David Lohnes, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Cdx Transcription Chromatin Knockout Stem Cell Wnt Colorectal Cancer Conditional Mutant

Latest papers

Cdx regulates gene expression through PRC2-mediated epigenetic mechanisms.
Developmental biology · 2022 · senior author
Regulation of axial elongation by Cdx.
Developmental biology · 2022 · senior author
The transcription factor Cdx2 regulates inflammasome activity through expression of the NLRP3 suppressor TRIM31 to maintain intestinal homeostasis.
The Journal of biological chemistry · 2022 · senior author

All 21 publications

Latest funding

Cdx and Intestinal Homeostasis
CIHR · 2022 · Nominated PI
$768,825
CDX and TRIM31: a novel pathway linking chronic inflammation and colorectal cancer.
CIHR · 2019 · Supervisor
$135,000
Intestinal homeostasis and cancer
CIHR · 2016 · Nominated PI
$699,520

All 6 grants and awards

21 publications.

01

Cdx regulates gene expression through PRC2-mediated epigenetic mechanisms.

Foley T, Lohnes D

Developmental biology2022Senior author

DOI: 10.1016/j.ydbio.2021.12.014 PMID: 34973175

02

Regulation of axial elongation by Cdx.

Zhu Y, Lohnes D

Developmental biology2022Senior author

DOI: 10.1016/j.ydbio.2021.12.011 PMID: 34958748

03

The transcription factor Cdx2 regulates inflammasome activity through expression of the NLRP3 suppressor TRIM31 to maintain intestinal homeostasis.

Jahan S, Awaja N, Hess B, Hajjar S, Sad S, Lohnes D

The Journal of biological chemistry2022Senior author

DOI: 10.1016/j.jbc.2022.102386 PMID: 35985421

04

Cdx2 regulates immune cell infiltration in the intestine.

Chewchuk S, Jahan S, Lohnes D

Scientific reports2021Senior author

DOI: 10.1038/s41598-021-95412-w PMID: 34349205

05

Cdx2 Regulates Intestinal EphrinB1 through the Notch Pathway.

Zhu Y, Hryniuk A, Foley T, Hess B, Lohnes D

Genes2021Senior author

DOI: 10.3390/genes12020188 PMID: 33525395

06

Role of Cdx factors in early mesodermal fate decisions.

Foley TE, Hess B, Savory JGA, Ringuette R, Lohnes D

Development (Cambridge, England)2019Senior author

DOI: 10.1242/dev.170498 PMID: 30936115

07

Cdx2 Regulates Gene Expression through Recruitment of Brg1-associated Switch-Sucrose Non-fermentable (SWI-SNF) Chromatin Remodeling Activity.

Nguyen TT, Savory JGA, Brooke-Bisschop T, Ringuette R, Foley T, Hess BL, Mulatz KJ, Trinkle-Mulcahy L, Lohnes D

The Journal of biological chemistry2017Senior author

DOI: 10.1074/jbc.m116.752774 PMID: 28082674

08

Essential roles for Cdx in murine primitive hematopoiesis.

Brooke-Bisschop T, Savory JGA, Foley T, Ringuette R, Lohnes D

Developmental biology2017Senior author

DOI: 10.1016/j.ydbio.2017.01.002 PMID: 28065741

09

A regulatory network controls nephrocan expression and midgut patterning.

Hou J, Wei W, Saund RS, Xiang P, Cunningham TJ, Yi Y, Alder O, Lu DY, Savory JG, Krentz NA, Montpetit R, Cullum R, Hofs N, Lohnes D, Humphries RK, Yamanaka Y, Duester G, Saijoh Y, Hoodless PA

Development (Cambridge, England)2014

DOI: 10.1242/dev.108274 PMID: 25209250

10

Cdx1 and Cdx2 function as tumor suppressors.

Hryniuk A, Grainger S, Savory JG, Lohnes D

The Journal of biological chemistry2014Senior author

DOI: 10.1074/jbc.m114.583823 PMID: 25320087

Cdx and Intestinal Homeostasis

Nominated PICIHR2022Project Grant

Principal investigators: Lohnes, David L

Keywords: Cdx; Colorectal Cancer; Conditional Mutant; Cytokines; Inflammasome; Intestinal Barrier; Intestinal Inflammation; Nf-Kb; Tnfa; Transcription

$768,825

CDX and TRIM31: a novel pathway linking chronic inflammation and colorectal cancer.

SupervisorCIHR2019CIHR Fellowship

Principal investigators: Jahan, Sanzida

Keywords: Cdx2 Transcription Factor; Chromatin Accessibility; Chromatin Remodelling; Chronic Inflammation; Colon Tumour; Transcription Regulation; Trim31

$135,000

Intestinal homeostasis and cancer

Nominated PICIHR2016Project Grant

Principal investigators: Lohnes, David L

Keywords: Cdx; Chromatin; Colo-Rectal Cancer; Crypt; Knockout; Notch; Patterning; Stem Cell; Transcription; Wnt

$699,520

Central roles for Cdx in organizing the vertebrate embryo

Nominated PICIHR2014Operating Grant

Principal investigators: Lohnes, David L

Keywords: Ap Patterning; Cdx; Chromatin; Intestinal Cancer; Knockout; Stem Cell; Swi/Snf; Transcription; Transgenic; Wnt

$658,115

Essential roles for Cdx2 in the intestine.

Nominated PICIHR2010Operating Grant

Principal investigators: Lohnes, David L

Keywords: Ap Patterning; Cdx; Colo-Rectal Cancer; Intestinal Cancer; Intestine; Knockout; Notch; Stem Cell; Transgenic; Wnt

$847,855

The Role of Cdx in Intestinal Development

SupervisorCIHR2008Doctoral Research Award - PA: Digestive Health (SHOPP)

Principal investigators: Grainger, Stephanie L

Keywords: Anterior-Posterior Patterning; Cdx; Conditional Knock Out Mouse; Development; Endoderm; Gastro-Intestinal Epithelium; Immunohistochemistry; In Situ Hybridization; Molecular Biology; Transcription

$33,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Cellular and Molecular Medicine
Biochemistry, Microbiology and Immunology
Surgery
Other

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Lisheng Wang

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2010

Yojiro Yamanaka

Faculty

1 shared papers, latest 2014

Laura Trinkle-Mulcahy

Cellular and Molecular Medicine

1 shared papers, latest 2017

Bill Wang

Surgery

1 shared papers, latest 2010

Rashmi Kothary

Cellular and Molecular Medicine

1 shared papers, latest 2009

Subash Sad

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Cdx Dear Professor Lohnes, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Cdx regulates gene expression through PRC2-mediated epigenetic mechanisms." (2022), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Cdx and Intestinal Homeostasis" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]