Faculty profile

Paul Delgado Olguin

ResearcherPhysiology and Experimental MedicineUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Paul Delgado Olguin

Researcher

Physiology and Experimental Medicine

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
7 publications in the last five years, latest in 2025.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 6 research grants (5 CIHR, 1 NSERC), most recently in 2021.
Supervised 1 trainee who won CIHR awards, most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Gene Regulation Epigenetic Control Of Gene Expression Vascular Development Heart Dysfunction Heart Disease Cardiac Development Cardiac Disease Cardiac Progenitors

Latest papers

Generation and characterization of a mouse model of Becker muscular dystrophy with a deletion of Dmd exons 52 to 55.
Disease models & mechanisms · 2025
Template-assisted sequence knockin rescues skeletal and cardiac muscle function in a deletion model of Duchenne muscular dystrophy.
Molecular therapy : the journal of the American Society of Gene Therapy · 2025
G9a inactivation in progenitor cells with Isl1-Cre with reduced recombinase activity models aspects of Dandy-Walker complex.
Biology open · 2023 · senior author

All 27 publications

Latest funding

Placenta-Heart Axis in Preeclampsia: Mechanisms and Therapeutic Targets
CIHR · 2025 · Co-investigator
$1,190,340
A molecular blueprint of heart metabolism control to reveal the root of dilated cardiomyopathy
CIHR · 2025 · Supervisor
$120,000
Dolutegravir, impaired vascular remodelling, and hypertesion in pregnancy.
CIHR · 2024 · Co-investigator
$1,235,475

All 12 grants and awards

27 publications.

Generation and characterization of a mouse model of Becker muscular dystrophy with a deletion of Dmd exons 52 to 55.

Perillat LOM, Wong TWY, Maino E, Ahmed A, Scott O, Hyatt E, Delgado-Olguin P, Visuvanathan S, Ivakine EA, Cohn RD

Disease models & mechanisms2025

DOI: 10.1242/dmm.050595 PMID: 39099311

Template-assisted sequence knockin rescues skeletal and cardiac muscle function in a deletion model of Duchenne muscular dystrophy.

Fatehi S, Rok MJ, Marks RM, Huynh E, Kozman N, Truong HA, Chi L, Yan B, Khazeeva E, Delgado-Olguin P, Ivakine EA, Cohn RD

Molecular therapy : the journal of the American Society of Gene Therapy2025

DOI: 10.1016/j.ymthe.2025.05.005 PMID: 40340246

G9a inactivation in progenitor cells with Isl1-Cre with reduced recombinase activity models aspects of Dandy-Walker complex.

Chi L, Zhong L, Lee D, Yu X, Caballero A, Nieman B, Delgado-Olguin P

Biology open2023Senior author

DOI: 10.1242/bio.059894 PMID: 37470706

Spontaneous urinary bladder regeneration after subtotal cystectomy increases YAP/WWTR1 signaling and downstream BDNF expression: Implications for smooth muscle injury responses.

Aitken KJ, Yadav P, Sidler M, Thanabalasingam T, Ahmed T, Aggarwal P, Yip ST, Jeffrey N, Jiang JX, Siebenaller A, Sotiropoulos C, Huang R, Le DMQ, Delgado-Olguin P, Bagli D

PloS one2023

DOI: 10.1371/journal.pone.0287205 PMID: 37494380

Loss of functional peroxisomes leads to increased mitochondrial biogenesis and reduced autophagy that preserve mitochondrial function.

Chi L, Lee D, Leung S, Hu G, Wen B, Delgado-Olguin P, Vissa M, Li R, Brumell JH, Kim PK, Bandsma RHJ

Cellular and molecular life sciences : CMLS2023

DOI: 10.1007/s00018-023-04827-3 PMID: 37338571

MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes.

Veitch S, Njock MS, Chandy M, Siraj MA, Chi L, Mak H, Yu K, Rathnakumar K, Perez-Romero CA, Chen Z, Alibhai FJ, Gustafson D, Raju S, Wu R, Zarrin Khat D, Wang Y, Caballero A, Meagher P, Lau E, Pepic L, Cheng HS, Galant NJ, Howe KL, Li RK, Connelly KA, Husain M, Delgado-Olguin P, Fish JE

Cardiovascular diabetology2022

DOI: 10.1186/s12933-022-01458-z PMID: 35209901

Structure–Function Relationships of Human Milk Oligosaccharides on the Intestinal Epithelial Transcriptome in Caco‐2 Cells and a Murine Model of Necrotizing Enterocolitis

Wu RY, Li B, Horne RG, Ahmed A, Lee D, Robinson SC, Zhu H, Cadete M, Alganabi M, Filler R

Molecular Nutrition and Food Research202218 citations

DOI: 10.1002/mnfr.202100893

Live Intravital Intestine with Blood Flow Visualization in Neonatal Mice Using Two-photon Laser Scanning Microscopy.

Koike Y, Li B, Chen Y, Ganji N, Alganabi M, Miyake H, Lee C, Hock A, Wu R, Uchida K, Inoue M, Delgado-Olguin P, Pierro A

Bio-protocol2021

DOI: 10.21769/bioprotoc.3937 PMID: 33796611

Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation.

Koike Y, Li B, Ganji N, Zhu H, Miyake H, Chen Y, Lee C, Janssen Lok M, Zozaya C, Lau E, Lee D, Chusilp S, Zhang Z, Yamoto M, Wu RY, Inoue M, Uchida K, Kusunoki M, Delgado-Olguin P, Mertens L, Daneman A, Eaton S, Sherman PM, Pierro A

Nature communications2020

DOI: 10.1038/s41467-020-18750-9 PMID: 33009377

Activation of Wnt signaling by amniotic fluid stem cell-derived extracellular vesicles attenuates intestinal injury in experimental necrotizing enterocolitis.

Li B, Lee C, O'Connell JS, Antounians L, Ganji N, Alganabi M, Cadete M, Nascimben F, Koike Y, Hock A, Botts SR, Wu RY, Miyake H, Minich A, Maalouf MF, Zani-Ruttenstock E, Chen Y, Johnson-Henry KC, De Coppi P, Eaton S, Maattanen P, Delgado Olguin P, Zani A, Sherman PM, Pierro A

Cell death & disease2020

DOI: 10.1038/s41419-020-02964-2 PMID: 32929076

Placenta-Heart Axis in Preeclampsia: Mechanisms and Therapeutic Targets

Co-investigatorCIHR2025Project Grant

Principal investigators: Caniggia, Isabella

Keywords: Cardiovascular System; Lipidome; Mitochondria Morphology And Function; Mouse Model Of Preeclampsia; Placenta; Preeclampsia; Small Extracellular Vesicles; Therapeutic Strategies; Trophoblas Organoids

$1,190,340

A molecular blueprint of heart metabolism control to reveal the root of dilated cardiomyopathy

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Aharon-Yariv, Adar

Keywords: Chromatin Organization; Dilated Cardiomyopathy; Epigenomics; Gene Regulation; Heart Failure; Metabolism; Mouse Models; Transcription Factors; Transcriptomics

$120,000

Dolutegravir, impaired vascular remodelling, and hypertesion in pregnancy.

