Diane Lagace, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Stroke Animal Model Behavior Motor Cortex Optogentics Recovery Adult Neurogenesis Electrophysiology

Latest papers

VGF is required for recovery after focal stroke.
Experimental neurology · 2023
Single-Cell and Single-Nucleus RNAseq Analysis of Adult Neurogenesis.
Cells · 2022 · senior author
Combination of Endothelin-1 (ET-1) and L-NAME to Induce Murine Focal Cortical Stroke with Persistent Sensorimotor Deficits.
Methods in molecular biology (Clifton, N.J.) · 2022

All 12 publications

Latest funding

Interrogating the Role of Chromatin Remodelling Proteins in Vision Health and Development using Mouse Models of Neurological System Diseases to Devise Novel Therapeutic Approaches for Visual Impairment
CIHR · 2023 · Supervisor
$180,000
Replacement of a high-throughput long-term live-cell analysis instrument
NSERC · 2022 · Co-investigator
$150,000
Regulation of Adult Neurogenesis by Autophagy
NSERC · 2020 · Principal investigator
$180,000

All 10 grants and awards

12 publications.

01

VGF is required for recovery after focal stroke.

Gillis HL, Kalinina A, Xue Y, Yan K, Turcotte-Cardin V, Todd MAM, Young KG, Lagace D, Picketts DJ

Experimental neurology2023

DOI: 10.1016/j.expneurol.2023.114326 PMID: 36682400

02

Single-Cell and Single-Nucleus RNAseq Analysis of Adult Neurogenesis.

Kalinina A, Lagace D

Cells2022Senior author

DOI: 10.3390/cells11101633 PMID: 35626670

03

Combination of Endothelin-1 (ET-1) and L-NAME to Induce Murine Focal Cortical Stroke with Persistent Sensorimotor Deficits.

Lui M, Gouveia A, Lagace D, Wang J

Methods in molecular biology (Clifton, N.J.)2022

DOI: 10.1007/978-1-0716-2409-8_5 PMID: 35776346

04

Metformin promotes CNS remyelination and improves social interaction following focal demyelination through CBP Ser436 phosphorylation.

Kosaraju J, Seegobin M, Gouveia A, Syal C, Sarma SN, Lu KJ, Ilin J, He L, Wondisford FE, Lagace D, De Repentigny Y, Kothary R, Wang J

Experimental neurology2020

DOI: 10.1016/j.expneurol.2020.113454 PMID: 32877653

05

An antibody for analysis of autophagy induction.

Tian W, Alsaadi R, Guo Z, Kalinina A, Carrier M, Tremblay ME, Lacoste B, Lagace D, Russell RC

Nature methods2020

DOI: 10.1038/s41592-019-0661-y PMID: 31768061

06

Role of Myocardial Infarction-Induced Neuroinflammation for Depression-Like Behavior and Heart Failure in Ovariectomized Female Rats.

Najjar F, Ahmad M, Lagace D, Leenen FHH

Neuroscience2019

DOI: 10.1016/j.neuroscience.2019.07.017 PMID: 31351141

07

Inhibition of inflammation by minocycline improves heart failure and depression-like behaviour in rats after myocardial infarction.

Wang HW, Ahmad M, Jadayel R, Najjar F, Lagace D, Leenen FHH

PloS one2019

DOI: 10.1371/journal.pone.0217437 PMID: 31233508

08

Sex differences in depression-like behavior and neuroinflammation in rats post-MI: role of estrogens.

Najjar F, Ahmad M, Lagace D, Leenen FHH

American journal of physiology. Heart and circulatory physiology2018

DOI: 10.1152/ajpheart.00615.2017 PMID: 30052050

09

Short- and Long-term Exposure to Low and High Dose Running Produce Differential Effects on Hippocampal Neurogenesis.

Nguemeni C, McDonald MW, Jeffers MS, Livingston-Thomas J, Lagace D, Corbett D

Neuroscience2018

DOI: 10.1016/j.neuroscience.2017.11.026 PMID: 29175485

10

The aPKC-CBP Pathway Regulates Adult Hippocampal Neurogenesis in an Age-Dependent Manner.

Gouveia A, Hsu K, Niibori Y, Seegobin M, Cancino GI, He L, Wondisford FE, Bennett S, Lagace D, Frankland PW, Wang J

Stem cell reports2016

DOI: 10.1016/j.stemcr.2016.08.007 PMID: 27618724

Interrogating the Role of Chromatin Remodelling Proteins in Vision Health and Development using Mouse Models of Neurological System Diseases to Devise Novel Therapeutic Approaches for Visual Impairment

SupervisorCIHR2023CIHR REDI Early Career Transition Award - Eye Diseases

Principal investigators: Lagali, Pamela S

Keywords: Chromatin Remodelling; Epigenetics; Gene; Gene Expression; Mouse Models; Neurodevelopment; Neuroprotection; Photoreceptors; Retinal Degeneration; Retinal Development

$180,000

Replacement of a high-throughput long-term live-cell analysis instrument

Co-investigatorNSERC2022Research Tools and Instruments

Principal investigators: Côté, Marceline

$150,000

Regulation of Adult Neurogenesis by Autophagy

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Lagace, Diane

$180,000

Rapid non-invasive body composition analysis in non-anesthetized small mammals

Co-investigatorNSERC2016Research Tools and Instruments

Principal investigators: Harper, MaryEllen

$127,309

Role of Post-Synaptic Density Proteins in the Integration of Dopamine and Glutamate Receptor Functions

Co-investigatorCIHR2016Project Grant

Principal investigators: Tiberi, Mario; Béïque, Jean-Claude

Keywords: Dopamine; Electrophysiology; G Protein-Coupled Receptors; Intracellular Trafficking; Knockout Mouse; Motor Behavior; N-Methyl-D-Aspartate Receptors; Psd Proteins; Signal Transduction; Synaptic-Associated Protein 102

$100,000

Role of Postsynaptic Density Proteins in Dopamine Receptor Function and Crosstalk

Co-investigatorCIHR2016Project Grant

Principal investigators: Tiberi, Mario; Béïque, Jean-Claude

Keywords: Dopamine; Electrophysiology; G Protein-Coupled Receptors; Intracellular Trafficking; Knockout Mouse; N-Methyl-D-Aspartate Receptors; Organotypic Slices; Psd Proteins; Signal Transduction; Synaptic-Associated Protein 102

$803,250

Stimulating Functional Networks to Enhance Stroke Recovery

Nominated PICIHR2016Project Grant

Principal investigators: Lagace, Diane C

Keywords: Animal Model; Behavior; Motor Cortex; Optogentics; Recovery; Stroke

$749,700

Mechanisms Underlying the Survival of Adult Generated Neurons

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Lagace, Diane

$165,000

The Function of Neurogenesis During Stroke Recovery

Nominated PICIHR2012Operating Grant

Principal investigators: Lagace, Diane C

Keywords: Adult Neurogenesis; Electrophysiology; Hippocampus; Mcao; Photothombosis; Rodent Behavior; Sensorimotor Cortex; Stroke; Subventricular Zone; Transgenic Mice

$667,926

Mechanisms underlying adult neurogenesis

Principal investigatorNSERC2009Discovery Grants Program - Individual

Principal investigators: Lagace, Diane

$160,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Cellular and Molecular Medicine
Molecular Medicine
Biochemistry, Microbiology and Immunology

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.