Faculty profile

Lesley Seymour

ResearcherQueen's University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Queen's University directory, so their courses may be missing. Find their university profile.

Lesley Seymour

Researcher

Health Sciences

Queen's University

Kingston, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
23 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 1 research grant (1 CIHR), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

1,379

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Aromatase Inhibitor And Cdk4/6 Inhibitor Resistance Biomarker Circulating Tumour Cells (Ctcs)Circulating Tumour Dna (Ctdna)Hormone-Positive Metastatic Breast Cancer Liquid Biopsy Platform Trial Umbrella Trial

Latest papers

The UVA-induced single-base mutational signature of CX-5461 in human cells.
Nucleic acids research · 2026
Germline CDK12 variants in aggressive prostate cancer.
Cancer discovery · 2026
Tumor-Agnostic Therapies: Translating Scientific Breakthroughs Into Global Implementation.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026

All 82 publications

Latest funding

The TACtful Trial: A first-in-human multi-centre trial of BCMA specific T-cell antigen coupler infusion, generated from cryopreserved G-CSF-mobilized peripheral blood, in patients with relapsed and refractory multiple myeloma.
CIHR · 2023 · Co-investigator
$3,056,176
A Liquid-Biopsy Informed Platform Trial to Evaluate Treatment in CDK4/6-Inhibitor Resistant ER+/HER2- Metastatic Breast Cancer
CIHR · 2022 · Principal investigator
$2,184,076
Immunophenotyping Malignant Pleural Mesothelioma: Identifying Predictive and Prognostic Biomarkers for Combinatorial Immunotherapy
CIHR · 2020 · Co-investigator
$872,865

All 4 grants and awards

82 publications.

The UVA-induced single-base mutational signature of CX-5461 in human cells.

Zaikova E, Yap D, Sarvar A, Hafezi A, Tan J, Cerda V, Li K, Lai D, Gelmon K, Hilton J, Seymour L, Stirling P, Cescon DW, Aparicio S

Nucleic acids research2026

DOI: 10.1093/nar/gkag836 PMID: 42639791

Germline CDK12 variants in aggressive prostate cancer.

Tolmeijer SH, Maurice-Dror C, Sandhu S, de la Calle CM, Kollmannsberger C, Adil M, Wang CK, Murtha AJ, Donnellan G, van Erp NP, Mehra N, Hofman MS, Azad AA, Davis ID, Bergman AM, Zwart W, van der Zande K, Seymour L, Black PC, Akbari V, Cordova L, Lansdorp PM, Jones SJ, Nelson PS, Castro E, Schrader KA, Ha G, Cheng HH, Ost P, Olmos D, Chi KN, Pritchard CC, Wyatt AW

Cancer discovery2026

DOI: 10.1158/2159-8290.cd-26-0084 PMID: 42392870

Tumor-Agnostic Therapies: Translating Scientific Breakthroughs Into Global Implementation.

Liu J, Beal J, Coleman N, Ma BBY, Loong HH, Zhao H, Seymour L, Westphalen CB, Curigliano G, Subbiah V

Journal of clinical oncology : official journal of the American Society of Clinical Oncology2026

DOI: 10.1200/jco-26-00034 PMID: 42224642

Randomized Phase II Study of Durvalumab with or without Tremelimumab in Patients with Metastatic Castration-Resistant Prostate Cancer.

Winquist E, Hotte SJ, Chi K, Sridhar S, Ellard S, Ong M, Iqbal N, Salim M, Emmenegger U, Gingerich JR

Clinical Cancer Research202511 citationsSenior author

DOI: 10.1158/1078-0432.ccr-24-1612

CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trials

Rekowski J, Guo C, Solovyeva O, Dimairo M, Rouhifard M, Patel D, Alger E, Ashby D, Berlin J, Boix O

EClinicalMedicine20255 citations

DOI: 10.1016/j.eclinm.2024.102987

SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocols

Ursino M, Villacampa G, Rekowski J, Dimairo M, Solovyeva O, Ashby D, Berlin J, Boix O, Calvert M, Chan A-W

EClinicalMedicine20255 citations

DOI: 10.1016/j.eclinm.2024.102988

Effects of cannabinoids on immune checkpoint inhibitor response: CCTG pooled analysis of individual patient data

Coschi CH, Ding K, Tong J, Tu D, O’Callaghan C, Leighl NB, Vera-Badillo F, Juergens RA, Hao D, Seymour L

Immunotherapy20253 citations

DOI: 10.1080/1750743x.2025.2485012

Effects of serotonergic drugs on immune checkpoint inhibitor response: a pooled analysis of individual patient data from four Canadian Cancer Trials Group (CCTG) trials

Coschi CH, Ding K, Tu D, O’Callaghan C, Leighl NB, Vera-Badillo F, Juergens RA, Hao D, Seymour L, Renouf DJ

Immunotherapy2025

DOI: 10.1080/1750743x.2025.2578164

Accelerating the Future of Oncology Drug Development: The Role of Consortia in the Delivery of Precision Oncology Early Phase Clinical Trials.

Liu J, Farrow M, Seymour L, Desai J, Loong HH, Ivy P, Koyoma T, Cook N, Blagden S, Garralda E, Massard C, Tolcher AW, Adashek JJ, Zhang L, Zhao S, Shen L, Kurzrock R, El-Deiry WS, Subbiah V, Joshua AM

Journal of clinical oncology : official journal of the American Society of Clinical Oncology2025

DOI: 10.1200/jco-24-01534 PMID: 39808749

Erratum to “Brief Report: Canadian Cancer Trials Group IND.227: A Phase II randomized study of pembrolizumab in patients with advanced malignant pleural mesothelioma (NCT02784171). [Journal of Thoracic Oncology Vol. 18 No. 6: 813–819]”

Piccirillo MC, Chu Q, Bradbury P, Tu W, Coschi CH, Grosso F, Florescu M, Mencoboni M, Goffin JR, Pagano M

Journal of Thoracic Oncology2024

DOI: 10.1016/j.jtho.2024.08.017

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Lesley Seymour

Research

Latest papers

Latest funding

The UVA-induced single-base mutational signature of CX-5461 in human cells.

Germline CDK12 variants in aggressive prostate cancer.

Tumor-Agnostic Therapies: Translating Scientific Breakthroughs Into Global Implementation.

Randomized Phase II Study of Durvalumab with or without Tremelimumab in Patients with Metastatic Castration-Resistant Prostate Cancer.

CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trials

SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocols

Effects of cannabinoids on immune checkpoint inhibitor response: CCTG pooled analysis of individual patient data

Effects of serotonergic drugs on immune checkpoint inhibitor response: a pooled analysis of individual patient data from four Canadian Cancer Trials Group (CCTG) trials

Accelerating the Future of Oncology Drug Development: The Role of Consortia in the Delivery of Precision Oncology Early Phase Clinical Trials.

Erratum to “Brief Report: Canadian Cancer Trials Group IND.227: A Phase II randomized study of pembrolizumab in patients with advanced malignant pleural mesothelioma (NCT02784171). [Journal of Thoracic Oncology Vol. 18 No. 6: 813–819]”

The TACtful Trial: A first-in-human multi-centre trial of BCMA specific T-cell antigen coupler infusion, generated from cryopreserved G-CSF-mobilized peripheral blood, in patients with relapsed and refractory multiple myeloma.

A Liquid-Biopsy Informed Platform Trial to Evaluate Treatment in CDK4/6-Inhibitor Resistant ER+/HER2- Metastatic Breast Cancer

Immunophenotyping Malignant Pleural Mesothelioma: Identifying Predictive and Prognostic Biomarkers for Combinatorial Immunotherapy

The Terry Fox Foundation Training Program in Transdiciplinary Cancer Research at CIHR

Frequent collaborators

Ming-Sound Tsao

John Goffin

Peter Ellis

Courtney Heather Coschi

Glenwood Goss

An-Wen Chan

Sebastien Hotte

Janet Dancey

John Hilton

Paul Wheatley-Price

Rosalyn Juergens

Andrew Arnold

Christopher O'Callaghan

Christina Canil

Derek Jonker

Eric Winquist

William Evans

Geoffrey Liu

Samuel Aparicio

Wei Xu

Kim Chi

Versha Banerji

Michael Ong

Eitan Amir

Tony Reiman

Urban Emmenegger

Sevtap Savas

Holger Hirte

Peter Stirling

Adam Fleming

John Kuruvilla

Samuel Weiss