Faculty profile

Jacques Thibodeau

ResearcherMicrobiologie, infectiologie et immunologieUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Jacques Thibodeau

Researcher

Microbiologie, infectiologie et immunologie

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
1 publication in the last five years, latest in 2026.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 8 research grants (5 NSERC, 3 CIHR), most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Flow cytometry 14-3-3 BioID COPII di-arginine motifs endoplasmic reticulum endosomes Invariant chain

Latest papers

Invariant chain controls HLA-DQ folding and shapes the HLA class II proxiome.
Journal of immunology (Baltimore, Md. : 1950) · 2026 · senior author
The transmembrane domain and luminal C-terminal region independently support invariant chain trimerization and assembly with MHCII into nonamers.
BMC immunology · 2021 · senior author
Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice.
Frontiers in immunology · 2020 · senior author

All 17 publications

Latest funding

Role of MHC class II molecule pairing in antigen presentation and disease
NSERC · 2024 · Principal investigator
$24,800
A Seahorse analyzer for the multiparametric study of cellular metabolism in prokaryotes and eukaryotes.
NSERC · 2020 · Principal investigator
$150,000
Intracellular transport of proteins containing di-arginine endoplasmic reticulum-retention motifs
NSERC · 2020 · Principal investigator
$252,000

All 10 grants and awards

17 publications.

Invariant chain controls HLA-DQ folding and shapes the HLA class II proxiome.

Moulefera MA, Mitchell W, Bilali NE, Majdoubi A, Panès R, Salti S, Lippé R, Gagnon É, Mourad W, Thibodeau J

Journal of immunology (Baltimore, Md. : 1950)2026Senior author

DOI: 10.1093/jimmun/vkag201 PMID: 42632754

The transmembrane domain and luminal C-terminal region independently support invariant chain trimerization and assembly with MHCII into nonamers.

Cloutier M, Fortin JS, Thibodeau J

BMC immunology2021Senior author

DOI: 10.1186/s12865-021-00444-6 PMID: 34384367

Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice.

Majdoubi A, Lee JS, Kishta OA, Balood M, Moulefera MA, Ishido S, Talbot S, Cheong C, Alquier T, Thibodeau J

Frontiers in immunology2020Senior author

DOI: 10.3389/fimmu.2020.01953 PMID: 32973799

Downregulation of MHC Class II by Ubiquitination Is Required for the Migration of CD206+ Dendritic Cells to Skin-Draining Lymph Nodes.

Majdoubi A, Lee JS, Balood M, Sabourin A, DeMontigny A, Kishta OA, Moulefera MA, Galbas T, Yun TJ, Talbot S, Ishido S, Cheong C, Thibodeau J

Journal of immunology (Baltimore, Md. : 1950)2019Senior author

DOI: 10.4049/jimmunol.1900593 PMID: 31659013

On the structure-function of MHC class II molecules and how single amino acid polymorphisms could alter intracellular trafficking.

Thibodeau J, Moulefera MA, Balthazard R

Human immunology2019First author

DOI: 10.1016/j.humimm.2018.10.001 PMID: 30321632

Conventional Dendritic Cells Impair Recovery after Myocardial Infarction.

Lee JS, Jeong SJ, Kim S, Chalifour L, Yun TJ, Miah MA, Li B, Majdoubi A, Sabourin A, Keler T, Guimond JV, Haddad E, Choi EY, Epelman S, Choi JH, Thibodeau J, Oh GT, Cheong C

Journal of immunology (Baltimore, Md. : 1950)2018

DOI: 10.4049/jimmunol.1800322 PMID: 30097529

Streptococcus suis Serotype 2 Infection Impairs Interleukin-12 Production and the MHC-II-Restricted Antigen Presentation Capacity of Dendritic Cells.

Letendre C, Auger JP, Lemire P, Galbas T, Gottschalk M, Thibodeau J, Segura M

Frontiers in immunology2018

DOI: 10.3389/fimmu.2018.01199 PMID: 29899744

March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation.

Kishta OA, Sabourin A, Simon L, McGovern T, Raymond M, Galbas T, Majdoubi A, Ishido S, Martin JG, Thibodeau J

Journal of immunology research2018Senior author

DOI: 10.1155/2018/3823910 PMID: 29854835

MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice.

Galbas T, Raymond M, Sabourin A, Bourgeois-Daigneault MC, Guimont-Desrochers F, Yun TJ, Cailhier JF, Ishido S, Lesage S, Cheong C, Thibodeau J

Journal of immunology (Baltimore, Md. : 1950)2017Senior author

DOI: 10.4049/jimmunol.1601168 PMID: 27940660

Immune-responsiveness of CD4+ T cells during Streptococcus suis serotype 2 infection.

