Faculty profile

Marco Leyton

ResearcherPsychiatryMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Marco Leyton

Researcher

Psychiatry

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
27 publications in the last five years, latest in 2026.
Senior (last) author on 9 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (8 CIHR), most recently in 2020.
Supervisor on 2 trainee awards (2 CIHR), most recently in 2014.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Reward Dopamine Impulsivity Risk Trajectories Pet Addiction Child Abuse Depression

Latest papers

Reimagining the Biopsychosocial Model: Transdiagnostic Factors to Precision Psychiatry.
Biological psychiatry global open science · 2026 · senior author
Reimagining the biopsychosocial model: hierarchical mechanisms from transdiagnostic to precision psychiatry.
Journal of psychiatry & neuroscience : JPN · 2026 · first author
Memory erasure by dopamine-gated retrospective learning.
bioRxiv : the preprint server for biology · 2026

All 99 publications

Latest funding

Prospective PET Study of High-Risk Youth
CIHR · 2020 · Nominated PI
$1,950,752
Lysergic acid diethylamide (LSD) and social behavior. A translational study.
CIHR · 2020 · Co-investigator
$784,126
Cocaine Addiction: Epigenetic Studies in Living and Postmortem Brain
CIHR · 2016 · Nominated PI
$1,235,475

All 12 grants and awards

99 publications.

Reimagining the Biopsychosocial Model: Transdiagnostic Factors to Precision Psychiatry.

Nikolic M, Caswell CB, Prada NP, Iqbal M, Cox SML, Jaworska N, Castellanos-Ryan N, Vitaro F, Brendgen M, Parent S, Boivin M, Côté S, Tremblay RE, Séguin JR, Leyton M

Biological psychiatry global open science2026Senior author

DOI: 10.1016/j.bpsgos.2026.100734 PMID: 42293407

Reimagining the biopsychosocial model: hierarchical mechanisms from transdiagnostic to precision psychiatry.

Leyton M

Journal of psychiatry & neuroscience : JPN2026First author

DOI: 10.1139/jpn-2026-0063 PMID: 42599006

Memory erasure by dopamine-gated retrospective learning.

Jeong H, Zsembik L, Farouq F, Chakraborty R, Belur N, Zhou M, Sanders AD, Wang SX, Srinivasan A, Cox SML, Garr E, Brooke S, Janak PH, Leyton M, Chen R, Namboodiri VMK

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.01.17.700100 PMID: 41648262

Inter-individual variability of neurotransmitter receptor and transporter density in the human brain.

Hansen JY, Tuisku J, Johansson J, Chang Z, McGinnity CJ, Beliveau V, Guimond S, Ganz M, Nørgaard M, Galovic M, Bezgin G, Cox SML, Hietala J, Leyton M, Kobayashi E, Rosa-Neto P, Funck T, Palomero-Gallagher N, Knudsen GM, Marsden P, Hammers A, Nummenmaa L, Tuominen L, Misic B

Brain structure & function2026

DOI: 10.1007/s00429-025-03069-2 PMID: 41528514

Quantification of [11C]ABP688 Binding to mGluR5 in Human Brain using Cerebellum as Reference Region: Biological Interpretation and Limitations

Milella MS, Minuzzi L, Benkelfat C, Soucy J-P, Kirlow A, Schirrmacher E, Angle M, Verhaeghe JAJ, Massarweh G, Reader AJ

Current Neuropharmacology20252 citationsSenior author

DOI: 10.2174/1570159x23666250127161855

Differential effects of psilocybin and lisuride on serotonin and dopamine neuronal activity and behavior.

Richardson B, Inserra A, Pileggi M, Prud'Homme T, Bruno V, Wan-Yan-Chan D, Shareghi-Ghahreman I, Nasini S, Strand T, Leyton M, Sonenberg N, De Gregorio D, Sprouse J, Bambico FR, Gobbi G

Progress in neuro-psychopharmacology & biological psychiatry2025

DOI: 10.1016/j.pnpbp.2025.111522 PMID: 41077262

Experiences and barriers to alcohol use disorder treatment among adults with and without self-reported executive functioning challenges: A mixed-methods study.

Russell C, Wiese JL, Ruocco AC, Bozinoff N, Gonzalez R, Jennings S, Leyton M, Nikolova YS, Orson J, Potenza MN, Quilty LC, Shield KD, Verdejo-Garcia A, Wells S, Lange S, CDiA Program Study Group

Alcohol, clinical & experimental research2025

DOI: 10.1111/acer.70154 PMID: 40890992

Resting-state alterations in emotion salience and default-mode network connectivity in atypical trajectories of psychotic-like experiences.

Assaf R, Ouellet J, Bourque J, Stip E, Leyton M, Conrod P, Potvin S

Development and psychopathology2025

DOI: 10.1017/s0954579424001317 PMID: 39297232

A Novel Diathesis-Stress Model of Comorbid Early Onset Psychiatric Disorders.

Caswell CB, Hosseini-Kamkar N, Cox SM, Prada NP, Iqbal M, Nikolic M, Banaschewski T, Barker GJ, Bokde ALW, Brühl R, Desrivières S, Flor H, Garavan H, Gowland P, Grigis A, Heinz A, Martinot JL, Paillère Martinot ML, Artiges E, Nees F, Orfanos DP, Poustka L, Smolka MN, Hohmann S, Vaidya N, Walter H, Whelan R, Schumann G, Paus T, Leyton M, IMAGEN Consortium

medRxiv : the preprint server for health sciences2025Senior author

DOI: 10.1101/2025.04.08.25325481 PMID: 40297443

A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography.

