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Seung-Hwan Lee

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Assistant ProfessorBiochemistry, Microbiology and ImmunologyUniversity of Ottawa

Seung-Hwan Lee

Assistant Professor

Biochemistry, Microbiology and Immunology

Faculty of Medicine

University of Ottawa

Ottawa, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
26 publications in the last five years, latest in 2026.
Senior (last) author on 6 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (7 CIHR, 1 SSHRC), most recently in 2024.
Supervisor on 1 trainee award (1 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Read how they describe their research on their University of Ottawa profile.

Natural Killer Cells Cytokines Chimeric Activating Receptors Immunotherapy Virus Infection Crispr/Cas9 Genome Editing Genetic Engineering Multiple Myeloma

Latest papers

Anti-BCMA-CAR-IL15 natural killer cells prevent multiple myeloma growth in the bone marrow but allow subsequent emergence of extramedullary disease
Cancer Letters · 2026 · senior author
Natural killer cell-derived extracellular vesicles reprogram cellular human immunity to enhance tumor cytotoxicity.
Molecular therapy. Oncology · 2026
Development of Genetically Modified ARH-77 Feeder Cells for Efficient Expansion of Natural Killer Cells with Potent Anti-Tumor Activity.
Cancers · 2026

All 51 publications

Latest funding

Optimizing the Large-Scale Expansion of Primary Human NK Cells Using a G-Rex Bioreactor System
CIHR · 2025 · Supervisor
$6,000
A mechanistic investigation of NK cell disarming.
CIHR · 2024 · Co-investigator
$906,525
CIACCO- a multidisciplinary symposium on Cytokines, Immunity, Ageing, CanCer and Obesity
CIHR · 2024 · Co-investigator
$12,000

All 12 grants and awards

51 publications.

Anti-BCMA-CAR-IL15 natural killer cells prevent multiple myeloma growth in the bone marrow but allow subsequent emergence of extramedullary disease

Kaczmarek S, Jo D, Ghaziasgar S, Marr B, Berton S, Wang L, Arbabi Ghahroudi M, Jang M, Visram A, McComb S

Cancer Letters20263 citationsSenior author

DOI: 10.1016/j.canlet.2025.218235

Natural killer cell-derived extracellular vesicles reprogram cellular human immunity to enhance tumor cytotoxicity.

St-Denis-Bissonnette F, Mediratta K, Ho N, Kirkby M, Stalker A, Muradia G, Shrestha A, Ardolino M, Lee SH, Burger D, Mer A, Wang L, Lavoie JR

Molecular therapy. Oncology2026

DOI: 10.1016/j.omton.2026.201261 PMID: 42383255

Development of Genetically Modified ARH-77 Feeder Cells for Efficient Expansion of Natural Killer Cells with Potent Anti-Tumor Activity.

Lim YJ, Marr B, Ghaziasgar S, Kim CJ, Baek YJ, Kim GS, Lee JJ, Park YJ, An Y, Lee SH, Kim SK

Cancers2026

DOI: 10.3390/cancers18111833 PMID: 42279415

BaEV-pseudotyped lentiviral vectors enable stable CAR expression and cytotoxic function in NK cells.

Park M, Lim Y, Jo Y, Jo DH, Kim SK, Kim HY, Lee SH, Lee M, Cho D

PloS one2026

DOI: 10.1371/journal.pone.0348674 PMID: 42166452

Correction: Limited immune perturbations in mice exposed to sustained low-dose ionizing radiation.

Marr B, Laakso H, Blimkie M, Cao A, Lee SH, Khan AUH

Frontiers in immunology2026

DOI: 10.3389/fimmu.2026.1880777 PMID: 42317315

Limited immune perturbations in mice exposed to sustained low-dose ionizing radiation.

Marr B, Laakso H, Blimkie M, Cao A, Lee SH, Khan AUH

Frontiers in immunology2026

DOI: 10.3389/fimmu.2026.1642012 PMID: 42088506

Rapid CAR screening and circRNA-driven CAR-NK cells for persistent shed-resistant immunotherapy.

Chung JY, Hong J, Yee SM, Lim HW, Lee D, Yoon S, Lee SH, Jung Y, Shin SH, Kim SC, Lee CH, Jang M

Signal transduction and targeted therapy2026

DOI: 10.1038/s41392-026-02623-6 PMID: 41963304

Enhancing cancer killing and natural killer cell persistence by targeting NOXA, a predictor of poor patient survival.

Kang SB, Jeong JH, Kim SW, Yoo H, Lee S, Oh JH, Sung CO, Lee SH, Jun E, Jang M

Molecular therapy. Oncology2026

DOI: 10.1016/j.omton.2026.201152 PMID: 41783357

Natural Killer Cell-Derived Extracellular Vesicles Exhibit Cytotoxicity Against Bulk Tumor Cells and Cancer Stem Cells in Triple-Negative Breast Cancer.

Kirkby M, St-Denis-Bissonnette F, Diab MD, Mediratta K, Korobkow A, Humber J, Han P, Muradia G, Ardolino M, Lee SH, Gibbings DJ, Burger D, Wang L, Lavoie JR

Nanomaterials (Basel, Switzerland)2026

DOI: 10.3390/nano16090525 PMID: 42117942

Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression

Jo D-H, Kaczmarek S, Khan AUH, Pervin J, Clark DM, Gadde S, Wang L, McComb S, Visram A, Lee S-H

Frontiers in Immunology202516 citationsSenior author

DOI: 10.3389/fimmu.2025.1533044

Optimizing the Large-Scale Expansion of Primary Human NK Cells Using a G-Rex Bioreactor System

SupervisorCIHR2025Undergraduate Student Research Awards (USRA)

Principal investigators: Nworah, Uche P

Keywords: Bioreactor; Car-Nk; Cell Expansion; Cell Therapy; Cells; Culture Period; Gmp-Grade

$6,000

A mechanistic investigation of NK cell disarming.

Co-investigatorCIHR2024Project Grant

Principal investigators: Ardolino, Michele

Keywords: Immune Dysfunction; Nk Cells; Tumor Immunology

$906,525

CIACCO- a multidisciplinary symposium on Cytokines, Immunity, Ageing, CanCer and Obesity

Co-investigatorCIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Menendez, Alfredo; Ferbeyre, Gerardo

Keywords: Ageing; Cancer; Cytokines; Immunity; Infection; Infllammation; Obesity; Senescence

$12,000

Developing Natural Killer Cell-Mediated Combination Immunotherapies for the Treatment of Multiple Myeloma

Nominated PICIHR2024Project Grant

Principal investigators: Lee, Seung-Hwan

Keywords: Chimeric Activating Receptors; Crispr/Cas9 Genome Editing; Cytokines; Genetic Engineering; Immunotherapy; Multiple Myeloma; Natural Killer Cells

$1,162,800

CIACCO-2024 (11th Annual symposium on Cytokines in Inflammation, Ageing, CanCer and Obesity)

Principal investigatorCIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Rafei, Moutih; Del Rincon, Sonia V; Ferbeyre, Gerardo; Fritz, Jorg H; Ilangumaran, Subburaj; Lee, Seung-Hwan; Menendez, Alfredo; Rangachari, Manu; Saucier, Caroline

Keywords: Ageing; Basic Research; Cancer; Cytokines; Immune Response; Infectious Diseases; Inflammation; Novel Therapies; Obesity; Translational Medicine

$10,000

CIACCO-2023 (10th Annual symposium on Cytokines in Inflammation, Ageing, CanCer and Obesity)

Principal investigatorCIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Fritz, Jorg H; Del Rincon, Sonia V; Ferbeyre, Gerardo; Ilangumaran, Subburaj; Lee, Seung-Hwan; Menendez, Alfredo; Rafei, Moutih; Ramanathan, Sheela; Rodrigue-Gervais, Ian Gaël; Saucier, Caroline

Keywords: Ageing; Basic Research; Cancer; Cytokines; Immune Response; Infectious Diseases; Inflammation; Novel Therapies; Obesity; Translational Medicine

$10,000

Hypoxic-specific activation of natural killer cells: Being resilient in the tumor microenvironment

Nominated PICIHR2021Project Grant

Principal investigators: Lee, Seung-Hwan

Keywords: Adoptive Transfer; Anti-Tumour Response; Cancer; Chimeric Activating Receptors; Cytokine Signaling; Immunotherapy; Natural Killer Cells

$918,000

Effects of extremely low-frequency electromagnetic fields and acoustic energy on anti-tumor activity and proliferation of natural killer cells

Principal investigatorSSHRC2020New Frontiers in Research Fund - Exploration

Principal investigators: Lee, Seung-Hwan

Keywords: Natural Killer Cells Electromagnetic Fields Anti-Tumor Immunity Immunotherapy Cell Proliferation Adoptive Transfer Ex vivo Cell Expansion Acoustic Metamaterials Electromagnetic Metamaterials

$250,000

CIACCO-2019 (8th Annual symposium on Cytokines in Inflammation, Ageing, CanCer and Obesity)

Co-investigatorCIHR2018Planning and Dissemination Grant - Institute Community Support

Principal investigators: Fritz, Jorg H

Keywords: Aging; Basic Research; Cancer; Cytokines; Immune Response; Infectious Diseases; Inflammation; Novel Therapeutics; Obesity; Translational Medicine

$10,000

IL-18: A KEY CYTOKINE LINKING METABOLISM TO IMMUNITY IN NATURAL KILLER AND CD8 T CELLS

Nominated PICIHR2017Project Grant

Principal investigators: Lee, Seung-Hwan

Keywords: Cytokines; Essential Amino Acids; Il-18; Immunometabolism; Mtorc1; Natural Killer Cells; Nutrient Transporters; Virus Infection

$745,875

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 26, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Seung-Hwan Lee

Research

Latest papers

Latest funding

Anti-BCMA-CAR-IL15 natural killer cells prevent multiple myeloma growth in the bone marrow but allow subsequent emergence of extramedullary disease

Natural killer cell-derived extracellular vesicles reprogram cellular human immunity to enhance tumor cytotoxicity.

Development of Genetically Modified ARH-77 Feeder Cells for Efficient Expansion of Natural Killer Cells with Potent Anti-Tumor Activity.

BaEV-pseudotyped lentiviral vectors enable stable CAR expression and cytotoxic function in NK cells.

Correction: Limited immune perturbations in mice exposed to sustained low-dose ionizing radiation.

Limited immune perturbations in mice exposed to sustained low-dose ionizing radiation.

Rapid CAR screening and circRNA-driven CAR-NK cells for persistent shed-resistant immunotherapy.

Enhancing cancer killing and natural killer cell persistence by targeting NOXA, a predictor of poor patient survival.

Natural Killer Cell-Derived Extracellular Vesicles Exhibit Cytotoxicity Against Bulk Tumor Cells and Cancer Stem Cells in Triple-Negative Breast Cancer.

Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression

Effects of extremely low-frequency electromagnetic fields and acoustic energy on anti-tumor activity and proliferation of natural killer cells

Frequent collaborators

Lisheng Wang

Michele Ardolino

Suresh Gadde

Dylan Burger

Alissa Visram

Juthaporn Cowan

Tommy Alain

David Cook

Nicolas Jacquelot

Marc Ekker

Subash Sad

David Allan

Mary-Ellen Harper

Daniel Figeys

Arvind Mer

Jean-Simon Diallo