Co-investigatorCIHR2024Project Grant

Principal investigators: Serghides, Lena

Keywords: Heart; Hiv Antiretroviral Therapy; Hypertension; Mmp; Placenta; Pregnancy; Vascular Stability; Zinc

$1,235,475

Delivery of nucleic acids using lipid nanoparticles to counteract intestinal injury during necrotizing enterocolitis

Co-investigatorCIHR2023Project Grant

Principal investigators: Pierro, Agostino

Keywords: Necrotizing Enterocolitis

$1,016,686

Hormonal modulation of the gut-brain axis in necrotizing enterocolitis

Co-investigatorCIHR2022Project Grant

Principal investigators: Pierro, Agostino

Keywords: Brain Injury; Glp Signaling; Intestinal Injury; Necrotizing Enterocolitis; Neonate; Prematurity

$826,200

Uncovering the cause of placental abruption

Nominated PICIHR2021Project Grant

Principal investigators: Delgado Olguin, Paul; Hui, Chi-Chung

Keywords: Gene Regulation; Vascular Development

$1,040,400

Activating the piRNA pathway to prevent heart disease

Nominated PICIHR2020Project Grant

Principal investigators: Delgado Olguin, Paul

Keywords: Epigenetic Control Of Gene Expression; Gene Regulation; Heart Dysfunction

$891,226

Contribution of endothelial fatty acid metabolism to diabetes-associated heart failure with preserved ejection fraction

Co-investigatorCIHR2020Project Grant

Principal investigators: Fish, Jason E

Keywords: Biomarker; Diabetes; Endothelial Cell; Extracellular Vesicles; Fatty Acid; Heart Failure; Metabolism; Microrna; Microvascular; Therapy

$822,376

Epigenetic regulation of dilated cardiomyopathy by histone demethylation

Nominated PICIHR2018Project Grant

Principal investigators: Delgado Olguin, Paul

Keywords: Epigenetic Control Of Gene Expression; Gene Regulation; Heart Disease

$772,650

Epigenetic Control of Endothelial Gene Expression and Vascular Development

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: DelgadoOlguin, Paul

$168,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Paul Delgado Olguin

Research

Latest papers

Latest funding

Generation and characterization of a mouse model of Becker muscular dystrophy with a deletion of Dmd exons 52 to 55.

Template-assisted sequence knockin rescues skeletal and cardiac muscle function in a deletion model of Duchenne muscular dystrophy.

G9a inactivation in progenitor cells with Isl1-Cre with reduced recombinase activity models aspects of Dandy-Walker complex.

Spontaneous urinary bladder regeneration after subtotal cystectomy increases YAP/WWTR1 signaling and downstream BDNF expression: Implications for smooth muscle injury responses.

Loss of functional peroxisomes leads to increased mitochondrial biogenesis and reduced autophagy that preserve mitochondrial function.

MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes.

Structure–Function Relationships of Human Milk Oligosaccharides on the Intestinal Epithelial Transcriptome in Caco‐2 Cells and a Murine Model of Necrotizing Enterocolitis

Live Intravital Intestine with Blood Flow Visualization in Neonatal Mice Using Two-photon Laser Scanning Microscopy.

Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation.

Activation of Wnt signaling by amniotic fluid stem cell-derived extracellular vesicles attenuates intestinal injury in experimental necrotizing enterocolitis.

Placenta-Heart Axis in Preeclampsia: Mechanisms and Therapeutic Targets

A molecular blueprint of heart metabolism control to reveal the root of dilated cardiomyopathy

Dolutegravir, impaired vascular remodelling, and hypertesion in pregnancy.

Delivery of nucleic acids using lipid nanoparticles to counteract intestinal injury during necrotizing enterocolitis

Hormonal modulation of the gut-brain axis in necrotizing enterocolitis

Uncovering the cause of placental abruption

Activating the piRNA pathway to prevent heart disease

Contribution of endothelial fatty acid metabolism to diabetes-associated heart failure with preserved ejection fraction

Epigenetic regulation of dilated cardiomyopathy by histone demethylation

Epigenetic Control of Endothelial Gene Expression and Vascular Development

Frequent collaborators

Agostino Pierro

Augusto Zani

Rosanna Weksberg

Shaiya Robinson

Isabella Caniggia

Brian Nieman

Luc Mertens

Tanja Gonska

Norman Rosenblum

Mansoor Husain

Sevan Hopyan

Darius Bagli

Ren-Ke Li

Bruno Leslie