Faculty profile

Sylvia Van Drunen Littel-van den Hurk

ResearcherUniversity of Saskatchewan

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Saskatchewan directory, so their courses may be missing. Find their university profile.

Sylvia Van Drunen Littel-van den Hurk

Researcher

Health Sciences

University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
4 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 15 research grants (10 NSERC, 5 CIHR), most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Vaccine Adjuvant Elderly Fusion Protein Iga Class Switch Immune Memory Mucosal Immunity Respiratory Syncytial Virus

Latest papers

Evaluation of a Respiratory Syncytial Virus Subunit Vaccine Candidate in IgA-Deficient Mice: Insights into the Role of IgA in Vaccine-Induced Immunity and Protection.
Vaccines · 2026 · senior author
The biology and development of vaccines for bovine alphaherpesvirus 1.
Veterinary journal (London, England : 1997) · 2024 · senior author
Comprehensive Analysis of the Tegument Proteins Involved in Capsid Transport and Virion Morphogenesis of Alpha, Beta and Gamma Herpesviruses.
Viruses · 2023 · senior author

All 76 publications

Latest funding

COVID-19 Variant Supplement - Vaccine efficacy in nonhuman primates against SARS-CoV-2: protection, cross-protection and immune enhancement
CIHR · 2021 · Co-investigator
$50,000
Animal models for SARS-CoV-2: vaccines and immune enhancement
CIHR · 2020 · Co-investigator
$999,793
Vaccine efficacy in nonhuman primates against SARS-CoV-2: protection, cross-protection and immune enhancement
CIHR · 2020 · Co-investigator
$1,459,325

All 21 grants and awards

76 publications.

Evaluation of a Respiratory Syncytial Virus Subunit Vaccine Candidate in IgA-Deficient Mice: Insights into the Role of IgA in Vaccine-Induced Immunity and Protection.

Gonzalez Gonzalez L, Zhiani M, Witt J, van Drunen Littel-van den Hurk S

Vaccines2026Senior author

DOI: 10.3390/vaccines14010097 PMID: 41601012

The biology and development of vaccines for bovine alphaherpesvirus 1.

Krishnagopal A, van Drunen Littel-van den Hurk S

Veterinary journal (London, England : 1997)2024Senior author

DOI: 10.1016/j.tvjl.2024.106152 PMID: 38821207

Comprehensive Analysis of the Tegument Proteins Involved in Capsid Transport and Virion Morphogenesis of Alpha, Beta and Gamma Herpesviruses.

Sucharita S, Krishnagopal A, van Drunen Littel-van den Hurk S

Viruses2023Senior author

DOI: 10.3390/v15102058 PMID: 37896835

Bovine Herpesvirus-1 Glycoprotein M Mediates the Translocation to the Golgi Apparatus and Packaging of VP8.

Sucharita S, Tikoo S, van Drunen Littel-van den Hurk S

Viruses2022Senior author

DOI: 10.3390/v14091985 PMID: 36146791

Chitosan nanoparticles fabricated through host-guest interaction for enhancing the immunostimulatory effect of CpG oligodeoxynucleotide.

Wang Z, van Drunen Littel-van den Hurk S, Chen L

Carbohydrate polymers2021

DOI: 10.1016/j.carbpol.2021.118417 PMID: 34364558

VP8, the Major Tegument Protein of Bovine Herpesvirus-1, Is Partially Packaged during Early Tegument Formation in a VP22-Dependent Manner.

Sucharita S, Zhang K, van Drunen Littel-van den Hurk S

Viruses2021Senior author

DOI: 10.3390/v13091854 PMID: 34578435

Low molecular weight chitosan nanoparticles for CpG oligodeoxynucleotides delivery: Impact of molecular weight, degree of deacetylation, and mannosylation on intracellular uptake and cytokine induction.

Babii O, Wang Z, Liu G, Martinez EC, van Drunen Littel-van den Hurk S, Chen L

International journal of biological macromolecules2020

DOI: 10.1016/j.ijbiomac.2020.05.048 PMID: 32437810

Comprehensive Lipidomic and Metabolomic Analysis for Studying Metabolic Changes in Lung Tissue Induced by a Vaccine against Respiratory Syncytial Virus.

Zardini Buzatto A, Sarkar I, van Drunen Littel-van den Hurk S, Li L

ACS infectious diseases2020

DOI: 10.1021/acsinfecdis.0c00210 PMID: 32633123

Innate immune protection from pneumonia virus of mice induced by a novel immunomodulator is prolonged by dual treatment and mediated by macrophages.

Martinez EC, Garg R, van Drunen Littel-van den Hurk S

Antiviral research2019Senior author

DOI: 10.1016/j.antiviral.2019.104594 PMID: 31470041

Selection of adjuvants for vaccines targeting specific pathogens.

Sarkar I, Garg R, van Drunen Littel-van den Hurk S

Expert review of vaccines2019Senior author

DOI: 10.1080/14760584.2019.1604231 PMID: 31009255

COVID-19 Variant Supplement - Vaccine efficacy in nonhuman primates against SARS-CoV-2: protection, cross-protection and immune enhancement

Co-investigatorCIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 1

Principal investigators: Falzarano, Darryl

Keywords: Animal Model; Immune Enhancement; Immunogenicity; Nonhuman Primate; Pre-Clinical; Protection; Sars-Cov-2; Vaccine; Vaccine Safety

$50,000

Animal models for SARS-CoV-2: vaccines and immune enhancement

Co-investigatorCIHR2020Operating Grant: COVID-19 - Vaccines

Principal investigators: Falzarano, Darryl

Keywords: Animal Model; Coronavirus; Covid-19; Immune Enhancement; One Health; Pre-Existing Immunity; Sars-Cov; Sars-Cov-2; Transmission; Vaccine

$999,793

Vaccine efficacy in nonhuman primates against SARS-CoV-2: protection, cross-protection and immune enhancement

Co-investigatorCIHR2020Operating Grant: COVID-19 Rapid Research Funding Opportunity - Vaccines

Principal investigators: Falzarano, Darryl

Keywords: Animal Model; Immune Enhancement; Immunogenicity; Nonhuman Primate; Pre-Clinical; Protection; Sars-Cov-2; Vaccine; Vaccine Safety

$1,459,325

Sex as a Biological Variable Supplement - Animal models for SARS-CoV-2: vaccines and immune enhancement

Co-investigatorCIHR2020Op Grant: Sex as a Biological Variable Supplement: COVID-19 Rapid Research FO

Principal investigators: Falzarano, Darryl

Keywords: Animal Model; Coronavirus.; Covid-19; Immune Enhancement; One Health; Pre-Existing Immunity; Sars-Cov; Sars-Cov-2; Transmission; Vaccine

$50,000

Long-term immune activation by a mucosal RSV subunit vaccine: mechanism of action and application to vaccination of elderly

Nominated PICIHR2019Project Grant

Principal investigators: Van Drunen Littel-van den Hurk, Sylvia

Keywords: Adjuvant; Elderly; Fusion Protein; Iga Class Switch; Immune Memory; Mucosal Immunity; Respiratory Syncytial Virus; Vaccine

$753,525

Impact of BHV-1 tegument proteins on the innate response to infection and virion morphogenesis.

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: vanDrunenLittelvandenHurk, Sylvia

$264,000

Developing novel vaccines for respiratory syncytial virus and parainfluenza virus type 3

Co-investigatorCIHR2013Operating Grant: Canada-China Human Vaccines - Full Application

Principal investigators: Potter, Andrew

Keywords: Novel

$485,283

Characterization of dendritic cells in hepatitis C patients and applications to dendritic cell-based therapy.

Nominated PICIHR2012Operating Grant - PA: Regional Partnership Program - Saskatchewan

Principal investigators: Van Drunen Littel-van den Hurk, Sylvia

Keywords: Adaptive Immunity; Dendritic Cells; Gene Expression; Hepatitis C Virus; Immune Modulation; Immunotherapy; Innate Immunity; Vaccine

$133,736

Mechanism of immune activation by respiratory syncytial virus fusion protein in virus-sized particles

Nominated PICIHR2011Operating Grant

Principal investigators: Van Drunen Littel-van den Hurk, Sylvia

Keywords: Adjuvant; Dendritic Cells; Fusion Protein; Immune Modulator; Innate And Adaptive Immunity; Mucosal Immunity; Neonate; Respiratory Syncytial Virus; Vaccine; Virus-Sized Particles

$739,443

Functional characterization of BHV-1 tegument proteins

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: VanDrunenLittelvandenHurk, Sylvia

$336,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2019

Subject: Prospective PhD student: Vaccine Dear Professor Van Drunen Littel-van den Hurk, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Evaluation of a Respiratory Syncytial Virus Subunit Vaccine Candidate in IgA-Deficient Mice: Insights into the Role of IgA in Vaccine-Induced Immunity and Protection." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Long-term immune activation by a mucosal RSV subunit vaccine: mechanism of action and application to vaccination of elderly" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Sylvia Van Drunen Littel-van den Hurk

Research

Latest papers

Latest funding

Evaluation of a Respiratory Syncytial Virus Subunit Vaccine Candidate in IgA-Deficient Mice: Insights into the Role of IgA in Vaccine-Induced Immunity and Protection.

The biology and development of vaccines for bovine alphaherpesvirus 1.

Comprehensive Analysis of the Tegument Proteins Involved in Capsid Transport and Virion Morphogenesis of Alpha, Beta and Gamma Herpesviruses.

Bovine Herpesvirus-1 Glycoprotein M Mediates the Translocation to the Golgi Apparatus and Packaging of VP8.

Chitosan nanoparticles fabricated through host-guest interaction for enhancing the immunostimulatory effect of CpG oligodeoxynucleotide.

VP8, the Major Tegument Protein of Bovine Herpesvirus-1, Is Partially Packaged during Early Tegument Formation in a VP22-Dependent Manner.

Low molecular weight chitosan nanoparticles for CpG oligodeoxynucleotides delivery: Impact of molecular weight, degree of deacetylation, and mannosylation on intracellular uptake and cytokine induction.

Comprehensive Lipidomic and Metabolomic Analysis for Studying Metabolic Changes in Lung Tissue Induced by a Vaccine against Respiratory Syncytial Virus.

Innate immune protection from pneumonia virus of mice induced by a novel immunomodulator is prolonged by dual treatment and mediated by macrophages.

Selection of adjuvants for vaccines targeting specific pathogens.

COVID-19 Variant Supplement - Vaccine efficacy in nonhuman primates against SARS-CoV-2: protection, cross-protection and immune enhancement

Animal models for SARS-CoV-2: vaccines and immune enhancement

Vaccine efficacy in nonhuman primates against SARS-CoV-2: protection, cross-protection and immune enhancement

Sex as a Biological Variable Supplement - Animal models for SARS-CoV-2: vaccines and immune enhancement

Long-term immune activation by a mucosal RSV subunit vaccine: mechanism of action and application to vaccination of elderly

Impact of BHV-1 tegument proteins on the innate response to infection and virion morphogenesis.

Developing novel vaccines for respiratory syncytial virus and parainfluenza virus type 3

Characterization of dendritic cells in hepatitis C patients and applications to dendritic cell-based therapy.

Mechanism of immune activation by respiratory syncytial virus fusion protein in virus-sized particles

Functional characterization of BHV-1 tegument proteins

Frequent collaborators

Volker Gerdts

Andrew Potter

Liang Li

Jim Xiang

Hugh Townsend

Andrew Freywald

Philip Griebel