Jean-Francois Cloutier, McGill University

Research

Mouse Genetics Cytoskeleton Receptor Transport Synapse Synapse Structure Synaptic Inhibition Axon Guidance Cell Adhesion Molecules

Latest papers

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes.
Cell reports · 2024
Transsynaptic cerebellin 4-neogenin 1 signaling mediates LTP in the mouse dentate gyrus.
Proceedings of the National Academy of Sciences of the United States of America · 2022
Extracellular phosphorylation drives the formation of neuronal circuitry.
Nature chemical biology · 2019

All 4 publications

Latest funding

Brain circuitry in the regulation of social behaviour in mice.
NSERC · 2023 · Principal investigator
$104,000
Uncovering a novel role for the receptor Neogenin in synaptic function.
CIHR · 2021 · Nominated PI
$1,086,300
Uncovering a novel role for a Neogenin-WAVE regulatory complex interaction in modulating synaptic inhibition in cortical circuitry
CIHR · 2019 · Supervisor
$105,000

All 9 grants and awards

4 publications.

01

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes.

Megagiannis P, Mei Y, Yan RE, Yuan L, Wilde JJ, Eckersberg H, Suresh R, Tan X, Chen H, Farmer WT, Cha K, Le PU, Catoire H, Rochefort D, Kwan T, Yee BA, Dion P, Krishnaswamy A, Cloutier JF, Stifani S, Petrecca K, Yeo GW, Murai KK, Feng G, Rouleau GA, Ideker T, Sanjana NE, Zhou Y

Cell reports2024

DOI: 10.1016/j.celrep.2024.114637 PMID: 39154337

02

Transsynaptic cerebellin 4-neogenin 1 signaling mediates LTP in the mouse dentate gyrus.

Liakath-Ali K, Polepalli JS, Lee SJ, Cloutier JF, Südhof TC

Proceedings of the National Academy of Sciences of the United States of America2022

DOI: 10.1073/pnas.2123421119 PMID: 35544694

03

Extracellular phosphorylation drives the formation of neuronal circuitry.

Harada H, Farhani N, Wang XF, Sugita S, Charish J, Attisano L, Moran M, Cloutier JF, Reber M, Bremner R, Monnier PP

Nature chemical biology2019

DOI: 10.1038/s41589-019-0345-z PMID: 31451763

04

Complete Loss of Netrin-1 Results in Embryonic Lethality and Severe Axon Guidance Defects without Increased Neural Cell Death.

Bin JM, Han D, Lai Wing Sun K, Croteau LP, Dumontier E, Cloutier JF, Kania A, Kennedy TE

Cell reports2015

DOI: 10.1016/j.celrep.2015.07.028 PMID: 26257176

Brain circuitry in the regulation of social behaviour in mice.

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Cloutier, Jean-Francois

Keywords: axonal guidance; behaviour; dendrite branching; innate behaviour; mouse genetics; neuronal differentiation; olfactory system

$104,000

Uncovering a novel role for the receptor Neogenin in synaptic function.

Nominated PICIHR2021Project Grant

Principal investigators: Cloutier, Jean-Francois

Keywords: Cytoskeleton; Mouse Genetics; Receptor Transport; Synapse; Synapse Structure; Synaptic Inhibition

$1,086,300

Uncovering a novel role for a Neogenin-WAVE regulatory complex interaction in modulating synaptic inhibition in cortical circuitry

SupervisorCIHR2019Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Quilez, Sabrina

Keywords: Autism Spectrum Disorder; Cytoskeleton; Eif4e; Electrophysiology; Neogenin; Neurodevelopment; Primary Cortical Cultures; Protein Synthesis; Synapses; Wave Regulatory Complex

$105,000

Scanning histology and immunohistochemistry-prepared tissue for bridging across scales of molecular, cellular, systems and imaging neuroscience

Co-investigatorNSERC2018Research Tools and Instruments

Principal investigators: Shmuel, Amir

$150,000

Brain circuitry in the regulation of social behaviour in mice

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Cloutier, JeanFrancois

$204,000

Molecular Mechanisms of Sensory Systems Development

Nominated PICIHR2014Operating Grant

Principal investigators: Cloutier, Jean-Francois

Keywords: Axon Guidance; Cell Adhesion Molecules; Mouse Genetics; Olfactory System; Synaptogenesis

$839,884

Defining molecular pathways underlying craniofacial birth defects

Nominated PICIHR2013Operating Grant

Principal investigators: Cloutier, Jean-Francois

Keywords: Cell Differentiation; Craniofacial Birth Defects; Mouse Gentics; Neural Crest

$441,854

Brain circuitry and the control of social behaviour in mice.

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Cloutier, JeanFrançois

$165,000

CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA

Nominated PICIHR2009Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Cloutier, Jean-Francois

Keywords: Crc

$500,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Neurology and Neurosurgery
Physiology
Engineering Physics
Department of Biochemistry
Department of Molecular Genetics
Lunenfeld-Tanenbaum Research Institute
Other

Applying for

Paper to mentionMention their NSERC grant from 2023

Subject: Prospective PhD student: Mouse Genetics Dear Professor Cloutier, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Brain circuitry in the regulation of social behaviour in mice." (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]