Faculty profile

Sevan Hopyan

ResearcherDevelopmental and Stem Cell BiologyUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Sevan Hopyan

Researcher

Developmental and Stem Cell Biology

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
21 publications in the last five years, latest in 2026.
Senior (last) author on 7 recent papers, a sign of leading a research group.
Principal investigator on 12 research grants (9 CIHR, 3 SSHRC), most recently in 2026.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

330

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Morphogenesis Mouse Embryo Limb Development Conditional Mutagenesis Chromatin Conformation Capture Piezo1 Wnt5a Yap

Latest papers

CORR Insights®: Preliminary Surgical Findings and Complications After National Centralization of Pediatric Bone Sarcoma Resections in the Netherlands: a Benchmarking Study.
Clinical orthopaedics and related research · 2026 · first author
Sufficiency of Isolated Vascularised Fibular Free Flaps for Pediatric Intercalary Lower Limb Reconstruction.
JB & JS open access · 2026 · senior author
Canadian Spine Society
Canadian Journal of Surgery · 2025

All 70 publications

Latest funding

The biophysical origin of limb pattern
CIHR · 2026 · Nominated PI
$1,036,576
Force dependent chromatin conformation and transcription
CIHR · 2025 · Nominated PI
$1,021,276
Canadian Developmental Biology Conference
CIHR · 2022 · Nominated PI
$15,000

All 15 grants and awards

70 publications.

CORR Insights®: Preliminary Surgical Findings and Complications After National Centralization of Pediatric Bone Sarcoma Resections in the Netherlands: a Benchmarking Study.

Hopyan S

Clinical orthopaedics and related research2026First author

DOI: 10.1097/corr.0000000000003871 PMID: 41758758

Sufficiency of Isolated Vascularised Fibular Free Flaps for Pediatric Intercalary Lower Limb Reconstruction.

Saenz L, Wong KW, Davidge KM, Hopyan S

JB & JS open access2026Senior author

DOI: 10.2106/jbjs.oa.25.00267 PMID: 41550578

Canadian Spine Society

Chan V, Gausper A, Liu A, Andras LM, Illingworth KD, Skaggs DL, Imbeault R, Dufresne J, Parent S, Deschênes S

Canadian Journal of Surgery2025

DOI: 10.1503/cjs.020125

Shoulder Motion Following Combined Glenoid Anteversion Osteotomy Compared with Soft Tissue Rebalancing Alone for Brachial Plexus Birth Injury.

James D, Anthony A, Clarke H, Davidge K, Hopyan S

JB & JS open access2025Senior author

DOI: 10.2106/jbjs.oa.25.00274 PMID: 41378140

A thermodynamic perspective on mammalian neural crest ingression.

Pasiliao CC, Thomas EC, Yung T, Zhu M, Tao H, Sun Y, Goyal S, Hopyan S

Proceedings of the National Academy of Sciences of the United States of America2025Senior author

DOI: 10.1073/pnas.2504185122 PMID: 40906808

Local Control for Pediatric Rhabdomyosarcoma of the Extremities: Is Radiotherapy Always Required After Adequate Surgical Resection? A CanSaRCC Study.

Nitzan-Luques A, Peretz Soroka H, Brzezinski J, Hopyan S, Gupta AA

Journal of pediatric surgery2025

DOI: 10.1016/j.jpedsurg.2024.162131 PMID: 39827486

Tissue stiffness mapping by light sheet elastography.

Zhu M, Zhang K, Thomas EC, Xu R, Ciruna B, Hopyan S, Sun Y

Science advances2025

DOI: 10.1126/sciadv.adt7274 PMID: 40085703

A fibronectin gradient remodels mixed-phase mesoderm.

Zhu M, Gu B, Thomas EC, Huang Y, Kim YK, Tao H, Yung TM, Chen X, Zhang K, Woolaver EK, Nevin MR, Huang X, Winklbauer R, Rossant J, Sun Y, Hopyan S

Science advances2024Senior author

DOI: 10.1126/sciadv.adl6366 PMID: 39028807

Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion.

Polsani N, Yung T, Thomas E, Phung-Rojas M, Gupta I, Denker J, Lau K, Feng X, Ibarra B, Hopyan S, Atit RP

Development (Cambridge, England)2024

DOI: 10.1242/dev.202596 PMID: 38814743

Apical expansion of calvarial osteoblasts and suture patency is dependent on fibronectin cues.

