Faculty profile

Subash Sad

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Full ProfessorBiochemistry, Microbiology and ImmunologyUniversity of Ottawa

Subash Sad

Full Professor

Biochemistry, Microbiology and Immunology

Faculty of Medicine

University of Ottawa

Ottawa, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
12 publications in the last five years, latest in 2026.
Senior (last) author on 6 recent papers, a sign of leading a research group.
Principal investigator on 9 research grants (6 CIHR, 3 NSERC), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

306

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Read how they describe their research on their University of Ottawa profile.

Inflammation Bacterial Infection Cytokine Signaling Innate Immunity Cell Death Gut Inflammatioin Metabolism

Latest papers

Processing of lysophosphatidylcholines by ExoU secreted by P. aeruginosa leads to inflammasome activation and cell death.
Cell reports · 2026 · senior author
The Parkinson's disease-linked G2019S mutation of LRRK2 increases NADPH oxidase-2 activity in neutrophils for superior control of bacterial infections.
Cellular & molecular immunology · 2026 · senior author
Human milk extracellular vesicles modulate inflammation and cell survival in intestinal and immune cells.
Pediatric research · 2025

All 57 publications

Latest funding

Role of type I interferon signaling in the murine typhoid model
CIHR · 2023 · Nominated PI
$975,376
Role of Type I interferon signaling in the murine typhoid model
CIHR · 2022 · Nominated PI
$100,000
Development of modified eggshell membrane formulations with enhanced immunomodulatory and anti-inflammatory activities to expand the non-food market for eggs._x000d_ _x000d_ _x000d_ _x000d_
NSERC · 2020 · Co-investigator
$120,000

All 16 grants and awards

57 publications.

Processing of lysophosphatidylcholines by ExoU secreted by P. aeruginosa leads to inflammasome activation and cell death.

Phuong MS, Mahdi A, Cai D, Noah K, Rijal D, Kaul R, Bhan A, Yadav S, Ariana A, El Hamra R, Chen W, Kassen R, Hernandez R, Wong A, Frank DW, Pier GB, Cheng Z, Cuperlovic-Culf M, Bennett SAL, Sad S

Cell reports2026Senior author

DOI: 10.1016/j.celrep.2026.118037 PMID: 42771524

The Parkinson's disease-linked G2019S mutation of LRRK2 increases NADPH oxidase-2 activity in neutrophils for superior control of bacterial infections.

Hurley K, Kaul R, Yadav S, Rijal D, Sam L, Bhan A, Hamra RE, Ariana A, Mahdi A, Brandt W, Tomlinson JJ, Schlossmacher MG, Sad S

Cellular & molecular immunology2026Senior author

DOI: 10.1038/s41423-026-01451-6 PMID: 42463806

Human milk extracellular vesicles modulate inflammation and cell survival in intestinal and immune cells.

Vahkal B, Altosaar I, Ariana A, Jabbour J, Pantieras F, Daniel R, Tremblay É, Sad S, Beaulieu JF, Côté M, Ferretti E

Pediatric research2025

DOI: 10.1038/s41390-024-03757-5 PMID: 39609615

The ER-phagy receptor FAM134B is targeted by Salmonella Typhimurium to promote infection.

Gatica D, Alsaadi RM, El Hamra R, Li B, Mueller R, Miyazaki M, Sun Q, Sad S, Russell RC

Nature communications2025

DOI: 10.1038/s41467-025-58035-7 PMID: 40133256

Isolation, Characterization, and Genomic Analysis of Bacteriophages Against Pseudomonas aeruginosa Clinical Isolates from Early and Chronic Cystic Fibrosis Patients for Potential Phage Therapy.

Nour El-Din HT, Kettal M, Granados Maciel JC, Beaudoin G, Oktay U, Hrapovic S, Sad S, Dennis JJ, Peters DL, Chen W

Microorganisms2025

DOI: 10.3390/microorganisms13030511 PMID: 40142404

Regulation of Zfp36 by ISGF3 and MK2 restricts the expression of inflammatory cytokines during necroptosis stimulation.

Yadav S, El Hamra R, Alturki NA, Ariana A, Bhan A, Hurley K, Gaestel M, Blackshear PJ, Blais A, Sad S

Cell death & disease2024Senior author

DOI: 10.1038/s41419-024-06964-4 PMID: 39117638

The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis.

Khan AUH, Ali AK, Marr B, Jo D, Ahmadvand S, Fong-McMaster C, Almutairi SM, Wang L, Sad S, Harper ME, Lee SH

Cellular & molecular immunology2023

DOI: 10.1038/s41423-023-01071-4 PMID: 37553427

XIAP promotes the expansion and limits the contraction of CD8 T cell response through cell extrinsic and intrinsic mechanisms respectively.

Thakker P, Ariana A, Hajjar S, Cai D, Rijal D, Sad S

PLoS pathogens2023Senior author

DOI: 10.1371/journal.ppat.1011455 PMID: 37347786

The transcription factor Cdx2 regulates inflammasome activity through expression of the NLRP3 suppressor TRIM31 to maintain intestinal homeostasis.

Jahan S, Awaja N, Hess B, Hajjar S, Sad S, Lohnes D

The Journal of biological chemistry2022

DOI: 10.1016/j.jbc.2022.102386 PMID: 35985421

Roles of natural resistance-associated macrophage protein-1 in modulating bacterial distribution and immune responses during Salmonella enterica serovar Typhimurium infection in murine pregnancy.

