Faculty profile

Samantha Gruenheid

ResearcherMicrobiology and ImmunologyMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Samantha Gruenheid

Researcher

Microbiology and Immunology

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
15 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 10 research grants (6 CIHR, 4 NSERC), most recently in 2023.
Supervisor on 7 trainee awards (7 CIHR), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Chronic Intestinal Inflammation Cystic Fibrosis (Cf)Cystic Fibrosis Transmembrane Conductance Regulator (Cftr)Dendritic Cells (Dc)Intestinal Health Gut-Brain Axis Inflammatory Bowel Disease Intestinal Health And Disease

Latest papers

A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss.
PLoS pathogens · 2026
STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation.
Cell reports · 2026
Author Correction: Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis.
NPJ Parkinson's disease · 2026 · senior author

All 51 publications

Latest funding

Defining tumor suppressive actions of Yap/Taz during metaplastic regeneration in the stomach.
CIHR · 2025 · Co-investigator
$940,950
A histology platform to visualize cells, tissues and organs across living systems
NSERC · 2024 · Co-investigator
$97,880
Investigating the impact of Parkinson's Disease-associated genes on intestinal homeostasis
CIHR · 2023 · Supervisor
$105,000

All 21 grants and awards

51 publications.

A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss.

Mukherjee S, Grouza V, Tchung A, Even A, Yaqubi M, Tuznik M, Cannon T, Recinto SJ, Gavino C, Bourque MJ, Giguère N, McBride H, Desjardins M, Gruenheid S, Stratton JA, Rudko DA, Trudeau LE

PLoS pathogens2026

DOI: 10.1371/journal.ppat.1014315 PMID: 42378309

STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation.

Fahmy AM, Ahmadi A, Lanoix J, Cannon T, Elemeery MN, Paredes CH, Barrette B, Bonneil E, Xu YZ, Ibrahim M, Arango-Duque G, Audemard EO, Lemieux S, Chevet E, Schurr E, Pierre P, Gruenheid S, Thibault P, McBride HM, Desjardins M

Cell reports2026

DOI: 10.1016/j.celrep.2026.117497 PMID: 42275211

Author Correction: Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis.

Pei J, Oliveira NL, Recinto SJ, Kazanova A, Queiroz-Junior CM, Li Z, Couto K, Westfall S, Fahmy AM, Tiefensee-Ribeiro C, King IL, Milnerwood AJ, Desjardins M, Thanabalasuriar A, Stratton JA, Gruenheid S

NPJ Parkinson's disease2026Senior author

DOI: 10.1038/s41531-026-01285-z PMID: 41826345

Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis.

NPJ Parkinson's disease2025Senior author

DOI: 10.1038/s41531-025-01077-x PMID: 40883285

PINK1 deficiency rewires early immune responses in a mouse model of Parkinson's disease triggered by intestinal infection.

Recinto SJ, Kazanova A, Liu L, Cordeiro B, Premachandran S, Bessaiah H, Allot A, Afanasiev E, Mukherjee S, Pei J, MacDonald A, Yaqubi M, McBride HM, Matheoud D, Trudeau LE, Gruenheid S, Stratton JA

NPJ Parkinson's disease2025

DOI: 10.1038/s41531-025-00945-w PMID: 40404738

Bioluminescent Pseudomonas aeruginosa and Escherichia coli for whole-cell screening of antibacterial and adjuvant compounds.

Farkas E, McKay GA, Hu LT, Nekouei M, Ho P, Moreira W, Chan CC, Dam LC, Auclair K, Gruenheid S, Whyte L, Dedon P, Nguyen D

Scientific reports2024

DOI: 10.1038/s41598-024-81926-6 PMID: 39730767

Characterizing enteric neurons in dopamine transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter content.

Recinto SJ, Premachandran S, Mukherjee S, Allot A, MacDonald A, Yaqubi M, Gruenheid S, Trudeau LE, Stratton JA

The European journal of neuroscience2024

DOI: 10.1111/ejn.16307 PMID: 38487941

Direct evidence of host-mediated glycosylation of NleA and its dependence on interaction with the COPII complex.

Burns L, Le Mauff F, Gruenheid S

Gut microbes2024Senior author

DOI: 10.1080/19490976.2024.2305477 PMID: 38298145

Over supplementation with vitamin B12 alters microbe-host interactions in the gut leading to accelerated Citrobacter rodentium colonization and pathogenesis in mice.

Forgie AJ, Pepin DM, Ju T, Tollenaar S, Sergi CM, Gruenheid S, Willing BP

Microbiome2023

DOI: 10.1186/s40168-023-01461-w PMID: 36737826

The bacterial virulence factor NleA undergoes host-mediated O-linked glycosylation.

Burns L, Giannakopoulou N, Zhu L, Xu YZ, Khan RH, Bekal S, Schurr E, Schmeing TM, Gruenheid S

Molecular microbiology2023Senior author

DOI: 10.1111/mmi.14989 PMID: 36196760

Defining tumor suppressive actions of Yap/Taz during metaplastic regeneration in the stomach.

