Faculty profile

Simon De Denus

ResearcherUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Simon De Denus

Researcher

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
19 publications in the last five years, latest in 2026.
Senior (last) author on 8 recent papers, a sign of leading a research group.
Principal investigator on 2 research grants (2 CIHR), most recently in 2019.
Supervisor on 2 trainee awards (2 CIHR), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

123

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Sex Drug Interactions Medications Pharmacogenomic Coronary Artery Disease Dose Drug Concentrations Gender

Latest papers

CYP2D6 Metabolizer Status and Mortality in Metoprolol Users.
Clinical and translational science · 2026 · first author
Pharmacogenomic study of the effects of saxagliptin on glucose control and hypoglycemic events.
BMC medical genomics · 2026
Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study.
Journal of the American College of Cardiology · 2026

All 90 publications

Latest funding

Étude de l'effet du sexe sur le dosage, les concentrations et la pharmacogénomique des inhibiteurs de l'enzyme de conversion de l'angiotensine dans la Cohorte hospitalière de l'Institut de cardiologie de Montréal
CIHR · 2022 · Supervisor
$135,000
Study of sex-specific biological factors underlying cognitive function and cardiovascular outcomes
CIHR · 2022 · Co-investigator
$439,875
Precision medicine study of treatment options in type 2 diabetes patients without cardiovascular disease
CIHR · 2021 · Co-investigator
$1,009,800

All 11 grants and awards

90 publications.

CYP2D6 Metabolizer Status and Mortality in Metoprolol Users.

de Denus S, Oussaïd E, Meloche M, Bertrand AX, Leclair G, Cyr MC, Jutras M, Gaulin MJ, Mongrain I, Busseuil D, Tardif JC, Dubé MP

Clinical and translational science2026First author

DOI: 10.1111/cts.70714 PMID: 42678095

Pharmacogenomic study of the effects of saxagliptin on glucose control and hypoglycemic events.

Pilon MO, de Denus S, Asselin G, Legault MA, Ngongang Kwandjang HB, Barhdadi A, Lemieux Perreault LP, Valois D, Mongrain I, Haefliger C, Paul DS, Pearson ER, Tardif JC, Dubé MP

BMC medical genomics2026

DOI: 10.1186/s12920-026-02348-z PMID: 41882721

Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study.

Sunderland N, Asselin G, Henry A, Nelson CP, Lemieux Perreault LP, Asselbergs FW, Boersma E, Cappola TP, Chazara O, Chutkow W, Cyr MC, Gkatzionis A, Gui H, Haefliger C, Hedman ÅK, Hillege H, Hyde CL, Kamanu FK, Kardys I, Koekemoer AL, Kraus WE, Lang CC, Malarstig A, Margulies KB, Marston NA, Melloni GEM, Morley MP, O'Donoghue ML, Owens AT, Paul DS, Tilling K, van der Harst P, van Setten J, van Vugt M, Verweij N, Veluchamy A, Wallentin L, Wang X, Xing H, Yang Y, White HD, Zannad F, Smith JG, Brunner-La Rocca HP, Lanfear DE, Mann DL, de Denus S, Tardif JC, Voors AA, Samani NJ, Ellinor PT, Ruff CT, Sabatine MS, Sattar N, McMurray JJV, Paternoster L, Dubé MP, Lumbers RT

Journal of the American College of Cardiology2026

DOI: 10.1016/j.jacc.2026.02.5093 PMID: 42017882

Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes

Henry A, Mo X, Finan C, Chaffin MD, Speed D, Issa H, Denaxas S, Ware JS, Zheng SL, Malarstig A

Nature Genetics202572 citations

DOI: 10.1038/s41588-024-02064-3

Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases.

Jordà P, Lai Y, Jeuken A, Lemieux Perreault LP, Goulet E, Lahrouchi N, Nozza A, Tanck MW, Guerra P, Cadrin-Tourigny J, de Denus S, Bezzina CR, Lettre G, Busseuil D, Dubé MP, Tardif JC, Tadros R

NPJ genomic medicine2025

DOI: 10.1038/s41525-025-00515-2 PMID: 41022758

A Study Of the effect of Sex on drug dosing, concentrations, and pharmacogenomics in the Montreal Heart Institute Hospital Cohort (SOS-PGx): methodology and research progress.

Pilon MO, Hindi J, St-Jean I, Jutras M, Brouillette MM, Mongrain I, Lagacé C, Vazquez K, Provost S, Lemieux Perreault LP, Oussaid E, Busseuil D, Cyr MC, Tardif JC, Dubé MP, Leclair G, de Denus S

European journal of clinical pharmacology2025Senior author

DOI: 10.1007/s00228-024-03786-3 PMID: 39704823

Clinically actionable genetic variation in patients with or at high-risk of cardiovascular diseases from the Montreal Heart Institute.

Pilon MO, Hindi J, Oussaïd E, Amani F, Cyr MC, Mongrain I, Sandoval J, Lemieux Perreault LP, Busseuil D, Tardif JC, Leclair G, Dubé MP, de Denus S

Pharmacogenomics2025Senior author

DOI: 10.1080/14622416.2025.2609367 PMID: 41524197

Rapid Corticosteroid Withdrawal After Cardiac Transplantation Improves Outcomes.

Minato C, Nasri A, Noly PE, Boulet J, Parent MC, Fortier A, de Denus S, Tremblsay-Gravel M, Giraldeau G, Lamarche Y, Ducharme A

Clinical transplantation2025

DOI: 10.1111/ctr.70420 PMID: 41405005

Cumulative weight-based rabbit antithymocyte globulin dosing for induction in heart transplantation: Impact on outcomes.

Bebawi E, Noly PE, Parent MC, Fortier A, de Denus S, Tremblay-Gravel M, Boulet J, Tran W, Giraldeau G, Lamarche Y, Ducharme A

JHLT open2025

DOI: 10.1016/j.jhlto.2025.100391 PMID: 41146911

High-sensitivity C-reactive protein in heart failure with preserved ejection fraction: Findings from TOPCAT.

Ferreira JP, Claggett BL, Liu J, Sharma A, Desai AS, Anand IS, O'Meara E, Rouleau JL, De Denus S, Pitt B, Pfeffer MA, Zannad F, Solomon SD

International journal of cardiology2024

DOI: 10.1016/j.ijcard.2024.131818 PMID: 38307421

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Simon De Denus

Research

Latest papers

Latest funding

CYP2D6 Metabolizer Status and Mortality in Metoprolol Users.

Pharmacogenomic study of the effects of saxagliptin on glucose control and hypoglycemic events.

Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study.

Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes

Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases.

A Study Of the effect of Sex on drug dosing, concentrations, and pharmacogenomics in the Montreal Heart Institute Hospital Cohort (SOS-PGx): methodology and research progress.

Clinically actionable genetic variation in patients with or at high-risk of cardiovascular diseases from the Montreal Heart Institute.

Rapid Corticosteroid Withdrawal After Cardiac Transplantation Improves Outcomes.

Cumulative weight-based rabbit antithymocyte globulin dosing for induction in heart transplantation: Impact on outcomes.

High-sensitivity C-reactive protein in heart failure with preserved ejection fraction: Findings from TOPCAT.

Frequent collaborators

Jean-Claude Tardif

Jean-Claude Tardif

Jean-Lucien Rouleau

Guillaume Lettre

Maxime Tremblay-Gravel

Thao Huynh

Paul Khairy

Nadia Giannetti

Julie Hussin

Alice Dragomir

Guillaume Pare

Julia Cadrin-Tourigny

Anil Nigam

Guillaume Fontaine

Rafik Tadros

Richard Leduc

Abhinav Sharma

Elham Emami

Rhian Touyz

Guillaume Fontaine

Rudolf Uher

Marie-Pierre Dubé

John Rioux

James Brophy

Valéry Ridde

Louise Potvin

Richard Leduc

Gregor Andelfinger

Elham Emami

Lambert Busque

Michel Bouvier

Katherine Frohlich

Christina Zarowsky

Benjamin Haibe-Kains

Carl-Ardy Dubois

Denis Roy