This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.
Latest papers
Promoters and Antagonists of Phagocytosis: A Plastic and Tunable Response.
Annual review of cell and developmental biology · 2021 · first author
Dual loss of p110δ PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features.
The Journal of allergy and clinical immunology · 2018
VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis.
The Journal of cell biology · 2017
Latest funding
- $120,000
Investigating the role of ITGAV-dependent B cell activation in allergy and autoimmunity
CIHR · 2025 · Supervisor
- $983,026
Solute recycling and its role in cell and tissue homeostasis
CIHR · 2025 · Nominated PI
- $120,000
The impacts of lysosomal mechanoresilience in vivo
CIHR · 2025 · Supervisor
5 publications.
Promoters and Antagonists of Phagocytosis: A Plastic and Tunable Response.
Freeman S, Grinstein S
Dual loss of p110δ PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features.
Sharfe N, Karanxha A, Dadi H, Merico D, Chitayat D, Herbrick JA, Freeman S, Grinstein S, Roifman CM
VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis.
Hua R, Cheng D, Coyaud É, Freeman S, Di Pietro E, Wang Y, Vissa A, Yip CM, Fairn GD, Braverman N, Brumell JH, Trimble WS, Raught B, Kim PK
Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells.
Badour K, McGavin MK, Zhang J, Freeman S, Vieira C, Filipp D, Julius M, Mills GB, Siminovitch KA
Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.
Leng Y, Zhang J, Badour K, Arpaia E, Freeman S, Cheung P, Siu M, Siminovitch K
Investigating the role of ITGAV-dependent B cell activation in allergy and autoimmunity
Principal investigators: Yu, Daniel D
Keywords: Allergy; Autoimmunity; Cell Signaling; Inflammatory Bowel Disease; Microscopy; Monogenic Diseases; Signal Transduction
Solute recycling and its role in cell and tissue homeostasis
Principal investigators: Freeman, Spencer A
Keywords: Cell Biology; Lysosomes; Macrophages; Mtor; Solute Transport
The impacts of lysosomal mechanoresilience in vivo
Principal investigators: Kim, Angelina
Keywords: Antigen Presentation; Cancer Immunity; Cell Biology; Lysosomes; Macrophage; Mechanotransduction
Canada Research Chair - Tier 2
Principal investigators: Freeman, Spencer A
Keywords: Crc
Phagocytosis-associated oxidative damage impairs phagosome resolution by the retinal pigment epithelium
Principal investigators: Kwon, Whijin
Keywords: Cell Biology; Phagocytosis; Vision
Investigating the role of Two Pore Channels in target lysis and resolution
Principal investigators: Chadwick, Sarah R
Keywords: Autophagy; Cell Biology; Genetics; Metabolism; Resolution
Mechanotransduction from lysosomes drives sterile inflammation
Principal investigators: Freeman, Spencer A
Keywords: Cytokines; Inflammation; Ion Channels; Lysosomes; Mechanotransduction; Slc17a5; Solute Transport; Tfeb/Tfe3
The role of chloride in supporting the degradative capacity of phagosomes and lysosomes
Principal investigators: Freeman, Spencer
Targeting cell autonomous fusion as a strategy to cripple tumor cell macropinocytosis and limit proliferation
Principal investigators: Cai, Ruiqi
Keywords: Cell Biology; Cell Signalling; Endocytosis; Imaging; Membrane Fusion
The role of chloride in supporting the degradative capacity of phagosomes and lysosomes
Principal investigators: Freeman, Spencer
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Cell Biology
- Research Institute
- Computer Science
- Medicine
- Human Genetics
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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