Faculty profile

Jean-Luc Parent

ResearcherMédecineUniversité de Sherbrooke

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Sherbrooke directory, so their courses may be missing. Find their university profile.

Jean-Luc Parent

Researcher

Médecine

Health Sciences

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
5 publications in the last five years, latest in 2026.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 10 research grants (5 CIHR, 5 NSERC), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Trafficking Medicinal Chemistry G Protein-Coupled Receptor Gpcr Breast Cancer Cancer Cell Biology Drug Development

Latest papers

Role of Rab4A in the enhancement of cancer cell invasion induced by plasma samples collected during radiotherapy in patients with triple-negative breast cancer.
PloS one · 2026 · senior author
Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions.
Life science alliance · 2024
Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.
The European journal of neuroscience · 2022

All 44 publications

Latest funding

Mechanisms of opioid tolerance: A role for the delta opioid receptor
CIHR · 2024 · Co-investigator
$100,000
The mitochondrial delta opioid receptor: role, targeting and molecular mechanisms
CIHR · 2023 · Nominated PI
$952,426
Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking
CIHR · 2023 · Co-investigator
$1,009,800

All 15 grants and awards

44 publications.

Role of Rab4A in the enhancement of cancer cell invasion induced by plasma samples collected during radiotherapy in patients with triple-negative breast cancer.

Paquette B, Therriault H, Gauthier I, Provencher S, Bourque JM, Naasri S, Oweida A, Geha S, Labrecque P, Parent JL

PloS one2026Senior author

DOI: 10.1371/journal.pone.0329717 PMID: 42743222

Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions.

Roy M, Mbous Nguimbus L, Badiane PY, Goguen-Couture V, Degrandmaison J, Parent JL, Brunet MA, Roux S

Life science alliance2024

DOI: 10.26508/lsa.202302348 PMID: 38395460

Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.

Quirion B, Beaulieu C, Côté L, Parent JL, Gendron L

The European journal of neuroscience2022

DOI: 10.1111/ejn.15733 PMID: 35674691

Knock-In Mouse Models to Investigate the Functions of Opioid Receptors in vivo.

Degrandmaison J, Rochon-Haché S, Parent JL, Gendron L

Frontiers in cellular neuroscience2022

DOI: 10.3389/fncel.2022.807549 PMID: 35173584

Differential barcoding of opioid receptors trafficking.

Degrandmaison J, Grisé O, Parent JL, Gendron L

Journal of neuroscience research2022

DOI: 10.1002/jnr.24949 PMID: 34559903

Identification of the interactome of the DP1 receptor for Prostaglandin D2: Regulation of DP1 receptor signaling and trafficking by IQGAP1.

Fréchette L, Degrandmaison J, Binda C, Boisvert M, Côté L, Michaud T, Lalumière MP, Gendron L, Parent JL

Biochimica et biophysica acta. General subjects2021Senior author

DOI: 10.1016/j.bbagen.2021.129969 PMID: 34352343

In-depth NMR characterization of Rab4a structure, nucleotide exchange and hydrolysis kinetics reveals an atypical GTPase profile.

Génier S, Létourneau D, Gauthier E, Picard S, Boisvert M, Parent JL, Lavigne P

Journal of structural biology2020

DOI: 10.1016/j.jsb.2020.107582 PMID: 32707235

GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D2 in a Rab4-dependent mechanism.

Fréchette L, Binda C, Génier S, Degrandmaison J, Boisvert M, Parent JL

Cellular signalling2020Senior author

DOI: 10.1016/j.cellsig.2020.109641 PMID: 32334026

In vivo mapping of a GPCR interactome using knockin mice.

Degrandmaison J, Abdallah K, Blais V, Génier S, Lalumière MP, Bergeron F, Cahill CM, Boulter J, Lavoie CL, Parent JL, Gendron L

Proceedings of the National Academy of Sciences of the United States of America2020

DOI: 10.1073/pnas.1917906117 PMID: 32457152

L-type prostaglandin D synthase regulates the trafficking of the PGD2 DP1 receptor by interacting with the GTPase Rab4.

Binda C, Génier S, Degrandmaison J, Picard S, Fréchette L, Jean S, Marsault E, Parent JL

The Journal of biological chemistry2019Senior author

DOI: 10.1074/jbc.ra119.008233 PMID: 31575663

Mechanisms of opioid tolerance: A role for the delta opioid receptor

Co-investigatorCIHR2024Project Grant - PA: IMHA: Myalgic Encephalomyelitis

Principal investigators: Gendron, Louis

Keywords: Analgesic Tolerance; Animal Behavior; Cellular And Molecular Biology; Electron Microscopy; Electrophysiology; Morphine; Opioid Receptors; Opioids; Pharmacology; Receptor Interactions

$100,000

The mitochondrial delta opioid receptor: role, targeting and molecular mechanisms

