Faculty profile

Ashok Kumar

ResearcherPathology and Laboratory MedicineUniversity of Ottawa

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Ottawa directory, so their courses may be missing. Find their university profile.

Ashok Kumar

Researcher

Pathology and Laboratory Medicine

Health Sciences

University of Ottawa

Ottawa, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
1 publication in the last five years, latest in 2023.
Principal investigator on 5 research grants (3 CIHR, 2 NSERC), most recently in 2016.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Anti-Apoptotic Genes Hiv Iaps Macrophages Samc Mimetics Signal Transduction

Latest papers

Using 10-K text to gauge COVID-related corporate disclosure.
PloS one · 2023
Author Correction: Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages.
Scientific reports · 2021 · senior author
HIF-1α Regulation of Cytokine Production following TLR3 Engagement in Murine Bone Marrow-Derived Macrophages Is Dependent on Viral Nucleic Acid Length and Glucose Availability.
Journal of immunology (Baltimore, Md. : 1950) · 2021

All 49 publications

Latest funding

Canadian HIV Cure Enterprise 2.0: Targeting the interplay between myeloid cells and CD4+ T-cells for HIV cure
CIHR · 2018 · Co-investigator
$6,000,000
Use of Smac Mimetics in Specific Killing of HIV-infected Macrophages
CIHR · 2016 · Nominated PI
$250,000
The Canadian HIV Cure Enterprise (CanCURE)
CIHR · 2013 · Co-investigator
$8,569,071

All 7 grants and awards

49 publications.

Using 10-K text to gauge COVID-related corporate disclosure.

Dutta S, Kumar A, Pant P, Walsh C, Dutta M

PloS one2023

DOI: 10.1371/journal.pone.0283138 PMID: 36947527

Author Correction: Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages.

Caballero RE, Dong SXM, Gajanayaka N, Ali H, Cassol E, Cameron WD, Korneluk R, Tremblay MJ, Angel JB, Kumar A

Scientific reports2021Senior author

DOI: 10.1038/s41598-021-03517-z PMID: 34880376

HIF-1α Regulation of Cytokine Production following TLR3 Engagement in Murine Bone Marrow-Derived Macrophages Is Dependent on Viral Nucleic Acid Length and Glucose Availability.

Ahmed D, Humphrey A, Roy D, Sheridan ME, Versey Z, Jaworski A, Edwards A, Donner J, Abizaid A, Willmore W, Kumar A, Golshani A, Cassol E

Journal of immunology (Baltimore, Md. : 1950)2021

DOI: 10.4049/jimmunol.2001282 PMID: 34740958

SMAC Mimetics as Therapeutic Agents in HIV Infection.

Molyer B, Kumar A, Angel JB

Frontiers in immunology2021

DOI: 10.3389/fimmu.2021.780400 PMID: 34899741

Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages.

Caballero RE, Dong SXM, Gajanayaka N, Ali H, Cassol E, Cameron WD, Korneluk R, Tremblay MJ, Angel JB, Kumar A

Scientific reports2021Senior author

DOI: 10.1038/s41598-021-02146-w PMID: 34824340

Selective Induction of Cell Death in Human M1 Macrophages by Smac Mimetics Is Mediated by cIAP-2 and RIPK-1/3 through the Activation of mTORC.

Ali H, Dong SXM, Gajanayaka N, Cassol E, Angel JB, Kumar A

Journal of immunology (Baltimore, Md. : 1950)2021Senior author

DOI: 10.4049/jimmunol.2100108 PMID: 34561230

TLR-4 Agonist Induces IFN-γ Production Selectively in Proinflammatory Human M1 Macrophages through the PI3K-mTOR- and JNK-MAPK-Activated p70S6K Pathway.

Gajanayaka N, Dong SXM, Ali H, Iqbal S, Mookerjee A, Lawton DA, Caballero RE, Cassol E, Cameron DW, Angel JB, Crawley AM, Kumar A

Journal of immunology (Baltimore, Md. : 1950)2021Senior author

DOI: 10.4049/jimmunol.2001191 PMID: 34551966

Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition.

Ali H, Caballero R, Dong SXM, Gajnayaka N, Vranjkovic A, Ahmed D, Iqbal S, Crawley AM, Angel JB, Cassol E, Kumar A

Journal of leukocyte biology2021Senior author

DOI: 10.1002/jlb.4a0220-114rr PMID: 33404106

Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening.