Co-investigatorCIHR2025Project Grant

Principal investigators: Gregorieff, Alex

Keywords: Bmp Signaling; Epithelial Regeneration; Gastric Cancer; Genetically Modified Mouse Models; Hippo Signaling; Inflammation; Metaplasia; Organoids; Yap And Taz

$940,950

A histology platform to visualize cells, tissues and organs across living systems

Co-investigatorNSERC2024Research Tools and Instruments

Principal investigators: Cockburn, Katherine

Keywords: Animal models; Biomedical engineering; Cell biology; Cell morphology; Gene expression; Histology; Materials science; Tissue architecture; Tissue sectioning

$97,880

Investigating the impact of Parkinson's Disease-associated genes on intestinal homeostasis

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Pei, Jessica

Keywords: Gut-Brain Axis; Intestinal Epithelium; Intestinal Infection; Organoids; Parkinson'S Disease; Single Cell Rna Sequencing

$105,000

Bacterial effector proteins as tools to investigate cell biology

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Gruenheid, Samantha

Keywords: Bacterial effector proteins; Cell Biology; EPEC, EHEC and Citrobacter rodentium; Epithelial biology; Glycosylation; Intestinal biology; Protein modification; Protein targeting; T3SS

$120,000

Inclusive SciComm: A Workshop Series by the SciComm Collective

Principal investigatorNSERC2020Science Communication Skills Grant

Principal investigators: Gruenheid, Samantha

$20,000

Role of the cystic fibrosis transmembrane conductance regulator (CFTR) in intestinal homeostasis

Principal investigatorCIHR2020Project Grant

Principal investigators: Fritz, Jorg H; Gruenheid, Samantha L

Keywords: Chronic Intestinal Inflammation; Cystic Fibrosis (Cf); Cystic Fibrosis Transmembrane Conductance Regulator (Cftr); Dendritic Cells (Dc); Intestinal Health

$895,050

Intestinal Microbial Composition Potentiates Citrobacter rodentium-Induced Autoimmunity and Parkinson's Disease-like Symptoms in Pink1-/- Mice

SupervisorCIHR2019Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Cannon, Tyler

Keywords: Autoimmune; Colitis; Infection; Intestinal; Microbiota; Neurodegeneration; Parkinson'S Disease

$105,000

A new model to study the role of intestinal inflammation as a driver of Parkinson's Disease development

Nominated PICIHR2018Project Grant

Principal investigators: Gruenheid, Samantha L

Keywords: Gut-Brain Axis; Inflammatory Bowel Disease; Intestinal Health And Disease; Intestinal Infection; Intestinal Inflammation; Mouse Models Of Disease

$875,925

Bacterial effector proteins as tools to study cell biology

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Gruenheid, Samantha

$328,000

Bacterial effector proteins as probes to study cell biology

Principal investigatorNSERC2013Discovery Grants Program - Individual

Principal investigators: Gruenheid, Samantha

$36,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2023

Subject: Prospective PhD student: Chronic Intestinal Inflammation Dear Professor Gruenheid, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Bacterial effector proteins as tools to investigate cell biology" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Samantha Gruenheid

Research

Latest papers

Latest funding

A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss.

STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation.

Author Correction: Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis.

Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis.

PINK1 deficiency rewires early immune responses in a mouse model of Parkinson's disease triggered by intestinal infection.

Bioluminescent Pseudomonas aeruginosa and Escherichia coli for whole-cell screening of antibacterial and adjuvant compounds.

Characterizing enteric neurons in dopamine transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter content.

Direct evidence of host-mediated glycosylation of NleA and its dependence on interaction with the COPII complex.

Over supplementation with vitamin B12 alters microbe-host interactions in the gut leading to accelerated Citrobacter rodentium colonization and pathogenesis in mice.

The bacterial virulence factor NleA undergoes host-mediated O-linked glycosylation.

Defining tumor suppressive actions of Yap/Taz during metaplastic regeneration in the stomach.

A histology platform to visualize cells, tissues and organs across living systems

Investigating the impact of Parkinson's Disease-associated genes on intestinal homeostasis

Bacterial effector proteins as tools to investigate cell biology

Inclusive SciComm: A Workshop Series by the SciComm Collective

Role of the cystic fibrosis transmembrane conductance regulator (CFTR) in intestinal homeostasis

Intestinal Microbial Composition Potentiates Citrobacter rodentium-Induced Autoimmunity and Parkinson's Disease-like Symptoms in Pink1-/- Mice

A new model to study the role of intestinal inflammation as a driver of Parkinson's Disease development

Bacterial effector proteins as tools to study cell biology

Bacterial effector proteins as probes to study cell biology

Frequent collaborators

Ajitha Thanabalasuriar

Danielle Malo

Michel Desjardins

Louis-Eric Trudeau

Dao Nguyen

Erwin Schurr

Maya Saleh

Sylvain Moineau

Yann Joly

Edward Harvey

Thien-Fah Mah

Jacques Thibodeau

Tracy Raivio

Amee Manges

Karine Auclair

Sanjoy Ghosh

Philippe Gros

Heidi McBride

Mathieu Blanchette

Mark Lathrop

Robert Sladek