Faculty profile

Alexandra Binnie

ResearcherCritical Care MedicineUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Alexandra Binnie

Researcher

Critical Care Medicine

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
11 publications in the last five years, latest in 2026.
Principal investigator on 5 research grants (5 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

1,429

Citations

h-index

191

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Clinical Trials Covid-19 Network Caregiver Health Clinical Presentations & Trajectories Full Spectrum Of Covid-19 Disease (Mild To Severe)Host Genetic Profiling Knowledge To Action Cycles

Latest papers

The spectrum of copy number variation in the Pan-Canadian HostSeq databank.
PloS one · 2026
Clinically significant DNA variation from the GENCOV and HostSeq COVID-19 genome sequencing studies.
Journal of medical genetics · 2026
Prevalence, semiology and neuroimaging of movements in comatose adults at risk of death by neurologic criteria: a prospective cohort study
Critical Care · 2026

All 14 publications

Latest funding

IMPACT-CC: Increasing Meaningful Participation and Access to Critical Care Trials in Community Intensive Care Units
CIHR · 2025 · Principal investigator
$20,000
Multistakeholder Knowledge Dissemination Meeting REVISE: Re-Evaluating the Inhibition of Stress Erosions in the ICU Trial
CIHR · 2024 · Co-investigator
$20,000
The Randomized Embedded Multifactorial Adaptive Platform Trial in Community-Acquired Pneumonia (REMAP-CAP): Enshrining a Global Pandemic Research Response to COVID-19 and Beyond
CIHR · 2022 · Co-investigator
$883,029

All 28 grants and awards

14 publications.

The spectrum of copy number variation in the Pan-Canadian HostSeq databank.

Aujla N, Thiruvahindrapuram B, Casalino S, Frangione E, Mahajan R, Di Iorio D, Fung CYJ, Jayachandran L, MacDonald G, Morgan G, Wolday D, Young J, Arshad M, Clausen M, Arnoldo S, Binnie A, Borgundvaag B, Chowdhary S, Dagher M, Devine L, Friedman SM, Gingras AC, Goneau LW, Khan Z, Lapadula E, Mazzulli T, McGeer A, McLeod S, Mighton C, Pugh TJ, Richardson D, Simpson J, Stern S, Taher A, Strug L, Bombard Y, Faghfoury H, Greenfeld E, CGEn HostSeq Initiative, Scherer SW, Taher J, Noor A, Lerner-Ellis J

PloS one2026

DOI: 10.1371/journal.pone.0359210 PMID: 42789588

Clinically significant DNA variation from the GENCOV and HostSeq COVID-19 genome sequencing studies.

Frangione E, Mahajan R, De Los Rios J, Casalino S, Aujla N, Arnoldo S, Binnie A, Borgundvaag B, Dagher M, Devine L, Faghfoury H, Friedman SM, Fung CYJ, Khan Z, Morgan G, Richardson D, Stern S, Taher A, Taher J, Lerner-Ellis J, GENCOV Study Workgroup, HostSeq Implementation Committee

Journal of medical genetics2026

DOI: 10.1136/jmg-2025-111029 PMID: 41760404

Prevalence, semiology and neuroimaging of movements in comatose adults at risk of death by neurologic criteria: a prospective cohort study

Neves Briard J, English SW, Fergusson DA, Dhanani S, Lauzier F, Turgeon AF, Ball I, Darvesh S, Titova P, Lebrasseur M

Critical Care2026

DOI: 10.1186/s13054-026-06037-2

Findings from comprehensive genome sequencing in the Canadian population: Results from the GENCOV Study

Casalino S, Aujla N, Frangione E, Mahajan R, Di Iorio D, Fung CYJ, Jayachandran L, MacDonald G, Morgan G, Wolday D

Genetics in Medicine Open2026

DOI: 10.1016/j.gimo.2026.104372

Computed Tomography Perfusion and Angiography for Death by Neurologic Criteria

Chassé M, Shankar JJS, Fergusson DA, English SW, Dhanani S, Lauzier F, Turgeon AF, Ball I, Darvesh S, Neves Briard J

JAMA Neurology202510 citations

DOI: 10.1001/jamaneurol.2025.2375

Association of Epigenetic Age and Outcome in Critically Ill Patients.

Sharma-Oates A, Sullivan J, Pestana D, Dos Santos CC, Binnie A, Lord JM

Critical care explorations2024

DOI: 10.1097/cce.0000000000001044 PMID: 38343441

A Genomic Counseling Model for Population-Based Sequencing: A Pre-Post Intervention Study.

