Faculty profile
Arshad Ayyaz
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Read how they describe their research on their University of Calgary profile.
Latest papers
A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer.
Cell reports. Medicine · 2026 · senior author
NOD2 drives regenerative fetal-like reprogramming in the intestinal epithelium.
Proceedings of the National Academy of Sciences of the United States of America · 2026
Lgr5+ Stem Cells Maintain Apex Position in Cell Hierarchy of the Intestinal Epithelium During Homeostasis and Injury.
bioRxiv : the preprint server for biology · 2025 · senior author
Latest funding
- $1,263,780
The regulation of intestinal first-pass metabolism by IL-22 - understanding the link between host-microbe/pathogen interactions and alterations in drug metabolism.
CIHR · 2025 · Co-investigator
- $120,000
Using Single-Cell Genomics to Discover Therapeutic Resistance Mechanisms in Human Colorectal Cancer
CIHR · 2024 · Supervisor
- $12,500
Intestinal Crypt Morphogenesis During Development and Reprogramming Following Somatic Injury
NSERC · 2024 · Principal investigator
12 publications.
A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer.
Chua J, Kaur A, Mitchell F, Korver A, Sakthivel P, Allapitan E, Uddin M, Maqsood A, Chege N, Leon-Coria A, Finney CAM, Bathe OF, Minoo P, Ayyaz A
NOD2 drives regenerative fetal-like reprogramming in the intestinal epithelium.
Tsang DKL, Maisonneuve C, Ayyaz A, Foerster EG, Nissan M, Baerg L, Trcka D, Ghoshal B, Tsankov BK, Bayer G, Denney M, Streutker CJ, Wrana JL, Girardin SE, Philpott DJ
Lgr5+ Stem Cells Maintain Apex Position in Cell Hierarchy of the Intestinal Epithelium During Homeostasis and Injury.
Chua J, Driver L, Narimatsu M, Fink M, Luo L, Tran J, Kaur A, Habib R, Roper J, Kirsch DG, Wrana JL, Lee CL, Ayyaz A
Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGFβ and Hippo signalling to drive regeneration.
Fink M, Njah K, Patel SJ, Cook DP, Man V, Ruso F, Rajan A, Narimatsu M, Obersterescu A, Pye MJ, Trcka D, Chan K, Ayyaz A, Wrana JL
PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance.
Baghdadi MB, Houtekamer RM, Perrin L, Rao-Bhatia A, Whelen M, Decker L, Bergert M, Pérez-Gonzàlez C, Bouras R, Gropplero G, Loe AKH, Afkhami-Poostchi A, Chen X, Huang X, Descroix S, Wrana JL, Diz-Muñoz A, Gloerich M, Ayyaz A, Matic Vignjevic D, Kim TH
Bottom-up or Top-down: Inflammation Reprograms Paneth Cells to Develop Bowel Cancers.
Chua J, Gregorieff A, Ayyaz A
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury.
Morral C, Ayyaz A, Kuo HC, Fink M, Verginadis II, Daniel AR, Burner DN, Driver LM, Satow S, Hasapis S, Ghinnagow R, Luo L, Ma Y, Attardi LD, Koumenis C, Minn AJ, Wrana JL, Lee CL, Kirsch DG
Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.
Dervovic D, Malik AA, Chen ELY, Narimatsu M, Adler N, Afiuni-Zadeh S, Krenbek D, Martinez S, Tsai R, Boucher J, Berman JM, Teng K, Ayyaz A, Lü Y, Mbamalu G, Loganathan SK, Lee J, Zhang L, Guidos C, Wrana J, Valipour A, Roux PP, Reimand J, Jackson HW, Schramek D
In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.
Dervovic D, Malik AA, Chen ELY, Narimatsu M, Adler N, Afiuni-Zadeh S, Krenbek D, Martinez S, Tsai R, Boucher J, Berman JM, Teng K, Ayyaz A, Lü Y, Mbamalu G, Loganathan SK, Lee J, Zhang L, Guidos C, Wrana J, Valipour A, Roux PP, Reimand J, Jackson HW, Schramek D
Intermittent fasting positively modulates human gut microbial diversity and ameliorates blood lipid profile.
Khan MN, Khan SI, Rana MI, Ayyaz A, Khan MY, Imran M
The regulation of intestinal first-pass metabolism by IL-22 - understanding the link between host-microbe/pathogen interactions and alterations in drug metabolism.
Principal investigators: Hirota, Simon A
Keywords: Cell Differentiation; Cytochrome P450; Drug Metabolism; Host-Microbe Interactions; Il-22; Innate Lymphoid Cells; Intestinal Epithelium; Intestinal Organoids; Intestinal Stem Cells
Using Single-Cell Genomics to Discover Therapeutic Resistance Mechanisms in Human Colorectal Cancer
Principal investigators: Chua, Julian C
Keywords: Adoptive Cell Therapy; Assay For Transposase-Accessible Chromatin Sequencing; Cd8 Positive T Cells; Colorectal Cancer; Immune Deficient Cancer Stem Cells; Immunotherapy; Immunotherapy Resistance; Microsatellite Stable; Patient Derived Organoids; Single-Cell Rna Sequencing
Intestinal Crypt Morphogenesis During Development and Reprogramming Following Somatic Injury
Principal investigators: Ayyaz, Arshad
Keywords: stem cells; single cell genomics; functional genetics; somatic cell reprogramming; regenerative plasticity; development; epigenetic regulation; cell signaling; lineage specification; oganogenesis
Intestinal Crypt Morphogenesis During Development and Reprogramming Following Somatic Injury
Principal investigators: Ayyaz, Arshad
Keywords: stem cells; single cell genomics; functional genetics; somatic cell reprogramming; regenerative plasticity; development; epigenetic regulation; cell signaling; lineage specification; oganogenesis
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Jeffrey Wrana and Daniel Schramek: 3 shared papers
- Jeffrey Wrana and Li Zhang: 2 shared papers
- Jeffrey Wrana and Cynthia Guidos: 2 shared papers
- Jeffrey Wrana and Arshad Ayyaz: 2 shared papers
- Li Zhang and Daniel Schramek: 2 shared papers
- Li Zhang and Cynthia Guidos: 2 shared papers
- Li Zhang and Arshad Ayyaz: 2 shared papers
- Daniel Schramek and Cynthia Guidos: 2 shared papers
- Daniel Schramek and Arshad Ayyaz: 2 shared papers
- Xi Huang and Tae-Hee Kim: 2 shared papers
- Cynthia Guidos and Arshad Ayyaz: 2 shared papers
- Daniel Schramek and Xi Huang: 1 shared paper
- Daniel Schramek and Alex Gregorieff: 1 shared paper
- Daniel Schramek and Tae-Hee Kim: 1 shared paper
- Xi Huang and Arshad Ayyaz: 1 shared paper
- Alex Gregorieff and Arshad Ayyaz: 1 shared paper
- Tae-Hee Kim and Arshad Ayyaz: 1 shared paper
- Lunenfeld-Tanenbaum Research Institute
- Department of Biological Sciences
- Cell and Systems Biology
- Laboratory Medicine & Pathobiology
- Department of Pathology
- Department of Molecular Genetics
- Developmental & Stem Cell Biology
Co-authors at University of Calgary, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Cynthia Guidos
Cell and Systems Biology
2 shared papers, latest 2023
Li Zhang
Laboratory Medicine & Pathobiology
2 shared papers, latest 2023
Daniel Schramek
Lunenfeld-Tanenbaum Research Institute
2 shared papers, latest 2023
Jeffrey Wrana
Lunenfeld-Tanenbaum Research Institute
2 shared papers, latest 2023
Xi Huang
Developmental & Stem Cell Biology
1 shared papers, latest 2024
Alex Gregorieff
Department of Pathology
1 shared papers, latest 2024
Tae-Hee Kim
Department of Molecular Genetics
1 shared papers, latest 2024
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Profile data last refreshed on September 27, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.