Lisa Topolnik, Université Laval

Research

Synapse Inhibition Interneuron Plasticity Disinhibition Two-Photon Imaging Calcium Dendrite

Latest papers

Sublayer- and pathway-specific control of CA1 input processing by VIP interneurons.
The Journal of physiology · 2026 · senior author
Protocol for synchronized wireless fiber photometry and video recordings in rodents during behavior.
STAR protocols · 2024 · senior author
Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer's disease.
eLife · 2024 · senior author

All 37 publications

Latest funding

Disinhibitory circuits for top-down information processing in the hippocampus
CIHR · 2026 · Nominated PI
$868,276
Global signals in dendrites of GABAergic inhibitory interneurons: mechanisms and function
CIHR · 2022 · Nominated PI
$1,032,750
Dendritic inhibition in hippocampal circuits
NSERC · 2020 · Principal investigator
$348,000

All 12 grants and awards

37 publications.

01

Sublayer- and pathway-specific control of CA1 input processing by VIP interneurons.

Iloun P, Grenier J, Veillette F, Topolnik L

The Journal of physiology2026Senior author

DOI: 10.1113/jp291223 PMID: 42711934

02

Protocol for synchronized wireless fiber photometry and video recordings in rodents during behavior.

Tamboli S, Topolnik D, Radhakrishnan R, Veilleux-Lemieux D, Topolnik L

STAR protocols2024Senior author

DOI: 10.1016/j.xpro.2024.103407 PMID: 39425933

03

Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer's disease.

Michaud F, Francavilla R, Topolnik D, Iloun P, Tamboli S, Calon F, Topolnik L

eLife2024Senior author

DOI: 10.7554/elife.95412 PMID: 39264364

04

Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory.

Tamboli S, Singh S, Topolnik D, El Amine Barkat M, Radhakrishnan R, Guet-McCreight A, Topolnik L

Cell reports2024Senior author

DOI: 10.1016/j.celrep.2024.114115 PMID: 38607918

05

Editorial: GABAergic circuits in health and disease.

Topolnik L, Di Cristo G, Rossignol E

Frontiers in neural circuits2023First author

DOI: 10.3389/fncir.2023.1322193 PMID: 38024809

06

Inhibitory circuits in fear memory and fear-related disorders.

Singh S, Topolnik L

Frontiers in neural circuits2023Senior author

DOI: 10.3389/fncir.2023.1122314 PMID: 37035504

07

The role of inhibitory circuits in hippocampal memory processing.

Topolnik L, Tamboli S

Nature reviews. Neuroscience2022First author

DOI: 10.1038/s41583-022-00599-0 PMID: 35637416

08

Enhanced motor cortex output and disinhibition in asymptomatic female mice with C9orf72 genetic expansion.

Amalyan S, Tamboli S, Lazarevich I, Topolnik D, Bouman LH, Topolnik L

Cell reports2022Senior author

DOI: 10.1016/j.celrep.2022.111043 PMID: 35793625

09

Structural analysis of the microglia-interneuron interactions in the CA1 hippocampal area of the APP/PS1 mouse model of Alzheimer's disease.

Gervais É, Iloun P, Martianova E, Gonçalves Bessa AC, Rivest S, Topolnik L

The Journal of comparative neurology2022Senior author

DOI: 10.1002/cne.25289 PMID: 34919273

10

Cholinergic Modulation of Dendritic Signaling in Hippocampal GABAergic Inhibitory Interneurons.

Pancotti L, Topolnik L

Neuroscience2022Senior author

DOI: 10.1016/j.neuroscience.2021.06.011 PMID: 34129910

Disinhibitory circuits for top-down information processing in the hippocampus

Nominated PICIHR2026Project Grant

Principal investigators: Topolnik, Lisa Y

Keywords: Connectivity; Contextual Memory; Cortical Circuits; Disinhibition; Inhibition; Interneuron; Vasoactive Intestinal Polypeptide

$868,276

Global signals in dendrites of GABAergic inhibitory interneurons: mechanisms and function

Nominated PICIHR2022Project Grant

Principal investigators: Topolnik, Lisa Y

Keywords: Calcium; Dendrite; Inhibition; Interneuron; Plasticity; Spatial Learning; Synapse; Two-Photon Imaging

$1,032,750

Dendritic inhibition in hippocampal circuits

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Topolnik, Lisa Yelyzaveta

$348,000

Inhibitory control of hippocampal inhibitory circuits: cell types, neuromodulation and function

Nominated PICIHR2019Project Grant

Principal investigators: Topolnik, Lisa Y

Keywords: Behavior; Calretinin; Circuitry; Disinhibition; Inhibition; Interneuron; Neuromodulation; Serotonin; Synapse; Vasoactive Intestinal Peptide

$948,600

Investigating the contribution of Shank3 in Alzheimer's disease

Co-investigatorCIHR2017Project Grant

Principal investigators: Calon, Frédéric

Keywords: Alzheimer; Animal Models; Drug Target; Shank; Synapse; Synaptic Proteins

$730,575

Mechanisms of dendritic integration and plasticity in GABAergic inhibitory interneurons

Nominated PICIHR2015Operating Grant

Principal investigators: Topolnik, Lisa Y

Keywords: Calcium; Dendrite; Gabaergic Interneuron; In Vivo; Input Integration; Optogenetics; Patch-Clamp; Plasticity; Synapse; Two-Photon Microscopy

$618,070

Targeting microglia-synapse interactions to rescue from brain circuits elimination and cognitive dysfunction

Co-investigatorCIHR2015Foundation Grant

Principal investigators: Tremblay, Marie-Ève

Keywords: 3d-Scanning Electron Microscopy; Aging; Alzheimer'S Disease; Chronic Stress; Cognitive Decline; Microglia-Synapse Interactions; Neuronal Activity; Super-Resolution Microscopy; Synaptic Loss; Two-Photon In Vivo Imaging

$953,804

Inhibitory control of hippocampal inhibitory circuits: cellular mechanisms and function

Nominated PICIHR2014Operating Grant

Principal investigators: Topolnik, Lisa Y

Keywords: Electrophysiology; Epilepsy; Inhibitory Interneuron; Neural Circuits; Neuroanatomy; Optogenetics; Plasticity; Synapse; Transgenic Mouse; Two-Photon Imaging

$732,370

Dendritic signal processing and functional compartmentalization in GABAergic interneurons

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Topolnik, LisaYelyzaveta

$238,000

Neurophysics CIHR Training Grant

Co-investigatorCIHR2008Training Grant

Principal investigators: De Koninck, Yves

Keywords: Advanced Microscopy; Cellular Imaging; Computational Neurosciences; Nanotechnologies; Neuroscience; Photonics

$1,950,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Neurosciences
Biochimie, microbiologie et bio-informatique
Microbiologie et immunologie
Molecular Medicine
Other

Co-authors at Université Laval, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Benoit Gosselin

Faculty

1 shared papers, latest 2017

Elsa Rossignol

Neurosciences

1 shared papers, latest 2023

Frédéric Calon

Neurosciences

1 shared papers, latest 2024

Serge Rivest

Molecular Medicine

1 shared papers, latest 2022

Graziella Di Cristo

Neurosciences

1 shared papers, latest 2023

Arnaud Droit

Microbiologie et immunologie

1 shared papers, latest 2019

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2026

Subject: Prospective PhD student: Synapse Dear Professor Topolnik, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Sublayer- and pathway-specific control of CA1 input processing by VIP interneurons." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Disinhibitory circuits for top-down information processing in the hippocampus" (2026), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]