Faculty profile

Xiao-Yan Wen

ResearcherMedicineUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Xiao-Yan Wen

Researcher

Medicine

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
1 publication in the last five years, latest in 2025.
Principal investigator on 2 research grants (1 CIHR, 1 NSERC), most recently in 2020.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Ards Coronavirus Drug Development High Throughput Screen Mortality Mouse Sepsis Therapeutics

Latest papers

Phenotypic screening in influenza-infected zebrafish identifies Nrf2-mediated compound protective against ischemia-reperfusion injury.
iScience · 2025
Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox.
PloS one · 2021
Zebrafish hhatla is involved in cardiac hypertrophy.
Journal of cellular physiology · 2021 · senior author

All 50 publications

Latest funding

Therapeutic Development for COVID-19 Coronavirus Induced Sepsis and ARDS Targeting Vascular Leakage
CIHR · 2020 · Nominated PI
$953,819
Mutagenic Gene Trapping to Study Novel Genes in Zebrafish Cardiovascular Development
NSERC · 2014 · Principal investigator
$205,000
Mechanisms of human neutrophil peptides in lung inflammation
CIHR · 2011 · Co-investigator
$806,879

All 3 grants and awards

50 publications.

Phenotypic screening in influenza-infected zebrafish identifies Nrf2-mediated compound protective against ischemia-reperfusion injury.

Latreille E, Mukkala AN, Sanwal R, Yun J, Wei K, Petrut R, Farahani NZ, Philip T, Xu L, Bateman T, Pan C, Williams DE, Moraes T, Wen XY, Rotstein O, Andersen RJ, Lee WL

iScience2025

DOI: 10.1016/j.isci.2025.113065 PMID: 40734676

Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox.

Guan R, Wen XY, Leung CH, Ciano-Oliveira CD, Lam S, Dai SY, Karbassi F, Mauro A, Wang Y, Rotstein O

PloS one2021

DOI: 10.1371/journal.pone.0260442 PMID: 34818339

Zebrafish hhatla is involved in cardiac hypertrophy.

Shi X, Zhang Y, Gong Y, Chen M, Brand-Arzamendi K, Liu X, Wen XY

Journal of cellular physiology2021Senior author

DOI: 10.1002/jcp.30106 PMID: 33052609

HACS1 signaling adaptor protein recognizes a motif in the paired immunoglobulin receptor B cytoplasmic domain.

Kwan JJ, Slavkovic S, Piazza M, Wang D, Dieckmann T, Johnson PE, Wen XY, Donaldson LW

Communications biology2020

DOI: 10.1038/s42003-020-01397-z PMID: 33188360

ndufa7 plays a critical role in cardiac hypertrophy.

Shi X, Zhang Y, Chen R, Gong Y, Zhang M, Guan R, Rotstein OD, Liu X, Wen XY

Journal of cellular and molecular medicine2020Senior author

DOI: 10.1111/jcmm.15921 PMID: 32989924

Building the vertebrate codex using the gene breaking protein trap library.

Ichino N, Serres MR, Urban RM, Urban MD, Treichel AJ, Schaefbauer KJ, Tallant LE, Varshney GK, Skuster KJ, McNulty MS, Daby CL, Wang Y, Liao HK, El-Rass S, Ding Y, Liu W, Anderson JL, Wishman MD, Sabharwal A, Schimmenti LA, Sivasubbu S, Balciunas D, Hammerschmidt M, Farber SA, Wen XY, Xu X, McGrail M, Essner JJ, Burgess SM, Clark KJ, Ekker SC

eLife2020

DOI: 10.7554/elife.54572 PMID: 32779569

The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms.

Boycott KM, Campeau PM, Howley HE, Pavlidis P, Rogic S, Oriel C, Berman JN, Hamilton RM, Hicks GG, Lipshitz HD, Masson JY, Shoubridge EA, Junker A, Leroux MR, McMaster CR, Michaud JL, Turvey SE, Dyment D, Innes AM, van Karnebeek CD, Lehman A, Cohn RD, MacDonald IM, Rachubinski RA, Frosk P, Vandersteen A, Wozniak RW, Pena IA, Wen XY, Lacaze-Masmonteil T, Rankin C, Hieter P

American journal of human genetics2020

DOI: 10.1016/j.ajhg.2020.01.009 PMID: 32032513

Protocol development for discovery of angiogenesis inhibitors via automated methods using zebrafish.

Mauro A, Ng R, Li JY, Guan R, Wang Y, Singh KK, Wen XY

PloS one2019Senior author

DOI: 10.1371/journal.pone.0221796 PMID: 31730619

Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy.

van Karnebeek CDM, Ramos RJ, Wen XY, Tarailo-Graovac M, Gleeson JG, Skrypnyk C, Brand-Arzamendi K, Karbassi F, Issa MY, van der Lee R, Drögemöller BI, Koster J, Rousseau J, Campeau PM, Wang Y, Cao F, Li M, Ruiter J, Ciapaite J, Kluijtmans LAJ, Willemsen MAAP, Jans JJ, Ross CJ, Wintjes LT, Rodenburg RJ, Huigen MCDG, Jia Z, Waterham HR, Wasserman WW, Wanders RJA, Verhoeven-Duif NM, Zaki MS, Wevers RA

American journal of human genetics2019

DOI: 10.1016/j.ajhg.2019.07.015 PMID: 31422819

In Vitro Validation of a CRISPR-Mediated CFTR Correction Strategy for Preclinical Translation in Pigs.

Zhou ZP, Yang LL, Cao H, Chen ZR, Zhang Y, Wen XY, Hu J

Human gene therapy2019

DOI: 10.1089/hum.2019.074 PMID: 31099266

Something wrong or missing on this profile? Suggest a correction

Xiao-Yan Wen

Research

Latest papers

Latest funding

Phenotypic screening in influenza-infected zebrafish identifies Nrf2-mediated compound protective against ischemia-reperfusion injury.

Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox.

Zebrafish hhatla is involved in cardiac hypertrophy.

HACS1 signaling adaptor protein recognizes a motif in the paired immunoglobulin receptor B cytoplasmic domain.

ndufa7 plays a critical role in cardiac hypertrophy.

Building the vertebrate codex using the gene breaking protein trap library.

The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms.

Protocol development for discovery of angiogenesis inhibitors via automated methods using zebrafish.

Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy.

In Vitro Validation of a CRISPR-Mediated CFTR Correction Strategy for Preclinical Translation in Pigs.

Therapeutic Development for COVID-19 Coronavirus Induced Sepsis and ARDS Targeting Vascular Leakage

Mutagenic Gene Trapping to Study Novel Genes in Zebrafish Cardiovascular Development

Mechanisms of human neutrophil peptides in lung inflammation

Frequent collaborators

Armand Keating

Ori Rotstein

Haibo Zhang

Maja Tarailo-Graovac

Mingyao Liu

Jim Hu

Pierre Drapeau

Anthony Gramolini

Zhengping Jia

Marc Ekker

Cecil Pace-Asciak

Ren-Ke Li

Brian Cox

Chun Peng

Arthur Slutsky

Paul Pavlidis

Jean-Pierre Julien

Philip Hieter

Peng Huang

Lawrence Korngut

Tammie Dewan