Faculty profile

David Mack

Back to faculty

Full ProfessorBiochemistry, Microbiology & ImmunologyUniversity of Ottawa

David Mack

Full Professor

Biochemistry, Microbiology & Immunology

Faculty of Medicine

University of Ottawa

Ottawa, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
13 publications in the last five years, latest in 2026.
Principal investigator on 7 research grants (7 CIHR), most recently in 2024.
Supervised 1 trainee who won CIHR awards, most recently in 2013.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

797

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

University Profile Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Read how they describe their research on their University of Ottawa profile.

Ibd Microbiome Diet Microbiota Cazyme Omics Chronic Kidney Disease Intestinal Barrier

Latest papers

Automated Eosinophil Quantification Using Deep Learning to Predict Therapy Escalation in Pediatric Ulcerative Colitis.
Clinical and translational gastroenterology · 2026
β-Glucan and Inulin Estimated Intake Are Associated With Reduced Risk of Crohn's Disease, Improved Gut Barrier and Systemic Inflammation Markers, and Multi-Omic Signatures in a High-Risk Cohort
Gastroenterology · 2026
Childhood exposure to a sibling with Crohn's disease alters gut microbiome and Crohn's disease susceptibility.
Gut · 2026

All 58 publications

Latest funding

Enabling precision interventions for individuals with IBD
CIHR · 2024 · Principal investigator
$20,000
Role of the gut microbiome in intestinal barrier function
CIHR · 2018 · Principal investigator
$25,000
The diet-microbiota-gut axis in pediatric IBD
CIHR · 2015 · Principal investigator
$1,921,800

All 10 grants and awards

58 publications.

Automated Eosinophil Quantification Using Deep Learning to Predict Therapy Escalation in Pediatric Ulcerative Colitis.

Reigle J, Liu X, Lopez-Nunez O, Drysdale E, Qtaish D, Walters TD, Mack D, Boyle BM, Kugathasan S, Denson N, Erdman L, Prasath S, Collins MH, Hyams JS, Denson LA, Griffiths AM, Siddiqui I, Dhaliwal J

Clinical and translational gastroenterology2026

DOI: 10.14309/ctg.0000000000001031 PMID: 42044208

β-Glucan and Inulin Estimated Intake Are Associated With Reduced Risk of Crohn's Disease, Improved Gut Barrier and Systemic Inflammation Markers, and Multi-Omic Signatures in a High-Risk Cohort

Xue M, McShane C, Kim J, Khorasaniha R, Leibovitzh H, Shao J, Chen R, Jeong S, Madsen KL, Griffiths AM

Gastroenterology20263 citations

DOI: 10.1053/j.gastro.2026.05.006

Childhood exposure to a sibling with Crohn's disease alters gut microbiome and Crohn's disease susceptibility.

Chen R, Kim HJ, Bushra M, Phi Dang C, Li Q, Espin-Garcia O, Huynh HQ, Jacobson K, Bitton A, Panaccione R

Gut2026

DOI: 10.1136/gutjnl-2026-339257

Psychological well-being is the major determinant of global health in the first year following a diagnosis of inflammatory bowel disease in children.

Mekhael AA, Nabbijohn AN, Mack D, Stintzi A, Cohen JS, McMurtry CM

Journal of psychosomatic research2025

DOI: 10.1016/j.jpsychores.2025.112142 PMID: 40412339

Early Life Exposure to Parental Crohn’s Disease Is Associated With Offspring’s Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn’s Disease

Lee S-H, Bushra M, Qiu L, Griffiths AM, Turpin W, Croitoru K, Lee S-H, Bushra M, Qiu L, Shao J

Gastroenterology202518 citations

DOI: 10.1053/j.gastro.2024.09.033

Adalimumab vs Infliximab in Luminal Pediatric Crohn's Disease: Comparable Outcomes in a Prospective Multicenter Cohort Study.

deBruyn JC, Huynh HQ, Griffiths AM, Jacobson K, Mack D, Deslandres C, El-Matary W, Otley AR, Church PC, Lawrence S, Wine E, Sherlock M, Critch J, Benchimol EI, Jantchou P, Rashid M, Carroll MW, Bax K, Ricciuto A, Carman N, Walters TD, and the Canadian Children IBD Network

The American journal of gastroenterology2024

DOI: 10.14309/ajg.0000000000002552 PMID: 37787642

Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease.

Hodgkinson K, El Abbar F, Dobranowski P, Manoogian J, Butcher J, Figeys D, Mack D, Stintzi A

Clinical nutrition (Edinburgh, Scotland)2023

DOI: 10.1016/j.clnu.2022.10.024 PMID: 36502573

Gut Microbiome Composition Is Associated With Future Onset of Crohn’s Disease in Healthy First-Degree Relatives

Garay JAR, Turpin W, Lee S-H, Smith MI, Goethel A, Griffiths AM, Moayyedi P, Espin-Garcia O, Abreu M, Aumais GL

Gastroenterology2023209 citationsOpen Access

DOI: 10.1053/j.gastro.2023.05.032 PMID: W4379094559

Tolerability and SCFA production after resistant starch supplementation in humans: a systematic review of randomized controlled studies.

Sobh M, Montroy J, Daham Z, Sibbald S, Lalu M, Stintzi A, Mack D, Fergusson DA

The American journal of clinical nutrition2022

DOI: 10.1093/ajcn/nqab402 PMID: 34871343

Indirect and Out-of-Pocket Disease-associated Costs in Pediatric Inflammatory Bowel Disease: A Cross-sectional Analysis.

El-Matary W, Witt J, Bernstein CN, Jacobson K, Mack D, Otley A, Walters TD, Huynh HQ, deBruyn J, Griffiths AM, Benchimol EI

Journal of pediatric gastroenterology and nutrition2022

DOI: 10.1097/mpg.0000000000003545 PMID: 35758424

Enabling precision interventions for individuals with IBD

Principal investigatorCIHR2024Team Gr.: Embracing Diversity to Achieve Precision/Health Equity -Gen. Omics-LOI

Principal investigators: Stintzi, Alain; Couture, Jean-François; Figeys, Daniel; Mack, David R; Roussel, Charlène R

Keywords: Cazyme; Ibd; Microbiome; Omics

$20,000

Role of the gut microbiome in intestinal barrier function

Principal investigatorCIHR2018Team Grant: Canadian Microbiome Initiative 2: Research Teams - LOI

Principal investigators: Stintzi, Alain; Burns, Kevin D; Fergusson, Dean A; Figeys, Daniel; Jimenez, Carolina; Lalu, Manoj M; Lavallée-Adam, Mathieu; Levy, Emile; Mack, David R

Keywords: Chronic Kidney Disease; Intestinal Barrier; Metagenomic; Metaproteomic; Microbiome; Non-Alcoholic Fatty Liver Disease; Pilot Clinical Trial; Therapeutic Approach

$25,000

The diet-microbiota-gut axis in pediatric IBD

Principal investigatorCIHR2015Environments, Genes and Chronic Disease

Principal investigators: Stintzi, Alain; Figeys, Daniel; Mack, David R; O'Doherty, Kieran C; Vallance, Bruce A

Keywords: Crohn'S Disease; Diet; Ibd; Metabolome; Metagenome; Microbiota; Proteome; Transcriptome; Ulcerative Colitis

$1,921,800

The diet-microbiota-gut axis in pediatric IBD

Principal investigatorCIHR2015Environments, Genes and Chronic Disease - LOI

Principal investigators: Stintzi, Alain; Figeys, Daniel; Mack, David R; O'Doherty, Kieran C

Keywords: Carbohydrate; Diet; Genomics; Inflammatory Bowel Disease; Metabolomics; Microbiota; Proteomics; Transcriptomics

Identifying bacterial taxa and/or metabolic pathways that provide mechanistic insight into inflammatory bowel disease pathogenesis by characterizing the gut microbiota composition of pediatric inflammatory bowel disease patients

SupervisorCIHR2013Fellowship - Priority Announcement - Inflammatory Bowel Disease

Principal investigators: Butcher, James

Keywords: Biomarker Discovery; Crohn'S Disease; Gut Microbiota; Inflammatory Bowl Disease; Ulcerative Colitis

$45,000

The Microbiota at the Intestinal Mucosa- Immune Interface: A gateway for personalized health

Co-investigatorCIHR2012Genomics and Personalized Health

Principal investigators: Stintzi, Alain

Keywords: Biomarkers; Children Health; Diabetes; Gut Microbiota; Inflammatory Bowel Disease

$748,360

Bone Development in Pediatric Health and Serious Chronic Disease: a Canadian Collaborative Initiative

Principal investigatorCIHR2011Team Grant: Bone Health - LOI

Principal investigators: Ward, Leanne M; Jasmin, Bernard J; Mack, David R; Rauch, Frank; Sigal, Ronald J

Keywords: Bone Development; Bone Fragility; Children; Chronic Illness; Glucocorticoids; Normative Data For Bone Health Outcomes; Osteoporosis; Physical Activity; Sarcopenia

$10,000

The gut microbiota in pediatric inflammatory bowel diseases

Principal investigatorCIHR2011Operating Grant

Principal investigators: Stintzi, Alain; Mack, David R

Keywords: Children; Crohn'S Disease; Gut Microbiota; Metagenomics; Metaproteomics; Systems Biology; Ulcerative Colitis

$724,500

Systems biology of pediatric inflammatory bowel disease: contribution of the gut microbiota

Principal investigatorCIHR2009Canadian Microbiome Initiative - LOI

Principal investigators: Stintzi, Alain; Britz-Mckibbin, Philip; Figeys, Daniel; Griffiths, Anne Marie; Hajibabaei, Mehrdad; Jacobson, Kevan; Mack, David R; Muise, Aleixo M; Otley, Anthony R; Vallance, Bruce A; Walters, Thomas D

Keywords: Children; Gut Microbiome; Inflammatory Bowel Disease; Systems Biology

Role of the gut microbiome in Pediatric Gastrointestinal Illnesses

Co-investigatorCIHR2008Catalyst Grant: Human Microbiome

Principal investigators: Stintzi, Alain

Keywords: 16s Rdna Sequencing And Microarray; Crohn'S Disease And Ulcerative Colitis; Human Microbiome; Inflamatory Bowel Syndrome; Metagenomic; Pediatric Patients

$98,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

Something wrong or missing on this profile? Suggest a correction

David Mack

Research

Latest papers

Latest funding

Automated Eosinophil Quantification Using Deep Learning to Predict Therapy Escalation in Pediatric Ulcerative Colitis.

β-Glucan and Inulin Estimated Intake Are Associated With Reduced Risk of Crohn's Disease, Improved Gut Barrier and Systemic Inflammation Markers, and Multi-Omic Signatures in a High-Risk Cohort

Childhood exposure to a sibling with Crohn's disease alters gut microbiome and Crohn's disease susceptibility.

Psychological well-being is the major determinant of global health in the first year following a diagnosis of inflammatory bowel disease in children.

Early Life Exposure to Parental Crohn’s Disease Is Associated With Offspring’s Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn’s Disease

Adalimumab vs Infliximab in Luminal Pediatric Crohn's Disease: Comparable Outcomes in a Prospective Multicenter Cohort Study.

Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease.

Gut Microbiome Composition Is Associated With Future Onset of Crohn’s Disease in Healthy First-Degree Relatives

Tolerability and SCFA production after resistant starch supplementation in humans: a systematic review of randomized controlled studies.

Indirect and Out-of-Pocket Disease-associated Costs in Pediatric Inflammatory Bowel Disease: A Cross-sectional Analysis.

Frequent collaborators

Alain Stintzi

Anthony Otley

Thomas Walters

Anne Griffiths

David Mack

Paul Moayyedi

Kenneth Croitoru

Osvaldo Espin Garcia

John Kenneth Marshall

Daniel Figeys

Wei Xu

Remo Panaccione

Michael Surette

Alain Bitton

Anthony Otley

Alaa Rostom

Dina El Demellawy

Eytan Wine

Karen Madsen

Sharon Unger

Heather Armstrong

Ramzi Fattouh

Osvaldo Espin Garcia

Brian Feagan

Gilaad Kaplan

Sanjay Murthy

Manoj Lalu

Heather Armstrong

Amanda Ricciuto

Valerie Marcil

Levinus Dieleman

Gilaad Kaplan

Prévost Jantchou

Johan Van Limbergen

Mary Sherlock

Prakeshkumar Shah

Paul Beck