Faculty profile

Frédéric Calon

ResearcherNeurosciencesUniversité Laval

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université Laval directory, so their courses may be missing. Find their university profile.

Frédéric Calon

Researcher

Neurosciences

Health Sciences

Université Laval

Quebec City, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
6 publications in the last five years, latest in 2026.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 16 research grants (11 CIHR, 5 NSERC), most recently in 2026.
Supervised 3 trainees who won CIHR awards, most recently in 2015.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Alzheimer Blood-Brain Barrier Diabetes Metabolism Tau Animal Models Amyloid-Beta Drug Targets

Latest papers

WDR44 drives de novo α-synuclein aggregation at the lysosomal membrane and promotes neuronal dysfunction in Parkinson's Disease.
bioRxiv : the preprint server for biology · 2026
CD2AP at the junction of nephropathy and Alzheimer's disease.
Molecular neurodegeneration · 2025
Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research
The journal of prevention of Alzheimer's disease · 2025

All 16 publications

Latest funding

Untangling the IGFBP2 paradox in the early stages of Alzheimer's disease
CIHR · 2026 · Nominated PI
$1,239,300
Early cholesterol blockade in advanced pancreatic cancer
CIHR · 2025 · Co-investigator
$719,100
Investigating cellular biomarkers of vascular white matter injury in neurodegeneration
CIHR · 2024 · Co-investigator
$1,075,000

All 27 grants and awards

16 publications.

WDR44 drives de novo α-synuclein aggregation at the lysosomal membrane and promotes neuronal dysfunction in Parkinson's Disease.

Teixeira M, Sheta R, Bérard M, Insinna C, Mahul-Mellier AL, Delmas CVL, Lépinay E, Idi W, Ricard A, Del Cid-Pellitero E, Trabolsi C, Gobeil S, Canron MH, Bézard E, Rajput A, Cicchetti F, Parent M, Fon EA, Ramalingam N, Dettmer U, Calon F, Westlake C, Lashuel HA, Oueslati A

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.04.03.716340 PMID: 41993512

CD2AP at the junction of nephropathy and Alzheimer's disease.

Vandal M, Janmaleki M, Rea I, Gunn C, Hirai S, Biernaskie J, Chun J, Gordon G, Shaw A, Sanati-Nezhad A, Pfeffer G, Calon F, Nguyen MD

Molecular neurodegeneration2025

DOI: 10.1186/s13024-025-00852-x PMID: 40462155

Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research

Smith EE, Phillips NA, Feldman HH, Borrie M, Ganesh A, Henri-Bhargava A, Desmarais P, Frank A, Badhwar A, Barlow L

The journal of prevention of Alzheimer's disease202537 citations

DOI: 10.1016/j.tjpad.2025.100068

Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer's disease.

Michaud F, Francavilla R, Topolnik D, Iloun P, Tamboli S, Calon F, Topolnik L

eLife2024

DOI: 10.7554/elife.95412 PMID: 39264364

State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer's Disease.

Rhea EM, Leclerc M, Yassine HN, Capuano AW, Tong H, Petyuk VA, Macauley SL, Fioramonti X, Carmichael O, Calon F, Arvanitakis Z

Aging and disease2024

DOI: 10.14336/ad.2023.0814 PMID: 37611907

Cerebrospinal fluid soluble insulin receptor levels in Alzheimer's disease.

Thomas P, Leclerc M, Evitts K, Brown C, Miller W, Hanson AJ, Banks WA, Gibbons L, Domoto-Reilly K, Jayadev S, Li G, Peskind E, Young JE, Consortium for the early identification of Alzheimer's disease‐Quebec (CIMA‐Q), Calon F, Rhea EM

Alzheimer's & dementia (Amsterdam, Netherlands)2024Senior author

DOI: 10.1002/dad2.12603 PMID: 38800123

Strategies in the design and development of (TAR) DNA-binding protein 43 (TDP-43) binding ligands.

Rao PPN, Shakeri A, Zhao Y, Calon F

European journal of medicinal chemistry2021Senior author

DOI: 10.1016/j.ejmech.2021.113753 PMID: 34388383

Diet enriched in omega-3 fatty acids alleviates olfactory system deficits in APOE4 transgenic mice.

Lessard-Beaudoin M, M Gonzalez L, AlOtaibi M, Chouinard-Watkins R, Plourde M, Calon F, Graham RK

The European journal of neuroscience2021

DOI: 10.1111/ejn.15472 PMID: 34549475

Dietary intake of branched-chain amino acids in a mouse model of Alzheimer's disease: Effects on survival, behavior, and neuropathology.

Tournissac M, Vandal M, Tremblay C, Bourassa P, Vancassel S, Emond V, Gangloff A, Calon F

Alzheimer's & dementia (New York, N. Y.)2018Senior author

DOI: 10.1016/j.trci.2018.10.005 PMID: 30560200

Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease.

