Hannes Rost, University of Toronto

Research

Mass Spectrometry Cancer Research Metabolism Diabetes Metabolomics Method Development Personalized Medicine Systems Medicine

Latest papers

Early Postpartum Glucose Tolerance Reclassification by Gestational Diabetes Subtype.
JAMA network open · 2025
Postpartum defects in inflammatory response after gestational diabetes precede progression to type 2 diabetes: a nested case-control study within the SWIFT study.
Metabolism: clinical and experimental · 2023
Heterogeneity in Early Postpartum Metabolic Profiles Among Women with GDM Who Progressed to Type 2 Diabetes During 10-Year Follow-Up: The SWIFT Study.
medRxiv : the preprint server for health sciences · 2023

All 5 publications

Latest funding

A multi-omic approach to characterize gestational diabetes mellitus for predicting patient diagnosis at pregnancy onset and future transition to type II diabetes
CIHR · 2023 · Supervisor
$105,000
Canada Research Chair - Tier 2
CIHR · 2023 · Nominated PI
$500,000
Targeting the metabolomic mechanisms underlying poor prognosis in Glioblastoma multiforme cancer stem cells.
CIHR · 2023 · Nominated PI
$990,676

All 10 grants and awards

5 publications.

01

Early Postpartum Glucose Tolerance Reclassification by Gestational Diabetes Subtype.

Van JAD, Lo JC, Zhu Y, King AS, Sun B, Hashimoto-Roth E, Rost H, Alexeeff S, Wheeler MB, Gunderson EP

JAMA network open2025

DOI: 10.1001/jamanetworkopen.2025.42668 PMID: 41212558

02

Postpartum defects in inflammatory response after gestational diabetes precede progression to type 2 diabetes: a nested case-control study within the SWIFT study.

Van JAD, Luo Y, Danska JS, Dai F, Alexeeff SE, Gunderson EP, Rost H, Wheeler MB

Metabolism: clinical and experimental2023

DOI: 10.1016/j.metabol.2023.155695 PMID: 37802200

03

Heterogeneity in Early Postpartum Metabolic Profiles Among Women with GDM Who Progressed to Type 2 Diabetes During 10-Year Follow-Up: The SWIFT Study.

Khan SR, Rost H, Cox B, Razani B, Alexeeff S, Wheeler MB, Gunderson EP

medRxiv : the preprint server for health sciences2023

DOI: 10.1101/2023.06.13.23291346 PMID: 37398098

04

Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK.

Tan C, Ginzberg MB, Webster R, Iyengar S, Liu S, Papadopoli D, Concannon J, Wang Y, Auld DS, Jenkins JL, Rost H, Topisirovic I, Hilfinger A, Derry WB, Patel N, Kafri R

Developmental cell2021

DOI: 10.1016/j.devcel.2021.04.030 PMID: 34022133

05

Longitudinal multi-omics of host-microbe dynamics in prediabetes.

Zhou W, Sailani MR, Contrepois K, Zhou Y, Ahadi S, Leopold SR, Zhang MJ, Rao V, Avina M, Mishra T, Johnson J, Lee-McMullen B, Chen S, Metwally AA, Tran TDB, Nguyen H, Zhou X, Albright B, Hong BY, Petersen L, Bautista E, Hanson B, Chen L, Spakowicz D, Bahmani A, Salins D, Leopold B, Ashland M, Dagan-Rosenfeld O, Rego S, Limcaoco P, Colbert E, Allister C, Perelman D, Craig C, Wei E, Chaib H, Hornburg D, Dunn J, Liang L, Rose SMS, Kukurba K, Piening B, Rost H, Tse D, McLaughlin T, Sodergren E, Weinstock GM, Snyder M

Nature2019

DOI: 10.1038/s41586-019-1236-x PMID: 31142858

A multi-omic approach to characterize gestational diabetes mellitus for predicting patient diagnosis at pregnancy onset and future transition to type II diabetes

SupervisorCIHR2023Doctoral Research Award - PA - Bioinformatics and Computational Biology

Principal investigators: Hashimoto-Roth, Emily

Keywords: Biological Mechanisms; Biomarker Discovery; Computational Biology; Gestational Diabetes Mellitus; Insulin Resistance; Lipidomics; Machine Learning; Mass Spectrometry; Metabolomics; Proteomics

$105,000

Canada Research Chair - Tier 2

Nominated PICIHR2023Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Rost, Hannes L

Keywords: Cr

$500,000

Targeting the metabolomic mechanisms underlying poor prognosis in Glioblastoma multiforme cancer stem cells.

Nominated PICIHR2023Project Grant

Principal investigators: Rost, Hannes L

Keywords: Cancer Research; Mass Spectrometry; Metabolism

$990,676

Understanding the metabolic underpinnings of future Type 2 Diabetes in women with a history of Gestational Diabetes: Disrupting the gluco-centric view of risk assessment and disease development.

Co-investigatorCIHR2021Project Grant

Principal investigators: Wheeler, Michael B

Keywords: Beta Cell Biology; Biomarkers; Diabetes Mellitus; Diabetes Risk Assessment; Gestational Diabetes; Human Diabetes Prospective Cohorts; Islet Biology; Knockout Mice; Metabolism

$960,075

Using trapped ion mobility to synchronize ions in data-independent acquisition (DIA) mass spectrometry

Principal investigatorNSERC2019Discovery Launch Supplement

Principal investigators: Rost, Hannes

$12,500

Using trapped ion mobility to synchronize ions in data-independent acquisition (DIA) mass spectrometry

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Rost, Hannes

$170,000

A novel approach for personalized metabolomics profiling using DIA mass spectrometry

Nominated PICIHR2019Project Grant

Principal investigators: Rost, Hannes L

Keywords: Diabetes; Mass Spectrometry; Metabolomics; Method Development; Personalized Medicine; Systems Medicine

$921,826

Integrative Personal Omics Profiles in Glioblastoma Recurrence and Therapy Resistance

Nominated PICIHR2018Team Grant: ERA-Net PerMed

Principal investigators: Rost, Hannes L

Keywords: Glioblastoma; Next Generation Sequencing; Proteomics; Recurrence; Stratification

$449,500

Canada Research Chair Tier 2

Nominated PICIHR2018Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Rost, Hannes L

Keywords: Crc

$500,000

Early detection of cancer using machine learning and mass spectrometry-based metabolomics

Principal investigatorSSHRC2018New Frontiers in Research Fund

Principal investigators: Rost, Hannes

Keywords: mass spectrometry, cancer, machine learning, metabolomics, precision medicine, bioinformatics

$273,310

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Donnelly Centre
Department of Physiology
Lady Davis Institute for Medical Research
Cell Biology
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Ivan Topisirovic

Faculty

1 shared papers, latest 2021

Brian Cox

Department of Physiology

1 shared papers, latest 2023

Ran Kafri

Cell Biology

1 shared papers, latest 2021

Ivan Topisirovic

Lady Davis Institute for Medical Research

1 shared papers, latest 2021

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Mass Spectrometry Dear Professor Rost, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Early Postpartum Glucose Tolerance Reclassification by Gestational Diabetes Subtype." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Canada Research Chair - Tier 2" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]