Lea Harrington, Université de Montréal

Research

Dna Damage Telomeres Aging Genome Instability Stem Cells Telomerase Cancer Crispr-Cas9

Latest papers

A CRISPR base editing approach for the functional assessment of telomere biology disorder-related genes in human health and aging.
Biogerontology · 2024 · senior author
Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.
PLoS genetics · 2022
Tieing together loose ends: telomere instability in cancer and aging.
Molecular oncology · 2022 · senior author

All 14 publications

Latest funding

Exploiting the synthetic-lethal vulnerabilities of stem cells and cancer cells with eroded telomeres
CIHR · 2021 · Nominated PI
$879,750
Genetic and chemical ablation of senescent cells that result from age-dependent telomere erosion
CIHR · 2018 · Nominated PI
$448,600
Telomere instability transforms differentiated stem cells into teratomas: implications for aging and disease
CIHR · 2016 · Nominated PI
$668,936

All 6 grants and awards

14 publications.

01

A CRISPR base editing approach for the functional assessment of telomere biology disorder-related genes in human health and aging.

Borges G, Benslimane Y, Harrington L

Biogerontology2024Senior author

DOI: 10.1007/s10522-024-10094-x PMID: 38310618

02

Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.

Stock AJ, McDevitt RA, Puligilla C, Wang Y, Zhang Y, Wang K, Sun C, Becker KG, Lehrmann E, Wood WH, Gong Y, Aqdas M, Sung MH, Hoffmann V, Liu C, Gorospe M, Harrington L, Ferrucci L, Liu Y

PLoS genetics2022

DOI: 10.1371/journal.pgen.1010506 PMID: 36441670

03

Tieing together loose ends: telomere instability in cancer and aging.

Borges G, Criqui M, Harrington L

Molecular oncology2022Senior author

DOI: 10.1002/1878-0261.13299 PMID: 35920280

04

Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.

Jiang Z, Li H, Schroer SA, Voisin V, Ju Y, Pacal M, Erdmann N, Shi W, Chung PED, Deng T, Chen NJ, Ciavarra G, Datti A, Mak TW, Harrington L, Dick FA, Bader GD, Bremner R, Woo M, Zacksenhaus E

The EMBO journal2022

DOI: 10.15252/embj.2020106825 PMID: 35023164

05

Catechin from Burkea africana Hook. Exhibits in vitro inhibition of human telomerase activity.

Eboji OK, Borges G, Harrington L, Lin W, Sofidiya MO, Sowemimo AA

Natural product research2021

DOI: 10.1080/14786419.2020.1831497 PMID: 33930985

06

Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.

Benslimane Y, Bertomeu T, Coulombe-Huntington J, McQuaid M, Sánchez-Osuna M, Papadopoli D, Avizonis D, Russo MST, Huard C, Topisirovic I, Wurtele H, Tyers M, Harrington L

Molecular cell2020Senior author

DOI: 10.1016/j.molcel.2020.07.010 PMID: 32755594

07

Editorial overview: The instability of the cancer genome: it starts at the end.

Harrington L, Baird DM

Current opinion in genetics & development2020First author

DOI: 10.1016/j.gde.2020.02.020 PMID: 32241622

08

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.

Dolma S, Selvadurai HJ, Lan X, Lee L, Kushida M, Voisin V, Whetstone H, So M, Aviv T, Park N, Zhu X, Xu C, Head R, Rowland KJ, Bernstein M, Clarke ID, Bader G, Harrington L, Brumell JH, Tyers M, Dirks PB

Cancer cell2016

DOI: 10.1016/j.ccell.2016.05.002 PMID: 27300435

09

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.

Fraser C, Dawson JC, Dowling R, Houston DR, Weiss JT, Munro AF, Muir M, Harrington L, Webster SP, Frame MC, Brunton VG, Patton EE, Carragher NO, Unciti-Broceta A

Journal of medicinal chemistry2016

DOI: 10.1021/acs.jmedchem.6b00065 PMID: 27115835

10

Lifelong leukocyte telomere dynamics and survival in a free-living mammal.