Nikolic M, Cox SML, Jaworska N, Castellanos-Ryan N, Dagher A, Vitaro F, Brendgen M, Parent S, Boivin M, Côté S, Tremblay RE, Séguin JR, Leyton M

Alcohol, clinical & experimental research2025Senior author

DOI: 10.1111/acer.15511 PMID: 39725679

Prospective PET Study of High-Risk Youth

Nominated PICIHR2020Project Grant

Principal investigators: Leyton, Marco; Castellanos Ryan, Natalie; Wazana, Ashley

Keywords: Addiction; Child Abuse; Depression; Dopamine; Glutamate; Impulsivity; Pet; Reward; Risk Trajectories; Vulnerability Markers

$1,950,752

Lysergic acid diethylamide (LSD) and social behavior. A translational study.

Co-investigatorCIHR2020Project Grant

Principal investigators: Gobbi, Gabriella

Keywords: Ampa; Bdnf; Behavior; Biomarkers; Electrophysiology; Hallucinogens; Healthy Volunteers; Lysergic Acid Diethylamide; Optogenetic; Serotonin

$784,126

Cocaine Addiction: Epigenetic Studies in Living and Postmortem Brain

Nominated PICIHR2016Project Grant

Principal investigators: Leyton, Marco

Keywords: Cocaine Addiction; Epigenetic; Hdac; Micropet; Motivation; Pet; Post-Mortem Brain; Reward

$1,235,475

The brain at risk: Neural features of addiction vulnerability

SupervisorCIHR2014CIHR Fellowship

Principal investigators: Jaworska, Natalia

Keywords: Addictions; Development; Dopamine; Fmri; Mental Health; Mri; Pet; Youth

$116,250

Dopamine and Risk for Addictions

Nominated PICIHR2013Operating Grant

Principal investigators: Leyton, Marco; Seguin, Jean R

Keywords: Addiction Vulnerability; Brain Imaging; Dopamine; Impulsivity; Limbic System; Longitudinal Cohorts; Reward; Risk Trajectories

$1,124,691

In vivo investigations of brain dopaminergic plasticity in humans

Principal investigatorCIHR2011Operating Grant

Principal investigators: Benkelfat, Chawki; Dagher, Alain; Leyton, Marco

Keywords: Addiction; Dopamine; Glutamate; Positron Emission Tomography; Psychostimulant; Sensitization

$1,163,010

Mapping Neural Function in Individuals with DCC Haplotype

Nominated PICIHR2011Operating Grant

Principal investigators: Leyton, Marco

Keywords: Axon Guidance Molecules; Brain Development; Dopamine; Genetic Imaging; Neuroanatomy; Neuroimaging; Neuropsychiatric Disorders

$590,325

In vivo investigations of brain dopaminergic plasticity in humans

Principal investigatorCIHR2010Operating Grant - PA: Prevention and Treatment of Illicit Drug Use

Principal investigators: Benkelfat, Chawki; Dagher, Alain; Leyton, Marco

Keywords: Addiction; Dopamine; Glutamate; Positron Emission Tomography; Psychostimulant; Sensitization

$100,000

Targetting reconsolidation of cocaine memories as a new treatment for cocaine addiction.

Principal investigatorCIHR2009Catalyst Grant: Prevention and Treatment of Illicit Substance Use

Principal investigators: Nader, Karim K; Leyton, Marco

Keywords: Addiction; Amnesic Agents; Reconsolidation Blockade

$99,966

The role of dopamine in executive cognitive function, mood and incentive salience: Individual differences in response to the dopamine augmenter, L-DOPA.

SupervisorCIHR2009Master's Award: Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Liggins, John

Keywords: Decision Making; Dopamine; Executive Cognitive Function; Incentive Motivation; Individual Differences; Mood; Reward; Subjective Effects; Working Memory

$17,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Marco Leyton

Research

Latest papers

Latest funding

Reimagining the Biopsychosocial Model: Transdiagnostic Factors to Precision Psychiatry.

Reimagining the biopsychosocial model: hierarchical mechanisms from transdiagnostic to precision psychiatry.

Memory erasure by dopamine-gated retrospective learning.

Inter-individual variability of neurotransmitter receptor and transporter density in the human brain.

Quantification of [11C]ABP688 Binding to mGluR5 in Human Brain using Cerebellum as Reference Region: Biological Interpretation and Limitations

Differential effects of psilocybin and lisuride on serotonin and dopamine neuronal activity and behavior.

Experiences and barriers to alcohol use disorder treatment among adults with and without self-reported executive functioning challenges: A mixed-methods study.

Resting-state alterations in emotion salience and default-mode network connectivity in atypical trajectories of psychotic-like experiences.

A Novel Diathesis-Stress Model of Comorbid Early Onset Psychiatric Disorders.

A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography.

Frequent collaborators

Marco Leyton

Alain Dagher

Natalia Jaworska

Michel Boivin

Frank Vitaro

Pedro Rosa-Neto

Natalie Castellanos Ryan

Natalie Castellanos Ryan

Linda Booij

Sophie Parent

Jean-Paul Soucy

Alexey Kostikov

Linda Booij

Linda Booij

Gabriella Gobbi

Patricia Conrod

Cecilia Flores

Cecilia Flores

Bratislav Misic

Ridha Joober

Ridha Joober

Synthia Guimond

Lauri Tuominen

Josiane Bourque

Lily Hechtman

Oury Monchi

Jens Pruessner

Linda Booij

Guy Rouleau

Petra Schweinhardt

Luciano Minuzzi

Abbas Sadikot

Andrew Nicholson

Karim Nader

Nahum Sonenberg

Michel Boivin