Dong SXM, Vizeacoumar FS, Bhanumathy KK, Alli N, Gonzalez-Lopez C, Gajanayaka N, Caballero R, Ali H, Freywald A, Cassol E, Angel JB, Vizeacoumar FJ, Kumar A

BMC infectious diseases2021Senior author

DOI: 10.1186/s12879-021-06346-7 PMID: 34233649

Vedolizumab treatment across antiretroviral treatment interruption in chronic HIV infection: the HAVARTI protocol for a pilot dose-ranging clinical trial to assess safety, tolerance, immunological and virological activity.

McGuinty M, Angel JB, Cooper CL, Cowan J, MacPherson PA, Kumar A, Murthy S, Sy R, Dennehy M, Tremblay N, Byrareddy SN, Cameron DW

BMJ open2020

DOI: 10.1136/bmjopen-2020-041359 PMID: 33033101

Canadian HIV Cure Enterprise 2.0: Targeting the interplay between myeloid cells and CD4+ T-cells for HIV cure

Co-investigatorCIHR2018Team Grant: HIV/AIDS Biomedical and Clinical Research - Cure - Large

Principal investigators: Cohen, Eric A; Margolese, Shari L; Rosenes, Ron; Ancuta, Petronela; Angel, Jonathan B; Chomont, Nicolas; Estaquier, Jérôme; Murooka, Thomas T; Routy, Jean-Pierre

Keywords: Hiv Cure; Hiv Latency; Hiv Persistence; Hiv Reservoirs; Human Studies; Humanized Mouse Models; Memory Cd4+ T-Cells; Myeloid Cells; Non-Human Primate Model; Therapeutic Interventions

$6,000,000

Use of Smac Mimetics in Specific Killing of HIV-infected Macrophages

Nominated PICIHR2016Operating Grant: Innovative Biomedical and Clinical HIV/AIDS Research

Principal investigators: Kumar, Ashok

Keywords: Anti-Apoptotic Genes; Hiv; Iaps; Macrophages; Samc Mimetics; Signal Transduction

$250,000

The Canadian HIV Cure Enterprise (CanCURE)

Co-investigatorCIHR2013Team Grant: Canadian Initiative for HIV Cure Research

Principal investigators: Cohen, Eric A; Ancuta, Petronela; Angel, Jonathan B; Estaquier, Jérôme; Fowke, Keith R; Mouland, Andrew J; Ostrowski, Mario A; Routy, Jean-Pierre; Tremblay, Michel J

Keywords: Cd4+ T Lymphocytes And Myeloid Cells; Hiv Cure; Hiv Eradication; Hiv Latency; Hiv Persistence; Human Trials; Humanized Blt Mice Model; Immune-Based Therapies; Non Human Primate Model; Oncolytic Viruses

$8,569,071

Molecular mechanisms underlying the development of resistance to apoptosis in response to HIV-Vpr protein and HIV infection in monocytic cells

Nominated PICIHR2010Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream

Principal investigators: Kumar, Ashok

Keywords: Apoptosis; Hiv; In Vitro Infection; Monocyte Derived Macrophages; Monocytic Cells; Signal Transduction; Vpr

$377,685

Regulation of IL-12 family of Th1 cytokines IL-12, IL-23 and IL-27 by HIV

Nominated PICIHR2009Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream

Principal investigators: Kumar, Ashok; Angel, Jonathan B

Keywords: Cytokine Regulation; Hiv; Il-12 Family Of Cytokines; Monocytic And Dendritic Cells; Tlrs

$576,420

Signaling pathways involved in CD44 regulation in human monocytic cells

Principal investigatorNSERC2007Discovery Grants Program - Individual

Principal investigators: Kumar, Ashok

$155,000

Regulation of CD44-hyaluronan interactions induced by bacterial product lipopolysaccharides in human monocytic cells

Principal investigatorNSERC2002Discovery Grants Program - Group

Principal investigators: Kumar, Ashok

$135,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Ashok Kumar

Research

Latest papers

Latest funding

Using 10-K text to gauge COVID-related corporate disclosure.

Author Correction: Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages.

HIF-1α Regulation of Cytokine Production following TLR3 Engagement in Murine Bone Marrow-Derived Macrophages Is Dependent on Viral Nucleic Acid Length and Glucose Availability.

SMAC Mimetics as Therapeutic Agents in HIV Infection.

Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages.

Selective Induction of Cell Death in Human M1 Macrophages by Smac Mimetics Is Mediated by cIAP-2 and RIPK-1/3 through the Activation of mTORC.

TLR-4 Agonist Induces IFN-γ Production Selectively in Proinflammatory Human M1 Macrophages through the PI3K-mTOR- and JNK-MAPK-Activated p70S6K Pathway.

Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition.

Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening.

Vedolizumab treatment across antiretroviral treatment interruption in chronic HIV infection: the HAVARTI protocol for a pilot dose-ranging clinical trial to assess safety, tolerance, immunological and virological activity.

Canadian HIV Cure Enterprise 2.0: Targeting the interplay between myeloid cells and CD4+ T-cells for HIV cure

Use of Smac Mimetics in Specific Killing of HIV-infected Macrophages

The Canadian HIV Cure Enterprise (CanCURE)

Molecular mechanisms underlying the development of resistance to apoptosis in response to HIV-Vpr protein and HIV infection in monocytic cells

Regulation of IL-12 family of Th1 cytokines IL-12, IL-23 and IL-27 by HIV

Signaling pathways involved in CD44 regulation in human monocytic cells

Regulation of CD44-hyaluronan interactions induced by bacterial product lipopolysaccharides in human monocytic cells

Frequent collaborators

Edana Cassol

Michaeline McGuinty

Jonathan Angel

Robert Korneluk

Alfonso Abizaid

Jesse Bertinato

Juthaporn Cowan

Martin Holcik

William Willmore

Sanjay Murthy

Jason Fernandes

Xiaohui Zha

Andrew Freywald

Ashok Kumar

Research

Latest papers

Latest funding

Using 10-K text to gauge COVID-related corporate disclosure.

Author Correction: Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages.

HIF-1&#x3b1; Regulation of Cytokine Production following TLR3 Engagement in Murine Bone Marrow-Derived Macrophages Is Dependent on Viral Nucleic Acid Length and Glucose Availability.

SMAC Mimetics as Therapeutic Agents in HIV Infection.

Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages.

Selective Induction of Cell Death in Human M1 Macrophages by Smac Mimetics Is Mediated by cIAP-2 and RIPK-1/3 through the Activation of mTORC.

TLR-4 Agonist Induces IFN-&#x3b3; Production Selectively in Proinflammatory Human M1 Macrophages through the PI3K-mTOR- and JNK-MAPK-Activated p70S6K Pathway.

Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition.

Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening.

Vedolizumab treatment across antiretroviral treatment interruption in chronic HIV infection: the HAVARTI protocol for a pilot dose-ranging clinical trial to assess safety, tolerance, immunological and virological activity.

Canadian HIV Cure Enterprise 2.0: Targeting the interplay between myeloid cells and CD4+ T-cells for HIV cure

Use of Smac Mimetics in Specific Killing of HIV-infected Macrophages

The Canadian HIV Cure Enterprise (CanCURE)

Molecular mechanisms underlying the development of resistance to apoptosis in response to HIV-Vpr protein and HIV infection in monocytic cells

Regulation of IL-12 family of Th1 cytokines IL-12, IL-23 and IL-27 by HIV

Signaling pathways involved in CD44 regulation in human monocytic cells

Regulation of CD44-hyaluronan interactions induced by bacterial product lipopolysaccharides in human monocytic cells

Frequent collaborators

Edana Cassol

Michaeline McGuinty

Jonathan Angel

Robert Korneluk

Alfonso Abizaid

Jesse Bertinato

Juthaporn Cowan

Martin Holcik

William Willmore

Sanjay Murthy

Jason Fernandes

Xiaohui Zha

Andrew Freywald

HIF-1α Regulation of Cytokine Production following TLR3 Engagement in Murine Bone Marrow-Derived Macrophages Is Dependent on Viral Nucleic Acid Length and Glucose Availability.

TLR-4 Agonist Induces IFN-γ Production Selectively in Proinflammatory Human M1 Macrophages through the PI3K-mTOR- and JNK-MAPK-Activated p70S6K Pathway.