Faculty profile

Simonetta Sipione

ResearcherPharmacologyUniversity of Alberta

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Alberta directory, so their courses may be missing. Find their university profile.

Simonetta Sipione

Researcher

Pharmacology

Health Sciences

University of Alberta

Edmonton, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
10 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (6 CIHR, 2 NSERC), most recently in 2024.
Supervisor on 2 trainee awards (2 CIHR), most recently in 2021.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

220

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Huntington'S Disease Neurodegeneration Heat Shock Response Lipid Droplets Misfolded Proteins Proteostasis Network Animal Models Biology Of Gangliosides

Latest papers

Native PLGA nanoparticles attenuate disease pathology via multiple pathways in 5xFAD Alzheimer's model.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Gangliosides in the 21st century: therapeutic prospects for the brain and spine.
Frontiers in neurology · 2026
Intracerebroventricular Administration of Gangliosides for In Vivo Functional Studies in Mice.
Methods in molecular biology (Clifton, N.J.) · 2026 · senior author

All 31 publications

Latest funding

The role of gangliosides in microglia biology and intercellular communication
NSERC · 2024 · Principal investigator
$63,000
A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system
CIHR · 2022 · Nominated PI
$975,375
The role of gangliosides in the secretion and clearance of mutant huntingtin through extracellular vesicles.
CIHR · 2021 · Supervisor
$105,000

All 10 grants and awards

31 publications.

Native PLGA nanoparticles attenuate disease pathology via multiple pathways in 5xFAD Alzheimer's model.

Karthivashan G, Wang S, Wu Q, Dahal A, Li X, Galleguillos D, Sipione S, Thinakaran G, Kar S

Alzheimer's & dementia : the journal of the Alzheimer's Association2026

DOI: 10.1002/alz.71348 PMID: 42162953

Gangliosides in the 21st century: therapeutic prospects for the brain and spine.

Magistretti PJ, Finsterwald C, Itokazu Y, Sipione S, Geisler FH, Filho TB

Frontiers in neurology2026

DOI: 10.3389/fneur.2026.1795901 PMID: 42434075

Intracerebroventricular Administration of Gangliosides for In Vivo Functional Studies in Mice.

Monyror J, Horkey M, Zaidi AK, Sipione S

Methods in molecular biology (Clifton, N.J.)2026Senior author

DOI: 10.1007/978-1-0716-5288-6_31 PMID: 42613543

Gangliosides modulate the secretion of extracellular vesicles and their misfolded protein cargo.

Monyror J, Kadam V, Morales LC, Ordóñez D, Ibanga J, Zaidi AK, McNamara E, Pink D, Stenlund M, Reyes K, Maguire AD, Huang J, Cortez LM, Sim VL, Mok SA, Posse de Chaves E, Sipione S

Science advances2025Senior author

DOI: 10.1126/sciadv.ady5212 PMID: 40961208

In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington's Disease.

Morales LC, Modi L, Abbasi Dezfouli S, Rajendran AP, Kc R, Kadam V, Sipione S, Uludağ H

Pharmaceutics2025

DOI: 10.3390/pharmaceutics17060726 PMID: 40574039

Naïve Huntington's disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1.

Steinberg N, Galleguillos D, Zaidi A, Horkey M, Sipione S

Journal of neuroinflammation2023Senior author

DOI: 10.1186/s12974-023-02963-y PMID: 37996924

Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket.

Schmidt EN, Lamprinaki D, McCord KA, Joe M, Sojitra M, Waldow A, Nguyen J, Monyror J, Kitova EN, Mozaneh F, Guo XY, Jung J, Enterina JR, Daskhan GC, Han L, Krysler AR, Cromwell CR, Hubbard BP, West LJ, Kulka M, Sipione S, Klassen JS, Derda R, Lowary TL, Mahal LK, Riddell MR, Macauley MS

Nature communications2023

DOI: 10.1038/s41467-023-38030-6 PMID: 37087495

Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model.

de Almeida MMA, Watson AES, Bibi S, Dittmann NL, Goodkey K, Sharafodinzadeh P, Galleguillos D, Nakhaei-Nejad M, Kosaraju J, Steinberg N, Wang BS, Footz T, Giuliani F, Wang J, Sipione S, Edgar JM, Voronova A

Stem cell reports2023

DOI: 10.1016/j.stemcr.2022.12.001 PMID: 36608690

In-Cell Labeling Coupled to Direct Analysis of Extracellular Vesicles in the Conditioned Medium to Study Extracellular Vesicles Secretion with Minimum Sample Processing and Particle Loss.

Viveiros A, Kadam V, Monyror J, Morales LC, Pink D, Rieger AM, Sipione S, Posse de Chaves E

Cells2022

DOI: 10.3390/cells11030351 PMID: 35159161

Anti-inflammatory role of GM1 and other gangliosides on microglia.

Galleguillos D, Wang Q, Steinberg N, Zaidi A, Shrivastava G, Dhami K, Daskhan GC, Schmidt EN, Dworsky-Fried Z, Giuliani F, Churchward M, Power C, Todd K, Taylor A, Macauley MS, Sipione S

Journal of neuroinflammation2022Senior author

DOI: 10.1186/s12974-021-02374-x PMID: 34991625

The role of gangliosides in microglia biology and intercellular communication

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Sipione, Simonetta

Keywords: gangliosides; intercellular communication; extracellular vesicles; microglia; neurons; glycans; inflammation; single-cell rna sequencing

$63,000

A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system

Nominated PICIHR2022Project Grant

Principal investigators: Sipione, Simonetta

Keywords: Heat Shock Response; Huntington'S Disease; Lipid Droplets; Misfolded Proteins; Neurodegeneration; Proteostasis Network

$975,375

The role of gangliosides in the secretion and clearance of mutant huntingtin through extracellular vesicles.

SupervisorCIHR2021Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Monyror, John G

Keywords: Extracellular Vesicles; Gangliosides; Huntington'S Disease; Microglia

$105,000

The role of glycosphingolipids in the secretion and clearance of extracellular vesicles in brain health and disease

Nominated PICIHR2020Project Grant

Principal investigators: Sipione, Simonetta

Keywords: Animal Models; Biology Of Gangliosides; Cell Models; Extracellular Vesicles; Huntington'S Disease; Microglia; Neurodegeneration; Neuroinflammation; Sialic Acid Binding Proteins

$1,040,400

Role of gangliosides in microglia biology

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Sipione, Simonetta

$186,000

Neuroprotective and disease modifying effects of GM1 and related compounds in Huntington Disease

SupervisorCIHR2013Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Alpaugh, Melanie

Keywords: Animal Behaviour; Flow Cytometry; Gangliomimmetic Compounds; Ganglioside Gm1; Huntington'S Disease; Neurodegeneration; Stereology; Transgenic Mouse Models

$105,000

Development of ganglioside-based therapies for Huntington's disease

Nominated PICIHR2011Proof of Principle Program Phase I - Drug Development

Principal investigators: Sipione, Simonetta

Keywords: Drug Administration; Ganglioside Metabolism; Huntington'S Disease; Neurodegenerative Disorders

$159,196

Cellular lipids in Huntington's disease

Nominated PICIHR2011Operating Grant - PA: Huntington's Society of Canada (Prize)

Principal investigators: Sipione, Simonetta

Keywords: Animal Studies; Cell Biology; Cell Signaling; Gangliosides; Huntington'S Disease; Lipid Metabolism; Neurobiology

CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA

Nominated PICIHR2011Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Sipione, Simonetta

Keywords: Chairs

$500,000

Cellular lipids in Huntington's disease

Nominated PICIHR2010Operating Grant

Principal investigators: Sipione, Simonetta

Keywords: Animal Studies; Cell Biology; Cell Signaling; Gangliosides; Huntington'S Disease; Lipid Metabolism; Neurobiology; Pharmacology

$815,339

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Something wrong or missing on this profile? Suggest a correction

Simonetta Sipione

Research

Latest papers

Latest funding

Native PLGA nanoparticles attenuate disease pathology via multiple pathways in 5xFAD Alzheimer's model.

Gangliosides in the 21st century: therapeutic prospects for the brain and spine.

Intracerebroventricular Administration of Gangliosides for In Vivo Functional Studies in Mice.

Gangliosides modulate the secretion of extracellular vesicles and their misfolded protein cargo.

In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington's Disease.

Naïve Huntington's disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1.

Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket.

Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model.

In-Cell Labeling Coupled to Direct Analysis of Extracellular Vesicles in the Conditioned Medium to Study Extracellular Vesicles Secretion with Minimum Sample Processing and Particle Loss.

Anti-inflammatory role of GM1 and other gangliosides on microglia.

The role of gangliosides in microglia biology and intercellular communication

A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system

The role of gangliosides in the secretion and clearance of mutant huntingtin through extracellular vesicles.

The role of glycosphingolipids in the secretion and clearance of extracellular vesicles in brain health and disease

Role of gangliosides in microglia biology

Neuroprotective and disease modifying effects of GM1 and related compounds in Huntington Disease

Development of ganglioside-based therapies for Huntington's disease

Cellular lipids in Huntington's disease

CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA

Cellular lipids in Huntington's disease

Frequent collaborators

Fabrizio Giuliani

Karim Fouad

Anastassia Voronova

Ray Truant

Sue-Ann Mok

Christopher Power

Marek Michalak

Ratmir Derda

Jing Wang

Anna Taylor

Richard Lehner

Satyabrata Kar

Simonetta Sipione

Research

Latest papers

Latest funding

Native PLGA nanoparticles attenuate disease pathology via multiple pathways in 5xFAD Alzheimer's model.

Gangliosides in the 21st century: therapeutic prospects for the brain and spine.

Intracerebroventricular Administration of Gangliosides for In Vivo Functional Studies in Mice.

Gangliosides modulate the secretion of extracellular vesicles and their misfolded protein cargo.

In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington's Disease.

Na&#xef;ve Huntington's disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1.

Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket.

Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model.

In-Cell Labeling Coupled to Direct Analysis of Extracellular Vesicles in the Conditioned Medium to Study Extracellular Vesicles Secretion with Minimum Sample Processing and Particle Loss.

Anti-inflammatory role of GM1 and other gangliosides on microglia.

The role of gangliosides in microglia biology and intercellular communication

Role of gangliosides in microglia biology

Frequent collaborators

Fabrizio Giuliani

Karim Fouad

Anastassia Voronova

Ray Truant

Sue-Ann Mok

Christopher Power

Marek Michalak

Ratmir Derda

Jing Wang

Anna Taylor

Richard Lehner

Satyabrata Kar

Naïve Huntington's disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1.