Faculty profile

Ivan Topisirovic

ResearcherUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses and email address may be missing. Find their university profile.

Ivan Topisirovic

Researcher

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
18 publications in the last five years, latest in 2026.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 1 research grant (1 CIHR), most recently in 2018.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

5,052

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Cellular Senescence Dna Damage Epigenetics Healthspan Inflammation Mrna Translation Organismal Aging Progeroid Syndromes

Latest papers

The Emerging Role of mTOR in Shaping the Cancer Cell Secretome and Plasticity.
Molecular and cellular biology · 2026
A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.
bioRxiv : the preprint server for biology · 2026
R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity.
Nucleic acids research · 2025

All 77 publications

Latest funding

Exploiting translational reprogramming in neoplasia to devise unique strategies to eliminate cancer and cancer-promoting senescent cells
CIHR · 2024 · Co-investigator
$940,950
Exploiting translational reprogramming in neoplasia to devise unique strategies to eliminate cancer and cancer-promoting senescent cells
CIHR · 2023 · Co-investigator
$100,000
Cholesterol metabolism and regulation of the senescence-associated secretory phenotype in retinopathy
CIHR · 2020 · Co-investigator
$868,276

All 5 grants and awards

77 publications.

The Emerging Role of mTOR in Shaping the Cancer Cell Secretome and Plasticity.

Cooper TT, Topisirovic I, Postovit LM

Molecular and cellular biology2026

DOI: 10.1080/10985549.2026.2699146 PMID: 42446400

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Coulombe-Huntington J, Bertomeu T, Huard C, Chatr-Aryamontri A, St-Cyr DJ, Sánchez-Osuna M, Papadopoli D, Normandin K, Paydar M, McLaughlan S, St-Denis C, Zhang L, Say H, Palou R, Stark C, Breitkreutz BJ, van der Sloot AM, Manohar S, Lavoie H, Borden KLB, Raught B, D'Amours D, Sicheri F, Verreault A, Mader S, Meloche S, Therrien M, Thibault P, Wilhelm B, Dirks PB, Aitchison JD, Patton E, King RW, Roux PP, Sauvageau G, Hoang T, Marinier A, Harrington L, Kwok B, Archambault V, Topisirovic I, Tyers M

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.01.28.701823 PMID: 41659671

R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity.

Couteau F, Gagné LM, Boulay K, Rousseau P, Carbonneau M, McQuaid M, Sharma J, Sawchyn C, Fernandez E, Glatz D, Rizk R, Lalonde ME, Mehrjoo Y, Chu TW, Moquin-Beaudry G, Beauséjour C, Sergeev M, Costantino S, Avizonis D, Topisirovic I, Jabado N, Wurtele H, Autexier C, Mallette FA

Nucleic acids research2025

DOI: 10.1093/nar/gkaf512 PMID: 40498073

Plasticity of the mammalian integrated stress response.

Chen CW, Papadopoli D, Szkop KJ, Guan BJ, Alzahrani M, Wu J, Jobava R, Asraf MM, Krokowski D, Vourekas A, Merrick WC, Komar AA, Koromilas AE, Gorospe M, Payea MJ, Wang F, Clayton BLL, Tesar PJ, Schaffer A, Miron A, Bederman I, Jankowsky E, Vogel C, Valášek LS, Dinman JD, Zhang Y, Tirosh B, Larsson O, Topisirovic I, Hatzoglou M

Nature2025

DOI: 10.1038/s41586-025-08794-6 PMID: 40140574

7SL RNA and signal recognition particle orchestrate a global cellular response to acute thermal stress.

Bujisic B, Lee HG, Xu L, Weissbein U, Rivera C, Topisirovic I, Lee JT

Nature communications2025

DOI: 10.1038/s41467-025-56351-6 PMID: 39952919

Corrigendum: Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex.

Feng Y, Grotegut S, Jovanovic P, Gandin V, Olson SH, Murad R, Beall A, Colayco S, De-Jesus P, Chanda S, English BP, Singer RH, Jackson M, Topisirovic I, Ronai ZA

Frontiers in pharmacology2024

DOI: 10.3389/fphar.2024.1528449 PMID: 39749209

SMYD5 methylation of rpL40 links ribosomal output to gastric cancer.

Park J, Wu J, Szkop KJ, Jeong J, Jovanovic P, Husmann D, Flores NM, Francis JW, Chen YC, Benitez AM, Zahn E, Song S, Ajani JA, Wang L, Singh K, Larsson O, Garcia BA, Topisirovic I, Gozani O, Mazur PK

Nature2024

DOI: 10.1038/s41586-024-07718-0 PMID: 39048817

ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis.

El Bakkouri Y, Chidiac R, Delisle C, Corriveau J, Cagnone G, Gaonac'h-Lovejoy V, Chin A, Lécuyer É, Angers S, Joyal JS, Topisirovic I, Hulea L, Dubrac A, Gratton JP

Nature communications2024

DOI: 10.1038/s41467-024-48852-7 PMID: 38782923

MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors.

Kim H, Lebeau B, Papadopoli D, Jovanovic P, Russo M, Avizonis D, Morita M, Afzali F, Ursini-Siegel J, Postovit LM, Witcher M, Topisirovic I

iScience2024Senior author

DOI: 10.1016/j.isci.2024.109188 PMID: 38433910

A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer.

Cencic R, Im YK, Naineni SK, Moustafa-Kamal M, Jovanovic P, Sabourin V, Annis MG, Robert F, Schmeing TM, Koromilas A, Paquet M, Teodoro JG, Huang S, Siegel PM, Topisirovic I, Ursini-Siegel J, Pelletier J

Proceedings of the National Academy of Sciences of the United States of America2024

DOI: 10.1073/pnas.2318093121 PMID: 38232291

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Ivan Topisirovic

Research

Latest papers

Latest funding

The Emerging Role of mTOR in Shaping the Cancer Cell Secretome and Plasticity.

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity.

Plasticity of the mammalian integrated stress response.

7SL RNA and signal recognition particle orchestrate a global cellular response to acute thermal stress.

Corrigendum: Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex.

SMYD5 methylation of rpL40 links ribosomal output to gastric cancer.

ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis.

MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors.

A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer.

Exploiting translational reprogramming in neoplasia to devise unique strategies to eliminate cancer and cancer-promoting senescent cells

Exploiting translational reprogramming in neoplasia to devise unique strategies to eliminate cancer and cancer-promoting senescent cells

Cholesterol metabolism and regulation of the senescence-associated secretory phenotype in retinopathy

Cholesterol metabolism and regulation of the senescence-associated secretory phenotype in retinopathy

Establishing a new class of senolytics to treat age-related pathologies and extending lifespan

Frequent collaborators

Ivan Topisirovic

Nahum Sonenberg

Laura Hulea

Julie St-Pierre

Michael Pollak

Simon-Pierre Gravel

Jerry Pelletier

Julie St-Pierre

Lynne-Marie Postovit

Lynne-Marie Postovit

Michael Witcher

Sylvain Meloche

Pierre Thibault

Martin Olivier

Stephane Angers

Arnim Pause

Antonis Koromilas

Shawn McGuirk

Martin Olivier

Sonia Del Rincon

Xi-Long Zheng

Peter Metrakos

Alexandre Dubrac

Morag Park

Gerardo Ferbeyre

Urban Emmenegger

William Muller

Rongtuan Lin

Michael Ohh

Mitsuhiko Ikura

Celia Greenwood

Gerardo Ferbeyre