Feng X, Molteni H, Gregory M, Lanza J, Polsani N, Gupta I, Wyetzner R, Hawkins MB, Holmes G, Hopyan S, Harris MP, Atit RP

Development (Cambridge, England)2024

DOI: 10.1242/dev.202371 PMID: 38602508

The biophysical origin of limb pattern

Nominated PICIHR2026Project Grant

Principal investigators: Hopyan, Sevan

Keywords: Conditional Mutagenesis; Limb Development; Live Imaging; Membrane Potential; Morphogenesis; Mouse Embryo; Skeletal Pattern; Spatial Transcriptomics; Stiffness; Transgenic Reporters

$1,036,576

Force dependent chromatin conformation and transcription

Nominated PICIHR2025Project Grant

Principal investigators: Hopyan, Sevan

Keywords: Chromatin; Chromatin Conformation Capture; Conditional Mutation; Embryonic Development; Gene Regulation; Limb Bud; Physical Forces; Polycomb Repressive Complex; Rna-Sequencing; Transcription

$1,021,276

Canadian Developmental Biology Conference

Nominated PICIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Hopyan, Sevan; Simard, Martin J

Keywords: 170-220 Participants Expected; Biennial Meeting; Canadian Developmental Biology Conference; Québec City

$15,000

Simple Bone Cysts in Kids (SBoCK)

Nominated PICIHR2022Project Grant

Principal investigators: Hopyan, Sevan; Wright, James G

Keywords: Bone Cysts; Bone Substitute; Clinical Trials; Functional Outcomes; Orthopaedics; Paediatric

$371,408

Endogenous electrical and mechanical gradients guide collective cell movements in vivo

Principal investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Hopyan, Sevan

Keywords: Morphogenesis; mouse embryo; collective cell movements; endogenous bioelectrical gradients; endogenous viscoelastic gradients; genetically encoded voltage sensor; light sheet microscopic elastography

$125,000

Endogenous electrical and mechanical gradients guide collective cell movements in vivo

Principal investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Hopyan, Sevan

Keywords: Morphogenesis mouse embryo collective cell movements endogenous bioelectrical gradients endogenous viscoelastic gradients genetically encoded voltage sensor light sheet microscopic elastography

$125,000

A Magnetic Micromanipulation System for Intra-Cellular and Intra-Tissue Mechanics

Co-investigatorNSERC2019Research Tools and Instruments

Principal investigators: Sun, Yu

$150,000

Biophysical control of mesenchymal morphogenesis in the mammalian embryo

Nominated PICIHR2019Project Grant

Principal investigators: Hopyan, Sevan

Keywords: Biophysical; Cellular Forces; Durotaxis; Mesenchymal Organs; Morphogenesis; Mouse Embryo; Piezo1; Tissue Viscoelasticity; Wnt5a; Yap

$810,900

The physical basis of morphogenesis

Principal investigatorSSHRC2019New Frontiers in Research Fund - Exploration

Principal investigators: Hopyan, Sevan

Keywords: Biophysics; Morphogenesis; Organ primordia; Rigidity transition; Durotaxis; Genetically encoded force sensors; Magnetic tweezers

$270,465

Physical regulation of chromatin during development

Nominated PICIHR2018Project Grant

Principal investigators: Hopyan, Sevan

Keywords: 5' Hoxa Cluster; Atomic Force Microscopy; Chromatin Conformation Capture; Limb Development; Mouse Embryo; Nuclear Lamina; Nuclear Mechanotransduction; Polycomb; Storm; Transgenic Force Sensors

$810,900

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Sevan Hopyan

Research

Latest papers

Latest funding

CORR Insights&#xae;: Preliminary Surgical Findings and Complications After National Centralization of Pediatric Bone Sarcoma Resections in the Netherlands: a Benchmarking Study.

Sufficiency of Isolated Vascularised Fibular Free Flaps for Pediatric Intercalary Lower Limb Reconstruction.

Canadian Spine Society

Shoulder Motion Following Combined Glenoid Anteversion Osteotomy Compared with Soft Tissue Rebalancing Alone for Brachial Plexus Birth Injury.

A thermodynamic perspective on mammalian neural crest ingression.

Local Control for Pediatric Rhabdomyosarcoma of the Extremities: Is Radiotherapy Always Required After Adequate Surgical Resection? A CanSaRCC Study.

Tissue stiffness mapping by light sheet elastography.

A fibronectin gradient remodels mixed-phase mesoderm.

Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion.

Apical expansion of calvarial osteoblasts and suture patency is dependent on fibronectin cues.

The biophysical origin of limb pattern

Force dependent chromatin conformation and transcription

Canadian Developmental Biology Conference

Simple Bone Cysts in Kids (SBoCK)

Endogenous electrical and mechanical gradients guide collective cell movements in vivo

Endogenous electrical and mechanical gradients guide collective cell movements in vivo

A Magnetic Micromanipulation System for Intra-Cellular and Intra-Tissue Mechanics

Biophysical control of mesenchymal morphogenesis in the mammalian embryo

The physical basis of morphogenesis

Physical regulation of chromatin during development

Frequent collaborators

Yu Sun

Chi-Chung Hui

Helen McNeill

Andrew Howard

Abha Gupta

Andrew Howard

Adam Shlien

David Malkin

Xi Huang

Janet Rossant

Brian Ciruna

Jun Liu

Angelo Iulianella

Mathieu Roy

Tae-Hee Kim

Peter Kannu

Sasha Carsen

James McDonald

Jefferson Wilson

Chester Ho

Natasha Saunders

Desmond Kwok

Michelle Ghert

Ian Scott

Benjamin Alman

Michael Fehlings

Anne-Claude Gingras

Teresa To

Paul Gibson

Milica Radisic

CORR Insights®: Preliminary Surgical Findings and Complications After National Centralization of Pediatric Bone Sarcoma Resections in the Netherlands: a Benchmarking Study.