François Mercier

Research

Acute Myeloid Leukemia Apoptosis Chemotherapy And Radiotherapy Leukemia Targets And Biomarkers Drug Delivery Drug Design Drug Development

Latest papers

Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML.
Nature communications · 2021
TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity.
Molecular cancer therapeutics · 2021
Immunophenotypic patterns of CD8+ T cell subsets expressing CD8alphaalpha and IL-7Ralpha in viremic, aviremic and slow progressor HIV-1-infected subjects.
Clinical immunology (Orlando, Fla.) · 2007

All 3 publications

Latest funding

Identifying novel therapeutic vulnerabilities in pediatric acute megakaryoblastic leukemia
CIHR · 2024 · Co-investigator
$1,017,450
Identifying novel therapeutic vulnerabilities in pediatric acute megakaryoblastic leukemia
CIHR · 2023 · Co-investigator
$100,000
Small activating RNAs targeting transcription factors as a therapeutic approach for acute myeloid leukemia
CIHR · 2022 · Principal investigator
$726,751

All 7 grants and awards

3 publications.

01

Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML.

Oki T, Mercier F, Kato H, Jung Y, McDonald TO, Spencer JA, Mazzola MC, van Gastel N, Lin CP, Michor F, Kitamura T, Scadden DT

Nature communications2021

DOI: 10.1038/s41467-020-20491-8 PMID: 33431855

02

TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity.

Abusarah J, Cui Y, El-Hachem N, El-Kadiry AE, Hammond-Martel I, Wurtele H, Beaudry A, Raynal NJ, Robert F, Pelletier J, Jankovic M, Mercier F, Kamyabiazar S, Annabi B, Rafei M

Molecular cancer therapeutics2021

DOI: 10.1158/1535-7163.mct-20-0333 PMID: 33087510

03

Immunophenotypic patterns of CD8+ T cell subsets expressing CD8alphaalpha and IL-7Ralpha in viremic, aviremic and slow progressor HIV-1-infected subjects.

Boulassel MR, Mercier F, Gilmore N, Routy JP

Clinical immunology (Orlando, Fla.)2007

DOI: 10.1016/j.clim.2007.05.005 PMID: 17560832

Identifying novel therapeutic vulnerabilities in pediatric acute megakaryoblastic leukemia

Co-investigatorCIHR2024Project Grant

Principal investigators: Mallette, Frédérick A

Keywords: Acute Megakaryoblastic Leukemia; Apoptosis; Chromatin Modifiers; Metabolism; Pediatric Cancer; Protein-Protein Interaction; Transcriptomics

$1,017,450

Identifying novel therapeutic vulnerabilities in pediatric acute megakaryoblastic leukemia

Co-investigatorCIHR2023Project Grant - Priority Announcement: Pediatric Cancer Research

Principal investigators: Mallette, Frédérick A

Keywords: Acute Megakaryoblastic Leukemia; Apoptosis; Chromatin Modifiers; Metabolism; Pediatric Cancer; Protein-Protein Interaction; Transcriptomics

$100,000

Small activating RNAs targeting transcription factors as a therapeutic approach for acute myeloid leukemia

Principal investigatorCIHR2022Project Grant

Principal investigators: McKeague, Maureen H; Luedtke, Nathan; Mercier, François

Keywords: Acute Myeloid Leukemia; Drug Delivery; Drug Design; Drug Development; Lipid Nanoparticles; Rna Activation; Rna Chemistry; Rna Expression; Therapeutic Oligonucleotides

$726,751

Deciphering the role of the E3 ubiquitin ligase HERC1 in the chemotherapy response of acute myeloid leukemia.

Nominated PICIHR2022CIHR - ICR / Cancer Research Society Partnership - Research Grants

Principal investigators: Mercier, François

Keywords: Apoptosis; Chemotherapy And Radiotherapy; Leukemia; Targets And Biomarkers

$60,000

Understanding the role of eIF4A in AML progression and relapse

Nominated PICIHR2022Project Grant

Principal investigators: Mercier, François

Keywords: Acute Myeloid Leukemia; Cancer Metabolism; Mrna Translation; Therapeutic Resistance

$929,475

Identification of in vivo regulators of leukemic growth.

Nominated PICIHR2018CIHR - ICR / Cancer Research Society Partnership - Research Grants

Principal investigators: Mercier, François

Keywords: In Vivo Regulators

$60,000

Identification of signaling pathways driving leukemic stem cell fitness in murine models of leukemia development

Nominated PICIHR2013CIHR Clinician Scientist - Phase 1

Principal investigators: Mercier, François

Keywords: Cancer Genetics; Dna Sequencing; Flow Cytometry; Gene Expression Profiline; Leukemia; Murine Models Of Cancer; Stem Cell Biology

$187,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Pharmacology and Therapeutics
Medicine
Microbiology and Immunology
Biochemistry
Microbiology
Physiology and Pharmacology

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Moutih Rafei

Physiology and Pharmacology

1 shared papers, latest 2021

Moutih Rafei

Microbiology

1 shared papers, latest 2021

Jean-Pierre Routy

Microbiology and Immunology

1 shared papers, latest 2007

Jerry Pelletier

Biochemistry

1 shared papers, latest 2021

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Acute Myeloid Leukemia Dear Professor Mercier, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML." (2021), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Small activating RNAs targeting transcription factors as a therapeutic approach for acute myeloid leukemia" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]