Casalino S, Mighton C, Clausen M, Frangione E, Aujla N, MacDonald G, Young J, Fung CYJ, Morgan G, Arnoldo S, Bearss E, Binnie A, Borgundvaag B, Chowdhary S, Dagher M, Devine L, Friedman SM, Hao L, Khan Z, Lane W, Lapadula E, Lebo M, Richardson D, Stern S, Strug L, Taher A, Greenfeld E, Noor A, Faghfoury H, Taher J, Bombard Y, Lerner-Ellis J, GENCOV Study Workgroup

Genetics in medicine : official journal of the American College of Medical Genetics2024

DOI: 10.1016/j.gim.2024.101272 PMID: 39301805

Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation

Iqbal M, Reeve B, Forrest D, Trop S, Reynolds S, Saunders L, Heels-Ansdell D, Marshall J, English S, Ostermann M

New England Journal of Medicine2024108 citations

DOI: 10.1056/nejmoa2404245

Decidual stromal cells for the treatment of severe COVID-19 ARDS

Granton J, Novitzky-Basso IN, Binnie A, Mattsson J

Intensive Care Medicine20231 citations

DOI: 10.1007/s00134-023-07262-x

Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial

Ali K, Azher T, Baqi M, Binnie A, Borgia S, Carrier FM, Cavayas YA, Chagnon N, Cheng MP, Conly J

CANADIAN MEDICAL ASSOCIATION JOURNAL2022173 citations

DOI: 10.1503/cmaj.211698

IMPACT-CC: Increasing Meaningful Participation and Access to Critical Care Trials in Community Intensive Care Units

Principal investigatorCIHR2025Planning and Dissemination Grants - Institute/Initiative Community Support

Principal investigators: Tsang, Jennifer L; Orlando, Elaina; Binnie, Alexandra; O'Grady, Heather

Keywords: Clinical Trials; Community Icu; Critical Care; Equity; Platform Trials; Research Capacity Building

$20,000

Multistakeholder Knowledge Dissemination Meeting REVISE: Re-Evaluating the Inhibition of Stress Erosions in the ICU Trial

Co-investigatorCIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Cook, Deborah J

Keywords: Critical Care; Evidence Based Practice; Gastrointestinal Bleeding; Intensive Care Unit; Knowledge Dissemination; Knowledge Translation; Patient And Family Centered Care; Pharmacists; Stakeholders; Stress Ulcer Prophylaxis

$20,000

The Randomized Embedded Multifactorial Adaptive Platform Trial in Community-Acquired Pneumonia (REMAP-CAP): Enshrining a Global Pandemic Research Response to COVID-19 and Beyond

Co-investigatorCIHR2022Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: Marshall, John C; Dalziel, Sandra; Kho, Michelle E; Lamontagne, Francois; Leligdowicz, Aleksandra; Murthy, Srinivas; Park, Jay; Smith, Kathleen F

Keywords: Acute Organ Dysfunction; Covid-19; Critical Illness; Global Health; Hemodynamic Management; Platform Trial; Research Collaboration; Ventilatory Support

$883,029

Randomized Embedded Multifactorial Adaptive Platform Trial of Community Acquired Pneumonia

Co-investigatorCIHR2022Operating Grant: Clinical Trials Projects-Canadian sites of international trials

Principal investigators: Murthy, Srinivas; Dalziel, Sandra; Kho, Michelle E; Marshall, John C; Park, Jay; Smith, Kathleen F

Keywords: Community Acquired Pneumonia; Critical Care; Randomized Clinical Trial

$2,588,010

Canadian Critical Care Trials Group COVID-19 Response: defining critical care capacity in Canada; testing treatments through large-scale adaptive clinical trials; & establishing the evidence base to inform clinical and health system management decisions

Principal investigatorCIHR2022Operating Grant: CNCCTN Extension - Indirect Costs

Principal investigators: Fowler, Robert A; Adhikari, Neill K; Archambault, Patrick; Bagshaw, Sean M; Binnie, Alexandra; Chasse, Michael; Cook, Deborah J; Daneman, Nick; Fiest, Kirsten M; Fox-Robichaud, Alison E; Goligher, Ewan C; Herridge, Margaret S; Kho, Michelle E; Lamontagne, Francois; Lawler, Patrick R; Lee, Todd C; Marshall, John C; McDonald, Emily G; McNally, James D; Meade, Maureen O; Mehta, Sangeeta; Menon, Kusum; Murthy, Srinivas; O'Hearn, Katharine J; Piquette, Dominique; Rochwerg, Bram N; Russell, James A; Tsang, Jennifer L; Turgeon, Alexis F; Wollny, Krista; Yada, Nicole; Zarychanski, Ryan

Keywords: Clinical Trials; Covid-19; Network

$1,000,000

BALANCE+: A Platform Trial for Gram Negative Bloodstream Infections

Co-investigatorCIHR2022Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: Daneman, Nick; Murthy, Srinivas; Yamamura, Deborah L; Fowler, Robert A; Johnstone, Jennie; Lee, Todd C; MacFadden, Derek R; McDonald, Emily G; Paterson, David L; Rogers, Benjamin A; Yahav, Dafna

Keywords: Adaptive Platform Trial; Antibiotic De-Escalation; Antibiotic Step-Down; Antimicrobial Resistance; Bloodstream Infection; Central Venous Catheter Infection; Gram Negative Bacteremia; Randomized Controlled Trial

$729,947

Stress Ulcer Prophylaxis in the Critically Ill; REVISE Renewal Grant

Co-investigatorCIHR2022Operating Grant: Clinical Trials Projects-Canadian sites of international trials

Principal investigators: Cook, Deborah J

Keywords: Clinically Important Gastrointestinal Bleeding; Clostridioides Difficile; Covid-19; Critical Care; Invasive Mechanical Ventilation; Mortality; Neurological Critical Illness; Pneumonia; Randomized Clinical Trial; Stress Ulcer Prophylaxis

$1,863,000

Driving Pressure-Limited Ventilation in Hypoxemic Respiratory Failure: the DRIVE RCT

Co-investigatorCIHR2022Project Grant - PA: Patient-Oriented Research: Early-Career Investigator

Principal investigators: Goligher, Ewan C; Fan, Eddy; Ferguson, Niall D; Sahetya, Sarina

Keywords: Adaptive Platform Clinical Trial; Hypoxemic Respiratory Failure; Lung-Protective Ventilation

$100,000

The Randomized Embedded Multifactorial Adaptive Platform Trial in Community-Acquired Pneumonia (REMAP-CAP): Enshrining a Global Pandemic Research Response to COVID-19 and Beyond

Co-investigatorCIHR2022Operating Grant: Clinical Trials Projects - CRPPHE

Principal investigators: Marshall, John C; Dalziel, Sandra; Kho, Michelle E; Lamontagne, Francois; Leligdowicz, Aleksandra; Murthy, Srinivas; Park, Jay; Smith, Kathleen F

Keywords: Acute Organ Dysfunction; Covid-19; Critical Illness; Global Health; Hemodynamic Management; Platform Trial; Research Collaboration; Ventilatory Support

$3,532,110

Driving Pressure-Limited Ventilation in Hypoxemic Respiratory Failure: the DRIVE RCT

Co-investigatorCIHR2022Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: Goligher, Ewan C; Fan, Eddy; Ferguson, Niall D; Heath, Anna; Sahetya, Sarina

Keywords: Adaptive Platform Clinical Trial; Hypoxemic Respiratory Failure; Lung-Protective Ventilation

$1,769,585

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Alexandra Binnie

Research

Latest papers

Latest funding

The spectrum of copy number variation in the Pan-Canadian HostSeq databank.

Clinically significant DNA variation from the GENCOV and HostSeq COVID-19 genome sequencing studies.

Prevalence, semiology and neuroimaging of movements in comatose adults at risk of death by neurologic criteria: a prospective cohort study

Findings from comprehensive genome sequencing in the Canadian population: Results from the GENCOV Study

Computed Tomography Perfusion and Angiography for Death by Neurologic Criteria

Association of Epigenetic Age and Outcome in Critically Ill Patients.

A Genomic Counseling Model for Population-Based Sequencing: A Pre-Post Intervention Study.

Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation

Decidual stromal cells for the treatment of severe COVID-19 ARDS

Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial

Frequent collaborators

Jennifer Tsang

Ryan Zarychanski

Ian Ball

Jennifer Taher

Maureen Meade

Karen Burns

Jordan Lerner-Ellis

Abdul Noor

Sangeeta Mehta

Francois Lamontagne

John Marshall

Deborah Cook

Erick Duan

Yvonne Bombard

Shane English

Bram Rochwerg

Francois Lamontagne

Bram Rochwerg

Nick Daneman

Jennifer Tsang

Alexis Turgeon

Francois Lamontagne

Ryan Zarychanski

John Muscedere

Jennifer Tsang

Alexis Turgeon

Shane English

Timothy A Karachi

Tony Mazzulli

Allison McGeer

Daniel Niven

Gloria Vazquez-Grande

Diane Heels-Ansdell

Patrick Archambault

John Muscedere

Jason Weatherald

Ranjani Somayaji

Patricia Fontela

Michael Fralick

Nick Daneman