SNAP-23 is critical for synaptic plasticity and spatial memory independently of NMDA receptor regulation.

Huang M, Bin NR, Rai J, Ma K, Chow CH, Eide S, Harada H, Xiao J, Feng D, Sun HS, Feng ZP, Gaisano HY, Pessin JE, Monnier PP, Okamoto K, Zhang L, Sugita S

iScience2023Senior author

DOI: 10.1016/j.isci.2023.106664 PMID: 37168570

Investigating the role of vesicular trafficking in oligodendrocytes to maintain myelination in health and diseases

Nominated PICIHR2024Project Grant

Principal investigators: Sugita, Shuzo

Keywords: Demyelination; Inflammation; Multiple Sclerosis; Myelin; Neurodegeneration; Oligodendrocyte; Snare; Vesicle Trafficking

$849,150

Defective vesicular transport in oligodendrocytes leading to demyelination and neuroinflammation in neurodegenerative diseases

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Chow, Chun Hin

Keywords: Alzheimer'S Disease; Autoimmune; Demyelination; Inflammation; Multiple Sclerosis; Myelin; Neurodegeneration; Oligodendrocyte; Snare; Vesicular Fusion

$105,000

The role of vesicular transport pathways in maintaining photoreceptor health and preventing degeneration

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Huang, Mengjia

Keywords: Exocytosis; Retina; Snare-Proteins; Synapses; Vision

$105,000

Investigating the fundamental mechanisms of immune cell exocytosis

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Sugita, Shuzo

$250,000

Roles and mechanisms of vesicular fusion machinery involved in receptor trafficking

Nominated PICIHR2019Project Grant

Principal investigators: Sugita, Shuzo

Keywords: Electrophysiology; Exocytosis; Immunofluorescence Microscopy; Knockout Mouse; Membrane Fusion Machinery; Postsynapse; Receptors For Transmitters; Snare Proteins

$814,726

Unveiling the molecular mechanisms of vesicular trafficking, membrane fusion, and intravesicular acidification

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Sugita, Shuzo

$190,000

The molecular mechanisms of exocytosis in mast cells

Nominated PICIHR2013Operating Grant

Principal investigators: Sugita, Shuzo

Keywords: Airway Inflammation; Asthma; Confocal And Electron Microscopy; Degranulation; Knockout Mouse; Lentivirus; Mast Cell; Rbl-2h3 Cells; Rna Interference; Tirfm

$252,555

Roles for the exocyst complex in vesicular trafficking

Principal investigatorNSERC2009Discovery Grants Program - Individual

Principal investigators: Sugita, Shuzo

$185,000

Structure/function analysis of neurotransmitter exocytosis

Nominated PICIHR2008Operating Grant

Principal investigators: Sugita, Shuzo

Keywords: Infection; Pc12 Cells; Rna Interference; Secretion Assay; Transfection

$444,521

Molecular mechanisms of GTP-dependent exocytosis

Principal investigatorNSERC2004Discovery Grants Program - Individual

Principal investigators: Sugita, Shuzo

$191,300

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Shuzo Sugita

Research

Latest papers

Latest funding

Munc18-1 is crucial for photoreceptor function, survival and regulation of syntaxin-3 localization and expression.

Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor.

SNAP-23 mediated vesicular trafficking in oligodendrocytes is necessary to maintain adult myelin integrity in mice.

The long-term impact of neonatal hypoxic-ischemic brain injury on neural dynamics in deep-layer retrosplenial cortex and hippocampus in mice.

The exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner at C. elegans excitatory synapses.

SNAP-25, but not SNAP-23, is essential for photoreceptor development, survival, and function in mice.

Double mutation of open syntaxin and UNC-18 P334A leads to excitatory-inhibitory imbalance and impairs multiple aspects of C. elegans behavior.

Progenitor division and cell autonomous neurosecretion are required for rod photoreceptor sublaminar positioning.

Structural and functional understanding of disease-associated mutations in V-ATPase subunit a1 and other isoforms.

Neuronal SNAP-23 is critical for synaptic plasticity and spatial memory independently of NMDA receptor regulation.

Investigating the role of vesicular trafficking in oligodendrocytes to maintain myelination in health and diseases

Defective vesicular transport in oligodendrocytes leading to demyelination and neuroinflammation in neurodegenerative diseases

The role of vesicular transport pathways in maintaining photoreceptor health and preventing degeneration

Investigating the fundamental mechanisms of immune cell exocytosis

Roles and mechanisms of vesicular fusion machinery involved in receptor trafficking

Unveiling the molecular mechanisms of vesicular trafficking, membrane fusion, and intravesicular acidification

The molecular mechanisms of exocytosis in mast cells

Roles for the exocyst complex in vesicular trafficking

Structure/function analysis of neurotransmitter exocytosis

Molecular mechanisms of GTP-dependent exocytosis

Frequent collaborators

Hong-Shuo Sun

Zhong-Ping Feng

Kenichi Okamoto

Mei Zhen

Rod Bremner

Michael Moran

Luka Milosevic

Zhengping Jia

Michael Reber

Liliana Attisano

Kaori Takehara-Nishiuchi

David Lee

Jean-Francois Cloutier

Mitsuhiko Ikura