Faculty profile

George Chaconas

ResearcherBiochemistry and Molecular BiologyUniversity of Calgary

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Calgary directory, so their courses may be missing. Find their university profile.

George Chaconas

Researcher

Biochemistry and Molecular Biology

Health Sciences

University of Calgary

Calgary, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
9 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 4 research grants (4 CIHR), most recently in 2021.
Supervised 1 trainee who won CIHR awards, most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Antigenic Variation Bacterial Pathogenesis Lyme Disease Bacterial Adhesins Bacterial Extravasation Endothelial Activation Recombination Dna Recombination

Latest papers

Making the best of a sticky situation: Infection-mediated endothelial activation promotes new interactions with adhesins of the host-adapted Lyme disease spirochete.
bioRxiv : the preprint server for biology · 2026 · senior author
Transendothelial migration of the Lyme disease spirochete involves spirochete internalization as an intermediate step through a transcellular pathway that involves Cdc42 and Rac1.
Microbiology spectrum · 2025 · senior author
Structure analysis of the telomere resolvase from the Lyme disease spirochete Borrelia garinii reveals functional divergence of its C-terminal domain.
Nucleic acids research · 2024

All 45 publications

Latest funding

The structure and function(s) of Borrelia telomere resolvase, ResT
CIHR · 2026 · Co-investigator
$100,000
Novel host-pathogen interactions promoting B. burgdorferi vascular dissemination
CIHR · 2024 · Supervisor
$140,000
Pathogenic Strategies of the Lyme Disease Spirochete
CIHR · 2021 · Nominated PI
$1,013,625

All 6 grants and awards

45 publications.

Making the best of a sticky situation: Infection-mediated endothelial activation promotes new interactions with adhesins of the host-adapted Lyme disease spirochete.

Olmedo DA, Tan X, Scott C, Shcherbakova A, Chaconas G

bioRxiv : the preprint server for biology2026Senior author

DOI: 10.64898/2026.02.20.707099 PMID: 41756944

Transendothelial migration of the Lyme disease spirochete involves spirochete internalization as an intermediate step through a transcellular pathway that involves Cdc42 and Rac1.

Alvarez-Olmedo D, Kamaliddin C, Verhey TB, Ho M, De Vinney R, Chaconas G

Microbiology spectrum2025Senior author

DOI: 10.1128/spectrum.02221-24 PMID: 39727396

Structure analysis of the telomere resolvase from the Lyme disease spirochete Borrelia garinii reveals functional divergence of its C-terminal domain.

Semper C, Watanabe N, Karimullina E, Patel DT, Di Leo R, Castellanos M, Patel DH, Chaconas G, Savchenko A

Nucleic acids research2024

DOI: 10.1093/nar/gkae580 PMID: 38979576

MINNO: An Open Source Software for Refining Metabolic Networks and Investigating Complex Network Activity Using Empirical Metabolomics Data.

Mandwal A, Bishop SL, Castellanos M, Westlund A, Chaconas G, Davidsen J, Lewis IA

Analytical chemistry2024

DOI: 10.1021/acs.analchem.3c04501 PMID: 38359900

Choreography of Lyme Disease Spirochete Adhesins To Promote Vascular Escape.

Tan X, Castellanos M, Chaconas G

Microbiology spectrum2023Senior author

DOI: 10.1128/spectrum.01254-23 PMID: 37255427

Metabolic Interactive Nodular Network for Omics (MINNO): Refining and investigating metabolic networks based on empirical metabolomics data.

Mandwal A, Bishop SL, Castellanos M, Westlund A, Chaconas G, Lewis I, Davidsen J

bioRxiv : the preprint server for biology2023

DOI: 10.1101/2023.07.14.548964 PMID: 37503268

DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice.

Pfeifle A, Thulasi Raman SN, Lansdell C, Zhang W, Tamming L, Cecillon J, Laryea E, Patel D, Wu J, Gravel C, Frahm G, Gao J, Chen W, Chaconas G, Sauve S, Rosu-Myles M, Wang L, Johnston MJW, Li X

Frontiers in immunology2023

DOI: 10.3389/fimmu.2023.1020134 PMID: 37006299

VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force.

Tan X, Lin YP, Pereira MJ, Castellanos M, Hahn BL, Anderson P, Coburn J, Leong JM, Chaconas G

PLoS pathogens2022Senior author

DOI: 10.1371/journal.ppat.1010511 PMID: 35605029

The Putative Endonuclease Activity of MutL Is Required for the Segmental Gene Conversion Events That Drive Antigenic Variation of the Lyme Disease Spirochete.

Castellanos M, Verhey TB, Goldstein M, Chaconas G

Frontiers in microbiology2022Senior author

DOI: 10.3389/fmicb.2022.888494 PMID: 35663861

The Lyme disease spirochete can hijack the host immune system for extravasation from the microvasculature.

Tan X, Petri B, DeVinney R, Jenne CN, Chaconas G

Molecular microbiology2021Senior author

DOI: 10.1111/mmi.14728 PMID: 33891779

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George Chaconas

Research

Latest papers

Latest funding

Making the best of a sticky situation: Infection-mediated endothelial activation promotes new interactions with adhesins of the host-adapted Lyme disease spirochete.

Transendothelial migration of the Lyme disease spirochete involves spirochete internalization as an intermediate step through a transcellular pathway that involves Cdc42 and Rac1.

Structure analysis of the telomere resolvase from the Lyme disease spirochete Borrelia garinii reveals functional divergence of its C-terminal domain.

MINNO: An Open Source Software for Refining Metabolic Networks and Investigating Complex Network Activity Using Empirical Metabolomics Data.

Choreography of Lyme Disease Spirochete Adhesins To Promote Vascular Escape.

Metabolic Interactive Nodular Network for Omics (MINNO): Refining and investigating metabolic networks based on empirical metabolomics data.

DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice.

VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force.

The Putative Endonuclease Activity of MutL Is Required for the Segmental Gene Conversion Events That Drive Antigenic Variation of the Lyme Disease Spirochete.

The Lyme disease spirochete can hijack the host immune system for extravasation from the microvasculature.

The structure and function(s) of Borrelia telomere resolvase, ResT

Novel host-pathogen interactions promoting B. burgdorferi vascular dissemination

Pathogenic Strategies of the Lyme Disease Spirochete

Pathogenic Strategies of the Lyme Disease Spirochete

Biochemistry and Molecular Biology of the Lyme Disease Spirochete

CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA

Frequent collaborators

Paul Kubes

Ian Lewis

Lisheng Wang

Alexei Savchenko

Cameron Semper

Alexei Savchenko