Faculty profile

Lisheng Wang

Back to faculty

Associate ProfessorBiochemistry, Microbiology and ImmunologyUniversity of Ottawa

Lisheng Wang

Associate Professor

Biochemistry, Microbiology and Immunology

Faculty of Medicine

University of Ottawa

Ottawa, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
40 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (3 CIHR, 2 NSERC), most recently in 2020.
Supervisor on 4 trainee awards (4 CIHR), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

University Profile Personal Website Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Read how they describe their research on their University of Ottawa profile.

Anti-Cancer Immunity Cancer Stem Cells Chemotherapeutic Drug Mouse Model Nanotherapeutics,Patient-Derived Xenograft Triple Negative Breast Cancer Wnt

Latest papers

Anti-BCMA-CAR-IL15 natural killer cells prevent multiple myeloma growth in the bone marrow but allow subsequent emergence of extramedullary disease
Cancer Letters · 2026
Role of N7-methylguanosine in gastrointestinal tumors: Molecular mechanisms and therapeutic targets.
Biochimica et biophysica acta. Reviews on cancer · 2026
Durability of DNA-LNP and mRNA-LNP vaccine-induced immunity against SARS-CoV-2 XBB.1.5.
NPJ vaccines · 2026

All 87 publications

Latest funding

CD40 ligand as a potential adjuvant for a pan-variant intranasal vaccine against SARS-CoV-2
CIHR · 2023 · Supervisor
$105,000
Development of a broadly protective mRNA vaccine for Lyme disease
CIHR · 2023 · Supervisor
$105,000
Investigating the PTK-Hippo axis in breast cancer metastasis
CIHR · 2022 · Co-investigator
$956,250

All 11 grants and awards

87 publications.

Anti-BCMA-CAR-IL15 natural killer cells prevent multiple myeloma growth in the bone marrow but allow subsequent emergence of extramedullary disease

Kaczmarek S, Jo D, Ghaziasgar S, Marr B, Berton S, Wang L, Arbabi Ghahroudi M, Jang M, Visram A, McComb S

Cancer Letters20263 citations

DOI: 10.1016/j.canlet.2025.218235

Role of N7-methylguanosine in gastrointestinal tumors: Molecular mechanisms and therapeutic targets.

Li J, Xu Y, Wang L, Ji G, Dang Y

Biochimica et biophysica acta. Reviews on cancer2026

DOI: 10.1016/j.bbcan.2025.189511 PMID: 41365470

Durability of DNA-LNP and mRNA-LNP vaccine-induced immunity against SARS-CoV-2 XBB.1.5.

Tamming L, Lansdell C, Zhang W, Duque D, Bavananthasivam J, Frahm G, Pfeifle A, Thulasi Raman SN, Wu J, Gravel C, Stalker A, Stuible M, Durocher Y, Chen W, Wang L, Sauve S, Tran A, Johnston MJW, Li X

NPJ vaccines2026

DOI: 10.1038/s41541-026-01382-3 PMID: 41620516

An Optimized Positive Staining Protocol Method for Clear Visualization of Extracellular Vesicles by TEM Using Uranyless and Lead Citrate.

St-Denis-Bissonnette F, Ngo B, Halabi H, Korobkow A, Wang J, Wang L, Lavoie JR

Langmuir : the ACS journal of surfaces and colloids2026

DOI: 10.1021/acs.langmuir.5c03977 PMID: 41454874

Ultracentrifugation and Ultrafiltration Differentially Alter the Composition and Functionality of the Biomolecular Corona of Extracellular Vesicles.

St-Denis-Bissonnette F, Halabi H, Creskey M, Kirkby M, Zhang X, Burger D, Wang L, Lavoie JR

Journal of extracellular biology2026

DOI: 10.1002/jex2.70132 PMID: 41939015

Natural killer cell-derived extracellular vesicles reprogram cellular human immunity to enhance tumor cytotoxicity.

