Kai-Florian Storch, McGill University

Research

Circadian Rhythms Dopamine Arousal Bipolar Disorder Locomotor Activity Mesolimbic Oscillator Sleep

Latest papers

Latent brain subtypes of chronotype reveal unique behavioral and health profiles across population cohorts.
Nature communications · 2025
Multimodal population study reveals the neurobiological underpinnings of chronotype.
Nature human behaviour · 2025
The Deubiquitinase USP2 Modulates Photic Entrainment of the Circadian Clock at the Level of the Suprachiasmatic Nucleus.
Journal of neurochemistry · 2025

All 28 publications

Latest funding

Objectively-Derived Biorhythm Measures for a Staging Model: Towards Research Exactness and Appropriate Treatments in Bipolar Disorder (TREAT-BD)
CIHR · 2022 · Co-investigator
$1,181,925
Dual oscillator control of rest-activity rhythms and its relevance for cyclicity in bipolar disorder
CIHR · 2022 · Nominated PI
$1,009,800
Dissecting the mechanistic basis of meal timing and food anticipation: a role for the DUO
NSERC · 2020 · Principal investigator
$240,000

All 15 grants and awards

28 publications.

01

Latent brain subtypes of chronotype reveal unique behavioral and health profiles across population cohorts.

Zhou L, Saltoun K, Marotta J, Aggarwal S, Kopal J, Carrier J, Storch KF, Dunbar RIM, Bzdok D

Nature communications2025

DOI: 10.1038/s41467-025-66784-8 PMID: 41429783

02

Multimodal population study reveals the neurobiological underpinnings of chronotype.

Zhou L, Saltoun K, Carrier J, Storch KF, Dunbar RIM, Bzdok D

Nature human behaviour2025

DOI: 10.1038/s41562-025-02182-w PMID: 40246996

03

The Deubiquitinase USP2 Modulates Photic Entrainment of the Circadian Clock at the Level of the Suprachiasmatic Nucleus.

Srikanta SB, Brown TW, Malescot A, Cloutier MÈ, Zhu L, Coutanson C, Malki M, Storch KF, Rungta R, Cayouette M, Dkhissi-Benyahya O, Cermakian N

Journal of neurochemistry2025

DOI: 10.1111/jnc.70018 PMID: 39967311

04

Mesolimbic dopamine neurons drive infradian rhythms in sleep-wake and heightened activity state.

Markam PS, Bourguignon C, Zhu L, Ward B, Darvas M, Sabatini PV, Kokoeva MV, Giros B, Storch KF

Science advances2025Senior author

DOI: 10.1126/sciadv.ado9965 PMID: 39742489

05

The neurons that drive infradian sleep-wake and mania-like behavioral rhythms.

Markam PS, Bourguignon C, Zhu L, Darvas M, Sabatini PV, Kokoeva MV, Giros B, Storch KF

bioRxiv : the preprint server for biology2023Senior author

DOI: 10.1101/2023.11.14.566955 PMID: 38014299

06

Behavioral and Transcriptomic Changes Following Brain-Specific Loss of Noradrenergic Transmission.

Isingrini E, Guinaudie C, Perret L, Guma E, Gorgievski V, Blum ID, Colby-Milley J, Bairachnaya M, Mella S, Adamantidis A, Storch KF, Giros B

Biomolecules2023

DOI: 10.3390/biom13030511 PMID: 36979445

07

Leptin receptor-expressing pericytes mediate access of hypothalamic feeding centers to circulating leptin.

Butiaeva LI, Slutzki T, Swick HE, Bourguignon C, Robins SC, Liu X, Storch KF, Kokoeva MV

Cell metabolism2021

DOI: 10.1016/j.cmet.2021.05.017 PMID: 34129812

08

Effects of antipsychotics on circadian rhythms in humans: a systematic review and meta-analysis.

Moon E, Lavin P, Storch KF, Linnaranta O

Progress in neuro-psychopharmacology & biological psychiatry2021

DOI: 10.1016/j.pnpbp.2020.110162 PMID: 33152385

09

Irregular eating patterns associate with hypomanic symptoms in bipolar disorders.

Buyukkurt A, Bourguignon C, Antinora C, Farquhar E, Gao X, Passarella E, Sibthorpe D, Gou K, Saury S, Beaulieu S, Storch KF, Linnaranta O

Nutritional neuroscience2021

DOI: 10.1080/1028415x.2019.1587136 PMID: 30873919

10

The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas.

