Manu Rangachari, Université Laval

Research

Multiple Sclerosis Experimental Autoimmune Encephalomyelitis Neuroinflammation Flow Cytometry Sex Differences Interleukin-17 Cytokines Multiple Sclerosis (Ms)

Latest papers

PKM2 works "off the books" to drive effector T cell function in MS.
Science immunology · 2026 · senior author
Myelin antigen-specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) · 2026 · senior author
Chemokines as targets to treat chronic postoperative pain.
Pain · 2026 · first author

All 33 publications

Latest funding

Stressed to a T: The role of stress granule dynamics in regulating effector T cell function
NSERC · 2023 · Principal investigator
$104,000
The interplay of sex hormones and chromosomes dictates pathogenicity in progressive CNS autoimmunity.
CIHR · 2023 · Nominated PI
$910,350
Cellular characterization of a novel putative immune biomarker of MS progression.
CIHR · 2021 · Nominated PI
$902,700

All 7 grants and awards

33 publications.

01

PKM2 works "off the books" to drive effector T cell function in MS.

Falle A, Rangachari M

Science immunology2026Senior author

DOI: 10.1126/sciimmunol.ael0168 PMID: 42566501

02

Myelin antigen-specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell-dependent manner.

Akbar I, Arokia Doss PMI, Patel PU, Surury B, Baillargeon J, Fazazi MR, Anderson AC, Rojas OL, Lassmann H, Rangachari M

Journal of immunology (Baltimore, Md. : 1950)2026Senior author

DOI: 10.1093/jimmun/vkag107 PMID: 42179347

03

Chemokines as targets to treat chronic postoperative pain.

Rangachari M, Ghasemlou N

Pain2026First author

DOI: 10.1097/j.pain.0000000000003940 PMID: 41800737

04

The CNS Meninges and the Synovial Joint: Parallel Immunological Structures in Autoimmune Disease.

Fazazi MR, Rangachari M

BioEssays : news and reviews in molecular, cellular and developmental biology2026Senior author

DOI: 10.1002/bies.70118 PMID: 41723725

05

Loss-of-function mutations ensure that response to immune checkpoint therapy is NOD2 be denied.

Anderson AC, Rangachari M

Science immunology2025Senior author

DOI: 10.1126/sciimmunol.aeb8333 PMID: 40911695

06

Effects of androgen modifying therapies on disease activity in older men with multiple sclerosis.

Zeydan B, Neyal N, Nathoo N, Rangachari M, Atkinson EJ, Son J, Conway BL, Tobin WO, Keegan BM, Weinshenker BG, Kantarci K, Oh J, Kantarci OH

Journal of neuroimmunology2025

DOI: 10.1016/j.jneuroim.2025.578589 PMID: 40139128

07

Sex chromosomes and sex hormones differently shape microglial properties during normal physiological conditions in the adult mouse hippocampus.

Bobotis BC, Khakpour M, Braniff O, de Andrade EG, Gargus M, Allen M, Carrier M, Baillargeon J, Rangachari M, Tremblay MÈ

Journal of neuroinflammation2025

DOI: 10.1186/s12974-025-03341-6 PMID: 39856696

08

Atypical B Cells Promote Cancer Progression and Poor Response to Bacillus Calmette-Guérin in Non-Muscle Invasive Bladder Cancer.

Yolmo P, Rahimi S, Chenard S, Conseil G, Jenkins D, Sachdeva K, Emon I, Hamilton J, Xu M, Rangachari M, Michaud E, Mansure JJ, Kassouf W, Berman DM, Siemens DR, Koti M

Cancer immunology research2024

DOI: 10.1158/2326-6066.cir-23-1114 PMID: 38916567

09

Myelin-reactive B cells exacerbate CD4+ T cell-driven CNS autoimmunity in an IL-23-dependent manner.

Fazazi MR, Doss PMIA, Pereira R, Fudge N, Regmi A, Joly-Beauparlant C, Akbar I, Yeola AP, Mailhot B, Baillargeon J, Grenier P, Bertrand N, Lacroix S, Droit A, Moore CS, Rojas OL, Rangachari M

Nature communications2024Senior author

DOI: 10.1038/s41467-024-49259-0 PMID: 38926356

10

Editorial: Understanding sex-specific issues in MS and its animal models: natural history, management and mechanisms.

Zeydan B, Rangachari M, Kantarci OH

Frontiers in neurology2024

DOI: 10.3389/fneur.2024.1366126 PMID: 38322587