Faculty profile

Agostino Pierro

ResearcherSurgeryUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Agostino Pierro

Researcher

Surgery

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
52 publications in the last five years, latest in 2026.
Senior (last) author on 25 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (5 CIHR, 2 SSHRC), most recently in 2025.
Supervised 2 trainees who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

175

Publications

546

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Necrotizing Enterocolitis Neonate Prematurity Multicenter Randomized Controlled Trial Remote Ischemic Conditioning Brain Injury Glp Signaling Intestinal Injury

Latest papers

Short-chain fructooligosaccharides protect against intestinal injury in NEC by restoring AKT/GSK-3β signaling.
Journal of pediatric surgery · 2026
NAD+ metabolic collapse and arrest of epithelial development in Hirschsprung disease.
World journal of pediatric surgery · 2026
Molecular and Chromatin Accessibility Programs Underlying Epithelial Injury and Impaired Regeneration in Neonatal Necrotizing Enterocolitis.
Cellular and molecular gastroenterology and hepatology · 2026 · senior author

All 175 publications

Latest funding

Necrotizing enterocolitis Ischemic Conditioning Efficacy (NICE) Trial
CIHR · 2025 · Nominated PI
$1,279,061
Delivery of nucleic acids using lipid nanoparticles to counteract intestinal injury during necrotizing enterocolitis
CIHR · 2023 · Nominated PI
$1,016,686
Modulation of intestinal blood flow by remote ischemic conditioning for necrotizing enterocolitis in neonates
CIHR · 2023 · Supervisor
$6,000

All 9 grants and awards

From the 150 most recent of 175 publications.

Short-chain fructooligosaccharides protect against intestinal injury in NEC by restoring AKT/GSK-3β signaling.

Huang Y, Zhang B, Wu RY, Lee C, Li B, Sherman P, Pierro A, Zhu H

Journal of pediatric surgery2026

DOI: 10.1016/j.jpedsurg.2026.162963 PMID: 41619835

NAD+ metabolic collapse and arrest of epithelial development in Hirschsprung disease.

Zhao Y, Yang J, Li B, Lee D, Xiong Y, Pierro A, Jiang Q

World journal of pediatric surgery2026

DOI: 10.1136/wjps-2026-001222 PMID: 42422596

Molecular and Chromatin Accessibility Programs Underlying Epithelial Injury and Impaired Regeneration in Neonatal Necrotizing Enterocolitis.

Xiong Y, Zito A, Liang H, Biouss G, Yang J, Balsamo F, Yeganeh M, Lee C, Lee D, Wang CY, Tahmasian N, Huang J, Minich A, Feizi M, Wang S, Tian Y, De Coppi P, Kalish BT, Olguin PD, Zhu H, Li B, Pierro A

Cellular and molecular gastroenterology and hepatology2026Senior author

DOI: 10.1016/j.jcmgh.2026.101730 PMID: 41571092

Exploring the Complex Pathophysiology of Necrotizing Enterocolitis in Preterm Neonates.

Li B, Yeganeh M, Lee D, Chusilp S, Balsamo F, Ganji N, Wang CY, Zito A, Biouss G, Pierro A

Annual review of pathology2026Senior author

DOI: 10.1146/annurev-pathmechdis-070224-014223 PMID: 40953322

Embryonic Gut Enteric Neural Crest Cells Derived Neurospheres.

Lee D, Fujiwara N, Pierro A

Methods in molecular biology (Clifton, N.J.)2026Senior author

DOI: 10.1007/978-1-0716-5126-1_8 PMID: 42162546

Embryonic Gut Explant Model for Enteric Neural Crest Cells Migration.

Lee D, Pierro A

Methods in molecular biology (Clifton, N.J.)2026Senior author

DOI: 10.1007/978-1-0716-5126-1_7 PMID: 42162545

Ex Vivo Organ Perfusion Systems for Disease Modeling and Therapeutic Applications in Small Animal Models.

Yeganeh M, Zito A, Sadat M, Pierro A, Rogers IM

Journal of tissue engineering and regenerative medicine2025

DOI: 10.1155/term/2583925 PMID: 41018117

Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis.

Zhang Z, Lee D, Liu L, Xiong Y, Lee C, Kim JE, Chusilp S, Lau E, Tian Y, Feizi M, Alganabi M, Lafreniere A, Cheng T, Zhou R, Han L, Wu L, Xiao P, Gao Y, Benedetti G, Holland L, Tullie L, Giobbe GG, Li L, Li Q, Yamataka A, Li VSW, De Coppi P, Jiang Q, Pierro A, Li B

Science translational medicine2025

DOI: 10.1126/scitranslmed.adp4679 PMID: 40737428

Predictive value of plasma zonulin for postoperative Hirschsprung-associated enterocolitis.

Wu L, Gao Y, Zhou R, Xiao P, Zhang Z, Li B, Pierro A, Li L, Jiang Q, Li Q

World journal of pediatric surgery2025

DOI: 10.1136/wjps-2025-001057 PMID: 40621058

Remote ischemic post-conditioning for neonatal encephalopathy: a safety and feasibility trial.

Lo E, Cizmeci MN, Wilson D, Ly LG, El-Shahed A, Offringa M, Pierro A, Kalish BT

Pediatric research2025

DOI: 10.1038/s41390-024-03625-2 PMID: 39396091

Necrotizing enterocolitis Ischemic Conditioning Efficacy (NICE) Trial

Nominated PICIHR2025Project Grant

Principal investigators: Pierro, Agostino; Gauda, Estelle; Kalish, Brian; Keijzer, Richard; Offringa, Martin; Shah, Prakeshkumar; Thorpe, Kevin E

Keywords: Multicenter Randomized Controlled Trial; Necrotizing Enterocolitis; Remote Ischemic Conditioning

$1,279,061

Delivery of nucleic acids using lipid nanoparticles to counteract intestinal injury during necrotizing enterocolitis

Nominated PICIHR2023Project Grant

Principal investigators: Pierro, Agostino

Keywords: Necrotizing Enterocolitis

$1,016,686

Modulation of intestinal blood flow by remote ischemic conditioning for necrotizing enterocolitis in neonates

SupervisorCIHR2023Canada Graduate Scholarships - Michael Smith Foreign Study Supplements

Principal investigators: Ganji, Niloofar

Keywords: Intestinal Perfusion; Ischemic Conditioning; Necrotizing Enterocolitis; Neonatal; Premature; Therapeutic Strategy

$6,000

Hormonal modulation of the gut-brain axis in necrotizing enterocolitis

Nominated PICIHR2022Project Grant

Principal investigators: Pierro, Agostino

Keywords: Brain Injury; Glp Signaling; Intestinal Injury; Necrotizing Enterocolitis; Neonate; Prematurity

$826,200

Exploring a novel therapy for Hirschsprung’s disease: stimulating the migration of endogenous enteric progenitors

Principal investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Pierro, Agostino

Keywords: Hirschsprung’s disease; enteric nervous system; cell migration; aganglionosis; glial cell line derived neurotrophic factor ; bioengineered materials

$125,000

Exploring a novel therapy for Hirschsprung's disease: stimulating the migration of endogenous enteric progenitors

Principal investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Pierro, Agostino

Keywords: Hirschsprung's disease enteric nervous system cell migration aganglionosis glial cell line derived neurotrophic factor bioengineered materials

$125,000

Modulation of intestinal blood flow by remote ischemic conditioning for necrotizing enterocolitis in neonates

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Ganji, Niloofar

Keywords: Abdominal Color Doppler Ultrasound; Intestinal Blood Flow; Near-Infrared Spectroscopy; Nec; Necrotizing Enterocolitis; Prematurity; Remote Ischemic Conditioning

$105,000

Development, validation and implementation of a reporting guideline for the selection and measurement of outcomes in clinical trials.

Principal investigatorCIHR2016Project Grant

Principal investigators: Offringa, Martin; Pierro, Agostino; Szatmari, Peter

Keywords: Clinical Trials; Medical Decision Making; Outcomes; Reporting Standard; Systematic Reviews

$344,025

Necrotizing Enterocolitis Research Program: introducing innovative therapies to halt the disease progression and promote recovery

Nominated PICIHR2015Foundation Grant

Principal investigators: Pierro, Agostino

Keywords: Necrotizing Enterocolitis; Neonate; Pediatric Surgery; Prematurity

$3,637,274

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Agostino Pierro

Research

Latest papers

Latest funding

Short-chain fructooligosaccharides protect against intestinal injury in NEC by restoring AKT/GSK-3&#x3b2; signaling.

NAD+ metabolic collapse and arrest of epithelial development in Hirschsprung disease.

Molecular and Chromatin Accessibility Programs Underlying Epithelial Injury and Impaired Regeneration in Neonatal Necrotizing Enterocolitis.

Exploring the Complex Pathophysiology of Necrotizing Enterocolitis in Preterm Neonates.

Embryonic Gut Enteric Neural Crest Cells Derived Neurospheres.

Embryonic Gut Explant Model for Enteric Neural Crest Cells Migration.

Ex Vivo Organ Perfusion Systems for Disease Modeling and Therapeutic Applications in Small Animal Models.

Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis.

Predictive value of plasma zonulin for postoperative Hirschsprung-associated enterocolitis.

Remote ischemic post-conditioning for neonatal encephalopathy: a safety and feasibility trial.

Necrotizing enterocolitis Ischemic Conditioning Efficacy (NICE) Trial

Delivery of nucleic acids using lipid nanoparticles to counteract intestinal injury during necrotizing enterocolitis

Modulation of intestinal blood flow by remote ischemic conditioning for necrotizing enterocolitis in neonates

Hormonal modulation of the gut-brain axis in necrotizing enterocolitis

Exploring a novel therapy for Hirschsprung’s disease: stimulating the migration of endogenous enteric progenitors

Exploring a novel therapy for Hirschsprung's disease: stimulating the migration of endogenous enteric progenitors

Modulation of intestinal blood flow by remote ischemic conditioning for necrotizing enterocolitis in neonates

Development, validation and implementation of a reporting guideline for the selection and measurement of outcomes in clinical trials.

Necrotizing Enterocolitis Research Program: introducing innovative therapies to halt the disease progression and promote recovery

Frequent collaborators

Augusto Zani

Martin Offringa

Paul Delgado Olguin

Tanja Gonska

Michael Surette

Shaiya Robinson

Mary Brindle

Estelle Gauda

Andy Willan

Michael Livingston

Milica Radisic

Richard Keijzer

Jaques Belik

Philip Sherman

Gaspard Montandon

Brian Kalish

Suneeta Monga

Anna Heath

Bowen Li

Poorva Deshpande

Michael Pitino

Anna Heath

Jacob Langer

Rahim Moineddin

Khosrow Adeli

James Anderson

Petros Pechlivanoglou

Tae-Hee Kim

Luc Mertens

Sunita Vohra

Salhab El Helou

Igor Jurisica

An-Wen Chan

Kyong-Soon Lee

Patrick Provost

Peter Szatmari

Andrew Baker

Marcelo Cypel

Wendy Ungar

Short-chain fructooligosaccharides protect against intestinal injury in NEC by restoring AKT/GSK-3β signaling.