Jean Gosselin, Université Laval

Research

Bronchiolitis/Pneumonia Influenza Virus Lung Infection Lung Innate Immunity Innate Sensors Nlrp3 Nod-Like Receptors Nod2

Latest papers

Correction to: Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer's disease.
Journal of neuroinflammation · 2020

All 24 publications

Latest funding

Contribution of the orphan receptor NR4A1 in the control of influenza virus infection and lung inflammation
CIHR · 2015 · Nominated PI
$643,906
Role of the innate immune system and evaluation of immunomodulatory strategies in herpes simplex virus encephalitis
CIHR · 2013 · Co-investigator
$694,650
Role of NOD-like receptors in lung immune response against respiratory virus infection
CIHR · 2012 · Nominated PI
$658,126

All 8 grants and awards

24 publications.

01

Correction to: Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis.

Fani Maleki A, Cisbani G, Laflamme N, Prefontaine P, Plante MM, Baillargeon J, Rangachari M, Gosselin J, Rivest S

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2021

DOI: 10.1007/s13311-021-01035-4 PMID: 33907979

02

Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis.

Fani Maleki A, Cisbani G, Laflamme N, Prefontaine P, Plante MM, Baillargeon J, Rangachari M, Gosselin J, Rivest S

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2021

DOI: 10.1007/s13311-020-00998-0 PMID: 33479802

03

Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer's disease.

Fani Maleki A, Cisbani G, Plante MM, Préfontaine P, Laflamme N, Gosselin J, Rivest S

Journal of neuroinflammation2020

DOI: 10.1186/s12974-020-01893-3 PMID: 32698829

04

Both IRF3 and especially IRF7 play a key role to orchestrate an effective cerebral inflammatory response in a mouse model of herpes simplex virus encephalitis.

Canivet C, Rhéaume C, Lebel M, Piret J, Gosselin J, Boivin G

Journal of neurovirology2018

DOI: 10.1007/s13365-018-0666-9 PMID: 30094631

05

Ly6Chigh monocytes facilitate transport of Murid herpesvirus 68 into inflamed joints of arthritic mice.

LeBel M, Egarnes B, Brunet A, Lacerte P, Paré A, Lacroix S, Brown JP, Gosselin J

European journal of immunology2018Senior author

DOI: 10.1002/eji.201747048 PMID: 28980305

06

Contribution of Regulatory T Cells in Nucleotide-Binding Oligomerization Domain 2 Response to Influenza Virus Infection.

Egarnes B, Gosselin J

Frontiers in immunology2018Senior author

DOI: 10.3389/fimmu.2018.00132 PMID: 29445379

07

Treatment with the NR4A1 agonist cytosporone B controls influenza virus infection and improves pulmonary function in infected mice.

Egarnes B, Blanchet MR, Gosselin J

PloS one2017Senior author

DOI: 10.1371/journal.pone.0186639 PMID: 29053748

08

Triggering of NOD2 Receptor Converts Inflammatory Ly6Chigh into Ly6Clow Monocytes with Patrolling Properties.

Lessard AJ, LeBel M, Egarnes B, Préfontaine P, Thériault P, Droit A, Brunet A, Rivest S, Gosselin J

Cell reports2017Senior author

DOI: 10.1016/j.celrep.2017.08.009 PMID: 28834747

09

Protective role of CX3CR1 signalling in resident cells of the central nervous system during experimental herpes simplex virus encephalitis.

Menasria R, Canivet C, Piret J, Gosselin J, Boivin G

The Journal of general virology2017

DOI: 10.1099/jgv.0.000667 PMID: 27902351

10

Both Cerebral and Hematopoietic Deficiencies in CCR2 Result in Uncontrolled Herpes Simplex Virus Infection of the Central Nervous System in Mice.

Menasria R, Canivet C, Piret J, Gosselin J, Boivin G

PloS one2016

DOI: 10.1371/journal.pone.0168034 PMID: 27930721

Contribution of the orphan receptor NR4A1 in the control of influenza virus infection and lung inflammation

Nominated PICIHR2015Operating Grant

Principal investigators: Gosselin, Jean

Keywords: Bronchiolitis/Pneumonia; Influenza Virus; Innate Sensors; Lung Infection; Lung Innate Immunity

$643,906

Role of the innate immune system and evaluation of immunomodulatory strategies in herpes simplex virus encephalitis

Co-investigatorCIHR2013Operating Grant

Principal investigators: Boivin, Guy

Keywords: Encephalitis; Glucocorticoids; Herpes Simplex Virus; Immunomodulators; Innate Immunity; Interferon; Macrophages; Microglial Cells; Toll-Like Receptors

$694,650

Role of NOD-like receptors in lung immune response against respiratory virus infection