Fairlie J, Holland R, Pilkington JG, Pemberton JM, Harrington L, Nussey DH

Aging cell2016

DOI: 10.1111/acel.12417 PMID: 26521726

Exploiting the synthetic-lethal vulnerabilities of stem cells and cancer cells with eroded telomeres

Nominated PICIHR2021Project Grant

Principal investigators: Harrington, Lea A

Keywords: Aging; Cancer; Crispr-Cas9; Dna Damage; Epigenetics; Genome Instability; Replication Stress; Stem Cells; Telomeres

$879,750

Genetic and chemical ablation of senescent cells that result from age-dependent telomere erosion

Nominated PICIHR2018Operating Grant: Geroscience Demonstration Grants

Principal investigators: Harrington, Lea A

Keywords: Age-Associated Diseases; Aging; Cellular Senescence; Chemical Inhibitor; Crispr/Cas9 Genetic Screen; Healthspan; Senolysis; Senotherapeutics; Telomerase Reverse Transcriptase; Telomere Dysfunction

$448,600

Telomere instability transforms differentiated stem cells into teratomas: implications for aging and disease

Nominated PICIHR2016Project Grant

Principal investigators: Harrington, Lea A

Keywords: Aging; Cell Differentiation; Disease; Dna Damage; Genome Instability; Pluripotency; Stem Cells; Telomerase; Telomeres; Tissue Dysfunction

$668,936

Telomere integrity and stability of the differentiated state

Nominated PICIHR2013Operating Grant

Principal investigators: Harrington, Lea A

Keywords: Apoptosis; Cell Proliferation And Cancer; Differentiation; Dna Damage; Dna Replication; Genome Stability; Telomerase; Telomeres

$797,880

2nd Canadian Symposium on Telomeres and Genome Integrity

Co-investigatorCIHR2013Dissemination Events - Priority Announcement: Cancer Research

Principal investigators: Masson, Jean-Yves

Keywords: Aging; Cancer; Cultivate Collaboration; Dna Repair; Facilitate Translational Research; Genome Integrity; Symposium; Telomerase; Telomeres; Trainee Development

$25,000

Blood telomere length and breast cancer risk

Co-investigatorCIHR2009Operating Grant

Principal investigators: Martin, Lisa J

Keywords: Breast Cancer; Quantitative Polymerase Chain Reaction (Q-Pcr); Single-Telomere Length Analysis (Stela); Telomere; Terminal Restriction Fragments (Trf)

$222,329

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Médecine
Cellular and Molecular Biology
Terrence Donnelly Centre for Cellular and Biomolecular Research
Lady Davis Institute for Medical Research
Department of Surgery
Medicine
Lunenfeld-Tanenbaum Research Institute

Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Gary Bader

Terrence Donnelly Centre for Cellular and Biomolecular Research

1 shared papers, latest 2016

Ivan Topisirovic

Lady Davis Institute for Medical Research

1 shared papers, latest 2020

Rod Bremner

Lunenfeld-Tanenbaum Research Institute

1 shared papers, latest 2022

Mark Bernstein

Department of Surgery

1 shared papers, latest 2016

Minna Woo

Medicine

1 shared papers, latest 2022

Eldad Zacksenhaus

Cellular and Molecular Biology

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2021

Subject: Prospective PhD student: Dna Damage Dear Professor Harrington, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A CRISPR base editing approach for the functional assessment of telomere biology disorder-related genes in human health and aging." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Exploiting the synthetic-lethal vulnerabilities of stem cells and cancer cells with eroded telomeres" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Lea Harrington

Research

Latest papers

Latest funding

A CRISPR base editing approach for the functional assessment of telomere biology disorder-related genes in human health and aging.

Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.

Tieing together loose ends: telomere instability in cancer and aging.

Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.

Catechin from Burkea africana Hook. Exhibits in&#xa0;vitro inhibition of human telomerase activity.

Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.

Editorial overview: The instability of the cancer genome: it starts at the end.

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.

Lifelong leukocyte telomere dynamics and survival in a free-living mammal.

Exploiting the synthetic-lethal vulnerabilities of stem cells and cancer cells with eroded telomeres

Genetic and chemical ablation of senescent cells that result from age-dependent telomere erosion

Telomere instability transforms differentiated stem cells into teratomas: implications for aging and disease

Telomere integrity and stability of the differentiated state

2nd Canadian Symposium on Telomeres and Genome Integrity

Blood telomere length and breast cancer risk

Frequent collaborators

Gary Bader

Ivan Topisirovic

Rod Bremner

Mark Bernstein

Minna Woo

Eldad Zacksenhaus

Catechin from Burkea africana Hook. Exhibits in vitro inhibition of human telomerase activity.