Petrenko V, Stolovich-Rain M, Vandereycken B, Giovannoni L, Storch KF, Dor Y, Chera S, Dibner C

Genes & development2020

DOI: 10.1101/gad.343137.120 PMID: 33184223

Objectively-Derived Biorhythm Measures for a Staging Model: Towards Research Exactness and Appropriate Treatments in Bipolar Disorder (TREAT-BD)

Co-investigatorCIHR2022Project Grant

Principal investigators: Beaulieu, Serge; Linnaranta, Outi

Keywords: Actigraphy; Bipolar Disorders; Longitudinal; Multi-Site; Sleep; Staging

$1,181,925

Dual oscillator control of rest-activity rhythms and its relevance for cyclicity in bipolar disorder

Nominated PICIHR2022Project Grant

Principal investigators: Storch, Kai-Florian

Keywords: Arousal; Bipolar Disorder; Circadian Rhythms; Dopamine; Locomotor Activity; Mesolimbic; Oscillator; Sleep; Ultra-Rapid Cycling; Ventral Tegmental Area

$1,009,800

Dissecting the mechanistic basis of meal timing and food anticipation: a role for the DUO

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Storch, Kai-Florian

$240,000

An integrated chronobiology facility for the large-scale study of biological rhythms at the behavioural, neurocircuit and cellular levels

Co-investigatorNSERC2018Research Tools and Instruments

Principal investigators: Cermakian, Nicolas

$148,717

Circadian disruption, cognitive deficits and schizophrenia

Co-investigatorCIHR2016Project Grant

Principal investigators: Cermakian, Nicolas; Srivastava, Lalit K

Keywords: Animal Model; Behaviour; Circadian Rhythms; Cognitive Deficits; Gene X Environment Interaction; Light; Risk Genes; Schizophrenia; Shift Work; Suprachiasmatic Nucleus

$849,150

The dopaminergic ultradian oscillator and psychopathology

Nominated PICIHR2016Project Grant

Principal investigators: Storch, Kai-Florian

Keywords: Circadian Rhythms; Dopamine; Dopamine Transporter; Molecular Biology Of Dopamine Neurons; Polarity In Mood Disorders; Rest:Activity Cycling; Sleep Regulation; Ultra-Rapid Mood Cycling; Ultradian Rhythms

$688,051

Characterization of a dopaminergic ultradian oscillator regulating arousal

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Storch, KaiFlorian

$140,000

Microscope and tissue preparation core facility for the molecular and neuroanatomical dissection of neurocircuits

Co-investigatorNSERC2014Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Walker, ClaireDominique

$149,528

An integrated detection platform for the study of neuroimmune interactions, neuroendocrine pathways and neurodevelopment

Co-investigatorNSERC2013Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Cermakian, Nicolas

$67,437

Genetic dissection of circadian pacemaker function in the suprachiasmatic nucleus

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Storch, KaiFlorian

$155,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Psychiatry
Biochemistry
Centre d'étude du sommeil
Psychology
Neurosciences
Medicine
Biochemistry, Microbiology and Immunology
Other

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Circadian Rhythms Dear Professor Storch, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Latent brain subtypes of chronotype reveal unique behavioral and health profiles across population cohorts." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Dual oscillator control of rest-activity rhythms and its relevance for cyclicity in bipolar disorder" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Kai-Florian Storch

Research

Latest papers

Latest funding

Latent brain subtypes of chronotype reveal unique behavioral and health profiles across population&#xa0;cohorts.

Multimodal population study reveals the neurobiological underpinnings of chronotype.

The Deubiquitinase USP2 Modulates Photic Entrainment of the Circadian Clock at the Level of the Suprachiasmatic Nucleus.

Mesolimbic dopamine neurons drive infradian rhythms in sleep-wake and heightened activity state.

The neurons that drive infradian sleep-wake and mania-like behavioral rhythms.

Behavioral and Transcriptomic Changes Following Brain-Specific Loss of Noradrenergic Transmission.

Leptin receptor-expressing pericytes mediate access of hypothalamic feeding centers to circulating leptin.

Effects of antipsychotics on circadian rhythms in humans: a systematic review and meta-analysis.

Irregular eating patterns associate with hypomanic symptoms in bipolar disorders.

The core clock transcription factor BMAL1 drives circadian &#x3b2;-cell proliferation during compensatory regeneration of the endocrine pancreas.

Objectively-Derived Biorhythm Measures for a Staging Model: Towards Research Exactness and Appropriate Treatments in Bipolar Disorder (TREAT-BD)

Dual oscillator control of rest-activity rhythms and its relevance for cyclicity in bipolar disorder

Dissecting the mechanistic basis of meal timing and food anticipation: a role for the DUO

An integrated chronobiology facility for the large-scale study of biological rhythms at the behavioural, neurocircuit and cellular levels

Circadian disruption, cognitive deficits and schizophrenia

The dopaminergic ultradian oscillator and psychopathology

Characterization of a dopaminergic ultradian oscillator regulating arousal

Microscope and tissue preparation core facility for the molecular and neuroanatomical dissection of neurocircuits

An integrated detection platform for the study of neuroimmune interactions, neuroendocrine pathways and neurodevelopment

Genetic dissection of circadian pacemaker function in the suprachiasmatic nucleus

Frequent collaborators

Outi Linnaranta

Serge Beaulieu

Bruno Giros

Bruno Giros

Nicolas Cermakian

Danilo Bzdok

Danilo Bzdok

Julie Carrier

Nahum Sonenberg

Shimon Amir

Shimon Amir

Tommy Alain

Cecilia Flores

Nathalie Labrecque

Alfonso Abizaid

Gustavo Turecki

Howard Steiger

Latent brain subtypes of chronotype reveal unique behavioral and health profiles across population cohorts.

The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas.