Faculty profile

Brett Trost

ResearcherUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Brett Trost

Researcher

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
37 publications in the last five years, latest in 2026.
Principal investigator on 2 research grants (2 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

870

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Genomics, Proteomics, And Bioinformatics

Latest papers

An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism.
Nature · 2026
Diagnostic Yield of Comprehensive Reanalysis After Nondiagnostic Short-Read Genome Sequencing in Infants With Unexplained Epilepsy.
Neurology · 2026
Mapping the inter- and intra-genic codon-usage landscape in Homo sapiens.
NAR genomics and bioinformatics · 2026

All 51 publications

Latest funding

Predicting Risk and Outcome in Paediatric Stroke
CIHR · 2025 · Co-investigator
$1,101,600
Combining genome and transcriptome sequencing data to better understand the genetic etiology of Autism Spectrum Disorder
CIHR · 2025 · Nominated PI
Clinical Translation of a Genetic Diagnosis for Mental Health in Autism: Linking Genome Sequencing Data to Health Administrative Data
CIHR · 2023 · Co-investigator
$366,353

All 6 grants and awards

51 publications.

An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism.

Bradley CA, Ko SY, Tian M, Ralph LT, D'Abate L, Lee J, Liu T, Wang J, Tidball P, Mendes M, Fan X, Howe JL, Alexandrova R, Pellecchia G, Casallo G, Paton T, Wybenga-Groot LE, Engchuan W, Thiruvahindrapuram B, Trost B, de Rijke J, Kadia A, Jin F, Salazar NB, Diaz-Mejia JJ, MacDonald JR, Deneault E, Ross PJ, Ellis J, Shum C, Georgiou J, Rennie O, Reuter MS, Hoang N, Sarikaya E, Selvanayagam T, Amini AE, Rutherford A, Rivera-Alfaro N, Marshall CR, Scala M, Runke CK, Kearney HM, Christodoulou J, Francis DI, Chung BHY, Pluciniczak J, Iaboni A, Wigby KM, Nordahl CW, Amaral DG, Hudson ML, Sjaarda CP, Guerin A, Elsabbagh M, Landa R, Mital S, Lesurf R, Jain A, Wilson MD, Ellegood J, Lerch JP, Lee LJ, Frey BJ, Salter MW, Vorstman JAS, Anagnostou E, Frankland PW, Collingridge GL, Scherer SW

Nature2026

DOI: 10.1038/s41586-026-10515-6 PMID: 42129557

Diagnostic Yield of Comprehensive Reanalysis After Nondiagnostic Short-Read Genome Sequencing in Infants With Unexplained Epilepsy.

Nguyen JNH, Lachgar-Ruiz M, Higginbotham EJ, Coleman M, Coleman J, Shao W, Scotchman E, Pritchard AJ, Bell KM, Chitty LS, Christodoulou J, De Fazio P, Deshwar AR, Eltze C, Griffiths AJS, Hassell J, Jain P, Kaliakatsos M, Liang NSY, Lombard P, Marshall CR, Marx C, McRae L, Mulhern S, Paternoster B, Perez Caballero A, Pipko N, Sidhu J, Smith L, Stark Z, Trost B, Wakeling E, White SM, Yoong M, Gene-STEPS Study Group, IPCHiP Executive Committee,, Chandler NJ, Cross JH, Scheffer IE, Chau V, Poduri A, Howell KB, Stephenson SEM, McTague A, Costain G, D'Gama AM

Neurology2026

DOI: 10.1212/wnl.0000000000214645 PMID: 41687048

Mapping the inter- and intra-genic codon-usage landscape in Homo sapiens.

Arshad M, Uchmanowicz M, Rana V, Trost B, Scherer SW, Rafiq MA

NAR genomics and bioinformatics2026

DOI: 10.1093/nargab/lqag024 PMID: 41782895

Autism data sharing: Benefits, challenges, and recommendations.

Lautarescu A, Trost B, Kushki A, Oakley B, Heraty S, Belton D, Boyle A, Douglas S, Molloy CJ, Holt R, Bloomfield M, Campana F, Cupak M, Stevenson E, Tillmann J, Chatham C, Anagnostou E, Hartley D, Charman T

PLOS digital health2026

DOI: 10.1371/journal.pdig.0001249 PMID: 41770754

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms.

Xu N, Rynard KM, Radley E, Tian A, Arshad M, Long C, Ly J, Luo H, Hogan E, Fafouti ME, Davie M, Naimi F, Li Y, Calarco JA, Trost B, Muffat J, Lee HO, Lipshitz HD, Smibert CA, Tripathy SJ

Nature communications2026

DOI: 10.1038/s41467-026-76675-1 PMID: 42680762

Characterizing features of the genetic architecture underlying autism from a multi-ancestry perspective.

Mendes M, Xu CY, Engchuan W, Trost B, Zhou X, Miwa BA, Salazar NB, Iglar J, Thiruvahindrapuram B, Wallich L, de Paiva TH, Tarazona-Santos E, Fernandez B, Borda V, Scherer SW

Molecular psychiatry2026

DOI: 10.1038/s41380-026-03886-9 PMID: 42728317

Genetic variants in DDX53 contribute to autism spectrum disorder associated with the Xp22.11 locus.

Scala M, Bradley CA, Howe JL, Trost B, Salazar NB, Shum C, Mendes M, Reuter MS, Anagnostou E, MacDonald JR, Ko SY, Frankland PW, Charlebois J, Elsabbagh M, Granger L, Anadiotis G, Pullano V, Brusco A, Keller R, Parisotto S, Pedro HF, Lusk L, McDonnell PP, Helbig I, Mullegama SV, Undiagnosed Diseases Network, Douine ED, Corona RI, Russell BE, Nelson SF, Graziano C, Schwab M, Simone L, Zara F, Scherer SW

American journal of human genetics2025

DOI: 10.1016/j.ajhg.2024.11.003 PMID: 39706195

Chromosome X-wide common variant association study in autism spectrum disorder.

Mendes M, Chen DZ, Engchuan W, Leal TP, Thiruvahindrapuram B, Trost B, Howe JL, Pellecchia G, Nalpathamkalam T, Alexandrova R, Salazar NB, McKee EA, Rivera-Alfaro N, Lai MC, Bandres-Ciga S, Roshandel D, Bradley CA, Anagnostou E, Sun L, Scherer SW

American journal of human genetics2025

DOI: 10.1016/j.ajhg.2024.11.008 PMID: 39706197

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms.

Xu N, Rynard KM, Radley E, Tian A, Arshad M, Long C, Ly J, Luo H, Hogan E, Fafouti ME, Davie M, Naimi F, Li Y, Calarco JA, Trost B, Muffat J, Lee HO, Lipshitz HD, Smibert CA, Tripathy SJ

bioRxiv : the preprint server for biology2025

DOI: 10.64898/2025.12.16.693263 PMID: 41446062

UBR5 loss-of-function variants in autism spectrum disorder and intellectual disability: case series and review of the literature.

Reuter MS, Salazar NB, Howe JL, Hoang N, Sarikaya E, Selvanayagam T, Mendes de Aquino M, Vicente AM, Oliveira G, Freitag CM, Thiruvahindrapuram B, Trost B, Scherer SW

NPJ genomic medicine2025

DOI: 10.1038/s41525-025-00536-x PMID: 41318701

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Brett Trost

Research

Latest papers

Latest funding

An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism.

Diagnostic Yield of Comprehensive Reanalysis After Nondiagnostic Short-Read Genome Sequencing in Infants With Unexplained Epilepsy.

Mapping the inter- and intra-genic codon-usage landscape in Homo sapiens.

Autism data sharing: Benefits, challenges, and recommendations.

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms.

Characterizing features of the genetic architecture underlying autism from a multi-ancestry perspective.

Genetic variants in DDX53 contribute to autism spectrum disorder associated with the Xp22.11 locus.

Chromosome X-wide common variant association study in autism spectrum disorder.

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms.

UBR5 loss-of-function variants in autism spectrum disorder and intellectual disability: case series and review of the literature.

Predicting Risk and Outcome in Paediatric Stroke

Combining genome and transcriptome sequencing data to better understand the genetic etiology of Autism Spectrum Disorder

Clinical Translation of a Genetic Diagnosis for Mental Health in Autism: Linking Genome Sequencing Data to Health Administrative Data

Chasing stochastics, a multidisciplinary approach to develop genetic models predicting the likelihood of stochastic events.

Examining the correlates of adaptive functioning in neurodevelopmental conditions: data from the Province of Ontario Neurodevelopmental Network

68th Lindau Nobel Laureate Meeting Travel Award Recipient

Frequent collaborators

Evdokia Anagnostou

Gregory Costain

Stelios Georgiades

Mayada Elsabbagh

Jacob Vorstman

Jennifer Crosbie

Peter Szatmari

Peter Szatmari

Elizabeth Kelley

Rosanna Weksberg

Azadeh Kushki

Lonnie Zwaigenbaum

Yun Li

Jessica Brian

Julien Muffat

Padmaja Subbarao

Seema Mital

James Ellis

Meng-Chuan Lai

Lei Sun

Padmaja Subbarao

Russell Schachar

Yi Lu

Eriskay Liston

Julia Orkin

Nomazulu Dlamini

Piush Mandhane

Xiao-Yan Wen

Paul Arnold

Paul Arnold

Maja Tarailo-Graovac

Ronit Mesterman

Eyal Cohen