Vandal M, White PJ, Tournissac M, Tremblay C, St-Amour I, Drouin-Ouellet J, Bousquet M, Traversy MT, Planel E, Marette A, Calon F

Neurobiology of aging2016Senior author

DOI: 10.1016/j.neurobiolaging.2016.03.024 PMID: 27255814

Untangling the IGFBP2 paradox in the early stages of Alzheimer's disease

Nominated PICIHR2026Project Grant

Principal investigators: Calon, Frédéric

Keywords: Alzheimer; Amyloid-Beta; Blood-Brain Barrier; Diabetes; Drug Targets; Human Cohorts; Igfbp2; Metabolism; Tau; Transgenic

$1,239,300

Early cholesterol blockade in advanced pancreatic cancer

Co-investigatorCIHR2025Project Grant

Principal investigators: Gangloff, Anne

Keywords: Lipids; Proof-Of-Concept Clinical Trial

$719,100

Investigating cellular biomarkers of vascular white matter injury in neurodegeneration

Co-investigatorCIHR2024Team Grant: CCNA Phase III - Cardiovascu. Disease/Age-Related Cognitive Changes

Principal investigators: Badhwar, Amanpreet; Smith, Eric E; Whitehead, Shawn N

Keywords: Alzheimer Disease; Blood Biomarkers; Brain Autopsy; Brain Imaging; Brain-Derived Extracellular Vesicles; Inflammation; Mass-Spectrometry Proteomics; Nanoflow Cytometry; Vascular Brain Injury; Vascular Cognitive Impairment And Dementia

$1,075,000

FGF-21 in Alzheimer's disease.

Nominated PICIHR2022Project Grant

Principal investigators: Calon, Frédéric

Keywords: Aging; Alzheimer; Amyloid; Blood-Brain Barrier; Diabetes; Fgf21; Hormones; Insulin; Metabolism; Tau

$960,076

Risk factors and markers for early detection of Alzheimer's Disease: focus on early-life stress, inflammation and lipid mediators

Nominated PICIHR2021Operating Grant: Joint Programme on Neurodegenerative Disease Research (JPND)

Principal investigators: Calon, Frédéric

Keywords: Alzheimer; Biomarkers; Cognitive Decline; Early-Life Adversity; Microglia; Neuroimmunology; Neuroinflammation; Nutrition; Polyunsaturated Fatty Acids; Specialized Pro-Resolving Mediators

$234,849

Health Research Training to Address Vascular Contributions to Cognitive Decline: the Vascular Training (VAST) Platform

Co-investigatorCIHR2021Tr. Grant: Health Research Training Platform - Vascular Cognitive Impairment

Principal investigators: Smith, Eric E; Badhwar, Amanpreet; Mazerolle, Erin L; Stefanovic, Bojana

Keywords: Vascular Cognitive Impairment

$2,380,292

Mechanisms of endocytosis and transcytosis into endothelial cells of the blood-brain barrier

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Calon, Frederic

$348,000

How does insulin interact with the blood-brain barrier? Therapeutic implications for diabetes and Alzheimer's disease.

Nominated PICIHR2019Project Grant

Principal investigators: Calon, Frédéric

Keywords: Alzheimer; Animal Models; Bioavailability; Blood Brain Barrier; Diabetes; Drug Development; Insulin Signaling; Lipidology; Neuropharmacology; Preclinical Assays

$841,500

Multi-pathway cholesterol depletion on top of FOLFIRINOX in newly diagnosed metastatic pancreatic adenocarcinoma: a feasibility and proof-of-concept study

Co-investigatorCIHR2019Project Grant

Principal investigators: Gangloff, Anne

Keywords: Acceptability Of The Regimen; Biomarkers (Lipid Profile, Tumoral Ldlr, Npc1l1, Srb1); Cholesterol-Lowering Drugs (Pcsk9 Inh, Statins, Ezetimibe); Clinical Trial (Non-Randomized, Open-Label); Dose-Limiting Toxicities; Estimates Of Progression-Free Survival; Estimates To Perform Power Calculation; Feasibility And Proof-Of-Concept Study; Folfirinox; Metastatic Pancreatic Ductal Adenocarcinoma

$153,000

Fatty acid metabolism in carriers of apolipoprotein E epsilon 4 allele: determining the blood-to-brain link

Co-investigatorCIHR2019Project Grant

Principal investigators: Plourde, Mélanie

Keywords: Apoe4 Carriers; Docosahexaenoic Acid; Metabolism

$864,450

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Frédéric Calon

Research

Latest papers

Latest funding

WDR44 drives de novo &#x3b1;-synuclein aggregation at the lysosomal membrane and promotes neuronal dysfunction in Parkinson's Disease.

CD2AP at the junction of nephropathy and Alzheimer's disease.

Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research

Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer's disease.

State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer's Disease.

Cerebrospinal fluid soluble insulin receptor levels in Alzheimer's disease.

Strategies in the design and development of (TAR) DNA-binding protein 43 (TDP-43) binding ligands.

Diet enriched in omega-3 fatty acids alleviates olfactory system deficits in APOE4 transgenic mice.

Dietary intake of branched-chain amino acids in a mouse model of Alzheimer's disease: Effects on survival, behavior, and neuropathology.

Impaired thermoregulation and beneficial effects of thermoneutrality in the 3&#xd7;Tg-AD model of Alzheimer's disease.

Mechanisms of endocytosis and transcytosis into endothelial cells of the blood-brain barrier

Frequent collaborators

Emmanuel Planel

André Marette

Robert Laforce

Grant Gordon

Gillian Einstein

Robert Bartha

Michael Borrie

Mario Masellis

Lisa Topolnik

Francesca Cicchetti

Mélanie Plourde

Martin Parent

Manuel Montero Odasso

Pedro Rosa-Neto

Zahinoor Ismail

Abid Oueslati

Simon Ducharme

Amir Sanati Nezhad

Justin Chun

Aravind Ganesh

Gerald Pfeffer

Linda Lee

Yves Giguere

WDR44 drives de novo α-synuclein aggregation at the lysosomal membrane and promotes neuronal dysfunction in Parkinson's Disease.

Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease.