Faculty profile

Ahmed Aman

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Assistant ProfessorUniversity of Toronto

Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Latest papers

Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.
Journal of medicinal chemistry · 2026
Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer.
European journal of medicinal chemistry · 2026
Discrimination of Chiral BCPs by Möbius Cyclacene: A DFT Study.
The journal of physical chemistry. A · 2026

All 54 publications

Latest funding

Rapid on-site mass spectrometry for non-subjective determination of lung cancer pathologies
CIHR · 2025 · Co-investigator
$753,526
Rapid high sensitivity and specificity diagnosis of melanoma with Picosecond infrared laser mass spectrometry
CIHR · 2023 · Co-investigator
$619,650

All 2 grants and awards

54 publications.

Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.

Yin J, Srivastava S, Tang X, Galbraith C, Uchenunu O, Miller J, Liu Y, Crescenzi I, Kiyota T, Kurinov I, Costa-Mattioli M, Laufer R, Aman A, Rottapel R, Ramnauth J, Haakonsen DL, Uehling DE, Sicheri F

Journal of medicinal chemistry2026

DOI: 10.1021/acs.jmedchem.5c03664 PMID: 42324916

Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer.

Smil D, Liu Y, Xin T, Kiyota T, Aman A, Grouleff J, Hoffer L, Joshi DC, Inanlou MR, Song S, Mao DYL, Ogunjimi AA, Pau V, Chini FD, Kurinov I, Zhang Y, Nguyen AT, Wrana JL, Sicheri F, Attisano L, Uehling D, Al-Awar R, Isaac MB

European journal of medicinal chemistry2026

DOI: 10.1016/j.ejmech.2026.118798 PMID: 41936796

Discrimination of Chiral BCPs by Möbius Cyclacene: A DFT Study.

Abbas A, Huzaifa M, Ghayur MN, Aman A, Nur-E-Alam M, Ul-Haq Z

The journal of physical chemistry. A2026

DOI: 10.1021/acs.jpca.6c01416 PMID: 42244267

Self-Dimerization Induced Proximity Targeting Chimeras (SDIPTAC) Lead to DCAF1 Loss of Function and Inhibition of HIV Replication.

Mabanglo MF, Srivastava S, Matsui Y, Li Z, Noureldin M, Pogmore JP, Hoffer L, Taherian F, Hajian T, Tucker S, Mamai A, Kiyota T, Aman A, Al-Awar R, Marcellus R, Uehling DE, Ott M, Ramnauth J, Vedadi M

Journal of medicinal chemistry2026

DOI: 10.1021/acs.jmedchem.6c00126 PMID: 42150007

Immunoinformatics driven multi-epitope vaccine design targeting clade IIb Mpox variant.

Tariq SS, Zia K, Ali N, Nur-E-Alam M, Ghayur MN, Aman A, Ul-Haq Z

Scientific reports2026

DOI: 10.1038/s41598-026-51311-6 PMID: 42092088

Discovery of pyrrolopyrimidinone inhibitors of the BCL6-SMRT corepressor interaction.

Watson IDG, Morin JA, Subramanian PR, Chau AM, Prakesch MA, Wilson BJ, Morshed MM, Joseph BB, Uehling DE, Poda G, Abibi A, Chan M, Cheung H, Griffin C, Mao V, Marcellus R, Strathdee C, Subramaniam R, Thériault BL, Winston J, Aman A, Kiyota T, Undzys E, Kuntz DA, Pomroy NC, Mamai A, Privé GG, Al-Awar R, Isaac MB

Bioorganic & medicinal chemistry2026

DOI: 10.1016/j.bmc.2026.118575 PMID: 41621194

Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.

Mamai A, Morshed MM, Prakesch M, Poda G, Subramanian P, Chau AM, Watson IDG, Joseph B, Wilson B, Morin JA, Marcellus R, Theriault B, Mohammed M, Abibi A, Chan M, Kiyota T, Aman A, Subramaniam R, Strathdee C, Winston J, O'Meara J, Kuntz D, Pomroy NC, Uehling D, Isaac M, Privé GG, Al-Awar R

Bioorganic & medicinal chemistry letters2026

DOI: 10.1016/j.bmcl.2025.130471 PMID: 41241078

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities.

Taherian F, Mabanglo MF, Hajian T, Tucker S, Kalinic E, Perveen S, Aman A, Vedadi M

Protein science : a publication of the Protein Society2026

DOI: 10.1002/pro.70428 PMID: 41432309

A molecular array for 10-second diagnosis of common spinal tumor types with picosecond infrared laser mass spectrometry.

Fiorante A, Woolman M, Munoz DG, Kiyota T, Ye LA, Farahmand Y, Vlaminck D, Talbot FO, Das S, Kellett S, Giuffrida C, Zadeh G, Ginsberg HJ, Aman A, Zarrine-Afsar A

Neuro-oncology2025

DOI: 10.1093/neuonc/noaf047 PMID: 39980445

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling.

Chandler F, Reddy PAN, Bhutda S, Ross RL, Datta A, Walden M, Walker K, Di Donato S, Cassel JA, Prakesch MA, Aman A, Datti A, Campbell LJ, Foglizzo M, Bell L, Stein DN, Ault JR, Al-Awar RS, Calabrese AN, Sicheri F, Del Galdo F, Salvino JM, Greenberg RA, Zeqiraj E

Nature structural & molecular biology2025

DOI: 10.1038/s41594-025-01517-5 PMID: 40097626

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Ahmed Aman

Research

Latest papers

Latest funding

Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.

Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer.

Discrimination of Chiral BCPs by Möbius Cyclacene: A DFT Study.

Self-Dimerization Induced Proximity Targeting Chimeras (SDIPTAC) Lead to DCAF1 Loss of Function and Inhibition of HIV Replication.

Immunoinformatics driven multi-epitope vaccine design targeting clade IIb Mpox variant.

Discovery of pyrrolopyrimidinone inhibitors of the BCL6-SMRT corepressor interaction.

Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities.

A molecular array for 10-second diagnosis of common spinal tumor types with picosecond infrared laser mass spectrometry.

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling.

Rapid on-site mass spectrometry for non-subjective determination of lung cancer pathologies

Rapid high sensitivity and specificity diagnosis of melanoma with Picosecond infrared laser mass spectrometry

Frequent collaborators

David Uehling

Arash Zarrine-Afsar

Dalia Barsyte-Lovejoy

Anne-Claude Gingras

Frank Sicheri

Matthieu Schapira

Sunit Das

Samuel Weiss

Brian Wilson

Chris McIntosh

Rachel Harding

Stéphane Richard

Robert Rottapel

Brian Raught

Liliana Attisano

Jason Moffat

Vijay Ramaswamy

Stéphane Richard

Colby Zaph

Eldad Zacksenhaus

Jakob Magolan

Gelareh Zadeh

Ahmed Aman

Research

Latest papers

Latest funding

Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.

Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer.

Discrimination of Chiral BCPs by M&#xf6;bius Cyclacene: A DFT Study.

Self-Dimerization Induced Proximity Targeting Chimeras (SDIPTAC) Lead to DCAF1 Loss of Function and Inhibition of HIV Replication.

Immunoinformatics driven multi-epitope vaccine design targeting clade IIb Mpox variant.

Discovery of pyrrolopyrimidinone inhibitors of the BCL6-SMRT corepressor interaction.

Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities.

A molecular array for 10-second diagnosis of common spinal tumor types with picosecond infrared laser mass spectrometry.

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling.

Rapid on-site mass spectrometry for non-subjective determination of lung cancer pathologies

Rapid high sensitivity and specificity diagnosis of melanoma with Picosecond infrared laser mass spectrometry

Frequent collaborators

David Uehling

Arash Zarrine-Afsar

Dalia Barsyte-Lovejoy

Anne-Claude Gingras

Frank Sicheri

Matthieu Schapira

Sunit Das

Samuel Weiss

Brian Wilson

Chris McIntosh

Rachel Harding

Stéphane Richard

Robert Rottapel

Brian Raught

Liliana Attisano

Jason Moffat

Vijay Ramaswamy

Stéphane Richard

Colby Zaph

Eldad Zacksenhaus

Jakob Magolan

Gelareh Zadeh

Discrimination of Chiral BCPs by Möbius Cyclacene: A DFT Study.