Lecours MP, Letendre C, Clarke D, Lemire P, Galbas T, Benoit-Biancamano MO, Thibodeau J, Gottschalk M, Segura M

Scientific reports2016

DOI: 10.1038/srep38061 PMID: 27905502

Role of MHC class II molecule pairing in antigen presentation and disease

Principal investigatorNSERC2024Alliance Grants

Principal investigators: Thibodeau, Jacques J

Keywords: autoimmunity; cancer; cell biology; immunology; inflammation; protein folding; protein function; protein structure; protein trafficking; vaccines

$24,800

A Seahorse analyzer for the multiparametric study of cellular metabolism in prokaryotes and eukaryotes.

Principal investigatorNSERC2020Research Tools and Instruments

Principal investigators: Thibodeau, Jacques

$150,000

Intracellular transport of proteins containing di-arginine endoplasmic reticulum-retention motifs

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Thibodeau, Jacques

Keywords: endoplasmic reticulum; copii; di-arginine motifs; mhc class ii molecules; invariant chain; 14-3-3; endosomes; bioid; pathogens; flow cytometry

$252,000

Characterization of the di-arginine (R-x-R) endoplasmic reticulum retention signal in health and disease.

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Thibodeau, Jacques

$170,000

Analysis of the molecular mechanisms by which the MARCH1 E3-ubiquitin ligase regulates immune responses and tolerance.

Nominated PICIHR2014Operating Grant

Principal investigators: Thibodeau, Jacques

Keywords: Energy Metabolism; Flow Cytometry; Il-10; Immunology; Inflammation; Knock Out Mice; Lps; Macrophages; Mhc Class Ii; Ubiquitin Ligase

$800,440

Canadian Cancer Immunotherapy Consortium Symposium 2012

Co-investigatorCIHR2011Dissemination Events

Principal investigators: Lapointe, Réjean

Keywords: Cancer; Clinical Trials; Immunology; Immunotherapy; Trainee Mentorship

$15,000

Effect of sialic acid of Gram-positive bacteria capsular polysaccharides on the immunogenic capacity of conjugate vaccines

Principal investigatorCIHR2009Vaccines of the 21st Century

Principal investigators: Segura, Mariela A; Gottschalk, Marcelo G; Roy, René; Thibodeau, Jacques

Keywords: Capsular Polysaccharides; Dendritic Cells; Mhc-Ii Antigen Presentation; Sialic Acid; Streptococcus; T Cell Activation

$98,222

Regulation of multiprotein complex assembly in the endoplasmic reticulum

Principal investigatorNSERC2009Discovery Grants Program - Individual

Principal investigators: Thibodeau, Jacques

$160,000

MHC II antigen presentation: Modulation by E3-ubiquitin ligases of the MARCH family

Nominated PICIHR2008Operating Grant

Principal investigators: Thibodeau, Jacques

Keywords: Antigen Presentation; Cytokines; Dendritic Cells; E3 Ubiquitin Ligase; Mhc Class Ii; Monocytes

$497,805

Imaging system for DNA, RNA and proteins

Co-investigatorNSERC2006Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Lemay, Guy

$150,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Jacques Thibodeau

Research

Latest papers

Latest funding

Invariant chain controls HLA-DQ folding and shapes the HLA class II proxiome.

The transmembrane domain and luminal C-terminal region independently support invariant chain trimerization and assembly with MHCII into nonamers.

Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice.

Downregulation of MHC Class II by Ubiquitination Is Required for the Migration of CD206+ Dendritic Cells to Skin-Draining Lymph Nodes.

On the structure-function of MHC class II molecules and how single amino acid polymorphisms could alter intracellular trafficking.

Conventional Dendritic Cells Impair Recovery after Myocardial Infarction.

Streptococcus suis Serotype 2 Infection Impairs Interleukin-12 Production and the MHC-II-Restricted Antigen Presentation Capacity of Dendritic Cells.

March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation.

MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice.

Immune-responsiveness of CD4+ T cells during Streptococcus suis serotype 2 infection.

Role of MHC class II molecule pairing in antigen presentation and disease

A Seahorse analyzer for the multiparametric study of cellular metabolism in prokaryotes and eukaryotes.

Intracellular transport of proteins containing di-arginine endoplasmic reticulum-retention motifs

Characterization of the di-arginine (R-x-R) endoplasmic reticulum retention signal in health and disease.

Analysis of the molecular mechanisms by which the MARCH1 E3-ubiquitin ligase regulates immune responses and tolerance.

Canadian Cancer Immunotherapy Consortium Symposium 2012

Effect of sialic acid of Gram-positive bacteria capsular polysaccharides on the immunogenic capacity of conjugate vaccines

Regulation of multiprotein complex assembly in the endoplasmic reticulum

MHC II antigen presentation: Modulation by E3-ubiquitin ligases of the MARCH family

Imaging system for DNA, RNA and proteins

Frequent collaborators

Marie-Claude Bourgeois-Daigneault

CHEOLHO Cheong

Mariela Segura

Marcelo Gottschalk

Walid Mourad

Daniel Lamarre

Sylvie Lesage

Lorraine Chalifour

Thierry Alquier

Slava Epelman

Leora Simon

Elie Haddad

Samantha Gruenheid