Nominated PICIHR2023Project Grant

Principal investigators: Parent, Jean-Luc; Gendron, Louis

Keywords: G Protein-Coupled Receptor; Gpcr; Mitochondria; Opioid; Signaling; Stress; Trafficking

$952,426

Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

Co-investigatorCIHR2023Project Grant

Principal investigators: Lavoie, Christine

Keywords: Endosomal Sorting; G Alpha S; G Protein Coupled Receptor (Gpcr); Heart-Cardiomyocytes; Heterotrimeric G Proteins; Intracellular Trafficking; Signal Transduction; Ubiquitin; Ubiquitin Interacting Motif (Uim)

$1,009,800

The thromboxane A2 receptor and peroxisomes

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Parent, Jean-Luc

$300,000

The small GTPase Rab4 as a target for breast cancer metastasis

Nominated PICIHR2019Project Grant

Principal investigators: Parent, Jean-Luc; Lavigne, Pierre; Marsault, Eric; Paquette, Benoît

Keywords: Breast Cancer; Cancer; Cell Biology; Drug Development; Inhibitor; Intracellular Trafficking; Medicinal Chemistry; Metastasis; Nmr; Rab4

$822,376

The small GTPase Rab4 as a target for breast cancer metastasis

Nominated PICIHR2018Project Grant

Principal investigators: Parent, Jean-Luc; Lavigne, Pierre; Marsault, Eric; Paquette, Benoît

Keywords: Breast Cancer; Cancer; Cell Biology; Drug Development; Inhibitor; Intracellular Trafficking; Medicinal Chemistry; Metastasis; Nmr; Rab4

$100,000

Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

Co-investigatorCIHR2018Project Grant

Principal investigators: Lavoie, Christine

Keywords: Endosomal Sorting; G Alpha S; G Protein Coupled Receptor; Heterotrimeric G Protein; Intracellular Trafficking; Signal Transduction; Ubiquitin; Ubiquitin Interacting Motif (Uim)

$665,550

Role, function, and regulation of the delta opioid receptor and its implications for the treatment of pain

Principal investigatorCIHR2018Project Grant

Principal investigators: Gendron, Louis; Lavoie, Christine; Marsault, Eric; Parent, Jean-Luc

Keywords: Animal Behavior; Biochemistry; Medicinal Chemistry; Molecular And Cellular Biology; Opioid Receptors; Opioids; Pain; Pharmacology; Protein-Protein Interactions; Trafficking

$967,725

Characterization of new GPCR signaling mechanisms involving WDR36 and Siva1

Principal investigatorNSERC2013Discovery Grants Program - Individual

Principal investigators: Parent, JeanLuc

$300,000

Identification of new pathways of DP biogenesis and trafficking

Nominated PICIHR2013Operating Grant

Principal investigators: Parent, Jean-Luc

Keywords: Confocal Microscopy; G Protein-Coupled Receptor; Gpcr; Immunoprecipitation; Mutagenesis; Protein Interaction; Rab; Sirna; Trafficking; Yeast Two Hybrid

$763,254

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Jean-Luc Parent

Research

Latest papers

Latest funding

Role of Rab4A in the enhancement of cancer cell invasion induced by plasma samples collected during radiotherapy in patients with triple-negative breast cancer.

Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions.

Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.

Knock-In Mouse Models to Investigate the Functions of Opioid Receptors in vivo.

Differential barcoding of opioid receptors trafficking.

Identification of the interactome of the DP1 receptor for Prostaglandin D2: Regulation of DP1 receptor signaling and trafficking by IQGAP1.

In-depth NMR characterization of Rab4a structure, nucleotide exchange and hydrolysis kinetics reveals an atypical GTPase profile.

GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D2 in a Rab4-dependent mechanism.

In vivo mapping of a GPCR interactome using knockin mice.

L-type prostaglandin D synthase regulates the trafficking of the PGD2 DP1 receptor by interacting with the GTPase Rab4.

Mechanisms of opioid tolerance: A role for the delta opioid receptor

The mitochondrial delta opioid receptor: role, targeting and molecular mechanisms

Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

The thromboxane A2 receptor and peroxisomes

The small GTPase Rab4 as a target for breast cancer metastasis

The small GTPase Rab4 as a target for breast cancer metastasis

Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

Role, function, and regulation of the delta opioid receptor and its implications for the treatment of pain

Characterization of new GPCR signaling mechanisms involving WDR36 and Siva1

Identification of new pathways of DP biogenesis and trafficking

Frequent collaborators

Louis Gendron

Christian Iorio-Morin

Sophie Roux

Hugues Allard-Chamard

Pierre Lavigne

Steve Jean

Benoît Paquette

Ayman Oweida

Christine Lavoie

Jana Stankova

Eric Marsault

Ghassan Bkaily

Mannix Auger-Messier