Faculty profile

Richard Lehner

ResearcherPediatricsUniversity of Alberta

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Alberta directory, so their courses may be missing. Find their university profile.

Richard Lehner

Researcher

Pediatrics

Health Sciences

University of Alberta

Edmonton, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
11 publications in the last five years, latest in 2025.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (6 CIHR, 2 NSERC), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Lipase Lipoproteins Fatty Liver Lipid Droplets Obesity Knockout Mice Lipid Metabolism Atherosclerosis

Latest papers

CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c.
Cells · 2025 · senior author
Alterations in phosphatidylethanolamine metabolism impacts hepatocellular lipid storage, energy homeostasis, and proliferation.
Biochimica et biophysica acta. Molecular and cell biology of lipids · 2025
FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver.
Molecular metabolism · 2024

All 58 publications

Latest funding

Dissecting the cell type-specific role of MT1-MMP/MMP14 in the development of liver fibrosis
CIHR · 2025 · Co-investigator
$1,067,175
Regulation of hepatic fat synthesis, turnover and transport by arylacetamide deacetylase (AADAC)
CIHR · 2023 · Nominated PI
$952,426
A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system
CIHR · 2022 · Co-investigator
$975,375

All 13 grants and awards

58 publications.

CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c.

Selvaraj R, Lian J, Watts R, Nelson R, Saikali MF, Cummins CL, Lehner R

Cells2025Senior author

DOI: 10.3390/cells14191548 PMID: 41090776

Alterations in phosphatidylethanolamine metabolism impacts hepatocellular lipid storage, energy homeostasis, and proliferation.

Holdaway CM, Leonard KA, Nelson R, van der Veen J, Das C, Watts R, Clugston RD, Lehner R, Jacobs RL

Biochimica et biophysica acta. Molecular and cell biology of lipids2025

DOI: 10.1016/j.bbalip.2025.159608 PMID: 40154596

FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver.

Wang H, Nikain C, Fortounas KI, Amengual J, Tufanli O, La Forest M, Yu Y, Wang MC, Watts R, Lehner R, Qiu Y, Cai M, Kurland IJ, Goldberg IJ, Rajan S, Hussain MM, Brodsky JL, Fisher EA

Molecular metabolism2024

DOI: 10.1016/j.molmet.2024.102048 PMID: 39426520

Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes.

Selvaraj R, Zehnder SV, Watts R, Lian J, Das C, Nelson R, Lehner R

Biochimica et biophysica acta. Molecular and cell biology of lipids2023Senior author

DOI: 10.1016/j.bbalip.2023.159376 PMID: 37516308

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes.

Datta R, Gholampour MA, Yang CD, Volk R, Lin S, Podolsky MJ, Arnold T, Rieder F, Zaro BW, Verzi M, Lehner R, Abumrad N, Lizama CO, Atabai K

Cell reports2023

DOI: 10.1016/j.celrep.2023.112249 PMID: 36924494

Interfering with lipid metabolism through targeting CES1 sensitizes hepatocellular carcinoma for chemotherapy.

Li G, Li X, Mahmud I, Ysaguirre J, Fekry B, Wang S, Wei B, Eckel-Mahan KL, Lorenzi PL, Lehner R, Sun K

JCI insight2023

DOI: 10.1172/jci.insight.163624 PMID: 36472914

Ethanol and its Nonoxidative Metabolites Promote Acute Liver Injury by Inducing ER Stress, Adipocyte Death, and Lipolysis.

Park SH, Seo W, Xu MJ, Mackowiak B, Lin Y, He Y, Fu Y, Hwang S, Kim SJ, Guan Y, Feng D, Yu L, Lehner R, Liangpunsakul S, Gao B

Cellular and molecular gastroenterology and hepatology2023

DOI: 10.1016/j.jcmgh.2022.10.002 PMID: 36243320

Carboxylesterase 1d Inactivation Augments Lung Inflammation in Mice.

Szafran BN, Borazjani A, Scheaffer HL, Crow JA, McBride AM, Adekanye O, Wonnacott CB, Lehner R, Kaplan BLF, Ross MK

ACS pharmacology & translational science2022

DOI: 10.1021/acsptsci.2c00098 PMID: 36268116

Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice.

Li G, Li X, Yang L, Wang S, Dai Y, Fekry B, Veillon L, Tan L, Berdeaux R, Eckel-Mahan K, Lorenzi PL, Zhao Z, Lehner R, Sun K

Life science alliance2022

DOI: 10.26508/lsa.202101209 PMID: 35459739

Attenuation of obesity-induced hyperlipidemia reduces tumor growth.

Hussain A, Lian J, Watts R, Gutiérrez T, Nelson R, Goping IS, Lehner R

Biochimica et biophysica acta. Molecular and cell biology of lipids2022Senior author

DOI: 10.1016/j.bbalip.2022.159124 PMID: 35150894

Dissecting the cell type-specific role of MT1-MMP/MMP14 in the development of liver fibrosis

Co-investigatorCIHR2025Project Grant

Principal investigators: Zhang, Dawei

Keywords: Extracellular Matrix; Fatty Liver; Hepatic Stellate Cells; Immunohistochemistry; Knockout Mice; Lipid Metabolism; Liver Fibrosis; Liver Steatosis; Matrix Metalloproteinase; Triglycerides

$1,067,175

Regulation of hepatic fat synthesis, turnover and transport by arylacetamide deacetylase (AADAC)

Nominated PICIHR2023Project Grant

Principal investigators: Lehner, Richard

Keywords: Cholesterol/Cholesteryl Ester; De Novo Lipogenesis; Endoplasmic Reticulum; Fatty Acid Oxidation; Fatty Liver; Lipase; Lipid Droplets; Mitochondria; Triglyceride; Vldl

$952,426

A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system

Co-investigatorCIHR2022Project Grant

Principal investigators: Sipione, Simonetta

Keywords: Heat Shock Response; Huntington'S Disease; Lipid Droplets; Misfolded Proteins; Neurodegeneration; Proteostasis Network

$975,375

How do canonical roles for peroxisomes and newly discovered non-canonical roles for Peroxins at lipid droplets support neuronal differentiation during early development?

Co-investigatorCIHR2022Project Grant

Principal investigators: Simmonds, Andrew J

Keywords: Animal Development; Cell Differentiation; Disease Modeling; Drosophila Melanogaster; Lipid Droplets; Lipid Metabolism; Live-Cell; Microscopy; Organelle Coordination; Peroxisomes

$906,525

Upgrades to Multi-Lab Gas Chromatography System

Co-investigatorNSERC2020Research Tools and Instruments

Principal investigators: Field, Catherine

$137,379

Role of a lipid hydrolase TGH in hepatic fat storage and lipoprotein secretion

Nominated PICIHR2017Project Grant

Principal investigators: Lehner, Richard

Keywords: Fatty Liver Disease; Insulin Resistance; Intestine; Knockout Mice; Lipase; Lipid Droplets; Lipid Metabolism; Lipoproteins; Liver; Obesity

$1,143,675

Dynamics of liver lipid droplets

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Lehner, Richard

$150,000

Metabolic role of arylacetamide deacetylase (AADAC)

Nominated PICIHR2016Project Grant

Principal investigators: Lehner, Richard

Keywords: Cholesterol; Flutamide Metabolism; Gene Expression; Knockout Mice; Lipase; Lipid Metabolism; Lipidomics; Lipoproteins; Liver And Intestine; Triglycerides

$688,051

Role of Es-x in lipid metabolism

Nominated PICIHR2013Operating Grant

Principal investigators: Lehner, Richard

Keywords: Atherosclerosis; Fatty Liver; Genetic Engineering; Lipase; Lipoprotein Secretion; Obesity; Type 2 Diabetes

$730,017

Role of triacylglycerol hydrolase in lipid metabolism

Nominated PICIHR2012Operating Grant

Principal investigators: Lehner, Richard

Keywords: Atherosclerosis; Lipolysis; Lipoproteins; Nafld; Type 2 Diabetes

$985,622

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Richard Lehner

Research

Latest papers

Latest funding

CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c.

Alterations in phosphatidylethanolamine metabolism impacts hepatocellular lipid storage, energy homeostasis, and proliferation.

FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver.

Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes.

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes.

Interfering with lipid metabolism through targeting CES1 sensitizes hepatocellular carcinoma for chemotherapy.

Ethanol and its Nonoxidative Metabolites Promote Acute Liver Injury by Inducing ER Stress, Adipocyte Death, and Lipolysis.

Carboxylesterase 1d Inactivation Augments Lung Inflammation in Mice.

Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice.

Attenuation of obesity-induced hyperlipidemia reduces tumor growth.

Dissecting the cell type-specific role of MT1-MMP/MMP14 in the development of liver fibrosis

Regulation of hepatic fat synthesis, turnover and transport by arylacetamide deacetylase (AADAC)

A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system

How do canonical roles for peroxisomes and newly discovered non-canonical roles for Peroxins at lipid droplets support neuronal differentiation during early development?

Upgrades to Multi-Lab Gas Chromatography System

Role of a lipid hydrolase TGH in hepatic fat storage and lipoprotein secretion

Dynamics of liver lipid droplets

Metabolic role of arylacetamide deacetylase (AADAC)

Role of Es-x in lipid metabolism

Role of triacylglycerol hydrolase in lipid metabolism

Frequent collaborators

Zamaneh Kassiri

Marek Michalak

Kirst King-Jones

Luca Pellegrini

Nicolas Touret

Michael Houghton

Katalin Toth

CHEOLHO Cheong

Simonetta Sipione

Jean Buteau

Bernardo Trigatti

Richard Lehner

Research

Latest papers

Latest funding

CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPAR&#x3b3;, LXR and SREBP1c.

Alterations in phosphatidylethanolamine metabolism impacts hepatocellular lipid storage, energy homeostasis, and proliferation.

FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in&#xa0;vitro and in mouse liver.

Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes.

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4&#x3b3;-dependent transcription of CES enzymes.

Interfering with lipid metabolism through targeting CES1 sensitizes hepatocellular carcinoma for chemotherapy.

Ethanol and its Nonoxidative Metabolites Promote Acute Liver Injury by Inducing ER Stress, Adipocyte Death, and Lipolysis.

Carboxylesterase 1d Inactivation Augments Lung Inflammation in Mice.

Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice.

Attenuation of obesity-induced hyperlipidemia reduces tumor growth.

Upgrades to Multi-Lab Gas Chromatography System

Dynamics of liver lipid droplets

Frequent collaborators

Zamaneh Kassiri

Marek Michalak

Kirst King-Jones

Luca Pellegrini

Nicolas Touret

Michael Houghton

Katalin Toth

CHEOLHO Cheong

Simonetta Sipione

Jean Buteau

Bernardo Trigatti

CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c.

FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver.

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes.