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Mario Tiberi

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Associate ProfessorCellular and Molecular MedicineUniversity of Ottawa

Mario Tiberi

Associate Professor

Cellular and Molecular Medicine

Faculty of Medicine

University of Ottawa

Ottawa, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
1 publication in the last five years, latest in 2024.
Principal investigator on 10 research grants (6 NSERC, 4 CIHR), most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Research

Read how they describe their research on their University of Ottawa profile.

Dopamine G Protein-Coupled Receptors Electrophysiology Intracellular Trafficking Knockout Mouse N-Methyl-D-Aspartate Receptors Psd Proteins Signal Transduction

Latest papers

The dopamine transporter antagonist vanoxerine inhibits G9a and suppresses cancer stem cell functions in colon tumors.
Nature cancer · 2024
Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer's disease model mice in a sex-selective manner.
Science signaling · 2020
Laser Doppler Flowmetry to Study the Regulation of Cerebral Blood Flow by G Protein-Coupled Receptors in Rodents.
Methods in molecular biology (Clifton, N.J.) · 2019

All 18 publications

Latest funding

Proteomic and Signaling Modalities of Dopamine D3 Receptor Polymorphic Variants
NSERC · 2024 · Principal investigator
$47,000
Defining the role of dopamine transporter in the hierarchical organization of colorectal tumors
CIHR · 2023 · Co-investigator
$1,086,300
The GPCR Retreat 2023
CIHR · 2023 · Co-investigator
$15,000

All 12 grants and awards

18 publications.

The dopamine transporter antagonist vanoxerine inhibits G9a and suppresses cancer stem cell functions in colon tumors.

Bergin CJ, Zouggar A, Mendes da Silva A, Fenouil T, Haebe JR, Masibag AN, Agrawal G, Shah MS, Sandouka T, Tiberi M, Auer RC, Ardolino M, Benoit YD

Nature cancer2024

DOI: 10.1038/s43018-024-00727-y PMID: 38351181

Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer's disease model mice in a sex-selective manner.

Abd-Elrahman KS, Albaker A, de Souza JM, Ribeiro FM, Schlossmacher MG, Tiberi M, Hamilton A, Ferguson SSG

Science signaling2020

DOI: 10.1126/scisignal.abd2494 PMID: 33323410

Laser Doppler Flowmetry to Study the Regulation of Cerebral Blood Flow by G Protein-Coupled Receptors in Rodents.

Toussay X, Tiberi M, Lacoste B

Methods in molecular biology (Clifton, N.J.)2019

DOI: 10.1007/978-1-4939-9121-1_22 PMID: 30969429

The Intersection of Central Dopamine System and Stroke: Potential Avenues Aiming at Enhancement of Motor Recovery.

Gower A, Tiberi M

Frontiers in synaptic neuroscience2018Senior author

DOI: 10.3389/fnsyn.2018.00018 PMID: 30034335

Characterization of 18F-FPyKYNE-Losartan for Imaging AT1 Receptors.

Hachem M, Tiberi M, Ismail B, Hunter CR, Arksey N, Hadizad T, Beanlands RS, deKemp RA, DaSilva JN

Journal of nuclear medicine : official publication, Society of Nuclear Medicine2016

DOI: 10.2967/jnumed.115.170951 PMID: 27199365

Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: insights from ligand binding and signal transduction responses of D1 and D5 dopaminergic receptor mutants.

Zhang B, Yang X, Tiberi M

Cellular signalling2015Senior author

DOI: 10.1016/j.cellsig.2015.07.006 PMID: 26186971

Constitutive activities and inverse agonism in dopamine receptors.

Zhang B, Albaker A, Plouffe B, Lefebvre C, Tiberi M

Advances in pharmacology (San Diego, Calif.)2014Senior author

DOI: 10.1016/b978-0-12-417197-8.00007-9 PMID: 24931197

Functional analysis of human D1 and D5 dopaminergic G protein-coupled receptors: lessons from mutagenesis of a conserved serine residue in the cytosolic end of transmembrane region 6.

Plouffe B, Tiberi M

Methods in molecular biology (Clifton, N.J.)2013Senior author

DOI: 10.1007/978-1-62703-251-3_10 PMID: 23296783

The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner.

Plouffe B, Yang X, Tiberi M

Cellular signalling2012Senior author

DOI: 10.1016/j.cellsig.2011.08.008 PMID: 21893192

In vivo and in vitro assessment of cardiac beta-adrenergic receptors in larval zebrafish (Danio rerio).

Steele SL, Yang X, Debiais-Thibaud M, Schwerte T, Pelster B, Ekker M, Tiberi M, Perry SF

The Journal of experimental biology2011

DOI: 10.1242/jeb.052803 PMID: 21490253

Proteomic and Signaling Modalities of Dopamine D3 Receptor Polymorphic Variants

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Tiberi, Mario

Keywords: dopamine; g protein-coupled receptors; d3 receptor; adenylyl cyclase 5; endocytosis; mutagenesis; proteomics; immunoprecipitation; gst-pulldown assays; bimolecular fluorescence complementation

$47,000

Defining the role of dopamine transporter in the hierarchical organization of colorectal tumors

Co-investigatorCIHR2023Project Grant

Principal investigators: Benoit, Yannick D

Keywords: Colorectal Cancer; Dopamine Transporter; Epigenetics; Stem Cells

$1,086,300

The GPCR Retreat 2023

Co-investigatorCIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Albert, Paul R

Keywords: Animal Models; Biochemistry; Cell Biology; Drug Design; G-Protein; Molecular Biology; Protein Structure; Receptor; Signalling; Therapeutics

$15,000

Role of Membrane-Associated Guanylate Kinases (MAGUKs) in Dopamine Receptor Signaling

Nominated PICIHR2022Project Grant

Principal investigators: Tiberi, Mario

Keywords: Dopamine; Electrophysiology; G Protein-Coupled Receptors; Intracellular Trafficking; Knockout Mouse; Motor Behavior; N-Methyl-D-Aspartate Receptors; Psd Proteins; Signal Transduction; Synaptic-Associated Protein 102

$921,826

Phosphatase-Dependent Regulation of Dopamine D3 Receptor-Adenylyl Cyclase Complexes

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Tiberi, Mario

$156,000

Role of Post-Synaptic Density Proteins in the Integration of Dopamine and Glutamate Receptor Functions

Nominated PICIHR2016Project Grant

Principal investigators: Tiberi, Mario; Béïque, Jean-Claude

$100,000

Role of Postsynaptic Density Proteins in Dopamine Receptor Function and Crosstalk

Nominated PICIHR2016Project Grant

Principal investigators: Tiberi, Mario; Béïque, Jean-Claude

Keywords: Dopamine; Electrophysiology; G Protein-Coupled Receptors; Intracellular Trafficking; Knockout Mouse; N-Methyl-D-Aspartate Receptors; Organotypic Slices; Psd Proteins; Signal Transduction; Synaptic-Associated Protein 102

$803,250

Signaling mechanisms of D1-class dopaminergic receptors

Nominated PICIHR2012Operating Grant

Principal investigators: Tiberi, Mario

Keywords: Desensitization; Dopamine; G Protein-Coupled Receptor Kinase; G Protein-Coupled Receptors; Internalization; Phosphorylation; Promyelocytic Leukemia Zinc Finger; Protein Kinase C; Protein-Protein Interactions; Sensitization

$720,315

Role of MAGUKs in assembly of transmembrane receptor signaling networks

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Tiberi, Mario

$135,000

Structure-activity relationships of D1-like dopaminergic receptors

Principal investigatorNSERC2007Discovery Grants Program - Individual

Principal investigators: Tiberi, Mario

$80,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Mario Tiberi

Research

Latest papers

Latest funding

The dopamine transporter antagonist vanoxerine inhibits G9a and suppresses cancer stem cell functions in colon tumors.

Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer's disease model mice in a sex-selective manner.

Laser Doppler Flowmetry to Study the Regulation of Cerebral Blood Flow by G Protein-Coupled Receptors in Rodents.

The Intersection of Central Dopamine System and Stroke: Potential Avenues Aiming at Enhancement of Motor Recovery.

Characterization of 18F-FPyKYNE-Losartan for Imaging AT1 Receptors.

Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: insights from ligand binding and signal transduction responses of D1 and D5 dopaminergic receptor mutants.

Constitutive activities and inverse agonism in dopamine receptors.

Functional analysis of human D1 and D5 dopaminergic G protein-coupled receptors: lessons from mutagenesis of a conserved serine residue in the cytosolic end of transmembrane region 6.

The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner.

In vivo and in vitro assessment of cardiac beta-adrenergic receptors in larval zebrafish (Danio rerio).

Proteomic and Signaling Modalities of Dopamine D3 Receptor Polymorphic Variants

Defining the role of dopamine transporter in the hierarchical organization of colorectal tumors

The GPCR Retreat 2023

Role of Membrane-Associated Guanylate Kinases (MAGUKs) in Dopamine Receptor Signaling

Phosphatase-Dependent Regulation of Dopamine D3 Receptor-Adenylyl Cyclase Complexes

Role of Post-Synaptic Density Proteins in the Integration of Dopamine and Glutamate Receptor Functions

Role of Postsynaptic Density Proteins in Dopamine Receptor Function and Crosstalk

Signaling mechanisms of D1-class dopaminergic receptors

Role of MAGUKs in assembly of transmembrane receptor signaling networks

Structure-activity relationships of D1-like dopaminergic receptors

Frequent collaborators

Marc Ekker

Michele Ardolino

Baptiste Lacoste

Richard Bergeron

Marzia Martina

Samantha Halman

Mario Tiberi

Research

Latest papers

Latest funding

The dopamine transporter antagonist vanoxerine inhibits G9a and suppresses cancer stem cell functions in colon tumors.

A&#x3b2; oligomers induce pathophysiological mGluR5 signaling in Alzheimer's disease model mice in a sex-selective manner.

Laser Doppler Flowmetry to Study the Regulation of Cerebral Blood Flow by G Protein-Coupled Receptors in Rodents.

The Intersection of Central Dopamine System and Stroke: Potential Avenues Aiming at Enhancement of Motor Recovery.

Characterization of 18F-FPyKYNE-Losartan for Imaging AT1 Receptors.

Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: insights from ligand binding and signal transduction responses of D1 and D5 dopaminergic receptor mutants.

Constitutive activities and inverse agonism in dopamine receptors.

Functional analysis of human D1 and D5 dopaminergic G protein-coupled receptors: lessons from mutagenesis of a conserved serine residue in the cytosolic end of transmembrane region 6.

The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner.

In vivo and in vitro assessment of cardiac beta-adrenergic receptors in larval zebrafish (Danio rerio).

Proteomic and Signaling Modalities of Dopamine D3 Receptor Polymorphic Variants

Defining the role of dopamine transporter in the hierarchical organization of colorectal tumors

The GPCR Retreat 2023

Role of Membrane-Associated Guanylate Kinases (MAGUKs) in Dopamine Receptor Signaling

Phosphatase-Dependent Regulation of Dopamine D3 Receptor-Adenylyl Cyclase Complexes

Role of Post-Synaptic Density Proteins in the Integration of Dopamine and Glutamate Receptor Functions

Role of Postsynaptic Density Proteins in Dopamine Receptor Function and Crosstalk

Signaling mechanisms of D1-class dopaminergic receptors

Role of MAGUKs in assembly of transmembrane receptor signaling networks

Structure-activity relationships of D1-like dopaminergic receptors

Frequent collaborators

Marc Ekker

Michele Ardolino

Baptiste Lacoste

Richard Bergeron

Marzia Martina

Samantha Halman

Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer's disease model mice in a sex-selective manner.