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Baptiste Lacoste

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Assistant ProfessorCellular and Molecular MedicineUniversity of Ottawa

Baptiste Lacoste

Assistant Professor

Cellular and Molecular Medicine

Faculty of Medicine

University of Ottawa

Ottawa, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
23 publications in the last five years, latest in 2026.
Senior (last) author on 9 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (3 CIHR, 2 NSERC, 1 SSHRC), most recently in 2024.
Supervised 2 trainees who won CIHR awards, most recently in 2026.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Read how they describe their research on their University of Ottawa profile.

Angiogenesis Cerebral Blood Flow Brain Endothelium Mouse Models Astrocytes Blood-Brain Barrier Ischemic Stroke

Latest papers

Protocol for assessing molecular signatures and metabolic function of primary murine cortical astrocytes.
STAR protocols · 2026 · senior author
Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1.
Scientific reports · 2026
Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis.
Nature metabolism · 2026

All 39 publications

Latest funding

Astrocyte-derived HMGB1: a developmental switch for stroke recovery
CIHR · 2026 · Supervisor
$140,000
Astrocyte-derived HMGB1: a developmental switch for functional stroke recovery.
CIHR · 2024 · Nominated PI
$1,113,075
Defective endothelial metabolism and mitochondrial biogenesis in autism spectrum disorders.
CIHR · 2023 · Nominated PI
$961,990

All 8 grants and awards

39 publications.

Protocol for assessing molecular signatures and metabolic function of primary murine cortical astrocytes.

Blakeley N, Lacoste B

STAR protocols2026Senior author

DOI: 10.1016/j.xpro.2026.104793 PMID: 42632024

Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1.

Salazar-Leon J, Freitas-Andrade M, Guadarrama-Perez V, Solari S, Hudak A, Stotts C, Simon N, Geoffrion M, Murray S, Slack R, Lacoste B, Rayner KJ

Scientific reports2026

DOI: 10.1038/s41598-026-54533-w PMID: 42321267

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis.

Manceau R, Cherian CM, Majeur D, Miller CJ, Fisher JD, Boisjoly F, Liston JB, Bako JA, Wat LW, Chao CF, Labarre A, Hollman S, Prakash S, Audet S, Depaauw-Holt L, Rogers B, Bosson A, Biswas P, Xi JJY, Callow CAS, Yoosefi N, Schikora N, Shahraki N, Xia YH, Hui A, VanderZwaag J, Bouyakdan K, Rodaros D, Kotchetkov P, Daneault C, Fallahpour G, Tetreault M, Tremblay MÈ, Ruiz M, Lacoste B, Parker JA, Murphy-Royal C, Huan T, Fulton S, Rideout EJ, Alquier T

Nature metabolism2026

DOI: 10.1038/s42255-026-01508-w PMID: 41981110

Volumetric Analysis of the Blood-Brain Barrier After Ischemic Stroke by Electron Tomography in Mice.

Kotchetkov P, Lacoste B

Microcirculation (New York, N.Y. : 1994)2025Senior author

DOI: 10.1111/micc.70025 PMID: 40975889

Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production.

Kasongo AA, Vijithakumar V, Abd-Elrahman KS, Prabhune R, Gharibeh L, Nadeau R, Robillard I, Spring S, Robichaud S, Asif S, Gibbings D, Moore KJ, Sled JG, Ruiz M, Lavallée-Adam M, Ferguson SSG, Lacoste B, Lagace DC, Ouimet M

Journal of lipid research2025

DOI: 10.1016/j.jlr.2025.100868 PMID: 40716750

A new dataset for measuring the performance of blood vessel segmentation methods under distribution shifts.

Viana da Silva M, de Carvalho Santos N, Ouellette J, Lacoste B, Comin CH

PloS one2025

DOI: 10.1371/journal.pone.0322048 PMID: 40424440

The Blood-Brain Barrier: Composition, Properties, and Roles in Brain Health.

Lacoste B, Prat A, Freitas-Andrade M, Gu C

Cold Spring Harbor perspectives in biology2025First author

DOI: 10.1101/cshperspect.a041422 PMID: 38951020

Zebrafish glial-vascular interactions progressively expand over the course of brain development.

Gall LG, Stains CM, Freitas-Andrade M, Jia BZ, Patel N, Megason SG, Lacoste B, O'Brown NM

iScience2025

DOI: 10.1016/j.isci.2024.111549 PMID: 39811646

Sensors in the microvascular web: Vital but vulnerable.

Lacoste B

Proceedings of the National Academy of Sciences of the United States of America2024First author

DOI: 10.1073/pnas.2417137121 PMID: 39401368

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis.

Manceau R, Majeur D, Cherian CM, Miller CJ, Wat LW, Fisher JD, Labarre A, Hollman S, Prakash S, Audet S, Chao CF, Depaauw-Holt L, Rogers B, Bosson A, Xi JJY, Callow CAS, Yoosefi N, Shahraki N, Xia YH, Hui A, VanderZwaag J, Bouyakdan K, Rodaros D, Kotchetkov P, Daneault C, Fallahpour G, Tetreault M, Tremblay MÈ, Ruiz M, Lacoste B, Parker JA, Murphy-Royal C, Huan T, Fulton S, Rideout EJ, Alquier T

bioRxiv : the preprint server for biology2024

DOI: 10.1101/2024.09.19.613929 PMID: 39345476

Astrocyte-derived HMGB1: a developmental switch for stroke recovery

SupervisorCIHR2026Fellowship: Canada Impact+ Research Training Awards - Postdoctoral

Principal investigators: Lopez Ortiz, Aida O

Keywords: Astrocyte; Brain Repair; Cerebral Blood Flow; Functional Recovery; Ischemic Stroke; Vascular Health

$140,000

Astrocyte-derived HMGB1: a developmental switch for functional stroke recovery.

Nominated PICIHR2024Project Grant

Principal investigators: Lacoste, Baptiste

Keywords: Angiogenesis; Astrocytes; Blood-Brain Barrier; Cerebral Blood Flow; Ischemic Stroke; Mouse; Plasticity; Stroke Recovery

$1,113,075

Defective endothelial metabolism and mitochondrial biogenesis in autism spectrum disorders.

Nominated PICIHR2023Project Grant

Principal investigators: Lacoste, Baptiste

Keywords: Autism; Brain; Cerebrovascular; Endothelium; Metabolism; Mitochondrion; Mouse Models

$961,990

Effect of neurovascular defects on brain metabolism in 16p11.2 deletion mouse model of autism spectrum disorders

SupervisorCIHR2020Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Ouellette, Julie

Keywords: Astrocytes; Autism Spectrum Disorders; Brain Metabolism; Brain Vasculature; Cell Biology; Endothelial Cells; Metabolomics; Mitochondria Function; Neurons; Neuroscience

$105,000

Cellular and molecular mechanisms underlying neurovascular deficiencies in autism

Principal investigatorSSHRC2019New Frontiers in Research Fund - Exploration

Principal investigators: Lacoste, Baptiste

Keywords: Neurovascular interactions; Autism; Brain organoïds; Pluripotent stem cells (iPSCs); Computational modeling ; Angiogenesis; Neurogenesis; Pattern analysis; Artificial intelligence

$273,175

Role of astrocytes in the control of cerebrovascular patterning during postnatal development.

Principal investigatorNSERC2018Discovery Launch Supplement

Principal investigators: Lacoste, Baptiste

$12,500

Role of astrocytes in the control of cerebrovascular patterning during postnatal development.

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Lacoste, Baptiste

$259,000

Role of cerebrovascular abnormalities in the pathophysiology of autism spectrum disorders.

Nominated PICIHR2017Project Grant

Principal investigators: Lacoste, Baptiste

Keywords: Angiogenesis; Autism Spectrum Disorders; Brain; Cerebral Blood Flow; Cerebrovascular Remodeling; Endothelium; Mouse Models; Mutations; Neurodevelopment; Vascular Patterning

$906,525

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Baptiste Lacoste

Research

Latest papers

Latest funding

Protocol for assessing molecular signatures and metabolic function of primary murine cortical astrocytes.

Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1.

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis.

Volumetric Analysis of the Blood-Brain Barrier After Ischemic Stroke by Electron Tomography in Mice.

Oxysterol-binding protein ORP6 regulates lipid metabolism and brain A&#x3b2; production.

A new dataset for measuring the performance of blood vessel segmentation methods under distribution shifts.

The Blood-Brain Barrier: Composition, Properties, and Roles in Brain Health.

Zebrafish glial-vascular interactions progressively expand over the course of brain development.

Sensors in the microvascular web: Vital but vulnerable.

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis.

Astrocyte-derived HMGB1: a developmental switch for stroke recovery

Astrocyte-derived HMGB1: a developmental switch for functional stroke recovery.

Defective endothelial metabolism and mitochondrial biogenesis in autism spectrum disorders.

Effect of neurovascular defects on brain metabolism in 16p11.2 deletion mouse model of autism spectrum disorders

Cellular and molecular mechanisms underlying neurovascular deficiencies in autism

Role of astrocytes in the control of cerebrovascular patterning during postnatal development.

Role of astrocytes in the control of cerebrovascular patterning during postnatal development.

Role of cerebrovascular abnormalities in the pathophysiology of autism spectrum disorders.

Frequent collaborators

Matthieu Ruiz

Thierry Alquier

Jing Wang

Natalina Salmaso

Mary-Ellen Harper

Dale Corbett

Julie St-Pierre

Ciaran Murphy-Royal

Stephanie Fulton

Sylvain Baillet

Mireille Ouimet

Derrick Gibbings

Ruth Slack

Marie-Ève Tremblay

Diane Lagace

Dylan Burger

Kathleen Macleod

Alexandre Blais

Mallar Chakravarty

Catherine Tsilfidis

Stephanie Fulton

Mario Tiberi

Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production.