St-Denis-Bissonnette F, Mediratta K, Ho N, Kirkby M, Stalker A, Muradia G, Shrestha A, Ardolino M, Lee SH, Burger D, Mer A, Wang L, Lavoie JR

Molecular therapy. Oncology2026

DOI: 10.1016/j.omton.2026.201261 PMID: 42383255

Natural Killer Cell-Derived Extracellular Vesicles Exhibit Cytotoxicity Against Bulk Tumor Cells and Cancer Stem Cells in Triple-Negative Breast Cancer.

Kirkby M, St-Denis-Bissonnette F, Diab MD, Mediratta K, Korobkow A, Humber J, Han P, Muradia G, Ardolino M, Lee SH, Gibbings DJ, Burger D, Wang L, Lavoie JR

Nanomaterials (Basel, Switzerland)2026

DOI: 10.3390/nano16090525 PMID: 42117942

Enhanced immunotherapy efficacy through molecularly imprinted nanoparticles co-targeting cluster of differentiation-73 and programmed death-ligand 1.

Han Y, Song H, Gu Z, Guan P, Li Y, Wang L, Zhao Q, Liu Z

Acta biomaterialia2026

DOI: 10.1016/j.actbio.2026.02.037 PMID: 41724344

Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression

Jo D-H, Kaczmarek S, Khan AUH, Pervin J, Clark DM, Gadde S, Wang L, McComb S, Visram A, Lee S-H

Frontiers in Immunology202516 citations

DOI: 10.3389/fimmu.2025.1533044

Nanoparticle-Mediated mRNA Delivery to Triple-Negative Breast Cancer (TNBC) Patient-Derived Xenograft (PDX) Tumors.

El-Sahli S, Manturthi S, Durocher E, Bo Y, Akman A, Sannan C, Kirkby M, Iroakazi CD, Deyell H, Kaczmarek S, Lee SH, Iqbal U, Côté M, Wang L, Gadde S

ACS pharmacology & translational science2025

DOI: 10.1021/acsptsci.4c00597 PMID: 39974646

CD40 ligand as a potential adjuvant for a pan-variant intranasal vaccine against SARS-CoV-2

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Tamming, Levi

Keywords: Adjuvants; Antibodies; Covid-19; Immunology; Pandemic; Sars-Cov-2; T Cells; Vaccines

$105,000

Development of a broadly protective mRNA vaccine for Lyme disease

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Pfeifle, Annabelle

Keywords: Antibodies; Antibody Effector Functions; Broad-Spectrum Protection; Cellular And Humoral Immune Responses; Immunology; Lipid Nanoparticles; Lyme Disease; Mrna Vaccine; Polyvalent Vaccine; Tick-Borne Illness

$105,000

Investigating the PTK-Hippo axis in breast cancer metastasis

Co-investigatorCIHR2022Project Grant

Principal investigators: Yang, Xiaolong

Keywords: Breast Cancer; Cell Migration And Invasion; Combination Therapy; Hippo Pathway; Kinases; Metastasis; Protein Tyrosine Kinases; Signal Transduction; Targeted Therapy; Xenograft Mouse Model

$956,250

Targeting triple-negative breast cancer stem cells and simultaneously boosting anti-tumor immunity.

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Mediratta, Karan

Keywords: Breast Cancer; Cancer Immunotherapy; Cancer Stem Cells; Cd73 Adenosine Signalling Pathway; Drug Repurposing; Exosomes For Drug Delivery; Immune Checkpoint Inhibition; In Vivo Tumor Modeling; Patient-Derived Xenograft (Pdx); Wnt, Yap, Pi3k, Akt Signalling Pathways

$105,000

A new strategy capable of directly killing cancer cells and concurrently boosting anti-tumor immunity for the effective treatment of TNBC

Nominated PICIHR2020Project Grant

Principal investigators: Wang, Lisheng; Gadde, Suresh

Keywords: Anti-Cancer Immunity; Cancer Stem Cells; Chemotherapeutic Drug; Mouse Model; Nanotherapeutics,; Patient-Derived Xenograft; Triple Negative Breast Cancer; Wnt; Yap/Mevalonate Pathway

