Faculty profile

Isabella Caniggia

ResearcherLunenfeld-Tanenbaum Research InstituteUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Isabella Caniggia

Researcher

Lunenfeld-Tanenbaum Research Institute

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
7 publications in the last five years, latest in 2025.
Senior (last) author on 7 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (6 CIHR, 1 NSERC), most recently in 2025.
Supervisor on 1 trainee award (1 CIHR), most recently in 2011.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

5,187

Citations

Collaborators

Grants

Publications by year

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Signals and details

Research

Preeclampsia Placenta Small Extracellular Vesicles Lipids Cardiovascular System Lipidome Mitochondria Morphology And Function Mouse Model Of Preeclampsia

Latest papers

Placental Hypoxia-Induced Ferroptosis Drives Vascular Damage in Preeclampsia.
Circulation research · 2025 · senior author
Intrauterine oxygen milieu governs placental sphingolipid metabolism.
Journal of lipid research · 2025 · senior author
Lipid profile of circulating placental extracellular vesicles during pregnancy identifies foetal growth restriction risk.
Journal of extracellular vesicles · 2024 · senior author

All 50 publications

Latest funding

Placenta-Heart Axis in Preeclampsia: Mechanisms and Therapeutic Targets
CIHR · 2025 · Nominated PI
$1,190,340
Heightened Ferroptosis in Preeclampsia: Consequences and Corrective Approaches
CIHR · 2023 · Nominated PI
$1,074,826
Placental contributions to maternal and fetal health outcomes: Lipid signatures in diabetes mellitus in pregnancy
CIHR · 2020 · Nominated PI
$997,180

All 8 grants and awards

50 publications.

Placental Hypoxia-Induced Ferroptosis Drives Vascular Damage in Preeclampsia.

Park C, Alahari S, Ausman J, Liu R, Nguyen F, Sallais J, Post M, Caniggia I

Circulation research2025Senior author

DOI: 10.1161/circresaha.124.325119 PMID: 39846172

Intrauterine oxygen milieu governs placental sphingolipid metabolism.

Sallais J, Post M, Caniggia I

Journal of lipid research2025Senior author

DOI: 10.1016/j.jlr.2025.100930 PMID: 41167398

Lipid profile of circulating placental extracellular vesicles during pregnancy identifies foetal growth restriction risk.

Klemetti MM, Pettersson ABV, Ahmad Khan A, Ermini L, Porter TR, Litvack ML, Alahari S, Zamudio S, Illsley NP, Röst H, Post M, Caniggia I

Journal of extracellular vesicles2024Senior author

DOI: 10.1002/jev2.12413 PMID: 38353485

Distinct Changes in Placental Ceramide Metabolism Characterize Type 1 and 2 Diabetic Pregnancies with Fetal Macrosomia or Preeclampsia.

Klemetti MM, Alahari S, Post M, Caniggia I

Biomedicines2023Senior author

DOI: 10.3390/biomedicines11030932 PMID: 36979912

Fibronectin and JMJD6 Signature in Circulating Placental Extracellular Vesicles for the Detection of Preeclampsia.

Alahari S, Ausman J, Porter T, Park C, Pettersson ABV, Klemetti MM, Zhang J, Post M, Caniggia I

Endocrinology2023Senior author

DOI: 10.1210/endocr/bqad013 PMID: 36683415

HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2.

Sallais J, Park C, Alahari S, Porter T, Liu R, Kurt M, Farrell A, Post M, Caniggia I

JCI insight2022Senior author

DOI: 10.1172/jci.insight.158908 PMID: 36227697

Dichotomy in hypoxia-induced mitochondrial fission in placental mesenchymal cells during development and preeclampsia: consequences for trophoblast mitochondrial homeostasis.

Gillmore T, Farrell A, Alahari S, Sallais J, Kurt M, Park C, Ausman J, Litvack M, Post M, Caniggia I

Cell death & disease2022Senior author

DOI: 10.1038/s41419-022-04641-y PMID: 35220394

JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration.

Alahari S, Farrell A, Ermini L, Park C, Sallais J, Roberts S, Gillmore T, Litvack M, Post M, Caniggia I

Frontiers in cell and developmental biology2021Senior author

DOI: 10.3389/fcell.2021.652607 PMID: 34055782

Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction.

Ermini L, Farrell A, Alahari S, Ausman J, Park C, Sallais J, Melland-Smith M, Porter T, Edson M, Nevo O, Litvack M, Post M, Caniggia I

Frontiers in cell and developmental biology2021Senior author

DOI: 10.3389/fcell.2021.652651 PMID: 34017832

Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis.

Kim MJ, Febbraro D, Farkona S, Gillmore T, Son JE, Regeenes R, Chang HH, Pollock-Tahiri E, Yang J, Park YJ, Sivasubramaniyam T, Oh SJ, Saraon P, Stagljar I, Rocheleau JV, Hui CC, Caniggia I, Hao Z, Mak TW, Konvalinka A, Woo M

Molecular metabolism2021

DOI: 10.1016/j.molmet.2021.101185 PMID: 33561544