Agbayani G, Clark K, Sad S, Murphy SP, Krishnan L

American journal of reproductive immunology (New York, N.Y. : 1989)2022

DOI: 10.1111/aji.13599 PMID: 35851978

Role of type I interferon signaling in the murine typhoid model

Nominated PICIHR2023Project Grant

Principal investigators: Sad, Subash

Keywords: Bacterial Infection; Cytokine Signaling; Inflammation; Innate Immunity

$975,376

Role of Type I interferon signaling in the murine typhoid model

Nominated PICIHR2022Project Grant

Principal investigators: Sad, Subash

Keywords: Bacterial Infection; Cytokine Signaling; Inflammation; Innate Immunity

$100,000

Development of modified eggshell membrane formulations with enhanced immunomodulatory and anti-inflammatory activities to expand the non-food market for eggs._x000d_ _x000d_ _x000d_ _x000d_

Co-investigatorNSERC2020Alliance Grants

Principal investigators: Hincke, Max

$120,000

FoxO3a acts as a key checkpoint that regulates inflammation in the gut

Nominated PICIHR2019Project Grant

Principal investigators: Sad, Subash

Keywords: Gut; Inflammatioin; Metabolism; Microbiome

$768,826

Identification of molecular mechanisms involved in the biological response to implant wear and corrosion

Co-investigatorCIHR2019Project Grant

Principal investigators: Catelas, Isabelle

Keywords: Animal Models; Biomaterials; Cell Culture; Implants; Inflammatory Response; Medical Devices; Metal Ions; Molecular Mechanisms; Wear Particles

$826,200

Identification of molecular mechanisms involved in the biological response to implant wear and corrosion

Co-investigatorCIHR2018Project Grant - PA: MSK, Skin and Oral Health: Clinical Research - MSK Health

Principal investigators: Catelas, Isabelle

Keywords: Animal Models; Biomaterials; Cell Culture; Implants; Inflammatory Response; Medical Devices; Metal Ions; Molecular Mechanisms; Wear Particles

$100,000

Activation and regulation of necrosis in macrophages

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Sad, Subash

$204,000

CIACCO-2018 (7th Annual symposium on Cytokines in Inflammation, Ageing, CanCer and Obesity)

Co-investigatorCIHR2017Planning and Dissemination Grant - Institute Community Support

Principal investigators: Menendez, Alfredo; Ilangumaran, Subburaj

Keywords: Aging; Basic Research; Cancer; Cytokines; Immune Response; Infectious Diseases; Inflammation; Novel Therapeutics; Obesity; Translational Medicine

$10,000

Role of XAF1 and MAP kinase-activated protein kinase-2 in necrosome signaling

Nominated PICIHR2016Project Grant

Principal investigators: Sad, Subash

Keywords: Bacterial Infections; Cell Death; Immune Response; Innate Immunitiy

$835,570

Flow Cytometer with High Throughput Sampler

Principal investigatorNSERC2016Research Tools and Instruments

Principal investigators: Sad, Subash

$149,888

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Subash Sad

Research

Latest papers

Latest funding

Processing of lysophosphatidylcholines by ExoU secreted by P. aeruginosa leads to inflammasome activation and cell death.

The Parkinson's disease-linked G2019S mutation of LRRK2 increases NADPH oxidase-2 activity in neutrophils for superior control of bacterial infections.

Human milk extracellular vesicles modulate inflammation and cell survival in intestinal and immune cells.

The ER-phagy receptor FAM134B is targeted by Salmonella Typhimurium to promote infection.

Isolation, Characterization, and Genomic Analysis of Bacteriophages Against Pseudomonas aeruginosa Clinical Isolates from Early and Chronic Cystic Fibrosis Patients for Potential Phage Therapy.

Regulation of Zfp36 by ISGF3 and MK2 restricts the expression of inflammatory cytokines during necroptosis stimulation.

The TNF&#x3b1;/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis.

XIAP promotes the expansion and limits the contraction of CD8 T cell response through cell extrinsic and intrinsic mechanisms respectively.

The transcription factor Cdx2 regulates inflammasome activity through expression of the NLRP3 suppressor TRIM31 to maintain intestinal homeostasis.

Roles of natural resistance-associated macrophage protein-1 in modulating bacterial distribution and immune responses during Salmonella enterica serovar Typhimurium infection in murine pregnancy.

Role of type I interferon signaling in the murine typhoid model

Role of Type I interferon signaling in the murine typhoid model

Development of modified eggshell membrane formulations with enhanced immunomodulatory and anti-inflammatory activities to expand the non-food market for eggs._x000d_ _x000d_ _x000d_ _x000d_

FoxO3a acts as a key checkpoint that regulates inflammation in the gut

Identification of molecular mechanisms involved in the biological response to implant wear and corrosion

Identification of molecular mechanisms involved in the biological response to implant wear and corrosion

Activation and regulation of necrosis in macrophages

CIACCO-2018 (7th Annual symposium on Cytokines in Inflammation, Ageing, CanCer and Obesity)

Role of XAF1 and MAP kinase-activated protein kinase-2 in necrosome signaling

Flow Cytometer with High Throughput Sampler

Frequent collaborators

Lakshmi Krishnan

Alexandre Blais

Alex Wong

Alex Wong

Mary-Ellen Harper

Tommy Alain

Zhenyu Cheng

Lisheng Wang

Miroslava Cuperlovic-Culf

Harold Atkins

Emanuela Ferretti

Illimar Altosaar

Rudolf Mueller

Terrence Ruddy

Kevin Coombs

Thien-Fah Mah

Shawn Hayley

David Lohnes

Jovian Tsang

Shawn Hayley

Brian Coombes

Karen Mossman

Brian Lichty

Jean-Simon Diallo

Seung-Hwan Lee

The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis.