Marlene Oeffinger

Research

Interactomes Nucleolar Stress Nucleolus Post-Translational Modifications Ribosomal Dna Maintenance Ribosomal Dna Stress Ribosome Biogenesis Nucleic Acid Binding Proteins

Latest papers

Altered rRNA processing disrupts nuclear RNA homeostasis via competition for the poly(A)-binding protein Nab2.
Nucleic acids research · 2020
Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.
Nature cell biology · 2018
The sole LSm complex in Cyanidioschyzon merolae associates with pre-mRNA splicing and mRNA degradation factors.
RNA (New York, N.Y.) · 2017

All 7 publications

Latest funding

Determining regulatory mechanisms of nucleolar and ribosomal DNA stress
CIHR · 2025 · Nominated PI
$1,120,725
Determining regulatory mechanisms of nucleolar and ribosomal DNA stress
CIHR · 2024 · Nominated PI
$100,000
Nuclear Transport Meeting 2022
CIHR · 2022 · Co-investigator
$10,000

All 16 grants and awards

7 publications.

01

Altered rRNA processing disrupts nuclear RNA homeostasis via competition for the poly(A)-binding protein Nab2.

Aguilar LC, Paul B, Reiter T, Gendron L, Arul Nambi Rajan A, Montpetit R, Trahan C, Pechmann S, Oeffinger M, Montpetit B

Nucleic acids research2020

DOI: 10.1093/nar/gkaa964 PMID: 33137177

02

Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.

Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G

Nature cell biology2018

DOI: 10.1038/s41556-018-0127-y PMID: 29941930

03

The sole LSm complex in Cyanidioschyzon merolae associates with pre-mRNA splicing and mRNA degradation factors.

Reimer KA, Stark MR, Aguilar LC, Stark SR, Burke RD, Moore J, Fahlman RP, Yip CK, Kuroiwa H, Oeffinger M, Rader SD

RNA (New York, N.Y.)2017

DOI: 10.1261/rna.058487.116 PMID: 28325844

04

Structural biology: Moulding the ribosome.

Oeffinger M

Nature2016First author

DOI: 10.1038/537038a PMID: 27582216

05

The nuclear basket mediates perinuclear mRNA scanning in budding yeast.

Saroufim MA, Bensidoun P, Raymond P, Rahman S, Krause MR, Oeffinger M, Zenklusen D

The Journal of cell biology2015

DOI: 10.1083/jcb.201503070 PMID: 26694838

06

A robust pipeline for rapid production of versatile nanobody repertoires.

Fridy PC, Li Y, Keegan S, Thompson MK, Nudelman I, Scheid JF, Oeffinger M, Nussenzweig MC, Fenyö D, Chait BT, Rout MP

Nature methods2014

DOI: 10.1038/nmeth.3170 PMID: 25362362

07

Sumoylation of the THO complex regulates the biogenesis of a subset of mRNPs.

Bretes H, Rouviere JO, Leger T, Oeffinger M, Devaux F, Doye V, Palancade B

Nucleic acids research2014

DOI: 10.1093/nar/gku124 PMID: 24500206

Determining regulatory mechanisms of nucleolar and ribosomal DNA stress

Nominated PICIHR2025Project Grant

Principal investigators: Oeffinger, Marlene H

Keywords: Interactomes; Nucleic Acid Binding Proteins; Nucleolar Stress; Nucleolus; Post-Translational Modifications; Ribosomal Dna Maintenance; Ribosomal Dna Repair; Ribosomal Dna Stress; Ribosome Biogenesis

$1,120,725

Determining regulatory mechanisms of nucleolar and ribosomal DNA stress

Nominated PICIHR2024Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)

Principal investigators: Oeffinger, Marlene H

Keywords: Interactomes; Nucleolar Stress; Nucleolus; Post-Translational Modifications; Ribosomal Dna Maintenance; Ribosomal Dna Stress; Ribosome Biogenesis; Rna Binding Proteins

$100,000

Nuclear Transport Meeting 2022

Co-investigatorCIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Zenklusen, Daniel R

Keywords: Meeting; Nuclear Transport

$10,000

Elucidating the role of TCOF1 in the nucleolar response to ribosomal DNA damage

SupervisorCIHR2021Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Panichnantakul, Pudchalaluck

Keywords: Genetic Crispr-Cas9 Screen; Nucleolar Caps, Immunofluorescence; Nucleolar Dna Damage Response; Proteomics - Affinity Purification, Bioid; Ribosomal Dna And Genome Instability

$105,000

Developing a real-time proteogenomics pipeline

Co-investigatorNSERC2021Alliance Grants

Principal investigators: Brunet, Marie

$135,000

Determining spatial arrangement, stoichiometry, and substrate specificity of messenger RNA-binding proteins along the gene expression pathway.

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Oeffinger, Marlene

$252,000

Determining spatial arrangement, stoichiometry, and substrate specificity of messenger RNA-binding proteins along the gene expression pathway.

Principal investigatorNSERC2020Discovery Grants Program - Accelerator Supplements

Principal investigators: Oeffinger, Marlene

$120,000

Determining the role of the nuclear basket protein Mlp1/TPR in mRNA homeostasis

Co-investigatorCIHR2019Project Grant

Principal investigators: Zenklusen, Daniel R

Keywords: Functional Specialization; Gene Expression; Mrna Export; Nuclear Basket; Nuclear Pore Complex; Phase Separation; Proteomics; Single Molecule Resolution Microscopy; Super-Resolution Microscopy

$822,375

Determining the pathways, components and functional niches that define specialized ribosomes.

Nominated PICIHR2016Project Grant

Principal investigators: Oeffinger, Marlene H

Keywords: Affinity Chromatography; Biochemistry; Bioinformatics; Molecular Biology; Proteomics; Ribonucleoprotein Maturation Pathways; Ribosome; Ribosomopathies; Rna; Translation Control

$814,725

Determining the molecular mechanisms of ribosomal export through the nuclear pore.

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Oeffinger, Marlene

$150,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochimie et médecine moléculaire
Systems Biology
Microbiology

Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Daniel Zenklusen

Biochimie et médecine moléculaire

2 shared papers, latest 2018

Gerardo Ferbeyre

Microbiology

1 shared papers, latest 2018

Gerardo Ferbeyre

Biochimie et médecine moléculaire

1 shared papers, latest 2018

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Interactomes Dear Professor Oeffinger, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Altered rRNA processing disrupts nuclear RNA homeostasis via competition for the poly(A)-binding protein Nab2." (2020), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Determining regulatory mechanisms of nucleolar and ribosomal DNA stress" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]