$837,675

The role of E-cadherin in regulating signalling pathways

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Wang, Lisheng

$192,000

The development of effective TNBC treatment through the co-inhibition of SCD1 and NF-kB pathways

SupervisorCIHR2019Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: El-Sahli, Sara

Keywords: Cancer Metabolism; Cancer Stem Cells; Cancer Therapy; Flow Cytometry; Gene Expression; Nf-Kb Signaling; Patient Derived Xenograft Model; Scd1 Signaling; Triple Negative Breast Cancer; Tumor Growth

$105,000

Alterations of Wnt, Akt and Yap signalling during bi-directional epithelial-mesenchymal transitions

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Wang, Lisheng

$28,000

Hematopoietic transcription factors and their role in leukemogenesis

Co-investigatorCIHR2011Operating Grant

Principal investigators: Brand, Marjorie C

Keywords: Aml; Chromatin Immunoprecipitation And Sequencing; Epigenetics; Gene Expression Profiling; Hemogen; Knock Down By Rna Interference; Leukemia; Quantitative Proteomics; Xenograft

$800,690

Molecular Mechanism of Self-renewal and Mesoderm Development of Human Pluripotent Stem Cells

Nominated PICIHR2011Maud Menten New Principal Investigator Prize - Clinical

Principal investigators: Wang, Lisheng

Keywords: Differentiation; E-Cadherin; Human Pluripotent Stem Cells; L1td1; Oct4; Reprogramming; Self-Renewal; Wnt

$1,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2020

Subject: Prospective PhD student: Anti-Cancer Immunity Dear Professor Wang, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Anti-BCMA-CAR-IL15 natural killer cells prevent multiple myeloma growth in the bone marrow but allow subsequent emergence of extramedullary disease" (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "A new strategy capable of directly killing cancer cells and concurrently boosting anti-tumor immunity for the effective treatment of TNBC" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

Something wrong or missing on this profile? Suggest a correction

Lisheng Wang

Research

Latest papers

Latest funding

Anti-BCMA-CAR-IL15 natural killer cells prevent multiple myeloma growth in the bone marrow but allow subsequent emergence of extramedullary disease

Role of N7-methylguanosine in gastrointestinal tumors: Molecular mechanisms and therapeutic targets.

Durability of DNA-LNP and mRNA-LNP vaccine-induced immunity against SARS-CoV-2 XBB.1.5.

An Optimized Positive Staining Protocol Method for Clear Visualization of Extracellular Vesicles by TEM Using Uranyless and Lead Citrate.

Ultracentrifugation and Ultrafiltration Differentially Alter the Composition and Functionality of the Biomolecular Corona of Extracellular Vesicles.

Natural killer cell-derived extracellular vesicles reprogram cellular human immunity to enhance tumor cytotoxicity.

Natural Killer Cell-Derived Extracellular Vesicles Exhibit Cytotoxicity Against Bulk Tumor Cells and Cancer Stem Cells in Triple-Negative Breast Cancer.

Enhanced immunotherapy efficacy through molecularly imprinted nanoparticles co-targeting cluster of differentiation-73 and programmed death-ligand 1.

Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression

Nanoparticle-Mediated mRNA Delivery to Triple-Negative Breast Cancer (TNBC) Patient-Derived Xenograft (PDX) Tumors.

The role of E-cadherin in regulating signalling pathways

Alterations of Wnt, Akt and Yap signalling during bi-directional epithelial-mesenchymal transitions

Frequent collaborators

Seung-Hwan Lee

David Safronetz

Suresh Gadde

Daniel Figeys

Dylan Burger

Zemin Yao

Christina Addison

Jim Dimitroulakos

Michele Ardolino

Angel Arnaout

David Allan

Darwyn Kobasa

Tommy Alain

Alissa Visram

Vanessa D'Costa

Arvind Mer

Juthaporn Cowan

George Chaconas

David Lohnes

Subash Sad

David Litchfield

Steffany Bennett

Mary-Ellen Harper

Bill Wang

Marc Ekker

Alexandre Blais

Anton Zilman