Faculty profile

Guillaume Lettre

ResearcherUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Guillaume Lettre

Researcher

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
44 publications in the last five years, latest in 2026.
Senior (last) author on 16 recent papers, a sign of leading a research group.
Principal investigator on 12 research grants (11 CIHR, 1 NSERC), most recently in 2022.
Supervised 6 trainees who won CIHR awards, most recently in 2026.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

128

Publications

842

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Human Genetics Sickle Cell Disease Crc Genome-Wide Association Study Genetic Association Study Biomarkers Drug Targets Polygenic Scores

Latest papers

Comparing bulk and single-cell methodologies and models to profile gene expression, chromatin accessibility and regulatory links in endothelial cells treated with TNFα.
bioRxiv : the preprint server for biology · 2026 · senior author
Comparing bulk and single-cell methodologies and models to profile gene expression, chromatin accessibility and regulatory links in endothelial cells treated with TNFα.
Biochemistry and biophysics reports · 2026 · senior author
Plasma proteome signatures are predictive of mortality in sickle cell disease.
Blood advances · 2026 · senior author

All 128 publications

Latest funding

Identification de biomarqueurs génétiques et protéomiques associés à la réponse aux entraînements physiques et cognitifs
CIHR · 2026 · Supervisor
$27,000
Projet Omics intégrés en maladie falciforme (Projet FALC-OMICS)
CIHR · 2026 · Supervisor
$140,000
Enabling sensitive genome-wide associations of structural variants with disease traits using a Quebec pangenome
CIHR · 2024 · Supervisor
$140,000

All 19 grants and awards

128 publications.

Comparing bulk and single-cell methodologies and models to profile gene expression, chromatin accessibility and regulatory links in endothelial cells treated with TNFα.

Zevounou J, Lo KS, McGinnis CS, Satpathy AT, Lettre G

bioRxiv : the preprint server for biology2026Senior author

DOI: 10.64898/2026.03.13.711357 PMID: 41889894

Comparing bulk and single-cell methodologies and models to profile gene expression, chromatin accessibility and regulatory links in endothelial cells treated with TNFα.

Zevounou J, Lo KS, McGinnis CS, Satpathy AT, Lettre G

Biochemistry and biophysics reports2026Senior author

DOI: 10.1016/j.bbrep.2026.102786 PMID: 42756083

Plasma proteome signatures are predictive of mortality in sickle cell disease.

Chignon A, Zaouali Y, Galactéros F, Bartolucci P, Lettre G

Blood advances2026Senior author

DOI: 10.1182/bloodadvances.2025019294 PMID: 41855503

Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification.

El Aouhel S, Bellegarde V, Da Silva Faria S, St-Laurent T, Lecluze E, Pham Hung d'Alexandry d'Orengiani AL, Galactéros F, Bartolucci P, Legault MA, Lettre G, Pincez T

American journal of hematology2026

DOI: 10.1002/ajh.70262 PMID: 41757739

Whole Blood Transcriptomic Analysis of Sickle Cell Trait.

Johnson M, Cai Y, Vasconcelos AG, Orchard P, Auer PL, Lettre G, Wen J, Franceschini N, Kooperberg C, Sun W, Hsu L, Raffield LM, Reiner AP

European journal of haematology2026

DOI: 10.1111/ejh.70114 PMID: 41528117

A multi-ancestry genetic reference for the Quebec population.

McClelland P, Femerling G, Laflamme R, Mejia-Garcia A, Sayahian Dehkordi M, Xiao H, Diaz-Papkovich A, Pelletier J, Grenier JC, Lo KS, Anderson-Trocmé L, Bellavance J, Chapdelaine V, Gagnon G, De Mori A, Martinez G, Mohler K, de Malliard T, Labbé C, Labrecque M, Montpetit A, Spiegelman D, Rouleau GA, Théroux JF, Zhou H, Girard SL, Hussin JG, Laberge AM, Bhérer C, Tetreault M, Gagliano Taliun SA, Taliun D, Gravel S, Lettre G

Nature communications2026Senior author

DOI: 10.1038/s41467-026-68820-7 PMID: 41634041

Long-read Sequences Mapped to a Complete Reference Genome Uncover Uncaptured Structural Variants across the Beta-globin Cluster in Africans with Sickle Cell Disease.

Lurie P, Mahmoud M, Haldipur A, Han Y, Li Q, Wonkam-Tingang E, Asmus N, Banfield E, Hall NJ, Tayo B, Cooper R, Akingbola T, Ayodo G, Obaro S, Lettre G, Meng Q, Jhangiani S, Harris RA, Worley KC, Kim J, Rhie A, Phillippy AM, Sedlazeck F, Wonkam A, Hanchard NA

HGG advances2026

DOI: 10.1016/j.xhgg.2026.100669 PMID: 42693638

Albuminuria Predicts a Rapid Decline in Kidney Function in 2 International, Longitudinal Cohorts of Adults With Sickle Cell Anemia.

Bartolucci P, Audureau É, Audard V, Galactéros F, Lettre G, Anthony C, Egbujo O, Han J, Ruiz MA, Lash JP, Gordeuk VR, Zhang X, Saraf SL

American journal of hematology2026

DOI: 10.1002/ajh.70155 PMID: 41334969

Using the ancestral recombination graph to study the history of rare variants in founder populations.

Mejia-Garcia A, Diaz-Papkovich A, Sillon G, D'Agostino D, Chong AL, Chong G, Lo KS, Baret L, Hamel N, Chapdelaine V, Foulkes WD, Taliun D, Shapiro AJ, Lettre G, Gravel S

American journal of human genetics2025

DOI: 10.1016/j.ajhg.2025.10.005 PMID: 41172993

Visceral adipose tissue and hepatic fat as determinants of carotid atherosclerosis.

de Souza RJ, Pigeyre ME, Schulze KM, Lamri A, Al-Khazraji BK, Awadalla P, Beyene J, Desai D, Despres JP, Dummer TJB, Friedrich MG, Hicks J, Ho V, LaRose É, Lear SA, Lee DS, Leipsic JA, Lettre G, Moody AR, Noseworthy MD, Pare G, Parraga G, Poirier P, Tardif JC, Yusuf S, Vena J, Anand SS

Communications medicine2025

DOI: 10.1038/s43856-025-01123-y PMID: 41107464

Identification de biomarqueurs génétiques et protéomiques associés à la réponse aux entraînements physiques et cognitifs

SupervisorCIHR2026CIHR Strategic Master's Award - Bioinformatics, Comput. Biology/Health Data Sci.

Principal investigators: van der Schaaf, Arianne

Keywords: Apprentissage Machine; Biobanques; Biomarqueurs; Entraînement Physique Et Cognitif; Génétique Humaine; Médecine De Précision; Protéomique; Réponse À L'Exercice; Santé Cardiovasculaire Et Cérébrale; Études De Population

$27,000

Projet Omics intégrés en maladie falciforme (Projet FALC-OMICS)

SupervisorCIHR2026Fellowship: Canada Impact+ Research Training Awards - Postdoctoral

Principal investigators: Hachemi, Hamid

Keywords: Bioinformatique; Génétique; Intelligence Artificielle; Maladie Falciforme; Médecine De Précision; Métabolomique; Protéomique; Prédiction; Sciences Omics

$140,000

Enabling sensitive genome-wide associations of structural variants with disease traits using a Quebec pangenome

SupervisorCIHR2024CIHR Fellowship

Principal investigators: Groza, Cristian

Keywords: Biostatistics; Genetics

$140,000

Discovery of new biomarkers and drug targets in sickle cell disease

Nominated PICIHR2022Project Grant

Principal investigators: Lettre, Guillaume

Keywords: Biomarkers; Drug Targets; Human Genetics; Polygenic Scores; Proteomics; Sickle Cell Disease; Single-Cell Transcriptomics

$1,151,325

Canada Research Chair Tier 1

Nominated PICIHR2020Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Lettre, Guillaume

Keywords: Crc

$1,400,000

Endothelial cell genetics and blood pressure regulation

Nominated PICIHR2019Project Grant

Principal investigators: Lettre, Guillaume

Keywords: Blood Pressure; Coding/Non-Coding Rare Variants; Crispr/Cas9; Functional Genomics; Genome-Wide Association Studies (Gwas); Human Genetics; Hypertension; Vascular Endothelial Cells; Whole-Genome Sequencing

$940,950

Complex genetics of hypertrophic cardiomyopathy: Towards an integration of polygenic risk in clinical care

Principal investigatorCIHR2019Project Grant

Principal investigators: Tadros, Rafik; Lettre, Guillaume

Keywords: Cardiac Arrhythmia; Cardiac Magnetic Resonance; Cardiac Ultrasound; Genetics; Genome-Wide Association Study; Hypertrophic Cardiomyopathy; Polygenic Risk Score

$1,038,180

The genetics of erythrocyte volume homeostasis

Nominated PICIHR2017Project Grant

Principal investigators: Lettre, Guillaume

Keywords: Anemia; Genome Editing/Crispr-Cas9; Genome-Wide Association Study; Malaria; Next-Generation Dna Sequencing; Red Blood Cell/Erythrocyte Volume; Sickle Cell Disease

$956,250

Developing cellular models to study hematopoiesis

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Lettre, Guillaume

$31,000

Identification of cardiovascular risk factors using whole-genome sequencing

SupervisorCIHR2016Undergraduate: Genetics - ICS

Principal investigators: Gauthier, Louis

Keywords: Ics Studentship

$5,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Guillaume Lettre

Research

Latest papers

Latest funding

Comparing bulk and single-cell methodologies and models to profile gene expression, chromatin accessibility and regulatory links in endothelial cells treated with TNF&#x3b1;.

Comparing bulk and single-cell methodologies and models to profile gene expression, chromatin accessibility and regulatory links in endothelial cells treated with TNF&#x3b1;.

Plasma proteome signatures are predictive of mortality in sickle cell disease.

Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification.

Whole Blood Transcriptomic Analysis of Sickle Cell Trait.

A multi-ancestry genetic reference for the Quebec population.

Long-read Sequences Mapped to a Complete Reference Genome Uncover Uncaptured Structural Variants across the Beta-globin Cluster in Africans with Sickle Cell Disease.

Albuminuria Predicts a Rapid Decline in Kidney Function in 2 International, Longitudinal Cohorts of Adults With Sickle Cell Anemia.

Using the ancestral recombination graph to study the history of rare variants in founder populations.

Visceral adipose tissue and hepatic fat as determinants of carotid atherosclerosis.

Developing cellular models to study hematopoiesis

Frequent collaborators

Jean-Claude Tardif

Jean-Claude Tardif

Simon De Denus

Rudolf Uher

Rafik Tadros

Eric Thorin

Eric Thorin

Julia Cadrin-Tourigny

Stanley Nattel

Simon Gravel

Daniel Taliun

Daniel Taliun

Marie-Claude Vohl

Matthieu Ruiz

Louis Pérusse

Manuel Mattheisen

Anne-Marie Laberge

Jason Roberts

Mark Walker

Alain Bitton

Christine Des Rosiers

Guillaume Pare

Jeff Healey

Comparing bulk and single-cell methodologies and models to profile gene expression, chromatin accessibility and regulatory links in endothelial cells treated with TNFα.

Comparing bulk and single-cell methodologies and models to profile gene expression, chromatin accessibility and regulatory links in endothelial cells treated with TNFα.