Faculty profile

Gerald Pfeffer

ResearcherClinical NeurosciencesUniversity of Calgary

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Calgary directory, so their courses may be missing. Find their university profile.

Gerald Pfeffer

Researcher

Clinical Neurosciences

Health Sciences

University of Calgary

Calgary, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
39 publications in the last five years, latest in 2026.
Senior (last) author on 9 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (4 CIHR, 1 SSHRC), most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Neuromuscular Disease Amyotrophic Lateral Sclerosis Neurodegeneration Depth Electrode Epilepsy Epilepsy Surgery Focal Epilepsy Genetics

Latest papers

A changed landscape: five-year retrospective on the paradigm shift in genetic testing practices for ALS in Canada
European Journal of Human Genetics · 2026
Conference proceedings from the Western Canadian Neuromuscular Conference (WCNMC) - September 27-29, 2024, Calgary, Canada.
Journal of neuromuscular diseases · 2026 · senior author
The m.14484T>C MT-ND6 Mutation Presenting with a Hereditary Spastic-Paraparesis Phenotype.
Movement disorders clinical practice · 2026

All 63 publications

Latest funding

Delineating the Functions of the Mitochondrial Protein MFN2
CIHR · 2025 · Co-investigator
$1,334,925
The hidden genetics of focal epilepsy: Brain-specific pathogenic somatic variants
CIHR · 2024 · Principal investigator
$1,185,750
Delineating the Functions of the Mitochondrial Protein MFN2
CIHR · 2024 · Co-investigator
$100,000

All 9 grants and awards

63 publications.

A changed landscape: five-year retrospective on the paradigm shift in genetic testing practices for ALS in Canada

Binet M, Jewett G, Breiner A, Chum M, Genge A, Schellenberg K, Shoesmith C, Pfeffer G, Salmon K

European Journal of Human Genetics2026

DOI: 10.1038/s41431-026-02171-1

Conference proceedings from the Western Canadian Neuromuscular Conference (WCNMC) - September 27-29, 2024, Calgary, Canada.

Jewett G, Luk C, Osman H, Pfeffer G

Journal of neuromuscular diseases2026Senior author

DOI: 10.1177/22143602251389759 PMID: 41117436

The m.14484T>C MT-ND6 Mutation Presenting with a Hereditary Spastic-Paraparesis Phenotype.

Amorelli G, Nilles C, Pfeffer G, Joel M, Martino D

Movement disorders clinical practice2026

DOI: 10.1002/mdc3.70703 PMID: 42236298

Impaired Myogenic Differentiation Is a Shared Feature Across Genetic Myopathies.

Soule TGB, Slavin MB, Pontifex CS, Dabaja MZ, Melnyk A, Dufour A, Dumont NA, Shutt TE, Pfeffer G

International journal of molecular sciences2026Senior author

DOI: 10.3390/ijms27146338 PMID: 42511681

The Oral Microbiome in Amyotrophic Lateral Sclerosis Shows Differentially Abundant Organisms in Limb Versus Bulbar Onset Disease: A Binational Study.

Jacob SM, Son B, Bagheri S, Lee S, Leckie J, Chohan B, Belway C, Mascarenhas J, Mobach T, Korngut LW, Sharkey KA, Park J, Nguyen MD, Kim SH, Pfeffer G

Journal of clinical neurology (Seoul, Korea)2026Senior author

DOI: 10.3988/jcn.2025.0219 PMID: 41517814

Assessing the socio-economic burden of inherited and inflammatory neuromuscular diseases (BIND study): a study protocol.

Smith IC, Abusetah Y, Osman H, Garg A, Grant A, Lochmuller H, McMillan H, Pfeffer G, Korngut L, Gagnon C, Lintern S, Wojtal D, Selby K, Thavorn K, Warman-Chardon J

Orphanet journal of rare diseases2025

DOI: 10.1186/s13023-025-03904-z PMID: 40770363

Tofersen Treatment Normalizes Neurofilament Levels in Autosomal Recessive SOD1 Amyotrophic Lateral Sclerosis.

De Wel B, Mobach T, Pfeffer G, Jewett G

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques2025

DOI: 10.1017/cjn.2025.10350 PMID: 40605360

CD2AP at the junction of nephropathy and Alzheimer's disease.

Vandal M, Janmaleki M, Rea I, Gunn C, Hirai S, Biernaskie J, Chun J, Gordon G, Shaw A, Sanati-Nezhad A, Pfeffer G, Calon F, Nguyen MD

Molecular neurodegeneration2025

DOI: 10.1186/s13024-025-00852-x PMID: 40462155

FGF14 GAA Intronic Expansion in Unsolved Adult-Onset Ataxia in the Care4Rare Canada Consortium.

Cuillerier A, Del Gobbo GF, Mackay L, Wall E, Couse M, McDonell LM, Cloutier M, Danzi MC, Warman-Chardon J, Bourque PR, Suchowersky O, Mears A, Seldenthuis L, Mears W, Larrigan L, White-Brown A, Pfeffer G, Bulman DE, Dyment D, Care4Rare Canada Consortium, Boycott KM

Annals of clinical and translational neurology2025

DOI: 10.1002/acn3.70016 PMID: 40191983

The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation.

Zaman M, Sharma G, Almutawa W, Soule TG, Sabouny R, Joel M, Mohan A, Chute C, Joseph JT, Pfeffer G, Shutt TE

Life science alliance2025

DOI: 10.26508/lsa.202402921 PMID: 40175090

Delineating the Functions of the Mitochondrial Protein MFN2

Co-investigatorCIHR2025Project Grant

Principal investigators: Shutt, Timothy E

Keywords: Inflammation; Integrated Stress Response; Mitochondria; Mitochondrial Dynamics; Mitofusin2 (Mfn2); Mtdna; Peripheral Neuropathy

$1,334,925

The hidden genetics of focal epilepsy: Brain-specific pathogenic somatic variants

Principal investigatorCIHR2024Project Grant

Principal investigators: Klein, Karl M; Pfeffer, Gerald; Tarailo-Graovac, Maja

Keywords: Depth Electrode; Epilepsy; Epilepsy Surgery; Focal Epilepsy; Genetics; Mosaic; Nonlesional Epilepsy; Seeg; Somatic Mutation; Somatic Variant

$1,185,750

Delineating the Functions of the Mitochondrial Protein MFN2

Co-investigatorCIHR2024Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)

Principal investigators: Shutt, Timothy E

Keywords: Inflammation; Integrated Stress Response; Mitochondria; Mitochondrial Dynamics; Mitofusin2 (Mfn2); Mtdna; Peripheral Neuropathy

$100,000

Spinal bulbar muscular atrophy in Indigenous peoples of the prairie provinces: an interdisciplinary study addressing community needs, developing clinical knowledge and therapies

Nominated PICIHR2024Project Grant

Principal investigators: Pfeffer, Gerald; King, Alexandra; Schellenberg, Kerri; Yokota, Toshifumi

Keywords: Disease Prevalence; Indigenous Health; Neuromuscular Disease

$1,361,700

Indigenous ways of knowing spinal bulbar muscular atrophy and directing translational research

Principal investigatorSSHRC2023New Frontiers in Research Fund - Exploration

Principal investigators: Pfeffer, Gerald

Keywords: spinal bulbar muscular atrophy; Kennedy disease; Indigenous health; qualitative methods; translational research; biomarkers

$250,000

NMD4C: the neuromuscular network for Canada

Co-investigatorCIHR2023Network Gr. in Skin Health, Bone Health, and Muscular Dyst. - Muscular Dystrophy

Principal investigators: Lochmüller, Hanns; Osman, Homira; Brais, Bernard; Campbell, Craig Gordon N; Chang, Natasha C; Dowling, James; Gagnon, Cynthia; Gonorazky, Hernan D; Hodgkinson, Victoria; Karamchandani, Jason; Korngut, Lawrence W; Kothary, Rashmi K; Mah, Jean K; O'Connell, Colleen; Patten, Kessen; Rossi, Fabio M; Schellenberg, Kerri; Selby, Kathryn A; Warman Chardon, Jodi

Keywords: Clinical Trial Networks; Networks; Neuromuscular Disease; Open Science; Patient Partnerships; Preclinical Research Resources; Training And Education; Translational Research

$1,000,000

Real-World Evidence for Canadian Neuromuscular Disease: Establishing a Framework for National Integration of Patient Reported Outcomes, Clinical Registry Data, Healthcare Utilization and Healthcare Associated Costs

Co-investigatorCIHR2023Team Grant: Improving Health and Admin Data and Monitor Rare Diseases

Principal investigators: Amin, Reshma; Osman, Homira; Cohen, Eyal; Hodgkinson, Victoria; Jewett, Gordon; Lochmüller, Hanns

Keywords: Health Services Research; Healthcare Service Utilization; Neuromuscular Disease; Registry

$1,597,256

The Gut Microbiota as a Contributor to Sexual Dimorphism in Amyotrophic Lateral Sclerosis

Principal investigatorCIHR2023Project Grant

Principal investigators: Nguyen, Minh Dang; Pfeffer, Gerald; Sharkey, Keith

Keywords: Amyotrophic Lateral Sclerosis; Bacteria And Their Metabolites; Energy Metabolism; Fecal Material Transplant; Gut Microbiome; Mitochondria; Neurodegeneration; Omics - Transcriptomics, Metagenomics, Metabolomics; Sexual Dimorphism; Transgenic & Germ-Free Mice

$845,325

The oral and gut microbiome and their derived metabolites in sex differences in amyotrophic lateral sclerosis

Nominated PICIHR2022Joint Canada-Israel Health Research Program

Principal investigators: Pfeffer, Gerald; Basak, Nazli; Elinav, Eran

Keywords: Amyotrophic Lateral Sclerosis; Microbiome; Neurodegeneration; Neuromuscular Disease

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Gerald Pfeffer

Research

Latest papers

Latest funding

A changed landscape: five-year retrospective on the paradigm shift in genetic testing practices for ALS in Canada

Conference proceedings from the Western Canadian Neuromuscular Conference (WCNMC) - September 27-29, 2024, Calgary, Canada.

The m.14484T>C MT-ND6 Mutation Presenting with a Hereditary Spastic-Paraparesis Phenotype.

Impaired Myogenic Differentiation Is a Shared Feature Across Genetic Myopathies.

The Oral Microbiome in Amyotrophic Lateral Sclerosis Shows Differentially Abundant Organisms in Limb Versus Bulbar Onset Disease: A Binational Study.

Assessing the socio-economic burden of inherited and inflammatory neuromuscular diseases (BIND study): a study protocol.

Tofersen Treatment Normalizes Neurofilament Levels in Autosomal Recessive SOD1 Amyotrophic Lateral Sclerosis.

CD2AP at the junction of nephropathy and Alzheimer's disease.

FGF14 GAA Intronic Expansion in Unsolved Adult-Onset Ataxia in the Care4Rare Canada Consortium.

The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation.

Indigenous ways of knowing spinal bulbar muscular atrophy and directing translational research

Frequent collaborators

Jodi Warman Chardon

Lawrence Korngut

Homira Osman

Davide Martino

Angela Genge

Maja Tarailo-Graovac

Bernard Brais

Cynthia Gagnon

Hanns Lochmüller

Kednapa Thavorn

Kednapa Thavorn

Homira Osman

Oury Monchi

Sanjay Kalra

Alexandra King

Malcolm King

Oury Monchi

Maryam Oskoui

Jason Karamchandani

Jason Karamchandani

Craig Campbell

Zahinoor Ismail

Antoine Dufour

Ekaterina Rogaeva

Amir Sanati Nezhad

Justin Chun