Nominated PICIHR2012Operating Grant

Principal investigators: Gosselin, Jean

Keywords: Bronchiolitis/Pneumonia; Influenza Virus; Lung Infection; Lung Innate Immunity; Nlrp3; Nod-Like Receptors; Nod2

$658,126

Role of NOD-like receptors in lung immune response against respiratory virus infection

Nominated PICIHR2011Operating Grant - Priority Announcement: Infection and Immunity (Bridge Funding)

Principal investigators: Gosselin, Jean

Keywords: Bronchiolitis/Pneumonia; Influenza/Respiratory Syncytial Viruses; Lung Infection; Lung Innate Immunity; Nlrp3; Nod-Like Receptors; Nod2

$100,000

Characterization of LTB4 action on innate immune pathways

Nominated PICIHR2011Operating Grant

Principal investigators: Gosselin, Jean

Keywords: Host Defense; Innate Receptors; Innate Response; Leukotrienes; Type 1 Ifn; Viral Infection

$627,415

Cellular Study of the Pulmonary Innate Immune Response to Respiratory Viruses

SupervisorCIHR2009Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Coulombe, François

Keywords: Influenza Virus; Innate Immunity; Mouse Model; Virology

$105,000

Triggering of lung innate response to control respiratory virus infections: a cellular and molecular study

Nominated PICIHR2009III: Pandemic Preparedness Strategic Research Initiative

Principal investigators: Gosselin, Jean

Keywords: Bronchiolitis/Pneumonia; Influenza/Respiratory Syncytial Viruses; Lung Infection; Lung Innate Immunity; Retinoic Acid-Inducible Gene I (Rig-I); Toll-Like Receptors

$100,000

Herpesvirus infection: An environmental factor contributing to the exacerbation of rheumatoid arthritis.

Nominated PICIHR2008Operating Grant: Fall 2008 Priority Announcement (IMHA)

Principal investigators: Gosselin, Jean

Keywords: Epstein-Barr Virus; Herpesviruses; Neutrophils; Rheumatoid Arthritis; Synoviocytes; Toll-Like Receptors

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Molecular Medicine
Microbiologie et immunologie
Pediatrics
Psychiatry
Médecine moléculaire
Other

Co-authors at Université Laval, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Serge Rivest

Molecular Medicine

4 shared papers, latest 2021

Louis Flamand

Microbiologie et immunologie

1 shared papers, latest 2005

Steve Lacroix

Médecine moléculaire

1 shared papers, latest 2018

Arnaud Droit

Microbiologie et immunologie

1 shared papers, latest 2017

Jasna Kriz

Psychiatry

1 shared papers, latest 2010

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mention

Subject: Prospective PhD student: Bronchiolitis/Pneumonia Dear Professor Gosselin, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Correction to: Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis." (2021), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Jean Gosselin

Research

Latest papers

Latest funding

Correction to: Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis.

Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis.

Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer's disease.

Both IRF3 and especially IRF7 play a key role to orchestrate an effective cerebral inflammatory response in a mouse model of herpes simplex virus encephalitis.

Ly6Chigh monocytes facilitate transport of Murid herpesvirus 68 into inflamed joints of arthritic mice.

Contribution of Regulatory T Cells in Nucleotide-Binding Oligomerization Domain 2 Response to Influenza Virus Infection.

Treatment with the NR4A1 agonist cytosporone B controls influenza virus infection and improves pulmonary function in infected mice.

Triggering of NOD2 Receptor Converts Inflammatory Ly6Chigh into Ly6Clow Monocytes with Patrolling Properties.

Protective role of CX3CR1 signalling in resident cells of the central nervous system during experimental herpes simplex virus encephalitis.

Both Cerebral and Hematopoietic Deficiencies in CCR2 Result in Uncontrolled Herpes Simplex Virus Infection of the Central Nervous System in Mice.

Contribution of the orphan receptor NR4A1 in the control of influenza virus infection and lung inflammation

Role of the innate immune system and evaluation of immunomodulatory strategies in herpes simplex virus encephalitis

Role of NOD-like receptors in lung immune response against respiratory virus infection

Role of NOD-like receptors in lung immune response against respiratory virus infection

Characterization of LTB4 action on innate immune pathways

Cellular Study of the Pulmonary Innate Immune Response to Respiratory Viruses

Triggering of lung innate response to control respiratory virus infections: a cellular and molecular study

Herpesvirus infection: An environmental factor contributing to the exacerbation of rheumatoid arthritis.

Frequent collaborators

Serge Rivest

Guy Boivin

Manu Rangachari

Louis Flamand

Steve Lacroix

Arnaud Droit

Jasna Kriz